Effects Of Maternal Parity Research Articles

Premasticated food transfer by wild chimpanzee mothers with their infants: Effects of maternal parity, infant age and sex, and food properties

Premasticated food transfer, when an individual partially breaks down food through chewing and feeds it to another individual, usually mouth-to-mouth, is described widely across human cultures. This behavior plays an important role in modern humans’ strategy of complementary feeding, which involves supplementing maternal milk in infant diets with processed, easily digestible versions of adult foods. The extent to which other primates engage in premasticated food transfer with infants is unclear, as premasticated food transfers have been only occasionally reported in other ape species. We investigated premasticated food transfers in 62 mother-infant pairs of wild chimpanzees at Ngogo, Uganda, as well as unresisted food taking, when mothers passively allow infants to seize food. We evaluated the presence or absence and rates of premasticated food transfer and unresisted food taking relative to maternal parity and infant age and sex and assessed the food species and part used. We found that chimpanzee mothers regularly shared premasticated food with their infants aged between 6 months and 4 years, but they were more likely to share, and more frequently shared, with younger infants. The frequency with which females shared premasticated food may relate to maternal experience, as multiparous females shared premasticated food more often than did first-time mothers, which we did not find with unresisted food taking. Both easy-to-chew, commonly eaten foods and tougher, rarely eaten foods were shared. Premasticated food transfer and unresisted food taking may be infant-rearing strategies to facilitate the transition from a diet of exclusive maternal milk to solid food during early infancy. Premasticated food transfer in particular may provide energetic, immune, or growth benefits to infants through reduced chewing effort and maternal saliva. Given our findings in chimpanzees and earlier reports in other ape species, we suggest that the foundation of complementary feeding, a uniquely hominin strategy, might have been present in a common ancestor shared with the other great apes in the form of premasticated, mouth-to-mouth food transfer by mothers with their offspring.

Effects of maternal parity on response of human myometrium to oxytocin and ergometrine in vitro

ObjectiveThe aim of this study was to compare the effects of oxytocin and ergometrine on the intrinsic contractile parameters of human uterine smooth muscle at term between primiparous and multiparous women. Study designMyometrial biopsies were obtained from women undergoing planned caesarean section at term. The biopsies were dissected into eight uniform strips and mounted in tissue baths for isometric recording. The strips were challenged with increasing concentrations of oxytocin and ergometrine. Parameters of contractile activity, including mean contractile force (MCF) and maximum amplitude of contractions (MAMP) were recorded and analysed. Results were compared between primiparous (Group 1) and multiparous (Group 2) women. ResultsMyometrial biopsies were obtained from n = 11 donors (88 tissue strips), of which n = 5 were Group 1 and n = 6 were Group 2. In relation to oxytocin, the MAMP value observed was significantly greater in Group 2 than in Group 1 (151 ± 18mN vs 67 ± 14mN, P < 0.01). Regarding ergometrine, the MCF response was greater in Group 2 samples (24 ± 10 mN) than that in Group 1 (18 ± 2mN) (P < 0.05). ConclusionOur findings highlight that women in a first pregnancy have a decreased response to both oxytocin and ergometrine in an in vitro setting when compared with women in a subsequent pregnancy, and this may have clinical implications regarding the management of postpartum haemorrhage in this cohort.

89 Effect of embryo transfer and recipient breed on offspring performance in equine show jumping

Maternal preconceptional, gestational, and postnatal environments alter offspring phenotype in humans and animals. In particular, embryo technologies were shown in horses and other species to affect offspring growth and metabolism. Quantitative genetic calculations in a database containing genealogy and a measured trait (performance) of individuals enable geneticists to estimate the respective contribution of (A) genetic aptitude for the trait (inherited from all parents), (B) genetic maternal aptitude (additional contribution of the mother and her ancestors, acting through pregnancy, lactation, and nursing), and (C) the permanent maternal environment (similarities between the offspring of a dam that are not attributed to genetics) to the variability of this trait in this population. Additionally, fixed effects can be introduced and estimated to take into account additional factors acting on individual performance. The aim of this project was to apply this method to estimate the respective contributions of A, B, and C as well as the fixed effects of maternal parity (D), age at foaling (E), foaling interval (F), embryo transfer (G), and breed of recipient mare (for ET recipients) on the adult offspring sport performance in show jumping horses. The data came from the French Horse Database established in 1976 for genealogy and performance; calculation was done using WOMBAT® software. The performance of 207,984 horses (4.5 years per horse), born to 90,438 dams (of which 4187 were ET recipients, the others being bred by AI or natural service), were studied. Performance was expressed as follows. For each event, points were distributed depending on the horse’s rank within the event and the event’s difficulty. The logarithm of the sum of points of the year has a Gaussian distribution and is then normalised to mean=0 and standard deviation=1. The genetic maternal aptitude and permanent maternal environment showed a small but significant contribution to the variance of performance (1.4 and 1.5%, respectively) compared to a direct genetic contribution of 24.4%. Within each age class of dam, offspring of primiparous mares have a handicap (−0.04 to −0.06) compared to multiparous mares. Within multiparous mares, a foaling interval of 1 year only provided a small advantage (+0.01, nonsignificant) compared to longer intervals (&amp;gt;2 years). The effect of embryo transfer was strong and significant (+0.24), which could reflect the better management of the horses produced by embryo transfer because of their genetic and financial value rather than a physiologic effect. The performance of offspring born to draft and warmblood recipients (+0.27v. +0.24, nonsignificant) were not different. In conclusion, although jumping performance occurs several years after birth, maternal effects are still measurable and embryo transfer is associated with a strongly increased performance independent of genetic value, probably due to better management of these horses. No effect of recipient mare’s breed was found.

