Elbow Loading Research Articles

Estimating elbow loading conditions through the motion behaviors of subchondral bone density during joint movements

Evaluating complicated stress across the elbow under joint motion remains difficult. Here, we aimed to evaluate the distribution of the subchondral bone density in the normal elbow bones and further characterize their spatial relationships during elbow motion to estimate the loading stress across the articular surface using three-dimensional computed tomography bone models. The normal elbow joint exhibited a consistent distribution pattern of subchondral bone density. High-density regions were distributed in the capitellum and posterior humeral trochlea, sagittal ridge of the ulnar trochlear notch and ulnar-volar side of the radial head. Motion analyses revealed that the high-density regions proximate with elbow flexion with forearm pronation in the radiocapitellar joint and in the fully extended position in the ulnohumeral joint. This reasonably reflects the stress acting on the joint surface under actual loading conditions. These findings suggest that daily activities involving lifting or carrying objects in these positions are stress-prone activities.

Evidence of the existence of multiple modules for the stroke-caused flexion synergy from Fugl-Meyer assessment scores.

Stroke-caused synergies may result from the preferential use of the reticulospinal tract (RST) due to damage to the corticospinal tract. The RST branches multiple motoneuron pools across the arm together resulting in gross motor control or abnormal synergies, and accordingly, the controllability of individual muscles decreases. However, it is not clear whether muscles involuntarily activated by abnormal synergy vary depending on the muscles voluntarily activated when motor commands descend through the RST. Studies showed that abnormal synergies may originate from the merging and reweighting of synergies in individuals without neurological deficits. This leads to a hypothesis that those abnormal synergies are still selectively excited depending on the context. In this study, we test this hypothesis, leveraging the Fugl-Meyer assessment that could characterize the neuroanatomical architecture in individuals with a wide range of impairments. We examine the ability to perform an out-of-synergy movement with the flexion synergy caused by either shoulder or elbow loading. The results reveal that about 14% [8/57, 95% confidence interval (5.0%, 23.1%)] of the participants with severe impairment (total Fugl-Meyer score <29) in the chronic phase (6 months after stroke) are able to keep the elbow extended during shoulder loading and keep the shoulder at neutral during elbow loading. Those participants underwent a different course of neural reorganization, which enhanced abnormal synergies in comparison with individuals with mild impairment (P < 0.05). These results provide evidence that separate routes and synergy modules to motoneuron pools across the arm might exist even if the motor command is mediated possibly via the RST.NEW & NOTEWORTHY We demonstrate that abnormal synergies are still selectively excited depending on the context.

Poster 171: Comparative Analysis of Kinetic Variables Between Different Pitch Types in Professional Baseball Pitchers

