Elderly Community Population Research Articles

Genetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population

In the present study, we investigated the association of genetic predisposition with specific dimensions of dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study, comprising 512 cognitively normal individuals over 64 years of age, with a mean follow-up of 2.9 years. Cognitive function was evaluated through a neuropsychological test battery, while genetic predisposition was assessed based on two distinct Polygenic Risk Scores (PRS) for amyloid-beta 42 (Aβ42) and white matter hyperintensities (WMH). The association of each PRS with the cognitive decline rate was examined using generalized estimating equation models. In the whole sample, higher PRSs Aβ42 (β = −0.042) and WMH (β =−0.029) were associated with a higher rate of global cognitive decline per year, an association which remained significant in age, sex, and education subgroups. Moreover, higher PRSs Aβ42 and WMH were related to significant memory decline only in females, older, and highly educated participants. Thus, while the association of both PRSs with global cognitive decline over time was independent of age, sex, or education, the relationship of the specific PRSs with the memory decline rate appeared to vary depending on these factors.

Construction and comparative analysis of an early screening prediction model for fatty liver in elderly patients based on machine learning

Objective: To construct a prediction model for fatty liver disease (FLD) among elderly residents in community using machine learning (ML) algorithms and evaluate its effectiveness. Methods: The physical examination data of 4989 elderly people (aged over 60 years) in a street of Shanghai from 2019 to 2023 were collected. The subjects were divided into a training set and a testing set in a 7:3 ratio. Using feature selection and importance sorting methods, eight indicators were selected, including high-density lipoprotein cholesterol, body mass index, uric acid, triglycerides, albumin, red blood cell, white blood cell, and alanine aminotransferase. Six ML models, including Categorical Features Gradient Boosting, eXtreme Gradient Boosting, Light Gradient Boosting Machine, Random Forest, Decision Tree, and Logistic Regression, were constricted, and their predictive performances were compared via accuracy, precision, recall, F1 score, and Area Under Receiver Operating Characteristic Curve. Results: Among the six ML models, the Categorical Features Gradient Boosting model demonstrated the highest prediction accuracy of 0.74 for FLD in elderly community population, along with a precision of 0.70, a recall of 0.73, a F1 score of 0.71, and an area under the curve of 0.74. Conclusions: In the context of rapid development of artificial intelligence, a community-based elderly FLD prediction model constructed using ML algorithms aid family general practitioners in the early diagnosis, early treatment, and health management of local FLD patients.

Prospective association of general anesthesia with risk of cognitive decline in a Chinese elderly community population

As life expectancy increases and the population grows, the number of surgeries performed each year is likely to continue to increase. We evaluated whether surgery with general anesthesia increases risk for cognitive impairment in a Chinese elderly community population. The current data was obtained from the China Longitudinal Aging Study (cohort 1) and Shanghai Brain Aging study (cohort 2). Cohort 1 included 1545 elderly people with normal cognitive function, who underwent a screening process that included physical examination, medical history, baseline and 1-year follow-up assessments of cognitive function by a face-to-face interview. Cohort 2 included an additional 194 elderly people with normal cognitive function, all of whom, unlike cohort 1, underwent T1-phase MR imaging scans. In cohort 1, 127 elderly people with normal cognitive function transformed into mild cognitive impairment, 27 into dementia, while 1391 still maintained normal cognitive function. By using Cox regression analysis, we found that surgery with general anesthesia was a risk factor for cognitive impairment (p = 0.013, HR = 1.506, 95% CI 1.091–2.078); In cohort 2, we found that elderly people with a history of surgery with general anesthesia had lower Montreal Cognitive Assessment (MoCA) scores and smaller right amygdala volume (p < 0.05). Through correlation analysis, we found that the volume of the right amygdala was significantly correlated (p = 0.003, r = 0.212) with MoCA. Then by using the linear regression analysis (mediation model), we found that surgery with general anesthesia directly affected the MoCA score by affecting the volume of the right amygdala (B = 1.315, p = 0.036 95% CI 0.088–2.542). We confirm surgery with general anesthesia as a risk factor for cognitive impairment, and its mechanism may be related to its effect on the volume of the right amygdala.

