Effects Of Whole-body Vibration Research Articles

Acute effects of whole body vibration combined with blood restriction on electromyography amplitude and hormonal responses.

The purpose of this study was to investigate the effects of whole body vibration (WBV) exercise with and without blood flow restriction (BFR) on electromyography (EMG) amplitude and hormonal responses. Eight healthy male adults who lacked physical activity participated in this study and completed 10 sets of WBV and WBV + BFR sessions in a repeated measures crossover design. In the WBV + BFR session, the participants wore a BFR device inflated to 140 mmHg around the proximal region of the thigh muscles. The results indicated that the EMG values from the rectus femoris and vastus lateralis during the WBV + BFR session were significantly higher than those during the WBV session (p < 0.05). Two-way analysis of variance with repeated measures showed that the WBV + BFR and WBV exercise sessions induced a significant (simple main effect for time) increase in lactate (LA) (0.61–4.68 vs. 0.46–3.44 mmol/L) and growth hormone (GH) (0.48–3.85 vs. 0.47–0.82 ng/mL) responses after some of the post-exercise time points (p < 0.05). WBV + BFR elicited significantly higher LA and GH (simple main effect for trial) responses than did WBV after exercise (p < 0.05). Although no significant time × trial interactions were observed for testosterone (T) (604.5–677.75 vs. 545.75–593.88 ng/dL), main effects for trial (p < 0.05) and for time (p < 0.05) were observed. In conclusion, WBV + BFR produced an additive effect of exercise on EMG amplitude and LA and GH responses, but it did not further induce T responses compared to those with WBV alone.

Comparison of the Effectiveness of Whole Body Vibration in Stroke Patients: A Meta-Analysis.

Objectives The goals of this study were to assess the effectiveness of WBV (whole body vibration) training through an analysis of effect sizes, identify advantages of WBV training, and suggest other effective treatment methods. Methods Four databases, namely, EMBASE, PubMed, EBSCO, and Web of Science, were used to collect articles on vibration. Keywords such as “vibration” and “stroke” were used in the search for published articles. Consequently, eleven studies were selected in the second screening using meta-analyses. Results The total effect size of patients with dementia in the studies was 0.25, which was small. The effect size of spasticity was the greatest at 1.24 (high), followed by metabolism at 0.99 (high), balance, muscle strength, gait, and circulation in the decreasing order of effect size. Conclusions The effect sizes for muscle strength and balance and gait function, all of which play an important role in performance of daily activities, were small. In contrast, effect sizes for bone metabolism and spasticity were moderate. This suggests that WBV training may provide a safe, alternative treatment method for improving the symptoms of stroke in patients.

Effects of Whole Body Vibration with Load Stimulation in Postmenopausal Women

Effects of Whole Body Vibration with Load Stimulation in Postmenopausal Women

Effects of Whole-Body Vibration on Jump Performance in Young Women

Acute effects of whole-body vibration (WBV) have recently gained attention for increasing muscle strength and countermovement jump performance in a short time period. WBV stimulates muscles through activation of the tonic vibration reflex and improves muscle performance. The purpose of this study was to compare acute effects of the Power Plate (PP) and Vibraflex (VF) WBV vibration devices on jump performance in recreationally active women, 20-30 years of age. Twelve female participants performed five protocols in a random order, separated by 48 hour washout periods: 1) Control (no vibration); 2) VF 18 Hz; 3) VF 21 Hz; 4) PP 30 Hz; and 5) PP 50 Hz. The low and high frequencies imposed similar G-forces between the devices. Subjects stood barefoot on the platform for five, 60-second bouts separated by 60 seconds rest. Participants performed jump tests immediately after the vibration exposure. A significant condition effect for jump power was found as the VF18 Hz frequency resulted in greater jump power compared to VF 21 Hz (p=0.01). None of the PP conditions were significantly different from the control condition. In conclusion, we demonstrated the side alternating VF platform is a more effective device for increasing jump performance compared to the synchronous PP platform.

