Under the strategic objectives of carbon peaking and carbon neutrality, clean and efficient coal combustion was important in China. As a novel combustion technology, purification-combustion technology had good research prospects, and high-temperature reduction unit (HTRU) played a crucial role in fuel activation, subsequent combustion and NOx emissions based on the design of this technology. Despite previous research had proved the pivotal role of fuel and combustion air distributions in combustor in influencing the entire thermochemical process, there was the lack of research on their effects in HTRU employing purification-combustion technology. To realize deep NOx emission reduction, this study focused on influences of activated fuel and staged secondary air distributions in HTRU on purification, combustion and NOx emission characteristics in a 30 kW purification-combustion test rig. With the exception of carbon microcrystalline structure, the majority of reductive char properties exhibited superior performance when activated fuel was introduced tangentially, as opposed to axially. Nevertheless, the relationship of carbon microcrystalline structure was regulated by staged secondary air ratio (c12). Properly increasing c12 improved reductive char properties. Additionally, axial introduction of activated fuel more consistently yielded ultra-low levels of NOx emissions; however, this often occurred at the expense of combustion efficiency (η). Properly increasing c12 reduced NOx emissions while increasing η; nevertheless, the benefits derived from c12 were limited. By adjusting introduction direction and c12 (axial, 0.33), minimum NOx emissions decreased to 39.10 mg/m3 (@6 % O2) while maintaining high η of 99.39 %.