Eggplant Extract Research Articles

In vitro and in silico study of eggplant extract on human cancer cell lines.

The aim of this research was to study the metabolite composition, antioxidative potential and cytotoxic activities of Solanum melongena fruit extracts. Phytochemical analyses of extracts were performed using LC-MS. Phenolic compounds were the major constituents present in the fruit extracts. Free radical scavenging activities were recorded and the highest activities were reported in methanolic extracts using DPPH (103.70 ± 2.75 EC50 μg/mL), ABTS (81.74 ± 3.64 EC50 μg/mL), and FRAP (22.39 ± 1.52 μmol TE/g) assays. Quantification has suggested the presence of delphinidin derivatives, and caffeic acid conjugates as major constituents of fruit extracts. The potential binding of these derivatives with human cell surface receptors was analysed using in silico analysis and validated for cytotoxic and apoptotic effects using in vitro studies on human cancer cell lines. The methanolic extract has shown the highest cytotoxic activity.

Assessment of the Antioxidant Potential of Anthocyanin-Rich Extract of Eggplant (Solanum melongena L.) and Evaluation of its Antimicrobial Activity

Assessment of the Antioxidant Potential of Anthocyanin-Rich Extract of Eggplant (Solanum melongena L.) and Evaluation of its Antimicrobial Activity

Enhanced Enzyme Inhibitory Effects of the Nanohybrid Eggplant Extract: An Unusual Pharmaceutical Form for Medicinal Plant

Objective: Recently, biosynthesis/synthesis of nanoflowers has become very attractive for chemical and pharmaceutical sciences, and enhanced enzyme activities. Various plant extracts and their active compounds are effectively used as organic component for novel nanoflowers synthesis. Solanum melongena L., commonly known as eggplant in English, a vegetable and medicinal plant belongs to Solanaceae family has several advantages in materials synthesis due to cheap and obtained easily. The aim of this study is to compare the enzyme ((alpha-glucosidase (AGase), alpha-amylase (AAase), tyrosinase (Tyr), acetylcholinesterase (AChE) and butyryl cholinesterase (BChE)) inhibitory effects of the eggplant’ calyx extract and its Solanum-inorganic hybrid nanoflower (Sm-ihNFs) via in vitro experimental methods. 
 Methods: The hybrid nanoflower was formed (NF) with organic molecules, eggplant extract (Sm), and inorganic compounds, copper to enhance the catalytic activities. The inhibition capacities of the eggplant extract, and its hybrid nanoflower were evaluated on selected enzymes (AGase, AAase, Tyr, AChE and BChE) which play significant roles physiologically by in vitro tests in this study. 
 Results: According to inhibition percentages and IC50 values, Sm-ihNFs showed higher inhibitory activities on enzymes other than ache than the plain crude plant extract. Among all the enzymes that were studied, Sm-ihNFs demonstrated significantly higher alpha-glucosidase and alpha-amylase inhibition activities compared to acarbose. And when compared to galanthamine hydrobromide Sm-ihNFs showed higher enzyme inhibition and significant IC50 value. 
 Conclusion: It was thought that Sm-ihNFs prepared from eggplant extract may have promising potential for antidiabetic drug formulations in the future. The hybrid nanoflowers will be promising and guide for the future work in terms of pharmaceutical and cosmeceutical industry.

EFEKTIVITAS EKSTRAK ETANOL KULIT TERONG UNGU (Solanum melongena L.) SEBAGAI ANTIMALARIA TERHADAP JUMLAH BASOFIL DARAH MENCIT (Mus musculus) YANG DIINDUKSI Plasmodium berghei

Malaria is one of the disease which spreads through the bite of female Anopheles mosquito caused by Plasmodium parasite. Malaria can be treated with antimalarial drugs such as chloroquine and artemisin, but in some malaria-endemic areas, parasitic resistance to chloroquine has been reported so that malaria eradication becomes increasingly difficult. The occurrence of such resistance causes the need for new antimalarial findings. Eggplant (Solanum melongena L.) has many secondary metabolites, such as alkaloids, terpenoids, and flavonoids which have antiplasmodial activity. The aim of this research is to determine the effectivity of the ethanol extract of eggplant peels as an antimalarial to basophil in mice induced by Plasmodium berghei. Eggplant peel was extracted by maceration method using 70% ethanol. The analysis of secondary metabolites from the ethanol extract of eggplant peels used tube test and thin layer chromatography. The level of parasitemia and the number of basophil were calculated from blood smear of mice (Mus musculus) which were treated with extracts at a dose of 0.075 mg/20 g of body weight; 0.15 mg/20 of body weight; and 0.3 mg/20 g of body weight. 3.744 mg/20 g of body weight DHP was used as positive control and aquades was used as negative control. Research result show that ethanol extract of the eggplant peels contains groups of alkaloids, flavonoids, terpenoids, steroids, phenolic and saponins. 0.075 mg/20 g body weight of ethanol extract of the eggplant peels effectively reduces parasitemia. Ethanol extract of the eggplant peels in all dose groups did not have an effect on basophils. The conclusion of this research is ethanol extract of the eggplant peels has antimalarial activity and does not increase the number of basophils.