Objectives: The persistent high rates of elbow injuries among professional baseball pitchers indicates a critical gap in our understanding of how a pitch influences load on the elbow. Traditionally, research has examined the maximum value of various kinetics experienced at the throwing arm during a pitch, especially elbow varus torque. The maximum elbow varus torque has been used as a surrogate for potential elbow injury; however, the elbow injury epidemic has still persisted. It is possible that analysis focused on only the maximum value misses the total load experienced on the throwing arm. Therefore, the purpose of this study was to investigate different metrics to evaluate elbow stress, including maximum elbow varus torque, elbow loading rate, and cumulative varus torque between different pitch types. By evaluating these aspects of elbow stress, our study aims to uncover previously overlooked kinetic variables that might be potential contributors to elbow injuries, bridging the gap between existing kinetic analyses and the persistent high injury rates. Methods: Data from a cohort of 41 professional baseball pitchers were utilized for this analysis (188 ± 6 cm; 91.9 ± 8.2 kg). Pitchers threw a series of fastball, changeup, and curveball pitches (fastball: 10 ± 3 pitches, changeup: 3 ± 1 pitches, curveball: 4 ± 1 pitches) captured using a 3D motion capture system (480 Hz). Kinetic variables were calculated for each pitch, including maximum elbow varus torque, loading torque rate (measured as the derivative of the varus torque curve), and cumulative elbow varus torque (measured as the area under the elbow varus torque curve). A linear mixed effects model was employed to examine within player associations between pitch type and ball velocity, maximum elbow varus torque, loading torque rate, and cumulative elbow varus torque. Statistical significance was set at p&lt;0.01. Results: Our findings reveal that the fastball pitch created greater loading on the elbow compared to the change up and curveball pitches (Table 1). Pitchers threw their fastball with increased ball velocity (40.3 ± 0.6 m/s) compared to throwing their changeup (36.6 ± 0.5 m/s) and curveball (33.7±0.5 m/s) (p&lt;0.001). Maximum elbow varus torque was also greater in the fastball pitch (93.7 ± 3.3 N∙m) compared to the changeup pitch (84.1 ± 2.4 N∙m) and curveball (91.0 ± 2.3 N∙m) (p&lt;0.001); the curveball pitch had greater maximum torque compared to changeup pitches (p&lt;0.001). The loading rate was 15% lower for the changeup pitch (690.0 ± 49.4 N∙m/s) (p&lt;0.001) and 6% lower for the curveball (753.6 ± 60.3 N∙m/s) compared to the fastball (820.1 ± 72.2 N∙m/s) (p&lt;0.001). The cumulative elbow varus torque for the fastball was 4% greater than the changeup pitch (2996.9 ± 92.9 vs 2894.1 ± 84.1 N∙m) and 7% greater than the curveball pitch (2996.9 ± 92.9 vs 2797.2 ± 85.8 N∙m) (p&lt;0.001). Conclusions: This study reveals the importance of considering pitch type when evaluating kinetic variables in professional baseball pitchers. The observed differences in elbow varus torque, loading rate, and other kinematic metrics between fastball, changeup, and curveball pitches highlights the need for a comprehensive understanding of biomechanical variations associated with different pitch types. These findings have implications for optimizing pitcher training programs, injury prevention strategies, and player management. By unraveling the intricate connections between kinetic variables and pitch types, this research contributes to advancing the biomechanical knowledge within the field of orthopedics and sports science.

Effect of Medial Opening Wedge and External Rotational Humeral Osteotomies on Medial Elbow Compartment Pressure: An Ex Vivo Study.

The aim of this study was to assess if the level of osteotomy (50 or 75% the length of the humerus), osteotomy angle (5, 10, or 20 degrees), direction of bone alteration (external rotational or medial opening wedge osteotomies), or orientation of osteotomy (perpendicular to the humeral long axis or perpendicular to the weight-bearing axis of the limb) affect pressure through the medial compartment of the elbow. Humeral osteotomies were performed at 50 and 75% the length of the humerus on 12 canine cadaver thoracic limbs and patient-specific three-dimensional (3D) printed plates applied to induce the desired alteration. Sensors were placed into the medial and lateral aspects of the elbow joint and the limb compressed to 90 N in a universal testing system. Increasing the angle of the induced change had a significant effect on the decreased load through the medial compartment. Performing the osteotomy at 75% of humeral length from proximal was significantly more effective at reducing the medial elbow load than performing it at 50%. Opening wedge osteotomies were more effective than external rotational osteotomies, but both were effective. Changing the direction of the osteotomy (comparing transverse to oblique) did not significantly affect the load reduction through the medial compartment. Performing an osteotomy at a more distal location along the humerus and increasing the angle of the induced change increased the effectiveness of load-shifting humeral osteotomies.

Predicting elbow load based on individual pelvis and trunk (inter)segmental rotations in fastball pitching

ABSTRACT The baseball pitch is a repetitive, full-body throwing motion that exposes the elbow to significant loads, leading to a high incidence of elbow injuries. Elbow injuries in pitching are often attributed to high external valgus torques as these are generally considered to be a good proxy for the load on the Ulnar Collateral Ligament. The aim of the study is to contribute to elbow load monitoring by developing a prediction model based on the pelvis and trunk peak angular velocities and their separation time. Eleven male youth elite baseball pitchers (age 17 ± 2.2 years) threw 25 fastballs at full effort off a mound. Two-level varying-intercept, varying-slope Bayesian models were used to predict external valgus torque based on (inter)segmental rotation in fastball pitching with pitcher’s weight and height added to strengthen the individualisation of the prediction. The results revealed the high predictive performance of the models including a set of kinematic parameters trunk peak angular velocity and the separation time between the pelvis and trunk peak angular velocities. Such an approach allows individualised prediction of the external valgus torque for each pitcher, which has a great practical advantage compared to group-based predictions in terms of injury assessment and injury prevention.

