Efficacy Of Aneurysm Treatment Research Articles

FRED-EPI study: Safety and efficacy of FRED/FRED Jr aneurysm treatment in current clinical practice.

Flow diversion is increasingly used as an endovascular treatment for intracranial aneurysms. FRED-EPI is a prospective, multicenter, French study, conducted to analyze the safety and efficacy of aneurysm treatment with FRED/FRED Jr (Microvention, AlisoViejo, CA, USA) in current clinical practice. Patients with intracranial aneurysms treated with FRED and FRED Jr who agreed to participate were prospectively and consecutively included in all French centers using these devices. From June 2020 to January 2022, 135 patients (110 females, 81.5%, and 25 males, 18.5%) with 154 aneurysms were included in 13 French interventional neuroradiology centers. The mean age was 53.9 ± 12.2 years (range: 20 - 77 years). Aneurysm was unruptured in 123 cases (79.9%), ruptured in 4 cases (2.6%), and recanalized in 27 cases (17.5%). Most aneurysms were small (135/154, 87.7%). Aneurysm locations were supraclinoid ICA in 83 (53.9%), cavernous and petrous ICA in 25 (16.2%), anterior cerebral artery or anterior communicating artery in 19 (12.3%), MCA in 7 (4.5%), and posterior circulation in 20 (13.0%). Three patients (2.2%) had hemorrhagic complications (1 delayed aneurysm rupture and 2 delayed remote hematoma) and 3 (2.2%) ischemic complications (2 intrastent thrombosis and 1 stroke related to atherosclerosis) leading to 1-year morbimortality of 4.4%. Complete aneurysm occlusion was reported in 105/139 aneurysms (75.5%). FRED-EPI confirms good safety of aneurysm treatment with FRED/FRED Jr in current clinical practice with 4.4% 1-year morbimortality.

Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series

BackgroundFlow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy.PurposeTo report clinical and...

The Combination of Endovascular and Surgical Techniques for the Treatment of Intracranial Aneurysms

Endovascular technique, primarily employing electrolytically detachable platinum coils--the Guglielmi Detachable Coil system--is a viable therapeutic option for the management of many intracranial aneurysms. Inclusion of endovascular techniques into a comprehensive intracranial aneurysm treatment program beneficially extends the options for treatment, and enhances safety and efficacy of aneurysm treatment. Endovascular therapy should be considered not a replacement for surgical clipping, but a welcome addition to the various techniques available for aneurysm treatment. The selection of surgical or endovascular treatment for ruptured and unruptured intracranial aneurysms requires an understanding of the relative physical, anatomical, and physiological characteristics of both endovascular and surgical treatment. This article discusses the selection of endovascular or surgical treatment for an individual patient, which requires a careful consideration of aneurysm-specific and patient-specific characteristics. This article also describes the combination of endovascular and surgical techniques for the management of complex aneurysms. The availability of high quality neurosurgical and endovascular treatment for intracranial aneurysms is expected to provide clinical outcomes superior to those achieved by using either method in isolation.