Several types of CLIPS are marketed for hemostasis of bleeding ulcers. Which to choose depends on market forces now because there are no reports comparing hemostasis efficacy, success rates of CLIP deployment onto bases of chronic ulcers (GU's) where stigmata lie, CLIP retention rates, or their influence on ulcer healing or complications. Our purposes were: 1) to compare success rates of deployment & retention rates of 3 different CLIP types on chronic appearing GU's, 2) on weekly endoscopies after treatment, to contrast GU diameter & stigmata with control or multipolar electrocoagulation (MPEC) treated GU's, & 3) to describe whether retained CLIPS influence GU healing or cause complications. Methods: Seven adult dogs with prehepatic portal hypertension received daily proton pump inhibitors (PPI's) & had chronic GU's created by rubber band ligation.One week later, 10 ulcers in pairs were randomized to control or to 4 different treatments to the base of GU's: 3 to CLIPs (Olympus-Oly, Wilson Cook-WC, Boston Scientific Corp-BSC) or to MPEC coagulation. For 11-13 GU's treated with each, ease & time of treatments were recorded. Success rate of CLIP placement onto ulcer bases was also quantitated. Animals were monitored clinically for GI bleeding, obstruction, or perforation. At weekly endoscopies, stigmata, CLIP retention, & ulcer healing were quantitated. Results: ∗p < 0.05 vs. other CLIPS. There were no major clinical complications of retained or excreted hemoclips. For WC, Oly, & BSC respectively, initial CLIP success rates were 25/27 (92.5%), 29/36 (80.6%), & 30/30 (100%). For WC, Oly, & BSC hemoclips respectively, % CLIPs retained @ 1 week were 7.4%, 25%, & 60%∗ & @ 2 wks were 7.4%, 13.9%, 36.6%∗. See Table for ulcer healing @ 2 & 3 wks. Ulcer healing rates were 0% @ 1 wk & 100% @ 4 wks. Conclusions: For the 3 CLIP devices: 1) Similar experience & time were required for successful hemoclipping of chronic GU's. 2) Initial success rates varied from 100% (BSC) to 80.6% (Oly). 3) CLIP retention rates were significantly higher with BSC CLIPs than Oly or WC at 1 & 2 wks. 4) Retained CLIPs appeared to accelerate rather than delay GU healing relative to control or MPEC. & 5) There were no major complications of retained or excreted hemoclips.