Magnitude and variability of individual elbow load in repetitive baseball pitching

In baseball pitchers the elbow is exposed to high and repetitive loads (i.e. external valgus torque), caused by pitching a high number of balls in a practice session or game. This can result in overuse injuries like the ulnar collateral ligament (UCL) injury. To understand injury mechanisms, the effect of repetitive pitching on the elbow load magnitude and variability was investigated. In addition, we explored whether repetitive pitching affects elbow muscle activation during pitching. Fifteen pitchers threw each 60 to 110 balls. The external valgus torque and electromyography of three elbow muscles were quantified during each pitch. Linear mixed model analyses were performed to investigate the effect of repetitive pitching. On a group level, the linear mixed models showed no significant associations of repetitive pitching with valgus torque magnitude and variability and elbow muscle activity. Significant differences exist between pitchers in their individual trajectories in elbow valgus torque and muscle activity with repetitive pitching. This shows the importance of individuality in relation to repetitive pitching. In order to achieve effective elbow injury prevention in baseball pitching, individual characteristics of changes in elbow load and muscle activity in relation to the development of UCL injuries should be investigated.

Elbow joint loads during simulated activities of daily living: implications for formulating recommendations after total elbow arthroplasty

Overloading of the elbow joint prosthesis following total elbow arthroplasty can lead to implant failure. Joint moments during daily activities are not well-contextualized for a prosthesis' failure limits and the effect of the current postoperative instruction on elbow joint loading is unclear. This study investigates the difference in elbow joint moments between simulated daily tasks and between flexion-extension, pronation-supination, varus-valgus movement directions. Additionally, the effect of the current postoperative instruction on elbow joint load is examined. Nine healthy participants (age 45.8 ± 17 years, 3 males) performed eight tasks; driving a car, opening a door, rising from chair, lifting, sliding, combing hair, drinking, emptying cup, without and with the instruction "not lifting more than 1 kg". Upper limb kinematics and hand contact forces were measured. Elbow joint angles and net moments were analyzed using inverse dynamic analysis, where the net moments are estimated from movement data and external forces. Peak elbow joint moments differed significantly between tasks (p < 0.01) and movement directions (p < 0.01). The most and least demanding tasks were, rising from a chair (13.4 Nm extension, 5.0 Nm supination, 15.2 Nm valgus) and sliding (4.3 Nm flexion, 1.7 Nm supination, 2.6 Nm varus). Net moments were significantly reduced after instruction only in the chair task (p < 0.01). This study analyzed elbow joint moments in different directions during daily tasks. The outcomes question whether postoperative instruction can lead to decreasing elbow loads. Future research might focus on reducing elbow loads in the flexion-extension and varus-valgus directions.

Quantifying Within-Individual Elbow Load Variability in Youth Elite Baseball Pitchers and Its Role in Overuse Injuries

Medial elbow overuse injuries are rising in baseball. The external valgus torque magnitude is a possible risk factor for medial elbow injuries. The magnitude on its own cannot explain why one pitcher sustains an injury and another does not. Therefore, the aim of this study is to describe the within-individual external valgus torque variability and to determine whether the within-individual external valgus torque variability can be described by a Gaussian distribution. Eleven youth elite baseball pitchers threw twenty-five fastball pitches. Body kinematics were measured with VICON motion capture at 400 Hz. Elbow valgus torques of the total 270 pitches were calculated with a custom-made inverse dynamic model in Python. Visual inspection and the Shapiro–Wilk test were performed to test for the within-individual elbow valgus torque normality. The results showed that within-individual valgus torque variability was present in pitchers and differed among pitchers. Furthermore, it was shown that the within-individual valgus torque variability was normally distributed in nine out of eleven subjects. In conclusion, the presence of and differences in within-individual elbow load variability among baseball pitchers can be useful variables as they might be related to overuse elbow injuries.