Effects of ankle-brachial index and brachial-ankle pulse wave velocity on all-cause mortality in a community-based elderly population.

BackgroundAnkle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are both important indicators of arterial stiffness and vascular injury. At present, most studies on the relationship between ABI and baPWV and all-cause mortality in community-based elderly are analyzing ABI or baPWV alone, and will focus on a single special population such as diabetes and stroke. The purpose of this study was to evaluate the relationship between ABI and baPWV in a Chinese community-based elderly population, and to analyze their impact on all-cause mortality in a community-based population through a follow-up of nearly 10 years.MethodsParticipants were residents of the Wanshou Road community in Beijing, China. A total of 2,162 people in the community were included, with an average age of 71.48 years. During a mean follow-up period of 9.87 years, 1,826 subjects completed follow-up. Kaplan-Meier survival analysis and different Cox regression models were used to verify the association of ABI and baPWV with all-cause mortality. The selected subjects were divided into two groups according to ABI and baPWV, and ABI was divided into two groups with 0.90 as the cut-off point (group 1: 0.9 < ABI ≤ 1.3; group 2: ABI ≤ 0.9); according to the level of baPWV, they were divided into three groups (Tertile 1: baPWV <1761.5 cm/s; Tertile 2: 1761.5 ≤ baPWV <2121.5 cm/s; Tertile 3: baPWV ≥2121.5 cm/s).Results1,826 people were included in the statistical analysis, and the total mortality rate was 181.3/1000. The 10-year all-cause mortality rate of the abnormal ABI group (group 2) was 44.7%, and that of the normal ABI group (group 1) was 17.0%; The 10-year all-cause mortality rates from low to high in the baPWV tertile were 10.0%, 18.7%, and 26.4%. In the Cox proportional hazards model, after adjusting for possible confounders, the effect of baPWV on all-cause mortality was significant, with the 3rd tertile having a 1.647-fold higher risk of all-cause mortality than the 1st tertile (P = 0.014 ).ConclusionsABI and baPWV are risk factors affecting all-cause mortality in the elderly community population, and baPWV is an independent predictor of all-cause mortality in the elderly community population.

Self-Efficacy, Exercise Anticipation and Physical Activity in Elderly: Using Bayesian Networks to Elucidate Complex Relationships.

AimTo explore the correlation of exercise anticipation, self-efficacy and lower limb function in the elderly, and identify active predictors of exercise. The time up and go (TUG) has been used to access basic mobility skills, as well as strength, balance and agility, which is used in a range of population.MethodsA cross-sectional survey approach was employed in this study, assessing the functional relationship of the level of exercise anticipation, modified gait efficacy scale (mGES), self-efficacy for exercise scale (SEE), perceived efficacy of patient–physician interactions (PEPPI-10), behavioral regulation in exercise questionnaire (BREQ), and the time up and go (TUG) and International Physical Activity Questionnaire (IPAQ). Consequently, we constructed the Bayesian network model utilizing Genie 2.3, in order to effectively determine clear negative and positive correlations.ResultsThis investigation incorporated a total of 285 patients. The results of Spearman's correlation analysis indicated that the TUG effectively correlated with age (r = 0.158, P < 0.01), drinking (r=−0.362, P < 0.01), mGES (r=−0.254, P < 0.01), PEPPI (r=−0.329, P < 0.01), SEE (r =−0.408, P < 0.01), BREQ (r = 0.676, P < 0.01), EA (r =−0.688, P < 0.01) and IPAQ (r =−0.742, P < 0.01). TUG can be used as the direct influencing factor of IPA, and five nodes in the model can be considered the primary indirect influencing factors of TUG, such as drinking, EA, age, sex and mGES in Bayesian network. The sensitivity analysis of the model confirmed that TUG (0.059), drinking (0.087), EA (0.335), age (0.080), sex (0.164), mGES (0.028) and hypertension (0.030) can become the sensitivity evaluation indicators of IPAQ in the elderly community population, in which the area under the ROC curve (AUC) was 59.6% (2207/3705), indicating a suitable prediction performance.ConclusionExercise anticipation and life behavior habit can effectively predict physical activity capability in the elderly. These findings can help clinicians establish effective intervention to improve the physical activity regularly of the elderly.

