A series of Ti-24Nb-xMn alloys were fabricated by no consumable electrode vacuum arc furnace, with the focus on the effect of Mn addition on the structure and mechanical properties of the alloys. Experimental results indicated that α” phase-dominated binary Ti-24Nb alloy exhibits a fine, acicular martensitic structure. When 1wt% Mn was added, equated β phase structure was retained. The M1 alloy with instability β phase exhibits the two-stage yielding from stress-strain curves due to the stress-induced martensite transformation from β to α” phase during tensile deformation. Addition of a small amount of Mn (1 and 3 wt %) improved the plasticity of alloys and the elongation increases from 33% to 41%. The strength of the alloy with Mn content of 3% is the highest, and the tensile strength is 893MPa. All the alloys with Mn exhibit the high micro hardness, the highest is 345HV, which is 1.13 times than binary Ti-24Nb alloy. The elastic modulus of M1 is the highest of all alloys-172GPa. The elastic modulus of the other alloys with Mn are about 82-87GPa, close to those of human skeletons. These alloys seem to have a great potential for use as an implant material.