Purpose: This study aims to determine how multiple role conflict, work stress, stress coping and the performance of female nurses at the SoE Regional General Hospital, whether dual role conflict affect the performance of female nurses at the General Hospital. SoE area, whether work stress affects the performance of female nurses at the SoE Regional General Hospital, whether coping stress affects the performance of female nurses at the SoE Regional General Hospital, does multiple role conflict affect the performance of female nurses through coping stress as an intervening variable at SoE Regional General Hospital, whether work stress affects the performance of female nurses through coping with stress as an intervening variable at the SoE Regional General Hospital. Research methodology: The sample in this study amounted to 35 respondents who were distributed to female nurses at SoE Hospital who were married. The data analysis method used is a quantitative analysis using a validity test, reliability test, classical assumption test, normality test, descriptive analysis, multiple linear analysis, t-test, and sobel test. Result: The results of the study using descriptive analysis using a range of scores are multiple role conflict variables are in the sufficient category, work stress, stress coping and performance are in a good category. The partial multiple-role conflict has a significant effect on performance, partial job stress has a significant effect on performance, Coping stress partially has a significant effect on performance, the effect of multiple role conflict on performance cannot be mediated by coping stress and the effect of work stress on performance can be mediated by coping stressed.
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