In hot and humid climates, dehumidification generally consumes more energy than cooling, and conventional mechanical vapor compression system is not efficient for dehumidification. Vacuum-based membrane dehumidification system have been developed as a more environmentally friendly alternative for dehumidification due to non-refrigerant system and isothermal dehumidification process. In this study, a novel hybrid air conditioning system that combines vacuum-based membrane dehumidification with an indirect evaporative cooler for pre-cooling is proposed to achieve efficient air conditioning in building with low sensible heat ratio. The energy performance of the proposed system is investigated by detailed thermodynamic simulations and compared with conventional variable air volume (VAV) system and indirect evaporative pre-coolers combined VAV system. The simulation results show that when the average sensible heat ratio of the space is 0.73 and the COP of the vacuum-based membrane dehumidifier is 1.0, the proposed system can reduce energy consumption by 16.1 % compared to conventional VAV system and by 6.4 % compared to indirect evaporative pre-cooler combined VAV system during the cooling season. The energy performance of the proposed system is significantly affected by the sensible heat ratio of the building and the energy efficiency of the vacuum-based membrane dehumidifier. When the COP of the vacuum-based membrane dehumidifier reaches 2.0, the proposed system can achieve an energy savings of 48.2 % compared to conventional VAV system.