Effectiveness Of Nasal Irrigation Research Articles

Effect of nasal irrigation with budesonide and normal saline on patients with chronic rhino-sinusitis surgery

Effect of nasal irrigation with budesonide and normal saline on patients with chronic rhino-sinusitis surgery

ASSESSMENT OF NASAL IRRIGATION WITH XYLITOL IN THE POSTOPERATIVE ENDOSCOPIC SURGERIES OF PARANASAL SINUSES

Chronic rhinosinusitis is a condition of nasal inflammation that requires multifactorial treatment, including surgery, with indication of nasal irrigation to reduce nasal symptoms. Xylitol can be associated with nasal irrigation due to its therapeutic effect. Our study aims to assess the relationship between the effects of nasal irrigation with saline solution compared to xylitol through clinical questionnaires (visual analogue scale, NOSE and SNOT-22). Fifty-two patients, divided into two groups (26 in the “Xylitol” group and 26 in the “Saline” group) answered validated questionnaires in Portuguese about their nasal symptoms (nasal obstruction, runny nose, need to blow out sneezes, among others), and general symptoms, before and after endoscopic endonasal surgery, after a period of 30 days of nasal irrigation. The “Xylitol” group showed significant improvement in pain symptoms and nasal symptoms after surgery and irrigation using a xylitol solution. The “Saline” group also showed improvement in symptoms, but to a lesser extent. Our study suggests that xylitol solutions can be used in the postoperative period of endoscopic endonasal surgery, as it leads to a greater reduction in nasal symptoms without incurring higher costs to patients.

The Effect of Nasal Irrigation with Dewandaru (Eugenia Uniflora L) Leaves Ethanol Extract on Il-4 Levels, Thymic Stromal Lymphopoiethin (TSLP) Expression and Expression of H4 Mucosa Receptors of Wistar Rats with Allergic Rhinitis

Nasal irrigation with Dewandaru leaf extract can reduce inflammatory cell infiltration in the nasal mucosa of rats, and is effective in reducing RA symptoms and has an effect no different from topical corticosteroids. This study aims to prove whether nasal irrigation with ethanolic extract of Dewandaru leaves can reduce the infiltration of allergic inflammatory mediators in the nasal mucosa of male white rats of Wistar strain suffering from RA after ovalbumin nasal spray was induced, by assessing IL-4 levels, TSLP expression and H4 receptor expression. The study was conducted with a randomized post test only control group design, using an animal model of allergic rhinitis, involving 34 male white rats of the Wistar strain, divided into 2, namely: 17 treatment groups and 17 control groups. After 4 weeks of exposure, termination and sampling of rat nasal mucosa was performed. Statistical analysis using the independent sample T test showed that the levels of IL-4 in the nasal mucosa of rats and the expression of H4 receptors on the nasal mucosa of rats were significantly lower than in the control group (p<0.05). Meanwhile, the TSLP expression of the nasal mucosa of rats in the treatment group (2.0154) was not significantly different from the control group (2.1891) with p=0.478, possibly associated with less severe damage to the epithelial barrier cells of the nasal mucosa of TSLP-producing in the group control. The ethanolic extract of Dewandaru leaves has the ability to suppress IL-4 cytokine levels through inhibition of the activity of RH4, so it can be used as a supporting therapy for nasal irrigation that can suppress allergic inflammatory mediators in the nasal mucosa of rats.

The Effect of Nasal Irrigation on COVID-19 Patient’s Mild Symptoms of Respiratory Tract

BACKGROUND OF THE STUDY: Severe Acute Respiratory Syndrome Corona virus-2 (SARS CoV-2) is a virus that causes covid-19. The initial symptoms put forward by WHO since 2020 is fever accompanied by cough and shortness of breath. Currently, the loss of smell and taste, accompanied by other symptoms, tends to be a strong predictor of COVID-19. The nose is the entrance for air, that's why the nose has an important role in the breathing process. In addition to warming, humidifying, and filtering incoming air, the nose can also maintain respiratory tract homeostasis. The use of nasal irrigation with isotonic saline solution (NaCl 0.9%) is a way to improve mucociliary clearance function by activating cilia as an olfactory sensory system.
 
 AIM OF THE STUDY: To evaluate the effect of nasal irrigation to covid patients who has mild symptoms in the upper respiratory tract
 
 METHODOLOGY: The purpose of this study was to see the effectiveness of nasal irrigation using 0.9% NaCl in COVID-19 patients with mild symptoms, by looking at the average duration of time complaints felt by patients compared to those without nasal irrigation intervention 
 
 RESULTS: This study found a significant difference (p-value = 0.000) between the control group and the intervention group where the mean duration of symptoms in the intervention group was shorter than the control group.
 
 CONCLUSION: anosmia is a symptom in covid-19 which is almost always accompanied by symptoms of loss of taste, various theories on the cause of anosmia have been put forward since the covid-19 pandemic broke out. Improvements in symptom duration were found to be shorter in COVID-19 patients who performed nasal irrigation using 0.9% NaCl independently for 10 days so that in the future it is hoped that nasal irrigation will become part of the comprehensive management of COVID-19 patients who have mild symptoms, especially symptoms related to nasal and upper respiratory complaints.
 

Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes

BackgroundNasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.MethodsAn open-label, controlled, non-randomized, real-life study was conducted to evaluate the effectiveness of NI with a new hypertonic solution as add-on treatment for AR. Children and adolescents with AR were prescribed symptomatic treatment. The active group also received an additional sea-water NI solution supplemented with algae extracts. The primary endpoint was symptom control, assessed by the control of allergic rhinitis and asthma test (CARAT) questionnaires. Moreover, the MASK/Allergy Diary was used to track symptoms and daily medication use that were combined in a novel total symptom/medication score (TSMS).ResultsWe assessed 76 patients. Overall, there was a significant improvement of CARAT results (median Z-score change of 1.1 in the active/NI group vs. 0.4 in the control group; p = 0.035). Among patients > 12 years old (n = 51), there was a significant improvement in CARAT10 results among participants receiving NI (21.0 to 25.5; p < 0.001), but not in the regular treatment group (21.5 to 24.0; p = 0.100). For children < 12 years old (n = 25), the ΝΙ group had significantly improved symptom control (CARATKids results: 5.0 to 2.0; p = 0.002), in contrast to the control group (4.0 to 2.5; p = 0.057). MASK data on allergic symptoms were comparable between groups. However, the NI group had lower TSMS, more days with < 20% symptoms and fewer days using symptomatic treatment (26.9% vs. 43.5%; p = 0.005).ConclusionAddition of NI with a sea-water solution to regular treatment improved AR symptom control. CARAT questionnaires and MASK application can be useful outcome tools in real-life studies.

The effects of nasal irrigation with various solutions after endoscopic sinus surgery: systematic review and meta-analysis.

Nasal irrigation is commonly performed in patients with chronic rhinosinusitis after functional endoscopic sinus surgery. This study systematically assessed the clinical efficacy of nasal irrigation from the medical literature. The PubMed, Embase and Cochrane Central Register of Controlled Trials databases were searched using a comprehensive strategy, limited to English-language articles, published from October 1971 to March 2017, and comprising human subjects. A total of 824 trials were identified, 5 of which, involving 331 participants, were included in this systematic review. After selection, only three trials were eligible for inclusion in a meta-analysis. Nasal irrigation using normal saline and various solutions was found to be effective in reducing symptom scores and endoscopic scores for chronic rhinosinusitis patients after functional endoscopic sinus surgery. Comparison of outcome measures, such as eosinophil count reduction, revealed that various solutions are more effective than normal saline alone; however, no statistical significance was found in terms of reduced symptom or endoscopic scores. Based on the current limited evidence, nasal irrigation is an effective therapy for chronic rhinosinusitis patients after functional endoscopic sinus surgery. However, when comparing various solutions with normal saline, no significant difference was found in symptom scores or endoscopic scores.

Nasal irrigation: opportunities and disadvantages

Despite the widespread use of nasal irrigation in routine medical practice and a significant list of salt solution for nasal irrigation on the pharmaceutical market, contradictions remain in understanding of process essence, when salt solution acts on the mucous membrane of nasal cavity and evaluation of their effectiveness. analysis of current data of frequency, methods and efficiency of systematic nasal irrigation and effect of salt solution at the mucous membrane of nasal cavity. In review the authors generalized and analyzed recent information about meaning of nasal irrigation for upper respiratory tract disease, about role of nasal mucus at maintaining homeostasis in nasal cavity and initial respiratory tract in general. Describes the data about effect of nasal irrigation on antinfectious protect of mucous membrane of nasal cavity.

Compliance and efficacy of saline irrigation in pediatric chronic rhinosinusitis

The objective of this study was to evaluate compliance with and effectiveness of nasal irrigation in children with chronic rhinosinusitis (CRS) and to assess its clinical course. Seventy-seven children with refractory CRS resistant to medical treatment including antibiotics and nasal corticosteroids were included. We evaluated patients' nasal symptom and Lund Mackay CT scores at baseline. All patients were educated about nasal irrigation and encouraged to perform nasal irrigation 1-3 times a day. After 1 month, patients were reevaluated regarding compliance with the protocol and improvement of CRS by assessing symptom score and endoscopic evaluation. The patients were followed up for at least two months to assess need for further treatment including surgery. Mean age of patients was 8.3 years ranging from 4 to 13 years. Mean follow-up duration with nasal saline irrigation was 6.2 months (2-32 months). Forty nine patients (63.6%) successfully carried out nasal irrigation during follow-up (good compliance [GC] group) and 28 patients (36.4%) did not successfully carry out nasal irrigation (poor compliance [PC] group). There were no significant differences between GC and PC groups regarding clinical characteristics and baseline Lund-MacKay CT scores. Subjective and objective improvements were observed in 36 patients (73.5%) in the GC group and 14 patients (50.0%) in the PC group. Surgery including endoscopic sinus surgery and/or adenoidectomy was performed in 8 patients (16.3%) in the GC group and 12 patients (42.9%) in the PC group. The rate of surgical treatment was significantly different between the groups (p=0.019). Nasal irrigation in children with long standing CRS is relatively well tolerated (63.6%) and effective. Nasal saline irrigation should be considered as a primary treatment tool in CRS even in pediatric age group.

スギ花粉症患者に対する鼻洗浄の効果

スギ花粉症患者に対する鼻洗浄の効果