Stride Length and Torso Biomechanics As They Relate To Medial Elbow Injuries In Adolescent Aged Baseball pitchers: A Clinical Commentary

There is a limited amount of literature examining torso biomechanics and stride length while addressing their relationship to medial elbow injuries in the adolescent baseball pitcher. Anatomical changes, growth, early sport specialization, multiple team participation, mound distance, mound height, and high pitch counts place adolescent pitchers at an exceptionally higher risk for medial elbow injuries. Existing evidence indicates that decreased stride length and altered trunk rotation is correlated with increased medial elbow loading for the adolescent overhead athlete. Further research is required to quantify adequate parameters for torso kinematics, control, and their correlation to stride length, in order to positively affect the biomechanical transfer of energy and potentially prevent injuries during the overhead throwing motion. The purpose of this clinical commentary is to examine and summarize the role of torso biomechanics and stride length in relation to medial elbow injuries in adolescent baseball pitchers. Level of Evidence 5

The Effects of Contralateral Trunk Tilt on Elbow Varus Torque in Baseball Pitchers: A Critically Appraised Topic.

Clinical Scenario: Ulnar collateral ligament injuries are common in baseball pitchers, with excessive elbow varus torque linked to medial elbow injuries. Trunk tilt, or motion in the frontal plane, could be an identifiable and modifiable factor in medial elbow loading. Clinical Question: In high school through professional baseball pitchers, how does increased contralateral trunk tilt compared with no/limited contralateral trunk tilt influence elbow varus torque? Summary of Key Findings: Four studies were included: all were labeled as "controlled" or "descriptive laboratory studies," representing cross-sectional observational analytic design. One study compared biomechanics of professional pitchers with and without ulnar collateral ligament reconstruction. Two studies measured biomechanics in college pitchers, one of which also included simulations of joint angles. The fourth study measured biomechanics of high school pitchers. All studies measured trunk tilt and its relationship to elbow varus torque, with 3 of the studies linking increased contralateral trunk tilt with increased elbow varus torque. Clinical Bottom Line: Moderate evidence indicated as contralateral trunk tilt increased, so did elbow varus torque, indicating trunk tilt may be a modifiable factor to decrease medial elbow loading during pitching. Strength of Recommendation: Majority consistent findings from the level 3 cross-sectional observational analytic designs suggest grade B evidence in support of trunk tilt as a factor in increasing elbow varus torque.

Optimizing Graft Extraction From the Femoral Condyle for Fresh Osteochondral Allograft Transplantation in Treating Osteochondritis Dissecans of the Capitellum: Best Fit Based on Radius of Curvature.

Osteochondritis dissecans (OCD) of the capitellum is a common cause of pain and dysfunction in adolescents that engage in repetitive elbow loading. For large, unstable lesions fresh osteochondral allograft transplantation (FOCAT) from the femoral condyle has been described as an effective treatment. Current practice involves significant guesswork in obtaining an appropriately sized graft, with anatomic variations resulting in poor graft fit. No studies currently exist that analyze and identify the best distal femur FOCAT graft site to repair OCD lesions of the capitellum based on the radius of curvature (ROC) and simulated matching. Computed tomography scans of the elbow were used to estimate the subchondral bone ROC of capitella in adolescents aged 11 to 21 years. The capitellar location used corresponds to the most commonly reported site of OCD lesions in the elbow. Computed tomography scans of the lower extremity were used to estimate the subchondral bone ROC of 4 potential donor femoral condyle grafts. ROC from distinct regions at the posterior section of both the medial and lateral femoral condyles were measured: 2 areas representing 10 mm grafts from the center (MC1 and LC1), and 2 areas estimating 10 mm grafts posterior and adjacent to the physeal scar (MC2 and LC2). Intraobserver and interobserver reliability measurements were preformed to corroborate precision and validate the method. The mean ROC of healthy subchondral bone at the region of the capitellum were OCD lesions most commonly occur was 9.79±1.39 mm. The mean ROC of MC1 was 18.61±2.26 mm. The average ROC of the MC2 was 15.23±1.43 mm. The average ROC of LC1 was 16.47±1.34 mm. The average ROC of LC2 was 18.19±3.09 mm. After 15,000 simulated condyle-to-capitellar site matchings based on these measurements, a good fit graft was achieved at a frequency of 15%. No site measured from the femoral condyle demonstrated a subchondral ROC that exactly matched the subchondral ROC of the capitellum at the center location where OCD lesions most commonly occur; of the locations measured, a 10 mm section from MC2 demonstrated the closest match. On the basis of this analysis, extracting a graft from MC2 has the potential to further optimize FOCAT fit to the capitellum. Level III.

Longitudinal Change of Forearm-Hand Inertia Value and Shoulder Musculature Using Dual X-ray Absorptiometry in Youth Japanese Baseball Players: Implications for Elbow Injury.