Nulliparous and primiparous cows produce less fertile female offspring with lesser concentration of anti-Müllerian hormone (AMH) as compared with multiparous cows

Nutritional partitioning to fetal development differ among nulliparous, primiparous and multiparous cows, leading to birth of smaller calves to nulliparous and primiparous than multiparous dams. The prenatal nutritional state could influence ovarian reserve and fertility in the adult offspring. The effect of maternal parity on ovarian reserve and reproduction of female offspring, however, has not been investigated in cattle. Accordingly, a retrospective research was conducted to study reproductive variables in nulliparous- (n = 310), primiparous- (n = 236) and multiparous-born (n = 323) female offspring during the first four lactation periods in dairy cows. Additionally, anti-Müllerian hormone (AMH), as a reliable marker of ovarian reserve, was measured in a subset of nulliparous- (n = 51), primiparous- (n = 51) and multiparous-born (n = 49) female offspring. Birth weight in multiparous-born calves was greater than that in nulliparous- and primiparous-born calves (P < 0.01). Days to first service was shorter in multiparous-born female offspring as compared with nulliparous- and primiparous-born female offspring (P < 0.05). First service conception rate, proportion of repeated breeders, service per conception and calving to conception interval were greater in multiparous-born than nulliparous-born cows (P < 0.05). Cumulative culling rate was greater in primiparous-born cows than nulliparous- and multiparous-born cows (P < 0.05). The AMH concentration was greater in multiparous-born than nulliparous- and primiparous-born cows (P < 0.05). In conclusion, the present study revealed that in comparison with multiparous cows, nulliparous and primiparous cows, particularly nulliparous cows, produce female offspring with lesser reproductive performance and smaller size of ovarian reserves.

Association of amniotic uric acid, glucose, lactate and creatinine concentrations and lactate/creatinine ratio with newborn survival in small-sized dogs - preliminary results.

In order to define the normal composition of canine amniotic fluid and to detect differences between surviving and non-surviving newborn puppies, the present study determined the uric acid, glucose, lactate and creatinine concentrations and the lactate to creatinine ratio in amniotic fluids collected during elective Caesarean section from small-sized purebred bitches. The possible relationship between newborn survival and the studied parameters, as well as the effects of maternal parity, fetal gender and Apgar score were assessed. The study enrolled 27 small-sized purebred bitches submitted to elective Caesarean section at term. After opening the fetal membranes, amniotic fluid samples were collected aseptically from the amniotic sac of each fetus. The data obtained from 74 amniotic fluid samples collected from 27 bitches showed that amniotic glucose concentration was lower (P < 0.05) in non-surviving than in surviving puppies. Within the normal, surviving puppies, amniotic glucose concentration was higher (P < 0.05) in male than in female newborns, and the lactate/creatinine ratio was significantly higher in multiparous than in primiparous bitches (P < 0.05). These preliminary results demonstrate the relevance of amniotic glucose, but not of uric acid, lactate, creatinine and the lactate to creatinine ratio for detecting puppies at risk of death immediately after birth.

