This study proposes an effective method to determine the stress intensity factors (SIFs) of the interface crack considering the viscoelasticities of the bilateral materials and verifies the feasibility of the initial fracture toughness-based fracture criterion for the concrete-rock interface under sustained loading. Firstly, low-level sustained loading tests were conducted on the composite concrete-rock specimens with respect to two interface roughness degrees and two sustained load levels less than the initial cracking load. Then, an implicit creep equation was employed to characterise the viscoelasticities of bilateral materials and then calculate the mechanical responses of the concrete-rock interface in the low-level sustained loading test. The SIFs of the interface crack under sustained loading were determined by using the elastic strain energy density ahead of the crack tip. By averaging the SIFs over the radius of the core region of the crack tip, the representative SIFs under sustained loading were obtained. The test results indicated that the SIFs showed decreasing tendencies under sustained loading, and the initial fracture toughness can be considered as a material property of the concrete-rock interface. The initial fracture toughness-based fracture criterion was verified to be feasible to determine the initial cracking status of the concrete-rock interface under sustained loading. In addition, due to the reductions of the SIFs under sustained loading, additional loads were required to compensate the losses of the SIFs, leading to the enhancement of the initial cracking loads after experiencing the sustained loading.