It is important to understand the timing of the maximum increase of forearm-hand inertia value and lean body mass (LBM) of the shoulder girdle musculature when elbow injury frequently occurs. This study aimed to clarify the discrepancies of those in youth baseball players. Forty-three male baseball players (8- to 14-years-old) participated in this study. The forearm-hand inertia value and LBM of the shoulder girdle musculature were calculated using dual-energy X-ray absorptiometry (DXA). A cubic spline fit was applied to the annual increase forearm-hand inertia value and LBM of the shoulder girdle musculature for each chronological age and years from peak height velocity (PHV) age. As a result of cubic splines fitting, the peak timing for forearm-hand inertia value and LBM of the shoulder girdle musculature was 12.42 and 12.75 years in chronological age, −0.66 and −0.11 years in PHV age. Therefore, the peak timing of forearm-hand inertia value was about 4 months earlier in chronological age and half a year earlier in PHV age than LBM of the shoulder girdle musculature. Acquiring sufficient shoulder girdle musculature during the period when the growth of the shoulder girdle musculature cannot catch up with forearm-hand inertial value is necessary to reduce the elbow load while throwing.

Biomechanics of axial load transmission across the native human elbow.

Elbow and forearm motion are thought to affect elbow load transmission, yet little empirical evidence exists to quantify the biomechanics. Eight fresh-frozen human cadaver upper extremities were utilized. A 100 N axial force was applied across the elbow joint at elbow flexion angles of (0°, 30°, 60°, and 90°) and forearm rotation angles (0°, 45° supination, and 45° pronation). Pressure mapping sensors were placed in both the radiocapitellar and ulnotrochlear joints. Force distributions and contact areas were measured, and paired t-tests were used for comparison (p < 0.05). The average maximum loading percentage of the radiocapitellar and ulnotrochlear joint pressures were 57.8 ± 4.6% and 42.2 ± 4.6%, respectively. Elbow flexion angle and forearm rotation did not significantly affect the joint loading. There was no significant difference between the contact areas of each joint, although ulnotrochlear and radiocapitellar joints demonstrated an inverse relationship. Our study is the only one to date to comprehensively evaluate loading mechanics throughout both functional elbow flexion and forearm rotation across both articulations. The load sharing ratio across the radiocapitellar and ulnotrochlear joints was 58%:42%, agreeing with previously reported ratios with limited parameters. A relationship may be present between increasing radiocapitellar and decreasing ulnotrochlear contact areas as elbow flexion increases.

Finite-element analysis of the mouse proximal ulna in response to elbow loading.

Bone is a mechano-sensitive tissue that alters its structure and properties in response to mechanical loading. We have previously shown that application of lateral dynamic loads to a synovial joint, such as the knee and elbow, suppresses degradation of cartilage and prevents bone loss in arthritis and postmenopausal mouse models, respectively. While loading effects on pathophysiology have been reported, mechanical effects on the loaded joint are not fully understood. Because the direction of joint loading is non-axial, not commonly observed in daily activities, strain distributions in the laterally loaded joint are of great interest. Using elbow loading, we herein characterized mechanical responses in the loaded ulna focusing on the distribution of compressive strain. In response to 1-N peak-to-peak loads, which elevate bone mineral density and bone volume in the proximal ulna in vivo, we conducted finite-element analysis and evaluated strain magnitude in three loading conditions. The results revealed that strain of ~ 1000 μstrain (equivalent to 0.1% compression) or above was observed in the limited region near the loading site, indicating that the minimum effective strain for bone formation is smaller with elbow loading than axial loading. Calcein staining indicated that elbow loading increased bone formation in the regions predicted to undergo higher strain.

Racquet string tension directly affects force experienced at the elbow: implications for the development of lateral epicondylitis in tennis players.