The Effects of Smartphone Usage Levels, Health Literacy, and Self-Efficacy on Self-Care Agency in an Elderly Community Population

The Effects of Smartphone Usage Levels, Health Literacy, and Self-Efficacy on Self-Care Agency in an Elderly Community Population

Population differences of metabolic associated fatty liver disease and nonalcoholic fatty liver disease based on a community elderly population

Population differences of metabolic associated fatty liver disease and nonalcoholic fatty liver disease based on a community elderly population

Hyperhomocysteinemia Increases Risk of Metabolic Syndrome and Cardiovascular Death in an Elderly Chinese Community Population of a 7-Year Follow-Up Study.

BackgroundHyperhomocysteinemia (HHcy) and abdominal obesity are risk factors for metabolic syndrome (MetS) and death from cardiovascular disease (CVD). Recent studies have shown a correlation between HHcy and abdominal obesity, suggesting that they may have a combined effect on the risk of MetS and CVD mortality. However, this suspicion remains to be confirmed, particularly in the elderly population. We explored their combined effects on the risk of MetS and CVD mortality among the community population aged 65 and above in China.Methods and ResultsThis prospective study enrolled 3,675 Chinese community residents aged 65 and above in May 2013 with 7-year follow-up of all-cause and CVD mortality. HHcy was defined as the blood homocysteine (Hcy) level >15 μmol/L and abdominal obesity as waist circumference (WC) ≥90 cm for men and ≥80 cm for women (HWC). All participants were grouped into four categories by WC and the blood level of Hcy: NWC (normal WC) /HHcy(–), NWC/HHcy(+), HWC/HHcy(–), and HWC/HHcy(+). The relationship of combined HHcy and abdominal obesity with MetS and metabolic profile was evaluated by logistic regression analysis and the association of combined HHcy and abdominal obesity with CVD and all-cause mortality evaluated by Cox regression analysis. The prevalence of HHcy, abdominal obesity and MetS in elderly Chinese community residents was 40.1, 59.3, and 41.4%, respectively. Using group without HHcy and abdominal obesity [NWC/HHcy(–)] as reference, the participants of other three groups had significantly higher risk of MetS and its component abnormalities, with HWC/HHcy(+) group having the highest risk (OR = 13.52; 95% CI = 8.61–14.55). After a median of 6.94 (±1.48) years follow-up, 454 deaths occurred with 135 CVD deaths. Compared with NWC/HHcy(–) group, the risk of 7-year follow-up CVD mortality (HR = 1.75; 95% CI = 1.02–3.03) and all-cause mortality (HR = 1.23; 95% CI = 1.04–2.18) of HWC/HHcy(+) group increased considerably after adjustment for major MetS and CVD risk factors.ConclusionsThere is high prevalence of HHcy, abdominal obesity, and MetS in the elderly Chinese community population. HHcy increases risk of MetS, CVD, and all-cause mortality, especially in the populations with abdominal obesity.

Prevalence and Risk Factors Associated with Low Back Pain in the Saudi Adult Community: A Cross-Sectional Study.

