Experiments were carried out to determine the effects of short-term changes in behavioral arousal on the responsiveness to auditory stimuli of medial geniculate and inferior colliculus neurons in the rat. The independent variable was the time of presentation of the signals after a food pellet, the assumption being that the animal's state of arousal might vary after a consummatory act, and that this fact in turn might modify unit activity. Eight different periods were tested in a random order of presentation, the periods varying between 20 and 180 s from the time of presentation of a food reward. The findings indicate increased responsiveness after long intervals, as measured in peak response firing rate, together with decreased spontaneous rate in a 200-ms period before the auditory signals (background rate). The results demonstrate that variations in arousal during the short periods between food rewards in the paradigm tested influence both the spontaneous rate of discharge and the responsiveness of auditory neurons to sensory input, but that the pattern of changes is different in the medial geniculate and in the inferior colliculus. These variations are of a short-term nature compared with the long-term variations that have come to be expected with changes in the motivational or sleep-wake state of the animal. Recognition of this type of modulating influence is of great importance to neurophysiological studies of learning, in view of the fact that associative neural changes have to be extracted from the nonassociative changes that occur simultaneously.