Lateral epicondylitis (LE) occurs in almost half of all tennis players. Racket-string tension is considered to be an important factor influencing the development of LE. No literature yet exists that substantiates how string-tension affects force transmission to the elbow, as implicated in LE development. We establish a quantitative relationship between string-tension and elbow loading, analyzing tennis strokes using rackets with varying string-tensions. Twenty recreational tennis players simulated backhand tennis strokes using three rackets strung at tensions of 200 N, 222 N and 245 N. Accelerometers recorded accelerations at the elbow, wrist and racket handle. Average peak acceleration was determined to correlate string-tension with elbow loading. Statistically significant differences (p < 0.05) were observed when average peak acceleration at the elbow at 200 N string-tension (acceleration of 5.58 m/s(2)) was compared with that at 222 N tension (acceleration of 6.83 m/s(2)) and 245 N tension (acceleration of 7.45 m/s(2)). The 200 N racket induced the least acceleration at the elbow. Although parameters determining force transmission to the elbow during a tennis stroke are complex, the present study was able to control these parameters, isolating the effect of string-tension. Lower string-tensions transmit less force to the elbow in backhand strokes. Reducing string-tension should be considered favourably with respect to reducing the risk of developing LE.

Effect of Radial Head Implant Shape on Joint Contact Area and Location During Static Loading

To examine the effect of implant shape on radiocapitellar joint contact area and location in vitro. We used 8 fresh-frozen cadaveric upper extremities. An elbow loading simulator examined joint contact in pronation, neutral rotation, and supination with the elbow at 90° flexion. Muscle tendons were attached to pneumatic actuators to allow for computer-controlled loading to achieve the desired forearm rotation. We performed testing with the native radial head, an axisymmetric implant, a reverse-engineered patient-specific implant, and a population-based quasi-anatomic implant. Implants were inserted using computer navigation. Contact area and location were quantified using a casting technique. We found no significant difference between contact locations for the native radial head and the 3 implants. All of the implants had a contact area lower than the native radial head; however, only the axisymmetric implant was significantly different. There was no significant difference in contact area between implant shapes. The similar contact areas and locations of the 3 implant designs suggest that the shape of the implant may not be important with respect to radiocapitellar joint contact mechanics when placed optimally using computer navigation. Further work is needed to explore the sensitivity of radial head implant malpositioning on articular contact. The lower contact area of the radial head implants relative to the native radial head is similar to previous benchtop studies and is likely the result of the greater stiffness of the implant. Radial head implant shape does not appear to have a pronounced influence on articular contact, and both axisymmetric and anatomic metal designs result in elevated cartilage stress relative to the intact state.

Biomechanical Comparison of the Interval Throwing Program and Baseball Pitching

Background: The interval throwing progression has been part of baseball rehabilitation and conditioning for decades, yet little is known about the upper extremity loads an athlete is subjected to during this progression. Hypothesis: A biomechanical comparison of fastball pitching, variable-effort pitching, and throwing various flat-ground distances will show significant torque differences in the throwing shoulder and elbow. Study Design: Descriptive laboratory study. Methods: Twenty-nine healthy college baseball pitchers were analyzed using a quantitative motion analysis system. The participants threw from flat ground at distances of 18, 27, 37, and 55 m, having been instructed to throw “hard, on a horizontal line.” The participants then threw fastballs 18.4 m from a mound at 3 different effort levels: 60%, 80%, and full effort. The kinetic values for humeral internal rotational torque (HIRT) and elbow valgus load (EVL) were extracted for each throw. Repeated-measures analyses of variance (ANOVAs) were used to compare all 7 throwing conditions within pitchers. The kinetic data were also compared against ball velocity to evaluate throwing efficiency. A separate analysis was conducted using a 3-level repeated-measures ANOVA with post hoc paired t tests comparing just the variable-effort throws from the mound. Results: No statistically significant differences were found in either HIRT or EVL between any of the flat-ground distances and throwing from the mound (P > .05). Despite similar biomechanical loads compared with the mound, throwing from flat ground showed significantly decreased ball velocity (82% of maximum). Statistically significant differences were found in humeral internal rotational torque and elbow valgus load between fastball pitching off the mound at 60% and 100%, as these parameters increased with throwing effort (P < .05). At 60% perceived effort from the mound, pitchers generated forces of 76% and ball speeds approaching 84% of maximum. Conclusion: Partial-effort pitching demonstrates significantly lower loads on the shoulder and elbow. Flat-ground throwing at even the shortest distances had similar biomechanical loads compared with pitching from the mound, yet at significantly lower ball velocity. This illustrates the mechanical advantage and increased efficiency of throwing from a mound. No increase in shoulder or elbow loads was seen with increasing distances from flat ground, as pitchers began using a “crow hop” for the longer distances, facilitating the throw with their lower extremity. The mechanical advantage of throwing from a mound or using the crow hop is likely protective during rehabilitation and training throws. Clinical Relevance: The findings of this study may be used to improve rehabilitation programs designed for baseball players returning from shoulder or elbow injury.