Worldwide, low back pain is common and linked with many risk factors. There is a lack of studies in the Saudi Arabian community on low back pain prevalence and risk factors. Therefore, the present research will investigate the prevalence of low back pain in the middle-aged and elderly community population and examine the risk factors contributing to low back pain in Saudi Arabia. The present paper is a cross-sectional study of the community living in Riyadh and the surrounding areas in Saudi Arabia. Data were collected between October 2019 and April 2020 via trained research assistants. A total of 276 participants were included in the analysis. The prevalence of low back pain was 27.9% (n = 77) among the participants included in this study. All participants reported low back pain severity with a mean of 4.35 ± 2.19 on the pain rating scale. Older age, arthritis, hypertension, anemia, osteoporosis, and a history of fractures were all associated with having LBP. Low back pain is highly prevalent in the Saudi community adult population living in Riyadh and its surrounding areas. More than a fourth of the sample reported experiencing back pain. The study outlines several modifiable risk factors (BMI, education, employment status, marital status, and smoking status) and unmodifiable risk factors (arthritis, hypertension, anemia, osteoporosis, and a history of fractures) associated with low back pain in the study sample.

Evaluation of Different Anthropometric Indicators for Screening for Nonalcoholic Fatty Liver Disease in Elderly Individuals.

Objective To explore the anthropometric indicators suitable for screening for nonalcoholic fatty liver disease (NAFLD) in the elderly population. Methods This cross-sectional study screened subjects over 65 years, who had undergone a physical examination in 2019. Their height, weight, waist circumference, and fasting blood glucose and triglyceride levels were measured. Body mass index (BMI), waist circumstance (WC), waist-to-height ratio (WHtR), relative fat mass (RFM), ponderal index (PI), conicity index (CI), lipid accumulation product (LAP), and body shape index (ABSI) were calculated. Statistical analyses were performed using the Chi-square test, logistic regression, and receiver operating characteristic (ROC) curve. Subjects Of a total of 4985 subjects, 1173 diagnosed with NAFLD and 3812 without NAFLD were included. Results The NAFLD group had increased BMI, WC, WHtR, RFM, PI, CI, and LAP. ABSI was only significantly different in males between the groups. Logistic regression analysis showed that RFM was an effective prognostic factor for males with NAFLD, and LAP, BMI, and WC were effective prognostic factors for females. ROC curve analysis showed that LAP played a significant role in the prediction of NAFLD. Conclusion LAP is closely related to the occurrence of NAFLD and could be an efficient screening and treatment tool for NAFLD in the elderly people. Lay Summary. We conducted a screening and study of nonalcoholic fatty liver disease in the elderly population by determining the association between obesity indexes and nonalcoholic fatty liver disease. We found that LAP is practical, easy-to-measure tool for screening and studying NAFLD in the high-risk community elderly population, making it a valuable indicator in research.

Relationship between Cognitive Performance and Depressive Symptoms in Chinese Older Adults: The China Health and Retirement Longitudinal Study (CHARLS)

BackgroundIn China, an increasing number of people are aging; therefore, attention should be paid to age-related cognitive impairment. With the increasing attention given to geriatric depression in recent years, we focused our investigation on the relationship between depression in the elderly and cognitive decline in a large Chinese community study. MethodsWe screened 4,771 subjects that met the inclusion criteria from the China Health and Retirement Longitudinal Study database. Depressive symptoms and cognitive performance were assessed using the 10-item Center for Epidemiological Studies Depression Scale (CESD-10) and Mini-Mental State Examination (MMSE), respectively. ResultsWe found that 4.46% of the elderly have depression and 35.19% have depressive symptoms. Lower education, higher CESD-10 score, increased age, and more negative marital status were associated with poor cognitive performance in the Chinese elderly. CESD-10 is negatively correlated with each MMSE item, including orientation, memory, attention and computation, and language. LimitationsIt was difficult to draw conclusions about causation since there was no follow-up data, and high CESD-10 scores do not represent the population study finally diagnosed with depression. Finally, it is not clear whether the decline in cognitive function had an impact on participants’ understanding of the problems in the CESD-10. ConclusionsThis study preliminary prompted severe depressive symptoms associated with worse cognitive performance in a Chinese elderly community population.

Autonomic Nervous System and Cognitive Impairment in Older Patients: Evidence From Long-Term Heart Rate Variability in Real-Life Setting.

