Efficient Copper-catalyzed Method Research Articles

Easy and Efficient Copper-Catalyzed Synthesis of Bicyclic Pyrimidinones under Mild Conditions

A simple and efficient copper-catalyzed method has been developed for synthesis of bicyclic pyrimidinones containing six-, seven-, eight-membered rings under mild conditions. The protocol uses readily available 2-bromocycloalk-1-enecarboxylic ac- , ids, amidines, and guanidines as the starting materials, copper-catalyzed cascade couplings provide the corresponding bicyclic pyrimidinones without addition of any ligand or additive, and the method is of economical and practical advantages.

ChemInform Abstract: A Simple Copper‐Catalyzed Cascade Synthesis of 2‐Amino‐1H‐indole‐3‐carboxylate Derivatives.

We have developed a simple and efficient copper-catalyzed method for the synthesis of 2-amino-1H-indole-3-carboxylate derivatives via cascade reactions of substituted N-(2-halophenyl)-2,2,2-trifluoroacetamide with alkyl 2-cyanoacetate or malononitrile under mild conditions, and the method is of wide practical application.

Efficient copper-catalyzed N-arylations of nitrogen-containing heterocycles and aliphatic amines in water

A simple and efficient copper-catalyzed method has been developed for N-arylations of nitrogen-containing heterocycles and aliphatic amines in water. The protocol uses (1E,2E)-oxalaldehyde dioxime (OADO) as the ligand, and water as the solvent, and shows good tolerance towards various functional groups.

Simple and efficient copper-catalyzed cascade synthesis of naphthols containing multifunctional groups under mild conditions

A simple and efficient copper-catalyzed method for synthesis of naphthols containing multifunctional groups has been developed under mild conditions (room temperature to 60 °C), and it can tolerate various functional groups.

Efficient Copper-Catalyzed Synthesis of 4-Aminoquinazoline and 2,4-Diaminoquinazoline Derivatives

We have developed an efficient copper-catalyzed method for the synthesis of 4-aminoquinazoline and 2,4-diaminoquinazoline derivatives via reactions of substituted 2-bromo-benzonitriles with amidines or guanidine, and the method is of economical and practical advantage.

An Efficient One-Pot Copper-Catalyzed Approach to Isoquinolin-1(2H)-one Derivatives

A simple and efficient copper-catalyzed method for synthesis of 3,4-disubstituted isoquinolin-1(2H)-one derivatives via cascade reactions of substituted 2-halobenzamides with beta-keto esters under mild conditions has been developed, and the method has economical and practical advantages.

Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.

Copper‐Catalyzed Coupling of Amides and Carbamates with Vinyl Halides.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Copper-catalyzed coupling of amides and carbamates with vinyl halides.

[reaction: see text] A general and efficient copper-catalyzed method for the amidation of vinyl bromides and iodides has been developed. This protocol uses a combination of 5 mol % copper iodide and 20 mol % N,N'-dimethyl ethylenediamine. Substrates bearing ester, silyl ether, and amino groups were successfully coupled under the reaction conditions. The double bond geometry of the vinyl halides was retained under the reaction conditions.