Whole-body Vibration Training as a Supportive Therapy During Allogeneic Haematopoietic Stem Cell Transplantation – A Randomised Controlled Trial

Effects of whole-body vibration (WBV) training in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) remain unknown. We examined whether additional WBV training during hospitalisation may stabilise the physical capacity of patients undergoing allogeneic HSCT, improve health-related quality of life (HRQOL) and fatigue status of these patients. In this randomised controlled trial, 26 subjects were randomly allocated 1:1 in an intervention group (INT; n=13) or a control group (CON; n=13). Patients in the CON received conventional physical therapy and patients in the INT completed further WBV training every other day. Isokinetic measurement of the muscular capacity of the lower extremities, functional endurance capacity and HRQOL were evaluated before and after the intervention period. No unwanted side effects were observed. We found a significant positive effect of the intervention on the maximum relative peak torque in extension in the INT compared to the CON (p=0.019) and patients in the INT experienced less pain (p=0.05). WBV training can be successfully implemented as a supportive therapy for patients undergoing allogeneic HSCT. Furthermore, WBV training represents a safe and effective option in the maintenance of muscular capacity of the musculature of the lower extremities and may contribute to pain release.

The immediate effect of whole-body vibration in patients after anterior cruciate ligament reconstruction

The immediate effect of whole-body vibration in patients after anterior cruciate ligament reconstruction

Whole-Body Vibration Does Not Seem to Affect Postural Control in Healthy Active Older Women.

Objective This study investigated the acute residual effects induced by different frequencies of whole-body vibration (WBV) on postural control of elderly women. Design Thirty physically active elderly women (67 ± 5 years) were randomly divided into three groups: two experimental groups (high WBV frequency: 45 Hz and 4 mm amplitude, n = 10; low WBV frequency: 30 Hz and 4 mm amplitude, n = 10) and one control group (n = 10), with no treatment. The participants were first subjected to stabilometry tests and were then guided through three sets of isometric partial squats for 60 s while the WBV stimulation was applied. The control group was subjected to the same conditions but without the WBV stimulation. The participants were again subjected to body balance tests immediately following the end of the intervention period and again at 8, 16, and 24 min. To measure body sway control, three 60 s tests were performed at 10 s intervals for each of the following experimental conditions: (1) eyes opened and (2) eyes closed. The following variables were investigated: the average velocity of the displacement of the centre of pressure in the anterior-posterior and medial-lateral planes as well as in the elliptical area. Results A 3 (condition) × 5 (test) two-way repeated-measures ANOVA did not identify significant differences in the stabilometric variables, regardless of group, time, or experimental condition. Conclusions The effect of WBV, regardless of the stimulation frequency, did not have a significant effect immediately after or up to 24 minutes after vibration cessation, on the variables involved in the control of postural stability in physically active elderly women.

Whole Body Vibration Retards Progression of Atherosclerosis via Insulin-Like Growth Factor 1 in Apolipoprotein E-Deficient Mice.

Whole body vibration (WBV) has a marked impact on lipid metabolism and the endocrine system, which is related to the progression of atherosclerosis (AS). To investigate the effects of WBV, we measured the atherosclerotic plaque area of apolipoprotein E-knockout (ApoE−/−) AS mice, which were trained by WBV (15 Hz, 30 min) for 12 weeks. Simultaneously, serum levels of lipids, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 1 receptor (IGF-1R), interleukin 6 (IL-6), and the mRNA and protein levels of the same in the aorta were compared between the control and WBV groups. The results indicated that WBV significantly reduced the atherosclerotic plaque area with lower very low-density lipoprotein (VLDL) and oxidized low-density lipoprotein (ox-LDL) in the blood. Moreover, the levels of IGF-1 in serum and expression of IL-6, IGF-1R, and p-IGF-1R protein in the mice aorta decreased significantly in the WBV group. In addition, we found that serum IGF-1 in mice increased to the highest concentration in 30 min after WBV for 10, 30, 60, and 120 minutes. These results suggested that appropriate WBV may delay the progression of AS, which was associated with acutely elevated serum IGF-1 and lower levels of IGF-1 and IL-6 in the aorta for long-term treatment.

What does the vibration therapy add? A quasi-experimental, pilot study on the short term effects of whole-body vibration as mode of exercise for nursing home residents aged 80+

Aims: To compare the responses of nursing home residents aged 80+ to an 8 weeks exercise program performed on a vibratory device and to the same exercise program preformed without vibration on lower limb performance, functional dependence and quality of life. Methods: Lower limb performance was evaluated using the 30 seconds Chair Sit to Stand test. Functional mobility was assessed using the timed up and go test. Postural stability was measured using a force platform. The Barthel Index was used to assess functional dependence and the EuroQol was used to evaluate Health-Related Quality of Life. 44 participants were allocated to the whole-body vibration group (n= 15), non-vibration group (n= 15) or to the control group (n= 14). Results: Significant differences were detected in favour of the whole-body vibration group in lower limb muscle performance (p = 0.001), mobility (p = 0.001), functional independence (p = 0.009) and quality of life (p < 0.001) as compared to the control and non-vibration groups. Conclusions: Whole body vibration based interventions may add additional benefits to conventional exercise programs in terms of lower limb muscle performance, functional dependence and quality of life among nursing home residents over 80 years.