Background: In geriatric age, cognitive impairment and cardiovascular disorders are frequent comorbidities. Age-related anatomical and functional cardiac changes, including the autonomic system, could interfere with the control of different cognitive domains. Therefore, we assess the relationship between long-term heart rate variability (HRV), as a measure of autonomic nervous system (ANS) functioning, and cognitive performance in elderly patients representative of outpatients in a real-life setting.Methods: Of 155 elderly outpatients (aged >65 years) screened, 117 enrolled patients underwent anthropometric evaluation, cardiac assessment by 12-lead electrocardiogram, 24-h ECG recording, and blood pressure (BP) measurement, as well as global cognitive evaluation by a standardized multidimensional assessment, including the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment test (MoCA). HRV analysis was performed on 24-h ECG recordings focusing on time-domain indices [Standard deviation of the NN intervals (SDNN), standard deviations of 5-min mean values of the NN intervals for each 5-min interval (SDANN), and root mean squares of successive differences of the NN intervals (RMSSD)] and on frequency-domain measurements [heart rate (HR), low frequency (LF), high frequency (HF), and LF/HF]. Multivariate linear analysis was used to explore the influence of the HRV significant variables on MMSE and MoCA test values.Results: The MMSE and MoCA scores were both significantly and positively correlated with the sympathetic system parameters (SDNN, SDANN, LF, and LF/HF ratio), but not with the parasympathetic system parameters (RMSSD and HF). Multivariate analysis confirms this relationship.Conclusions: Our results show that, in a representative real-life community elderly population, an increased sympathetic activity, but not decreased vagal activity, is associated with better cognitive performances. These results support the sympathetic autonomic function, in that the relationship between better cognitive performances and a moderate prevalence of autonomic function appears dependent on long-term changes in heart rate, mediated by sympathetic activation.

Relationship Between Metabolic Syndrome and Serum Uric Acid in an Iranian Community Elderly Population: A Cohort Aging Study

Introduction: Serum uric acid (UA) level is reported to be associated with a variety of cardiometabolic risk factors. Although various studies have reported elevated levels of UA in patients with metabolic syndrome (MetS), its clinical interpretation is still controversial and challenging. Thus, we examined the association between hyperuricemia (HUA) and UA levels with MetS, its components and number of components. Materials and Methods: This population-based cross-sectional study included 1561 older people who participated in Amirkola Health and Aging Project (AHAP) in North of Iran. MetS was defined based on the Iranian National Committee of Obesity criteria. Blood pressure, fasting blood glucose (FBG), lipid profiles, UA and anthropometric measures were determined. Results: The diagnosis of the MetS was not associated with UA levels and HUA. The results of this study showed that the only FBG is a component which increases the risk of HUA. Conclusions: Our findings from a community elderly population suggest that the UA levels and HUA were not associated with the diagnosis of the MetS by the stepwise logistic regression approach. However, in spite of various confounding factors, including metabolic and non-metabolic components in the association with MetS and UA, the whole relationship remains to be determined. A large prospective study is needed to reveal the clinical significance of UA in MetS.

The major causes and risk factors of total and cause-specific mortality during 5.4-year follow-up: the Shanghai Changfeng Study

