A methodology for numerically modeling 3D processes of acceleration of deformable bodies by detonation products of solid explosives in the air is described. Simultaneous motion of the explosion products, the air and the elastoplastic medium is numerically analyzed in Euler variables, using a modified Godunov scheme, which is applicable for both fluid dynamics and elastoplastic flows, and an exact solution of Riemann problem of discontinuity breakage in the media and along the gas-elastic body interface. The methodology uses three types of spatial grids. The grids of the first type are sets of triangles (STL files) defining the surfaces of the objects and updating those surfaces in the process of motion. The grids of the second type are base fixed Cartesian grids nested into each medium. The grids of the third type are local orthogonal movable grids coupled with each of the triangles of the grids of the first type. The integration of dynamic equations of continua and mutual interpolation of parameters among the different kinds of grids is done on base and local grids. To simulate the detonation propagation process in a solid explosive, an algorithm based on Huygens principle and the account of energy release upon the arrival of the detonation wave into the integrated cell are used. Examples of numerically modeling propagation of elastic and elastoplastic disc-shaped, tetrahedral and cubic bodies of various materials adjacent to the charge are given. The results of the analyses testify to the applicability of the above methodology for modeling coupled processes of acceleration of deform-able bodies by detonation products up to deceleration in the ambient medium. Certain laws of the acceleration process have been found for the case where detonation is initiated in the center of a spherical charge. In particular, the duration of the acceleration of a body is comparable with the time of the arrival of the detonation wave at the surface of the contact; the major residual strains altering the geometry of the bodies occur at the initial stage of the acceleration and affect both the interaction with the detonation products and the parameters of the motion of the bodies; the final acceleration velocity is observed to depend considerably on the initial geometry of the accelerated body, its orientation relative to the detonation front and the deformation properties for the same mass.Keywords: modeling, detonation, 3D processes, multi-grid approach, interpolation, Godunov scheme, nonlinear coupled problems, aeroelastoplasticity, acceleration of bodies.