Rapid Feedback Responses Correlate with Reach Adaptation and Properties of Novel Upper Limb Loads

A hallmark of voluntary motor control is the ability to adjust motor patterns for novel mechanical or visuomotor contexts. Recent work has also highlighted the importance of feedback for voluntary control, leading to the hypothesis that feedback responses should adapt when we learn new motor skills. We tested this prediction with a novel paradigm requiring that human subjects adapt to a viscous elbow load while reaching to three targets. Target 1 required combined shoulder and elbow motion, target 2 required only elbow motion, and target 3 (probe target) required shoulder but no elbow motion. This simple approach controlled muscle activity at the probe target before, during, and after the application of novel elbow loads. Our paradigm allowed us to perturb the elbow during reaching movements to the probe target and identify several key properties of adapted stretch responses. Adapted long-latency responses expressed (de-) adaptation similar to reaching errors observed when we introduced (removed) the elbow load. Moreover, reaching errors during learning correlated with changes in the long-latency response, showing subjects who adapted more to the elbow load displayed greater modulation of their stretch responses. These adapted responses were sensitive to the size and direction of the viscous training load. Our results highlight an important link between the adaptation of feedforward and feedback control and suggest a key part of motor adaptation is to adjust feedback responses to the requirements of novel motor skills.

Moderate Joint Loading Reduces Degenerative Actions of Matrix Metalloproteinases in the Articular Cartilage of Mouse Ulnae

Joint loading is a recently developed loading modality, which can enhance bone formation and accelerate healing of bone fracture. Since mechanical stimulation alters expression of matrix metalloproteinases (MMPs) in chondrocytes, a question addressed herein was, does joint loading alter actions of MMPs in the articular cartilage? We hypothesized that expression and activity of MMPs are regulated in a load–intensity-dependent manner and that moderate load scan downregulates MMPs. To test this hypothesis, a mouse elbow-loading model was employed. In the articular cartilage of an ulna, the mRNA levels of a group of MMPs as well as their degenerative activities were determined. The result revealed that elbow loading altered the expression and activities of MMPs depending on its loading intensity. Collectively, the data in this study indicate that 0.2 and 0.5 N joint loading significantly reduced the expression of multiple MMPs, that is, MMP-1, MMP-3, MMP-8, and MMP-13, and overall activities of collagenases or gelatinases in articular cartilage, while higher loads increased the expression and activity of MMP-1 and MMP-13. Furthermore, moderate loads at 1 N elevated the mRNA level of CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2), but higher loads at 4 N did not induce a detectable amount of CITED2 mRNA. Since CITED2 is known to mediate the downregulation of MMP-1 and MMP-13, the result indicates that joint loading at moderate intensity reduces MMP activities through potential induction of CITED2. MMPs such as MMP-1 and MMP-13 are predominant collagenases in the pathology of osteoarthritis. Therefore, joint loading could offer an interventional regimen for maintenance of joint tissues.

Posture and hand load alter muscular response to sudden elbow perturbations

Joint stiffness and stability are reliant on coordinated muscle activity which may differ depending on initial posture and loading during sudden perturbations. This study investigated the effects of arm posture and hand load on muscle activity during perturbations of the arm. Fifteen male participants experienced perturbations to the wrist causing elbow extension using a combination of three body postures (standing, supine, sitting) and three hand load conditions (no, solid, and fluid loads), with known and unknown timing. Surface EMG was collected from eight muscles of the right upper extremity. The response to sudden loading was examined using muscle activities pre (baseline) and post (reflex) perturbation. During the baseline period, known perturbation timing resulted in greater muscular activity than for unknown timing, while the opposite was found for the reflex period. During the reflex period with fluid load, biceps brachii and brachioradialis demonstrated increased activity of 2.4% and 4.0% of maximum respectively, from supine to standing. During the reflex period, the fluid load resulted in forearm co-contraction 23% and 47% greater than the solid and no load conditions. Body orientation and hand loading influenced muscular response to elbow perturbations. Muscle co-contraction at the elbow during known timing suggests a contribution to elbow joint stability that may reduce injury risk caused by sudden elbow loading.