Hepato-Protective Activities of Ethanol Extracts of African Eggplant and Bitter Leaf in Alloxan Induced Diabetic Rats

Diabetes is a metabolic disorder, which affect all system of the body including the liver. This study focused on the effect of the ethanol extract of African eggplant and bitter leaf and their combination on the liver structure, antioxidant enzymes activities and biochemical parameters in the liver of alloxan induced diabetic rats. Twenty-five male wistar rats were grouped into normal control group A, diabetic control group B, 100 mg/kg African eggplant extract treated group C, 100 mg/kg bitter leaf extract treated group D and combination of 100 mg/kg of African eggplant and 100 mg/kg bitter leaf treated group E. The results study showed that group E rats showed significant reduction in the activity of AST, ALP and AST. In the antioxidant enzyme activity, the administered extracts increased the antioxidant enzyme activities and reduced lipid peroxidation, thereby protecting the cells from oxidative stress. The micro- histo-architecture of the liver showed improvement and regenerative changes across the treated groups. The study reveal that combination of the ethanol leaf extract of bitter leaf and African eggplant can manage liver malfunction caused by diabetes.

Physical Characteristics of the Development of Edible Film Gelatin-Xylitol Using Butterfly Pea Extract as an Antioxidant

The study aims to determine a gelatin-xylitol edible film with the addition of butterfly pea extract (Clitoria ternatea L) using the Microwave Assisted Extraction method with optimal physical characteristics of the edible film. The research method uses the experimental method with calculations using a Completely Randomized Design (CRD), followed by Duncan analysis (DMRT) if there are significant or very significant effects in each treatment. This research method focuses on differences in the percentage of butterfly pea extract in the manufacture of gelatin-xylitol edible films with 5 treatments P0 (0%), P1 (1%), P2 (2%) P3 (3%), and P4 (4%) and 3 repetitions. The results of the second phase of the study showed the effect of different butterfly pea extracts on edible gelatin-xylitol. There was no significant effect (P>0.05) in the sedimentation test, L and a color, there was a significant effect (P<0.05) in the b color test analysis and in the antioxidant test analysis. The functional groups identified in the eggplant extract were alkanes, alkenes, fluorides, and aromatics. The analysis of the Scanning Electron Microscope test showed the presence of particles in the edible film was 3% addition of butterfly pea extract produces an edible film that has antioxidants.

Toxicity of the Concurrent Administration of the Ethanol Leaf Extract of African Eggplant and Bitter Leaf on the Stomach and Selected Haematological Ratios in Adult Male Wistar Rats

Toxicity of the Concurrent Administration of the Ethanol Leaf Extract of African Eggplant and Bitter Leaf on the Stomach and Selected Haematological Ratios in Adult Male Wistar Rats

Study to detect cytotoxicity of The eggplant plant ( Solanum melongena L)

The current study included the cytotoxicity test of the active compounds isolated from the peels of the fruits of the eggplant plant, which is found in the local markets of Dhi Qar governorate and used for food and grown within the governorate and not imported during the period (July, August, September, October, November, December. January), the trend of human red blood cells for the purpose of determining the possibility of using them as drug alternatives in the future.
 The peels of the eggplant plant were extracted with hexane once, then the alkaloid extract was prepared from it again. The alkaloid compounds were detected using the Drankcroff reagent and Mayer's reagent. The positive result of the detection gave an indication of the presence of alkaloid substances that are antioxidants and have a high nutritional value.
 The concentrations of plant extracts represented by hexane eggplant extract and its alkaloid extract at concentrations (75,50,25,10,5,100) mg/ml were prepared using DMSO solution as a solvent, and a negative control factor containing physiological salt and blood, and a positive control factor (tap water) were prepared. ), and a third control factor consisted of blood solution with DMSO solvent, and the solution was monitored for (3-24) hours to observe the dissolution of blood cells.
 The cytotoxicity results of plant extracts of Solanum melongena L. showed that the concentrations (75,50,25,10,5,100) mg/ml did not cause any hemolytic and therefore do not cause any cytotoxicity towards red blood cells, and the bottom layer appeared in red color Which represents human blood, and the upper layer represents the extract as well as the physiological solution. If these compounds were toxic, the decomposition of red blood cells would result. Room temperature is 30°C and inside the incubator is 27°C. Incubator made by Dander, Germany and the concentration of the substance.