The Multisystem Effects of Simulated Agricultural Whole Body Vibration on Acute Sensorimotor, Physical, and Cognitive Performance.

Exposure to whole body vibration (WBV) is common in construction, agriculture, mining, and transportation. There is strong epidemiological evidence linking WBV with adverse health outcomes in the long-term, including low back pain. Fortunately, WBV exposure guidelines to prevent long-term musculoskeletal disorders and discomfort exist. In the shorter-term, it has been speculated that occupational levels of WBV may lead to increased risk of vehicle accidents and falls during egress; however, the acute effects of different vibration intensities remain poorly understood and it is uncertain whether established standards protect the worker from injurious short-term effects. The aim of this study was to investigate the acute sensorimotor, physical, and cognitive effects of occupationally-relevant, simulated whole body vibration (WBV) at levels equivalent to international standard guideline thresholds for long-term discomfort and musculoskeletal disorder risk. Eighteen participants were recruited to perform four, 60-min conditions: (i) Control-no vibration, (ii) Low vibration-equivalent to the exposure action value, (iii) Shock-transient impacts at 1-min intervals superimposed on the Low condition, and (iv) High vibration-equivalent to the exposure limit value. Whole body vibration was simulated using data based on field-collected accelerations experienced by rural workers while operating an all-terrain vehicle. This vibration signal was manipulated to achieve required intensities for each condition and simulated with a 6 degree-of-freedom hexapod platform. Before and after each condition, we collected: rating of perceived body discomfort, rating of perceived headache, postural sway, blink frequency, King-Devick test, and psychomotor vigilance task. Pre- and post-condition data in each condition were submitted to either a paired t-test (parametric) or Wilcoxon signed-rank test (non-parametric). To determine differences between conditions, each condition's post-condition data was normalized to its pre-condition value and entered as the dependent variable in a repeated measures analysis of variance. All conditions, including Control, led to increased upper body discomfort when compared to pre-exposure baseline. The Low condition led to increased discomfort in seven body locations, headache (91% increase from baseline; t = -2.44, P = 0.03), and postural imbalance (53% increase from baseline; t = -2.88, P = 0.01), but the effect on cognitive functioning was less clear. Shock condition led to whole body discomfort, specifically at nine upper body and lower body locations. The High condition led to increased whole body discomfort at all 10 body locations, headache (154% increase from baseline; t = -2.91, P = 0.01), postural imbalance (61% increase from baseline; t = -2.57, P = 0.02), and decrements in vigilance (mean reaction time: 6% increase from baseline, t = -3.27, P = 0.005; Number of lapses: 100% increase from baseline, S = -42.5, P = 0.002). Although the number of pre-post condition effects increased with higher vibration intensity, these effects were not significantly different from sitting without vibration. Therefore, current guideline thresholds might not protect the worker from acute WBV effects. However, further research is needed to discern these effects from other sources of WBV. Based on this study, future WBV interventions and action controls should not only address vibration reduction, but also consider potential effects from prolonged sitting.

The Effect of Whole-Body Vibration on Lower-Body Resistance Detraining in College-Age Women

ABSTRACTPurpose: This study explored the effect of whole-body vibration (WBV) using accelerations of 2.56 g to 7.68 g on lower-body detraining. Methods: All participants (N = 20) were trained using a lower-body resistance-training program for 30 min twice per week from Week 0 to Week 6. At the end of the program, they were randomly assigned to a control group that performed no further training or a WBV group that performed a progressive static WBV program. Data for the 5-repetition-maximum (5RM) squat and extensors and flexors of the knee and ankle were collected at Weeks 0, 6, 8, 10, and 12 for all participants. Results: Two-way (condition vs. time) analysis of variance revealed that although the WBV group maintained strength in the 5RM from Week 6 through Week 8 and the control group had a lower 5RM in Week 8 from Week 6, no differences in the 5RM squat existed between the groups at Week 8. Two-way factorial multivariate analysis of variance revealed no differences between the groups at any of the time for torque of knee flexion, dorsiflexion, or plantar flexion. Conclusion: Static WBV of 2.56 g to 7.68 g did not attenuate detraining of the flexors and extensors of the knee and ankle.

The effect of whole-body vibration training on lean mass: A PRISMA-compliant meta-analysis.