To investigate the major causes and predictive factors of death in a middle-aged and elderly Chinese population. A total of 6591 residents aged ≥ 45 years from Shanghai Changfeng community were followed up for an average of 5.4 years. The causes of death were coded according to the 10th Revision of International Classification of Diseases. The mortality rate was calculated by person-years of follow up and age-standardized according to the 2010 Chinese census data. Multivariable-adjusted Cox proportional hazards model was performed to investigate the predictors of all-cause and cause-specific mortality. During the total follow-up of 35,739 person-years, 370 deaths were documented (157 from malignant neoplasms, 70 from heart diseases, 68 from cerebrovascular diseases, 75 from other causes). The age-standardized all-cause mortality rate was 798.2 per 100,000 person-years (927.9 among men and 716.7 among women). Results from multivariable analyses showed that aging, diabetes, and osteoporosis at baseline were independent predictors of all-cause mortality, with hazard ratios (HR) of 1.11 (95% CI 1.10–1.13), 1.91 (1.51–2.42), and 1.71 (1.24–2.35), respectively. The population attributable risk percent of diabetes and osteoporosis was 19.7% and 11.7%, respectively. Cigarette smoking was associated with a higher risk of all-cause mortality in men (HR and 95%CI 1.44, 1.01–2.06). In women, diabetes and osteoporosis were related to a higher risk of cardiovascular mortality (3.27, 1.82–5.88 and 1.89, 1.04–3.46, respectively). While in men, osteoporosis was related to a higher risk of malignant neoplasms mortality (2.39, 1.07–5.33). Malignant neoplasms, heart diseases, and cerebrovascular diseases are the leading causes of death. Aging, smoking, underweight, diabetes, and osteoporosis are independent predictors of premature death among middle-aged and elderly Chinese community population. Moreover, there may have been some differences in the causes and predictors of premature death between men and women.

Estimating the glomerular filtration rate and tubular dysfunction in an elderly population with normoalbuminuria in China

BackgroundThe prevalence and clinical risk factors of normoalbuminuric renal impairment have not yet been investigated in elderly Chinese populations. To clarify this, we conducted survey research on an elderly Chinese community population. MethodsA total of 691 elderly community participants were included in this study. Normoalbuminuria was defined as a urinary albumin to creatinine ratio (ACR) <30 mg/g in morning urine. The estimated glomerular filtration rate (eGFR) and urinary alpha-1-microglobulin to creatinine ratio (MCR) were evaluated to assess normoalbuminuric kidney impairment in this elderly population. ResultsAmong the whole cohort, 30.25% had albuminuria, 8.68% showed reduced eGFR and 49.78% had increased MCR. Normoalbuminuric subjects also showed a high prevalence of low eGFR and increased MCR (6.02% for reduced eGFR and 37.55% for increased MCR). Among the normoalbuminuric participants, the highest prevalence of increased MCR was found in the subjects with diabetes (50%), whereas the highest prevalence of low eGFR was found in women (8.11%). There was no significant difference in ln-MCR values between normoalbuminuric subjects with eGFR>60 and < 60 ml/min/1.73 m2. Age, gender, diabetes and hypertension were all independent risk factors of increased MCR. Diabetes and hypertension showed no statistical influence on decreased eGFR,whereas gender carried the highest risk for reduced eGFR. ConclusionsAlbuminuria may have limited utility as a screening marker of renal injury, as a considerable proportion of the elderly population have renal impairment despite normoalbuminuria. Rather than focusing solely on patients with diabetes or hypertension, normoalbuminuric renal impairment should be given more attention within the overall elderly population.

Frailty phenotype, frailty index and risk of mortality in Chinese elderly population- Rugao longevity and ageing study

Background: To explore the associations of frailty phenotype and frailty index (FI) defined frailty and pre-frailty with mortality in a Chinese elderly population.Methods: Data of 1788 community-dwelling elders aged 70–84 years from the ageing arm of Rugao Longevity and Ageing Study, a prospective cohort study, were used. Frailty phenotype was defined using modified Fried’s phenotype (FP) criteria and FI was constructed using 45 health deficits. Mortality was ascertained using the Death Registry of Rugao's Civil Affairs Bureau.Results: During 3-year follow-up, 149 (8.3%) of the 1788 elderly subjects died. For frailty phenotype, about 9.5% of the elderly were frail and 43% were pre-frail. For FI, frail (FI > 0.21) was approximately 27.5%, and pre-frail (FI: 0.1–0.21) was approximately 51.3%. Highest mortality was observed among frail participants defined by both FP and FI criteria (all Log Rank P < 0.05). Frailty defined by the frailty index was associated with a 2.31 fold (95% CI 1.16–4.6) risk of all-cause death compared with robust elderly. Compared with the robust elderly, not only frailty (HR 2.24, 95% CI 1.31–3.83) defined by frailty phenotype but also pre-frailty (HR 1.51, 95% CI 1.03–2.21) was associated with risk of all-cause mortality.Conclusions: Frailty, defined by either phenotype or index, is associated with increased risks of mortality in elderly Chinese community population.