Maternal parity affects placental development, growth and metabolism of foals until 1 year and a half

Primiparous mares are known to produce smaller foals than multiparous mares. This difference seems to be partly explained by the reduced exchange surface and volume of the placental villi in primiparous compared to multiparous placentas. The effect of maternal parity on foals' post-natal growth, metabolism and sexual maturation, however, has been given little consideration. The objectives of this work were to analyse placental biometry and structure at term, growth of foals and yearlings, their metabolism and testicular maturation at one year of age.Twenty multiparous mares (M), aged over 6 years and 12 primiparous mares (P), aged up to 5 years were artificially inseminated with the same stallion and monitored the same way until foaling. At birth, foals and placentas were measured and placentas were sampled above at the umbilical cord insertion, as well as in the pregnant and the non-pregnant horn to perform stereological analyses. Foals were weighed and measured until 540 days of age. At 120 and 360 days of age, an Intravenous Glucose Tolerance Test was performed on foals and yearlings. At 360 days of age, the males were castrated and testicular maturation analysed by RT-qPCR.At birth, P dams produced lighter and smaller foals and placentas. The foal birth weight to placental surface ratio was lower in the P compared to the M group. P Foals remained lighter than M foals until 360 days of age and smaller until at least 540 days of age. At 120 days of age, P foals had a higher glucose tolerance than M foals, and then may be less mature than M foals in terms of the control of their glucose homeostasis. At 360 days of age, the testicles of prepubertal P stallions were less mature in the P vs the M group.In conclusion, primiparous dams produce intrauterine growth restricted, less mature and smaller foals compared to multiparous dams with altered metabolism and growth until at least 540 days of age. These differences could affect the sport career of these foals, especially if it begins at an early age.

Effects of maternal parity on the pork quality traits of progeny

This study aimed to identify the influence of sow parity on the meat quality of progeny. A total of 656 progeny from 196 sows were categorised into three different groups based on parity: stage 1 (gilt), 2 (second to fourth parities), and 3 (over fifth parity). According to the significant differences between the parity stage groups in the multiple meat quality properties (P &lt; 0.05), the parity stage 1 had higher muscle pH and lower drip loss in meat quality traits and showed smaller area composition of type IIb muscle fibres in muscle fibre characteristics than the other older groups. Moreover, the parity stage 1 group had significantly higher springiness, adhesiveness and chewiness (P &lt; 0.001), whereas the stage 3 group showed relatively lower cohesiveness (P &lt; 0.05) in the meat texture properties. The principal component analysis displayed more distance between stage 1 and other two groups than the distance between stage 2 and 3. Therefore, we suggest that maternal parity may affect pork quality in progeny and the younger stage group could have better meat quality than the older group.

Effects of maternal parity, depression and stress on two-month-old infant expression of pain

Objective: This study investigates effects of maternal parity, mental health and frequency of touch on infant distress expressed during routine vaccination, as well as the ability of mothers to assess infant pain. Methods: 50 mothers (19 first-time mothers, 23 stressed, 8 depressed) and their 2-month-old infants (mean age 8.1 weeks, range 7–9 weeks) were videotaped during routine immunisation for off-line-analysis. Infant- related pain behaviours were coded before, during and after needle insertion. Maternal touch was coded throughout the immunisation procedure and maternal estimates of infant pain were established immediately after the procedure. Results: Infants of first-time mothers showed significantly more pain before the needle insertion as well as during the first vaccination, compared with infants of experienced mothers. In contrast to expectation, maternal mental health status and type of touch did not influence the level of pain expressed by infants. Mothers consistently overestimated infant pain and their assessments were poorly correlated with observed infant pain behaviours. Conclusion: These findings suggest that maternal parity may influence infant pain expression before vaccination. However, all mothers overestimate their infant’s pain. Further studies are required to resolve conflicting findings in this field of research, as findings may have policy implications in promoting adherence to the vaccination schedule.

Different effects of maternal parity, cold exposure and nutrient restriction in late pregnancy on the abundance of mitochondrial proteins in the kidney, liver and lung of postnatal sheep

Adaptation to the extrauterine environment at birth relies upon the onset of postnatal function and increased metabolism in the lungs, liver and kidney, mediated partly by activation of mitochondrial proteins such as the voltage-dependent anion channel (VDAC), cytochrome c and, in the lung only, uncoupling protein (UCP)2. The magnitude of adaptation is dependent on the maternal metabolic and endocrine environment. We, therefore, examined the influence of maternal cold exposure (MCE) induced by winter shearing of pregnant sheep in conjunction with nutrient restriction (NR; 50% reduction in maternal food intake from 110 days gestation up to term). The effect of parity was also examined, as the offspring of nulliparous mothers are growth restricted compared with multiparous offspring. All sheep were twin bearing. One twin was sampled after birth and its sibling at 30 days. In the lung, both MCE and maternal nulliparity enhanced UCP2 abundance. However, whilst VDAC abundance was decreased in both the offspring of nulliparous mothers and by NR, it was transiently raised by MCE. Kidney VDAC abundance was reduced by MCE and nulliparity, adaptations only influenced by NR in multiparous mothers. Cytochrome c abundance was raised by MCE and by NR in multiparous controls and raised in offspring of nulliparous mothers. Liver VDAC and cytochrome c abundance were transiently reduced by MCE and persistently lower in offspring of nulliparous mothers. In conclusion, changes in the maternal metabolic environment have marked tissue-specific effects on mitochondrial protein abundance in the lungs, liver and kidney that may be important in enabling the newborn to effectively adapt to the extrauterine environment.

