Solar panel installation is generally exposed to dust. Therefore, soiling on the surface of the solar panels significantly reduces the effectiveness of solar panels. Accumulation of dust also shortens their lifespan and reduces efficiency by about 15% to 20%. A significant reduction in the efficiency of solar photovoltaic panels has been observed due to inadequate insulation and dust deposition or shading. To harness maximum solar energy from solar panels up to their rated capacity, they need to be cleaned periodically. Therefore, the current study focuses on the comparative performance analysis of two distinct types of self-cleaning mechanisms, namely self-cleaning wiper (SCW) and nano-coating method. These methods are economical and sustainable for the standard atmospheric conditions of Pakistan. Solar panels (reference, nano-coated, and self-cleaning wiper mechanism) were placed on the roof of the Mechanical Engineering Department MUST Mirpur AJK for five weeks. Solar irradiance, dust density & performance parameters of these three panels were recorded on weekly basis. It was observed that an increase in the rate of dust deposition negatively affects the conversion efficiency of solar panels. When dust density was increased from 7.5 to 18.15 (g/m2), the percentile drops in rated power (50W) for reference, nano-coated, and self-cleaning wiper mechanisms are 37%, 33% and 23%, respectively. Moreover, the payback period of nano-coated and SCW is 1.07 years and 2.79 years, respectively.