Background:Whole-body vibration training (WBVT) confers a continuous vibration stimuli to the body. Although some reports have discussed the effects of whole-body vibration (WBV) on bone mineral density and muscle strength, study of WBV effects on lean mass have not been determined. The purpose of the present meta-analysis was to evaluate published, randomized controlled trials (RCTs) that investigated the effects of WBVT on lean mass.Methods:We identified only RCTs by searching databases, including Web of Science, PubMed, Scopus, Embase, and the Cochrane Library from inception to March 2017. Data extraction, quality assessment, and meta-analysis were performed.Results:Ten RCTs with 5 RCTs concentrating on older people, 3 on young adults, and 2 on children and adolescents were included. We additionally explored the effect of WBVT on postmenopausal women (6 trials from the 10 trials). Significant improvements in lean mass with WBVT were merely found in young adults (P = .02) but not in other populations compared to control group.Conclusion:The effect of WBVT found in the present meta-analysis may be used in counteracting the loss of muscle mass in younger adults. Moreover, optimal WBVT protocols for greater muscle hypertrophy are expected to be investigated.

Whole-Body Vibration Improves Early Rate of Torque Development in Individuals With Anterior Cruciate Ligament Reconstruction

Pamukoff, DN, Pietrosimone, B, Ryan, ED, Lee, DR, Brown, LE, and Blackburn, JT. Whole body vibration improves early rate of torque development in individuals with anterior cruciate ligament reconstruction. J Strength Cond Res 31(11): 2992-3000, 2017-The purpose of this study was to compare the effect of whole-body vibration (WBV) and local muscle vibration (LMV) on early and late quadriceps rate of torque development (RTD), and electromechanical delay (EMD) in individuals with anterior cruciate ligament reconstruction (ACLR). Twenty individuals with ACLR were recruited for this study. Participants performed isometric squats while being exposed to WBV, LMV, or no vibration (control) in a randomized order during separate visits. Early and late quadriceps RTD and EMD were assessed during a maximal voluntary isometric knee extension before and immediately after WBV, LMV, or control. There was a significant condition by time interaction for early RTD (p = 0.045) but not for late RTD (p = 0.11) or EMD of the vastus medialis (p = 0.15), vastus lateralis (p = 0.17), or rectus femoris (p = 0.39). Post hoc analyses indicated a significant increase in early RTD after WBV (+5.59 N·m·s·kg; 95% confidence interval, 1.47-12.72; p = 0.007). No differences were observed in the LMV or control conditions, and no difference was observed between conditions at posttest. The ability to rapidly produce knee extension torque is essential to physical function, and WBV may be appropriate to aid in the restoration of RTD after ACLR.

Effects of whole body vibration training and mental training on mobility, neuromuscular performance, and muscle strength in older men.

This study was designed to evaluate the effects of whole body vibration (WBV) exercise, mental training (MT), and the concurrent effect of WBV and MT on lower body balance, neuromuscular performance, and leg muscle strength in elderly men. In a randomized control trial study with parallel group design, 42 older men (mean±standard deviation age, 68±5.78 years) were randomly divided into four groups: WBV (n=11), MT (n=12), WBV+MT (n=10), and control (n=9) groups. The protocol of training consisted of three sessions per week for 8 weeks and about 30 min for each session. The WBV exercise was performed on a vibration machine. In MT group, participants were asked to mentally visualize to do the Timed Up and Go and relaxation technics. postural stability, the Timed Up and Go test, 5-repetition chair-rising test, 6-m tandem gait test, 10-m walking, and leg isometric strength were measured in baseline and after 8-week intervention. Repeated measures-analysis of variance followed by post hoc was used to analyses the data. The results of this study showed that there were significant improvements (P<0.05) in postural stability, Timed Up and Go, 5-repetition chair-rising, 6-m tandem gait test, 10-m walking, and leg isometric strength in WBV, MT, and WBV+MT in comparison with baseline and in comparison with control group. It seems that older adults can take benefit from WBV and MT and WBV+MT exercise as a cost-effective and practical way without side effects to improve postural control, mobility, and functional performance.

The Influence of an Acute Bout of Whole Body Vibration on Human Postural Control Responses

ABSTRACTThe use of vibrating platforms has become increasingly available, and popular at sports and rehabilitation institutes. Given the discrepancies in the literature regarding whole body vibration (WBV) and human reflexive responses, the purpose of this study was to examine the acute effects of WBV on postural response latencies, as well as associated electromyography measures of the lower extremities during balance perturbations. Reflexive responses during backward and forward balance perturbations were examined before, after, and 10 min after a bout of WBV. The findings suggest that following an acute bout of whole body vibration, muscle activity of the lower extremities is decreased during a reflexive response to an unexpected perturbation, and may be associated with faster reaction time.