Effects of maternal parity and late gestational nutrition on mRNA abundance for growth factors in the liver of postnatal sheep

The liver is a major metabolic and endocrine organ in growing neonates, but the extent to which its hormone receptor (R) sensitivity is potentially determined by maternal parity and the mother's nutritional environment is unknown. This was therefore investigated by sampling livers from postnatal sheep born to nulliparous or multiparous mothers. Offspring were sampled 1 or 30 days after birth from mothers consuming either 100 or 50% [i.e., nutrient-restricted (NR) group] of total metabolizable energy requirements from 110 days gestation to term ( approximately 147 days). Regardless of maternal diet, offspring of nulliparous mothers were lighter at birth and had smaller livers. By 1 mo of age, they exhibited catch-up growth, an adaptation not seen when mothers were NR, but they retained their lighter livers. At both sampling ages, livers from offspring born to nulliparous mothers exhibited increased mRNA abundance for growth hormone (GH) receptor, IGF-IR, plus hepatocyte growth factor (HGF); and at day 1 only IGF-I, but not IGF-IIR mRNA was decreased. In addition, mRNA for IGF-II, the HGFR, c-Met, and Bax were persistently reduced in these offspring. Effects of parity were largely unaffected by maternal nutrient restriction. Maternal parity therefore has a substantial effect on liver size during postnatal development and its receptor population that is not dependent on maternal diet. First-born offspring appear to exhibit a resetting of the endocrine control of hepatic growth within the HGF and GH-IGF axis, which could have later consequences after their growth has caught up.

Is routine episiotomy beneficial in the low birth weight delivery?

The outcome of 439 idiopathic singleton low birth weight spontaneous vertex deliveries in the university hospital of a developing country was analyzed. Any patient with a known complication of pregnancy was excluded from the study. The effects of maternal age were minimized by including only those mothers between the age of 17 and 34. The effect of maternal parity was minimized by analyzing the study in two parity groups. The birth weight distributions of the episiotomized and non-episiotomized groups were comparable. There was no significant difference in the Apgar scores and neonatal mortality rates between these neonates delivered with an episiotomy and those without. This was the case, regardless of parity. The value of an episiotomy in the delivery of the low birth weight infant is questioned.

Effect of maternal parity on aneuploidy in early mouse embryos.

An attempt to evaluate the incidence of chromosomal aneuploidy in mouse blastocysts recovered from females of various ages and parity levels revealed an insignificant regression coefficient for aneuploidy on age of the female and its square, and an insignificant correlation coefficient for aneuploidy with the number of previous offspring born to the dam. However, significant regression coefficients were obtained for aneuploidy on parity of the dam and its square. These results indicate that not only does aneuploidy increase with parity level, but the rate of increase accelerates as parity level increases. Possible explanations for the increase in aneuploidy and its detrimental effect on reproductive efficiency were discussed.

FEEDING BEHAVIORS OF NEWBORN INFANTS AS A FUNCTION OF PARITY OF THE MOTHER

THOMAN, EVELYN B.; BARNETT, C. R.; and LEIDERMAN, P. H. Feeding Behaviors of Newborn Infants as a Function of Parity of the Mother. CHILD DEVELOPMENT, 1971, 42, 1471-1483. The effects of maternal parity on bottle-feeding behaviors of neonates were investigated. In order to assess the feeding behavior of infants independent of the contribution of the mother, the following 3 groups of infants were observed: (1) 125 infants given their first feeding at 12 hours of age by a nurse, a standardized situation designed to permit assessment of prenatal effects due to parity of the mother; (2) 41 infants fed by the mother and observed throughout the 3-day lying-in period; and (3) 115 infants fed by a nurse at some time during the first 3 postnatal days, a standardized feeding condition designed to provide a comparison group for the mother-fed infants. Observations were obtained by means of an automatic, continuously recording apparatus. At 12 hours of age, the nurse feedings revealed a prenatal effect of maternal parity: infants of multiparous mothers required more feeding intervals than did infants of primiparous mothers. Primiparous mothers consistently used a greater number of feeding intervals and more time in nonfeeding activities than multiparous mother-infant pairs. The primiparous pairs showed a marked decrease in the number of intervals over the 3 days of observation.