Infertility Impact of Cotton Seeds (Ceiba pentandra) and Eggplant Cepoka (Solanum torvum) on the Nfkb Expression and Seminiferous Tubules Diameter

The presence of the solasodine and gossypol compounds in Kapok seeds (Ceiba pentandra) and cepoka eggplant (Solanum torvum) suggest the use of these two as an herbal contraceptive ingredient in male animal fertility. This study aimed to determine the effect of cepoka eggplant extract (S. torvum) and kapok seed (C. pentandra) on infertility in rats (Rattus norvegicus) through NFkB expression and seminiferous tubule diameter. The study was carried out on 75 to 90 days old male Wistar rats having 150-200 grams of body weight. The experimental design used in this study was a completely randomized design (CRD) with three treatment groups i.e. C (control), KP1, and KP2 having six rats in each group. Here the rats of group C were not treated with gossypol or solasodine while the rats of group KP1 were treated with solasodine compound at a dose of 1g/kg BW and rats of group KP2 were treated with gossypol induction at a dose of 0.1 g/kg BW. Kapok seed extract and eggplant cepoka extract were extracted by the maceration method with 70% ethanol solvent. NFkB expression was examined using the immunohistochemical (IHK) method, which was analyzed with immunoratio software. Histopathological preparations (HE) of seminiferous tubule diameter were analyzed using raster image software 3. All the obtained data were analyzed by the One Way ANOVA test and Tukey's follow-up test with a 95% confidence level (α = 0.05). The results showed that the administration of cepoka eggplant extract could significantly increase the expression of NFkB (p<0.05) with an average amount of 87.22 ± 6.89 with a dose of 1 g/kg BW. Treatment with Kapok seed extract can reduce the diameter of the seminiferous tubules (STs) by an average of 0.31 ± 0.016 at a dose of 0.1 g/kg BW. The results of the study can be concluded that the extract of cepoka eggplant and kapok seeds can be used as candidates for herbal contraceptives.

Pemanfaatan Ekstrak Terung Asam Pada Pakan Buatan Terhadap Pertumbuhan Udang Vaname (Litopenaeus Vannamei)

Abstract This study aims to determine the effect of tamarind eggplant extract added to feed on the growth of vannamei shrimp and to determine the dose of tamarind eggplant extract which gives the highest growth in vaname shrimp. This research was conducted on 17 December 2020 - 14 January 2021 at the Brackish and Marine Aquaculture Laboratory, Faculty of Fisheries, Pekalongan University, Jalan Pantai Dewi No. 1, Slamaran Pekalongan. The experimental design used was a completely randomized design (CRD) with 4 treatments and 3 replications. Treatment A (0 ml / L sour eggplant extract / kg feed), B (50 ml / L sour eggplant extract / kg feed), C (100 ml / L sour eggplant extract / kg feed), and D (150 ml / L sour eggplant extract / kg of feed). The results showed that the addition of tamarind eggplant extract at different doses to the feed had a very significant effect on the growth of vaname shrimp seeds. Treatment B had the best growth which was 5.05 gr, then treatment C was 4.33 gr, treatment D was 3.99 gr, and the lowest was treatment A was 3.05 gr. Keywords: Vanname Shrimp, Tamarind Eggplant, Growth

New Insight on the Bioactivity of Solanum aethiopicum Linn. Growing in Basilicata Region (Italy): Phytochemical Characterization, Liposomal Incorporation, and Antioxidant Effects

