This study explored the relationships among reading motivation, reading strategy use and, reading comprehension in EFL reading. A cohort of 308 male and female EFL students at the preparatory year of an emerging Saudi university completed a reading motivation questionnaire, a reading strategy questionnaire, and a reading comprehension test. Independent samples t-test results revealed that students with high reading motivation (extrinsic, intrinsic, and efficacy) used three reading strategy categories (pre, while, and post-reading strategies) more frequently than students with moderate reading motivation. Similarly, students with high reading motivation were found to have better reading comprehension. Reading strategy use was also found to induce significant differences in students’ reading comprehension. Results of multiple regression revealed that extrinsic motivation was the best predictor of students’ reading strategy use and reading comprehension. Of all strategy categories, while-reading strategies were the best predictor of students’ reading comprehension. Of all motivation and strategy factors, while-reading strategies, reading efficacy and extrinsic motivation significantly predicted reading comprehension, with while-reading strategies being the strongest predictor. Implications for reading instruction and suggestions for further research are offered.