Effect of whole body vibration on spasticity in hemiplegic legs of patients with stroke

Background: Several reports have focused on the effects of whole body vibration (WBV) on spasticity with differing results. Most studies used modified Ashworth scale (MAS) for qualitative measurements, but the effect was small.Objective: To investigate the effect of WBV on spasticity in hemiplegic legs of patients with stroke using F-wave parameters.Methods: Sixteen patients with stroke (mean age, 54.7 ± 13.5 years: time after stroke, 28.0 ± 26.3 months) were enrolled in a comparative before-and-after intervention trial. WBV was applied at 30 Hz (4–8 mm amplitude) for 5 min on the hamstrings, gastrocnemius, and soleus muscles in a sitting position. Spasticity was assessed according to the F-wave parameters, MAS, and active and passive range of motion (A-ROM and P-ROM, respectively). These assessments were obtained before, immediately after, and 20 min after each intervention.Results: The F-wave parameters, MAS score, and P-ROM improved significantly after the WBV and remained below the baseline level, even after 20 min; no such change was noted in the unaffected limb via the F-wave parameters. The WBV also improved volitional movement immediately after intervention, as indicated by the A-ROM.Conclusions: These results confirmed a significant reduction of motor neuron excitability until 20 min after the WBV, as indicated by F-wave parameters.

Whole-Body Vibration Combined with Treadmill Training Improves Walking Performance in Post-Stroke Patients: A Randomized Controlled Trial.

BackgroundStroke is characterized by an asymmetrical gait pattern that causes poor stability and reduces overall activity levels. The aim of this study was to investigate the effect of whole-body vibration combined with treadmill training (WBV-TT) on walking performance in patients with chronic stroke.Material/MethodsThirty ambulatory chronic stroke patients were randomly allocated to the WBV-TT group or the treadmill training (TT) group. The participants in the WBV-TT group performed 6 types of exercises on a vibrating platform for 4.5 minutes and then walked on the treadmill for 20 minutes. The participants in the TT group conducted the same exercise on a platform without vibration and then walked on the treadmill in the same manner. The vibration lasted for 45 seconds in each exercise, and the intervention was performed 3 times weekly for 6 weeks. The treadmill walking speed was gradually increased by 5% in both groups. The outcome measures included the temporospatial parameter of gait (GAITRite®) and 6-minute walk test.ResultsThe WBV-TT group showed significant improvements in walking performance with respect to walking speed, cadence, step length, stride length, single-limb support, double-limb support, and 6-minute walk test compared with baseline (p<0.05). Significant improvements were also seen in walking speed, step length, stride length, and double-limb support compared with the TT group (p<0.05).ConclusionsThese findings indicate that WBV-TT is more effective than TT for improving walking performance of patients with chronic stroke.

Acute effects of whole body vibration on heart rate variability in elderly people

BackgroundWhole body vibration (WBV) has been widely used as a modality for physical activity. In fact, WBV has been used for physical rehabilitation, and to improve muscle performance; but there is little information about its effects on heart rate variability (HRV). AimThe aim of this study was to evaluate the effect of vibration on HRV of the elderly using the vibratory platform. MethodsEleven older adults (7 men, 4 women), aged between 60 and 75 years, were subjected to WBV. The study consisted of a single session of WBV with volunteers standing upright for 10 min on the oscillating platform, with frequency of vibration set at 20 Hz (displacement ± 6 mm; orbital vibration). Pre (baseline) and post-WBV electrocardiograph signals were acquired using a cardiac monitor; and data were statistically analyzed using paired Student's t-test or Wilcoxon test, as appropriate. ResultsThe results demonstrated an increase in SDNN (standard deviation (SD) beat-to-beat, N–N intervals), rMSSD (square root of the mean squared difference of successive N–Ns) and pNN50 (proportion of N–N50 divided by total number of N–Ns) post WBV (p = 0.032, p = 0.024 e p = 0.044, respectively), compared to baseline. The present study thus demonstrated that time domain variables (i.e., SDNN, rMSSD, and pNN50) increase post WBV. ConclusionsOlder individuals are at high risk of developing cardiovascular diseases. As seen in the study, WBV improves HRV; and may help reduce risk of cardiac ailments. Moreover, WBV does not require extensive physical activity on the part of the participant. This makes WBV potentially beneficial to the elderly population. Further studies on WBV using different frequencies and training schedules may improve its applicability in clinics.

