An experimental investigation of the fatigue behaviour of plain and notched specimens made of 40 % wt. short glass fibre-reinforced PolyPhenylene sulfide is presented. To this end, plain and V-notched specimens (with notch root radius ranging from 0.2 mm to 10 mm) were produced by injection moulding, and the final geometries were obtained by means of two different technological processes (i.e., directly after the injection moulding process and by machining them from injected plates). To investigate the effect of notch root radius and fibre orientation, tension–tension fatigue tests were carried out in load control mode, and the experimental results were reanalysed in terms of net stress amplitude defining the traditional stress-life curves. During the fatigue tests, the damage evolution was monitored using a travelling microscope to define the number of cycles spent for fatigue crack nucleation. Furthermore, the fracture surfaces were observed at the microscopic level to investigate the damage mechanisms and the actual fibre orientation was evaluated by computed tomography analysis. Then, by employing coupled finite element analysis of the injection moulding process and the structural behaviour, four different approaches available in the open literature were used to correlate the geometrical and/or manufacturing process effects in the fatigue strength of the considered material.