GW29-e1052 The relationship evaluation between ASCVD and diabetes status in elderly community population in Shanghai

To estimate the prevalence of ASCVD and to explore the relationship between ASCVD and diabetes status in elderly community population in Shanghai. Total 3950 subjects were recruited during the period of May 1 to July 31 2013. The t-test was employed to analysis the difference between ASCVD group

A11199 Prevalence of Cardio-cerebrovascular Risk Factors in the Middle-aged and Elderly Community Population

Objectives: We investigated the prevalence of cardio-cerebrovascular risk factors in the middle-aged and elderly community population to determine the 10-year risk for coronary heart disease for the further risk management. Methods: 1140 subjects aged 40 years or older was selected from May 2016 to July 2016 in two communities in Fujian Province. The demographic information, physical examination and laboratory examination were conducted. Binary logistic regression or covariance analysis was used to analyze the relationship between cardio-cerebrovascular risk factors and education levels or average income levels. Results: 1. The subjects including 382 men and 758 women, with the average age of 57.9 ± 10.1 years. 198 subjects with high risk of stroke were screened out (17.4%). The 10-year risk for coronary heart disease was 2% (1%, 8%). 2. Prevalence of hypertension and diabetes, which standardized by age in the population, were significant lower while prevalence of dyslipidemia and atrial fibrillation were higher in men than those in women (all P < 0.05). 3. There were higher proportion of high risk of stroke among men, urban residents, population with higher education levels, higher income levels and older population (all P < 0.05). 4. The 10-year risk of coronary heart disease was higher in urban residents, the population with higher education levels, higher income levels, higher risk of stroke, heavy drinking and diabetes (all P < 0.05). Conclusion: The prevalence of cardio-cerebrovascular risk factors and proportion of high risk of stroke were higher in the middle aged and elderly population. Framingham risk score and stroke risk rating can be complementary for the prediction of cardiovascular and cerebrovascular diseases.

Fragile X Low Normal Alleles are not associated with Cognitive Dysfunction in an Elderly Community Population (P1.068)

Fragile X Low Normal Alleles are not associated with Cognitive Dysfunction in an Elderly Community Population (P1.068)

Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the Rugao Longevity and Ageing Study.

BackgroundRisk factors for heart rate-corrected QT interval (QTc) proglongation should be explored to stratify high-risk individuals to aid the prevention of incident cardiovascular events and mortality. The diversity of risk factors for QTc prolongation suggests that use of the frailty index (FI), indicating general health deficits, may be an effective approach, especially in the elderly, to identify the risk of QTc prolongation.MethodsWe used the data of 1,780 individuals aged 70–87 years from the Rugao Longevity and Ageing Study (RuLAS), a community-based longitudinal study. The FI was constructed using 20 routine laboratory tests, plus the body mass index and measures of systolic and diastolic blood pressures (FI-Lab).ResultsThe mean FI-Lab value was 0.24±0.09. The mean heart rate-corrected QT interval (QTc) was 407±38 ms. The prevalence of QTc prolongation was 5.2% in elderly community populations aged 70–87 years. A higher FI-Lab value was associated with a higher risk for QTc prolongation. Each 10% increase in the FI-Lab value increased the odds ratio (OR) by 33% (OR: 1.33; 95% CI: 1.07–1.64). Compared with the lowest quartile, the top quartile FI-Lab score was associated with a 2.50-fold QTc prolongation risk in elderly individuals (95% CI: 1.21–5.19).ConclusionAn FI based on routine laboratory data can identify older adults at increased risk for QTc prolongation. The FI approach may therefore be useful for the risk stratification of QTc prolongation.