Vortex beams carrying orbital angular momentum (OAM) modes offer a compelling avenue for increasing optical communication capacity. Despite significant efforts in OAM mode (de)multiplexing, challenges persist in signal demodulation and noise monitoring of multiplexed channels. This challenge largely stems from the absence of efficient feature extraction methods capable of analyzing the OAM spectrum, which delineates mode components and intensity weights. Herein, we introduce a novel strategy for OAM mode spectrum analysis using a residual neural network incorporating interference techniques. By introducing interference between target vortex beams and a spherical wave, resulting in the mapping of OAM distributions onto the stripe features observed in the interferogram. To effectively extract spectrum details from these interferograms, we construct a residual neural network exhibiting high feature processing capabilities, which enables precise analysis of intricate OAM mode spectrum. We demonstrate the effectiveness of this OAM spectrum analysis by obtaining the intensity weights for 15 superimposed modes ranging from −10 to +10, achieving a mean-square-error of 2.3 × 10−4. To validate its practicality, we showcase an 80-channel three-dimensional multiplexing communication system including five OAM modes, two polarizations, and eight wavelengths. The 4 Tbit/s quadrature-phase-shift-keying signals are successfully demodulated with a bit-error rate below 3.34 × 10−6. Additionally, the measured optical signal-to-noise ratio reaches 11.5 dB, indicating the potential applications of this OAM spectrum analysis strategy in signal demodulation and noise monitoring.