Effect Of Low-level Laser Therapy Research Articles

Effectiveness of low-level Diode laser therapy in recurrent aphthous stomatitis treatment at Can Tho University of Medicine And Pharmacy Hospital in 2020-2022

Background: Recurrent aphthous stomatitis (RAS) are the most common oral ulceration in lesions of the oral mucosa. Treatment aims to reduce pain and healing time. Low-level Diode laser therapy can relieve pain, anti-inflammatory, reduce edema, stimulate cell biology, and stimulate healing. Low-level Diode laser therapy is an alternative therapy to conventional drug use, promising to help improve the quality of life, improve the patient's quality of life and avoid complications caused by long-term drug use. Objectives: To evaluate the therapeutic effect of a low-level Diode laser on RAS treatment to reduce pain, size of ulcers, and healing time. Materials and methods: A clinical study was conducted on 30 patients who presented RAS lesions were treated with low-level laser therapy. The patients were evaluated for the size, position, pain score, form of ulcers, healing time before and immediately, fourth and sixth day after treatment. The data was analyzed using SPSS 20. Results: The VAS score pre-treatment was 4.33±1.65, immediately post-treatment was 1.20±1.06. The size of ulcers pre-treatment was 4.58±2.35mm, and post-treatment fourth day was 2.47±2.30mm. The healing time was 5.04±0.32 days. Conclusion: Low-level Diode laser therapy is effective in RAS treatment to reduce pain, size of ulcers, and healing time.

Low-level laser therapy with different irradiation methods modulated the response of bone marrow mesenchymal stem cells in vitro.

Low-level laser therapy (LLLT) also known as photobiomodulation is a treatment to change cellular biological activity. The exact effects of LLLT remain unclear due to the different irradiation protocols. The purpose of this study was to investigate the effects of LLLT by three different irradiation methods on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro. BMSCs were inoculated in 24-well plates and then irradiated or not (control) with a laser using three different irradiation methods. The irradiation methods were spot irradiation, covering irradiation, and scanning irradiation according to different spot areas (0.07 cm2 or 1.96 cm2) and irradiation areas (0.35 cm2 or 1.96 cm2), respectively. The laser was applied three times at energy densities of 4J/cm2. The cell proliferation by CCK-8. ALP activity assay, alizarin red, and quantitative real-time polymerase chain reaction (RT-PCR) were performed to assess osteogenic differentiation and mineralization. Increases in cell proliferation was obvious following irradiation, especially for covering irradiation. The ALP activity was significantly increased in irradiated groups compared with non-irradiated control. The level of mineralization was obviously improved following irradiation, particularly for covering irradiation. RT-PCR detected significantly higher expression of ALP, OPN, OCN, and RUNX-2 in the group covering than in the others, and control is the lowest. The presented results indicate that the biostimulative effects of LLLT on BMSCs was influenced by t he irradiation method, and the covering irradiation is more favorable method to promote the proliferation and osteogenic differentiation of BMSCs.

Therapeutic Effects of Low-Level Laser Therapy on Cognitive Symptoms of Patients with Dementia: A Double-Blinded Randomized Clinical Trial.

Objective: To investigate the effects of low-level laser therapy (LLLT) as a new nonpharmaceutical approach to improve cognitive symptoms in patients with dementia. Background: Routine pharmacological treatment of dementia patients is inefficient and has considerable adverse effects. Recent attempts to develop nonpharmaceutical approaches are considered favorable for patients with dementia. Methods: Thirty-two patients with dementia were randomly divided into the same population of LLLT and sham groups. The LLLT group underwent transcranial LLLT, and the sham group received the same protocol with a zero-intensity laser. All patients in the two groups were evaluated using the minimental state examination (MMSE) and clinical dementia rating (CDR) tests at the time of admission as baseline at 2 and 6 weeks postintervention. Results: The rate of change of MMSE scores in sham and LLLT groups was 0.13 ± 0.96 and 2.31 ± 1.81 in week 2 (p = 0.00005) and also -0.25 ± 0.86 and 2.53 ± 1.73 in week 8 (p = 0.000003). In the LLLT group, the mean scores of CDR were 1.28 ± 0.71, 1.28 ± 0.71, and 1.25 ± 0.80 at baseline, week 2, and week 8 (p = 0.605 and p = 0.742), respectively. The mean scores of CDR in the sham group were 1.69 ± 0.73, 1.75 ± 0.68, and 1.72 ± 0.82 at baseline, week 2, and week 8, respectively. Conclusions: These findings suggest that laser therapy could be a promising treatment modality and an adjunct to pharmacotherapy in dementia patients. Clinical Trial Registration: IRCT20191018045148N1 was obtained from the Iranian Registry of Clinical Trials (IRCT.ir).

Modulation of the autonomic nervous system by one session of spinal low-level laser therapy in patients with chronic colonic motility dysfunction.

Patients with a defecation disorder may not evoke a normal defecation reflex, or the reflex may be excessive, as a dysfunction of the spinal autonomic nervous system. Treatment with various forms of lumbar and sacral neuromodulation have shown symptom improvement, but potential changes in autonomic functioning are rarely studied. Here we evaluate the effects on autonomic function of a single session of low-level laser therapy (LLLT) on the lumbar and sacral spine in 41 patients with chronic gastrointestinal motor dysfunction. The LLLT protocol used red LED light at a wavelength of 660 nm for 10 min and infrared LED light at a wavelength of 840 nm for 10 min, followed by infrared laser light at a wavelength of 825 nm for 10 min. Effects on the autonomic nervous system were assessed by measuring heart rate variability (HRV) changes. Respiratory Sinus Arrhythmia (RSA) and Root Mean Square of Successive Differences (RMSSD) were used to quantify parasympathetic reactivity; the Baevsky’s Stress Index (SI) reflected sympathetic activity while the ratios SI/RSA and SI/RMSSD were used to show shifts in autonomic dominance. The results indicate that lumbar and sacral neuromodulation using light arrays reduced, whereas stimulation by the laser probes significantly increased parasympathetic activity. The light arrays increased whereas the laser probes significantly decreased sympathetic activity (SI). The entire protocol shifted the autonomic balance toward parasympathetic activity. The comparison of actual vs. sham neuromodulation proved that the change in HRV parameters was due to actual light stimulation and not due to the arrays and probe touching the skin. In conclusion, a single session of LLLT markedly affects autonomic nervous system activity reflected in changes in HRV which is only possible by generating activity in the spinal autonomic nerves. These results warrant a study into the effects of LLLT on restoring autonomic dysfunction in chronic refractory colonic motility disorders.