Food extract’s biological effect and its improvement using nanotechnologies is one of the challenges of the last and the future decades; for this reason, the antioxidant effect of scarlet eggplant extract liposomal incorporation was investigated. Scarlet eggplant (Solanum aethiopicum L.) is a member of the Solanaceae family, and it is one of the most consumed vegetables in tropical Africa and south of Italy. This study investigated the antioxidant activity and the phytochemical composition of S. aethiopicum grown in the Basilicata Region for the first time. The whole fruit, peel, and pulp were subjected to ethanolic exhaustive maceration extraction, and all extracts were investigated. The HPLC-DAD analysis revealed the presence of ten phenolic compounds, including hydroxycinnamic acids, flavanones, flavanols, and four carotenoids (one xanthophyll and three carotenes). The peel extract was the most promising, active, and the richest in specialized metabolites; hence, it was tested on HepG2 cell lines and incorporated into liposomes. The nanoincorporation enhanced the peel extract’s antioxidant activity, resulting in a reduction of the concentration used. Furthermore, the extract improved the expression of endogenous antioxidants, such as ABCG2, CAT, and NQO1, presumably through the Nrf2 pathway.

TESTING THE RESPONSIBILITY OF EGGPLANT THORN (SOLANUM CAROLINENSE) ETHANOL EXTRACT ON THE GROWTH OF BACTERIA (STREPTOCOCCUS MUTANS) IN VITRO

Streptococcus mutans is the main pathogenic bacteria causing caries and tooth enamel damage. Eggplant spines (Solanum carolinense) contains active substances that can inhibit the growth of Streptococcus mutans bacteria on teeth. The purpose of this study was to determine the inhibitory effect of the antibacterial activity of ethanol extract of thorn eggplant on the growth of Streptococcus mutans bacteria and to determine the optimal concentration of thorn eggplant extract on the growth of Streptococcus mutans bacteria in vitro. The type of method used in this study is an experimental study, with the dependent variable being the zone of inhibition of the growth of Streptococcus mutans, the independent variable being differences in the concentration of ethanol extract of thorn eggplant (Solanum carolinense) at concentrations of 20%, 40%, 60%, 80% and 96 ethanol. % as negative control and chloramphenicol as positive control, control variables for the presence of other microbial contamination, media thickness, turbidity of bacterial suspension, incubation temperature, disc distance, incubation time, sterilization of equipment, media and room. The results of this study were the effect of the ethanol extract of thorn eggplant on Streptococcus mutans and the optimal concentration of the ethanolic extract of thorn eggplant was 80% with an inhibition zone diameter of 11 mm (strong) which was indicated by the appearance of the diameter of the bacterial inhibition zone at each treatment

Bioactive properties and enzymatic activities in long and round type eggplant (Solanum melongena L.): Inferences for processable traits

Eggplant is a valuable commercial vegetable widely consumed due to its unique meaty taste and nutritional and functional properties. The present investigation was done with the aim to assess the bioactive properties and enzymatic activities in twenty three different long and round type eggplant genotypes to ascertain their amenability for processable traits. The eggplants were harvested at commercial maturity stage and assessed for total phenolics content, total flavonoids, antioxidant capacity and browning related enzymatic activities (polyphenol oxidase and peroxidase). The results indicated that there were significant dissimilarities among all genotypes with regard to their functional compounds content and browning enzyme activities. The biochemical screening showed maximum phenolics content in Kashi Taru (81.1 mg gallic acid equivalent/100 g fresh weight) which was about 4.0-fold higher than IVBL-23 (19.3 mg gallic acid equivalent/100 g fresh weight). Additionally, total flavonoids content varied from 1.86 (IVBHL-UT-6 and IVBHR-18) to 5.83 mg rutin equivalent/100 g fresh weight (IVBHL-UT-1). The total antioxidant capacity among different eggplant cultivars varied by about 1.3-fold. These findings are useful for pre-breeding parental selection and assorting genotypes for higher antioxidant capacity and processable traits. About 3.5-fold variation in browning enzymatic activity clearly indicates the scope for selecting cultivars with lesser flesh browning and thus, higher suitability for processing particularly for development of products like eggplant extract, dips or dried flakes.

