Effect Of Monoamine Oxidase Research Articles

The effect of monoamine oxidase A and B inhibitors on rat serum prolactin

Serum prolactin levels were assayed in rats treated with specific inhibitors of monoamine oxidase (MAO) A or B. Monoamine oxidase A was inhibited by MD780515, clorgyline and Lilly 51641, and MAO B by pargyline and deprenyl (all at 10 mg/kg, p.o.). Serum prolactin levels were significantly reduced 1 hour after treatment with MAO A inhibitors, but were unaltered by MAO B inhibitors. The time-course of the reduction in serum prolactin did not correspond to that of MAO A inhibition. When rats were treated with clorgyline, serum prolactin returned to control values by 6 hr after treatment, whereas MAO A was inhibited by 92–94% over the whole period. At a time when MAO A inhibitors produced no change in serum prolactin (5 hr after treatment) they abolished the rise in serum prolactin induced by reserpine (5 mg/kg, i.p.), indicating a continuing absence of MAO A activity in the neurones regulating prolactin release. Monoamine oxidase B inhibitors did not alter the effect of reserpine on serum prolactin. Possible reasons for the rapid recovery of serum prolactin levels are discussed.

Biological Treatment of Mental Illness

Over 100 individuals have contributed 65 articles to this massive volume of 1,000 pages, which records the proceedings of the second international conference of the Manfred Sakel foundation, held in October 1962. The material is divided into eight compartments. Of these, section II, on physiology and biochemistry, and section III, on plasma protein fractions in schizophrenia, are at once the most difficult and most intriguing, as well as most representative of the application of biological sciences to psychiatry. Detailed appraisal of each article is not feasible. However, the ingenuity of Curtis' efforts to measure the sensitivity of individual brain cells to psychomimetic drugs evokes special admiration. The work of Brodie and associates on the effect of monoamine oxidase (MAO) inhibitors, reserpine and other drugs on norepinephrine, and Himwich's data on the relationship between indole amines and psychotic reactions offer a glimpse into the future. Several groups of investigators have been

323 Methods of Discovering Thrombotic and Antithrombotic Substances. Discovery of a New Type of Antithrombotic Effect of Monoamine Oxidase (MAO) inhibitors

323 Methods of Discovering Thrombotic and Antithrombotic Substances. Discovery of a New Type of Antithrombotic Effect of Monoamine Oxidase (MAO) inhibitors