Transition metal selenides have been studied as potential anodes for sodium-ion batteries (SIBs) due to their high theoretical capacity and electric conductivity. However, the serious volume expansion, particle aggregation and the dissolution of polyselenium can lead to inferior cycle performance. Herein, the ingeniously designed FeSe2 hollow spheres with the nitrogen-doped carbon shells and Ti3C2Tx MXene materials have been synthesized and exhibited the excellent rate and cycle performance for SIBs, achieving the specific capacity of 344 mAh g−1 with the charging process of ∼26.4 s at 50 A g−1 and the reversible capacity of 287 mAh g−1 after 1200 cycles. The synergy effect of nitrogen-doped carbon shells and MXene layers with the inner void can facilitate mass transport/electron transfer, alleviate the volume expansion of FeSe2, and reduce the direct contact of FeSe2 with the electrolyte, satisfying the sodium storage performance and ultrahigh stability. Moreover, the full cells assembled with pre-sodiated FeSe2@NC@MXene as anode and Na3V2(PO4)3@C as cathode deliver a reversible capacity of 466 mAh g−1 after 600 cycles at 1 A g−1, with a capacity retention rate of 90.3 %. This work may present a promising way for the high-rate capacity materials for the applications as sodium-ion battery anode.