Extracts From Red Eggplant: Impact of Ohmic Heating and Different Extraction Solvents on the Chemical Profile and Bioactivity

Eggplants contain a multitude of biocompounds with nutritional and/or biological activities. The objective of this work was to study the nutritional, chemical and bioactive value of red eggplant from Rotonda, Italy. Ohmic heating (OH) was compared to conventional heating, as different solvents were used (water, ethanol 30, 50, and 90% and methanol) for biocompounds extraction. Extracts were evaluated for their total phenolic compounds, antioxidant and antibacterial activities, and its toxicity was assessed in cells, L929 and Caco-2. The nutritional characterization of Rotonda's eggplant demonstrated that it is rich in carbohydrates (65%), fiber (12.5%), proteins (13%), lipids (7.6%) and minerals. Potassium is the mineral with the highest concentration in the red eggplant (27.24 mg/g). Phenolic composition of the obtained extracts was dependent on the extraction method, as well as on the solvent. The use of OH method increased the extraction of biocompounds, especially when using 50% of ethanol as solvent. The main phenolic compounds found in the extracts of this eggplant variety were ellagic acid, p-coumaricic acid, epicatechin, narginin, taxifolin and kaempferol. Antioxidant activity was positively correlated with the total amounts of phenolics. Red Eggplant extracts showed activity against Gram-negative bacteria (E. coli and S. enterica), however, they did not demonstrate activity against Gram-positive bacteria. The extracts obtained did not show cytotoxic effects in fibroblast and colorectal studied cells. Ohmic heating is a sustainable technology that increases the extraction yield of biocompounds, with reduced energy consumption and the resulting extracts show low toxicity and high biological activity.

Modification of Cu2+ in polyphenol oxidase extract from purple eggplant for phenol degradation in coal wastewater treatment

Cracking coal-forming organic compounds during the gasification process produces liquid waste containing phenolic compounds that require special handling based on their toxicity. As one of the components, there is liquid waste resulting from the coal gasification process. The purpose of this research was to study the activity of polyphenol oxidase (PPO) on phenol after the addition of Cu2+ to purple eggplant (Solanum melongena L.) extract and its potential to work more effectively in phenol biodegradation for coal wastewater containing phenol. Enzyme activity and phenol determination were carried out spectrophotometrically. The results showed PPO activity of 25.90-38.10 U/mL; 4.0 mM phenol and the activity of PPO-Cu2+ was 21.58-46.32 U/mL; 2-10 mM CuSO4; 2.0-4.0 mM phenol. Based on Michaelis Menten’s graph, the initial rate of PPO-Cu2+ was 0.015 mM/min and the initial rate of PPO was 0.15 mM/min using 2 mM phenol as a substrate. Lineweaver-Burk’s graph shows the KM of PPO-Cu2+ = 6.92 mM, which is lower than KM of PPO = 13.05 mM. Its means that the phenol response has a higher affinity for PPO-Cu2+ than PPO. The application of PPO-Cu2+ in purple eggplant extract works effectively as much as 46.7% for artificial coal liquid waste containing phenol.

Study and Evaluation of the release of Flavonoids extracted from various Eggplant cones from Semisolid Pharmaceutical Forms (In vitro)

Various semisolid pharmaceutical forms have been prepared from eggplant calyx extract which rich in flavonoids and antioxidants. These ingredients were titrated in the prepared extracts, and then incorporated into the prepared pharmaceutical forms. Eggplant calyxes were used for three varieties cultivated in Syria. The flavonoids were extracted from them by using several aqueous and organic solutions. Three types of extracts were prepared for each type of eggplant (aqueous, ethanolic 70%, methanolic). The ethanolic extract of black eggplant showed the highest content of flavonoids. The black eggplant extract contained the largest amount of flavonoids in the three types of extracts. The antioxidant capacity of the plant extracts was measured by measuring its ability to remove free radicals of the fixed root DPPH, and the ethanolic extract of the black eggplant showed the best antioxidant capacity. Three topical pharmaceutical formulas were prepared of the ethanolic extract 70% for the rectangular black eggplant calyx, and the kinetics of the release of the main components from them in vitro was studied using a Franz cell, within four hours to determine the release model for each formulation in order to compare the formulas and select the best one. The cream of the (o / w) pattern gave the best release of the active substances because it released the highest percentage (92%) after two hours and the release pattern was of the zero order, while the rest of the formulas had the highest percentage of release after four hours with some deficiency of the active substances in them.

Reactive modification of gum Acacia biopolymer by natural pigment Anthocyanin and Tannin: their optical and impedance study

ABSTRACT In this study, plant biopolymer gum Acacia is synthesised and chemically modified by fruit extract of black grapes (Vitis vinifera), eggplant (Solanum melongena). Fruits contain functional groups called chromophore which confer colour. It is the region where radiation is absorbed and electron is transferred between two energy states. They absorb UV and/or visible light. They are conjugated unsaturated bonds and responsible for optical and electrical properties. In the present work, optical properties of biopolymer gum Acacia specimen and chromophore induced specimen of the above-mentioned fruits are examined by UV-visible spectroscopy. It is found that light absorption is pronounced in the visible range of spectrum compared to the pure specimen in which absorption is found to be observed in the deep ultraviolet range. Electrical characterisation of the modified gum Acacia biopolymer with grape fruit extract and eggplant extract are observed. Electrical conductivity is enhanced over pure specimen. These properties will be fruitful in dye-sensitised solar cells (DSSCs) application, which is an ongoing extensive research area.