Effects of whole-body vibration on balance and mobility in institutionalized older adults: a randomized controlled trial

Objective: To investigate whether a comprehensive exercise program was effective in improving physical function among institutionalized older adults and whether adding whole-body vibration to the program conferred additional therapeutic benefits. Design: A single-blinded randomized controlled trial was conducted. Setting: This study was carried out in residential care units. Participants: In total, 73 older adults (40 women, mean age: 82.3 ± 7.3 years) were enrolled into this study. Interventions: Participants were randomly allocated to one of the three groups: strength and balance program combined with whole-body vibration, strength and balance program without whole-body vibration, and social and recreational activities consisting of upper limb exercises only. All participants completed three training sessions per week for eight weeks. Outcome measures: Assessment of mobility, balance, lower limb strength, walking endurance, and self-perceived balance confidence were conducted at baseline and immediately after the eight-week intervention. Incidences of falls requiring medical attention were recorded for one year after the end of the training period. Results: A significant time × group interaction was found for lower limb strength (five-times-sit-to-stand test; P = 0.048), with the exercise-only group showing improvement (pretest: 35.8 ± 16.1 seconds; posttest: 29.0 ± 9.8 seconds), compared with a decline in strength among controls (pretest: 27.1 ± 10.4 seconds; posttest: 28.7 ± 12.3 seconds; P = 0.030). The exercise with whole-body vibration group had a significantly better outcome in balance confidence (pretest: 39.2 ± 29.0; posttest: 48.4 ± 30.6) than the exercise-only group (pretest: 35.9 ± 24.8; posttest: 38.2 ± 26.5; P = 0.033). Conclusion: The exercise program was effective in improving lower limb strength among institutionalized older adults but adding whole-body vibration did not enhance its effect. Whole-body vibration may improve balance confidence without enhancing actual balance performance.

Low-1 level mechanical vibration improves bone microstructure, tissue mechanical properties and porous titanium implant osseointegration by promoting anabolic response in type 1 diabetic rabbits

Type 1 diabetes mellitus (T1DM) is associated with reduced bone mass, increased fracture risk, and impaired bone defect regeneration potential. These skeletal complications are becoming important clinical challenges due to the rapidly increasing T1DM population, which necessitates developing effective treatment for T1DM-associated osteopenia/osteoporosis and bone trauma. This study aims to investigate the effects of whole-body vibration (WBV), an easy and non-invasive biophysical method, on bone microstructure, tissue-level mechanical properties and porous titanium (pTi) osseointegration in alloxan-diabetic rabbits. Six non-diabetic and twelve alloxan-treated diabetic rabbits were equally assigned to the Control, DM, and DM with WBV stimulation (WBV) groups. A cylindrical drill-hole defect was established on the left femoral lateral condyle of all rabbits and filled with a novel non-toxic Ti2448 pTi. Rabbits in the WBV group were exposed to 1h/day WBV (0.3g, 30Hz) for 8weeks. After sacrifice, the left femoral condyles were harvested for histological, histomorphometric and nanoindentation analyses. The femoral sample with 2-cm height above the defect was used for qRT-PCR analysis. The right distal femora were scanned with μCT. We found that all alloxan-treated rabbits exhibited hyperglycemia throughout the experimental period. WBV inhibited the deterioration of cancellous and cortical bone architecture and tissue-level mechanical properties via μCT, histological and nanoindentation examinations. T1DM-induced reduction of bone formation was inhibited by WBV, as evidenced by elevated serum OCN and increased mineral apposition rate (MAR), whereas no alteration was observed in bone resorption marker TRACP5b. WBV also stimulated more adequate ingrowths of mineralized bone tissue into pTi pore spaces, and improved peri-implant bone tissue-level mechanical properties and MAR in T1DM bone defects. WBV mitigated the reductions in femoral BMP2, OCN, Wnt3a, Lrp6, and β-catenin and inhibited Sost mRNA expression but did not alter RANKL or RANK gene expression in T1DM rabbits. Our findings demonstrated that WBV improved bone architecture, tissue-level mechanical properties, and pTi osseointegration by promoting canonical Wnt signaling-mediated skeletal anabolic response. This study not only advances our understanding of T1DM skeletal sensitivity in response to external mechanical cues but also offers new treatment alternatives for T1DM-associated osteopenia/osteoporosis and osseous defects in an economic and highly efficient manner.