Effect of incorporating extracts from natural pigments in alginate/starch films

Currently, growing interest exists in the development of packaging materials of natural origin for food applications. This study, conducted the extraction of pigments from natural sources (anthocyanin and betanin) from the exocarp of the black eggplant (Solanum melongena) and the mesocarp of beet (Beta vulgaris), which were incorporated in a film-forming solution based on sodium alginate and starch, as an indicator of films with natural pigment extract (FNE). In consequence, the objective of this work was to assess the effect caused by incorporating extracts of natural origin on the mechanical, optical, and structural properties of sodium alginate/yucca starch films. The films were elaborated with different concentrations of each pigment extracted (2% and 5%) and compared with a control film (CF). The films were exposed to a series of synthetic amines and the changes were observed in the UV-vis absorption spectra. In addition, the effect was evaluated when adding extracts from natural pigments into a polymer matrix, evaluating the mechanical, structural, and optical properties. The results showed that incorporation of natural extracts (NE) influenced on the mechanical properties, but did not influence on film thickness and water vapor permeability (WVP). X-ray diffraction (XRD) indicated increased film crystallinity when incorporating the natural extracts. The microstructure Fourier transform infrared analyses of the films showed that the extracts were compatible with the polymer matrix. Films with eggplant extract (FEE) had higher antioxidant activity against the 1,1–Diphenyl–2–picryl–hydrazyl (DPPH) radical and were more sensitive to the exposure of gaseous amines in comparison with films with beet extract (FBE). Hence, the results obtained show that the films developed with natural compounds are a visual method that could report and monitor the state of the foods.

The efficacy of eggplant (Solanum melongena) extract as bioinsecticide on mortality of Helopeltis antonii

The efficacy of eggplant (Solanum melongena) extract as bioinsecticide on mortality of Helopeltis antonii

Efektivitas Ekstrak Etanol Kulit Buah Terung Ungu (Solanum melongena L.) sebagai Antimalaria terhadap Jumlah Eosinofil pada Mencit (Mus musculus) yang Diinduksi Plasmodium berghei

Malaria adalah penyakit yang disebabkan oleh parasit Plasmodium yang ditularkan ke manusia melalui gigitan nyamuk Anopheles betina. Banyaknya kasus resistensi obat antimalaria seperti klorokuin menyebabkan perlunya dilakukan penemuan antimalaria baru. Terung ungu (Solanum melongena L.) memiliki banyak senyawa metabolit sekunder yang berpotensi sebagai antimalaria. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol kulit buah terung ungu sebagai antimalaria terhadap jumlah eosinofil pada mencit yang diinduksi Plasmodium berghei. Kulit buah terung ungu diekstraksi dengan metode maserasi menggunakan pelarut etanol 70%. Metabolit sekunder ekstrak etanol kulit buah terung ungu dianalisis menggunakan uji tabung dan kromatografi lapis tipis. Jumlah parasitemia dan eosinofil dihitung dari sediaan apus darah tepi mencit yang diberi perlakuan ekstrak dengan dosis 0,075; 0,15; dan 0,30 mg/20 gBB. Kontrol positif diberi 3,744 mg/20 gBB dihydroartemisinin-piperaquin, sedangkan kontrol negatif diberi air suling. Penelitian ini menunjukkan bahwa ekstrak etanol kulit buah terung ungu mengandung golongan senyawa alkaloid, flavonoid, terpenoid, steroid, fenolik dan saponin. Ekstrak paling efektif menurunkan jumlah parasitemia pada dosis 0,075 mg/20 gBB, namun tidak efektif meningkatkan jumlah eosinofil pada mencit. Tidak terdapat hubungan antara jumlah parasitemia dan jumlah eosinofil. Penelitian ini menyimpulkan bahwa ekstrak etanol kulit buah terung ungu memiliki aktivitas antimalaria tetapi tidak bersifat imunomodulator pada peningkatan eosinofil.