LOW-LEVEL LASER THERAPY MAY REDUCE PAIN ASSOCIATED WITH ORTHODONTIC SEPARATOR PLACEMENT

Farzan, A. K. Khaleghi (2021). "The Effectiveness of Low-Level Laser Therapy in Pain Induced by Orthodontic Separator Placement: A Systematic Review." J Lasers Med Sci 12: e29. None. Systematic review.

Efficacy of low-level laser therapy in patients with lower extremity tendinopathy or plantar fasciitis: systematic review and meta-analysis of randomised controlled trials

ObjectivesWe investigated the effectiveness of low-level laser therapy (LLLT) in lower extremity tendinopathy and plantar fasciitis on patient-reported pain and disability.DesignSystematic review and meta-analysis.Data sourcesEligible articles in any language were...

CAN COMBINING LOW LEVEL LASER THERAPY WITH COMPUTER GUIDED FLAPLESS PIEZOSURGICAL OSTEOTOMY ACHIEVE A PAINLESS IMPLANT SURGERY? FINDINGS OF SPLIT MOUTH RANDOMIZED CONTROLLED TRIAL.

Developing a safe and accurate surgical technique that offers higher patient satisfaction will be a great improvement in the field of oral implantology. This study was to investigate the effect of Low-Level Laser Therapy (LLLT) on pain and swelling after flapless computer guided implant site preparation utilizing a novel surgical guide designed to be used with piezotome. A total of thirty patients were enrolled in this study having history of bilateral extractions in the lower molar area not less than 6 months ago. One side from each patient was randomly selected for the intervention group to receive LLLT immediately after insertion of bendable one-piece implant (Rough-B Implant, Monoimplant, Novodent SA, Swizerland) using diode laser with a wavelength of 980 nm and a 100 mW energy for 1 minute. The other side received placebo LLLT and was regarded as a control group. Piezo-surgical implant site preparation was done on both sides using a third generation piezotome (Surgic Touch, Guilin Woodpecker Medical Instrument Co., Ltd, China). Pain and swelling scores were measured by utilizing a Visual Analogue Scale (VAS) and a graded swelling scale respectively. The measurements were recorded on both sides after 2, 6 and 24 hour of the day of surgery then at 2, 3, 4 and 7 days post-surgically. In general, the overall scores were ranging from very mild to mild degree of pain and swelling. Females reported significantly higher pain score than males with a mean score of 20.3 ± 5.1 for females and 14.7 ± 3.1 for males (P < .05). Swelling showed no statistically significant results between females and males (P> .05). Pain scores were found to be significantly lower in the LLLT side after 2, 6, 24, 48 hour of implant insertion (P < .05). Moreover, Sweling scores were also found to be significantly lower in the LLLT side after 2, 6, 24, 48 hour, and at day 3 of implant insertion (P < .05). However, day 4 and day 7 showed very minimal if any pain and swelling with insignificant differences between the 2 sides (P > .05). LLLT was found to be an effective non pharmacological method for relieving pain after implant insertion. Piezosurgical flapless implant placement combined with LLLT is considered an effective, tolerable and minimally invasive procedure (ClinicalTrials.gov NCT01857804).

A Comparison Between the Effect of Low-Level Laser Therapy and Clomiphene on Rats’ Ovarian Tissue Blood Vessels Under In Vivo Conditions

Background: Studying the prevalence of infertility as a common disease and its treatment have recently become an important issue. These treatments include drugs and surgery; and lasers have also been used complementarily. However, they affect the ovarian blood vessels number. Accordingly, the present study was conducted to investigate the photo-bio stimulation effect on near-infrared and red laser as of low-level lasers on the blood vessels in ovarian tissue, compared with the clomiphene’s effect.&#x0D; Methods: Twenty-eight female rats were randomly divided into four groups: Control (CT), Clomiphene Drug (D), Red Laser (RL) and Near-Infrared Laser (NIRL). Afterwards, the laser groups received irradiation (5 J/cm2 dose) and the rats in group D received clomiphene (1µg/kg). After the experiment, the animals were anesthetized and their ovaries were removed. Henceforth, the laser’s effect was investigated and compared with that of clomiphene.&#x0D; Results: The number of the blood vessels increased in NIRL (71.96%) and RL (67.070%) groups, compared with CT. It was also increased in NIRL (59.81%) and RL (14%) compared to D group. In addition, it increased in NIRL (53.27%) compared with RL. This increase was significant in the NIRL group indicating that NIRL increases ovarian activity to produce blood vessels that can be certainly used in future studies for finding a cure for ovarian negligence to produce more blood vessels and treat diseases caused by it.&#x0D; Conclusion: The results convinced us to introduce laser as a new method to increase the ovarian activation by increasing the blood vessels in a future study. Although the mechanism of low-level lasers action is not well known, it has been proved to be more effective than clomiphene.

Time response of increases in muscle performance after Low-Level Laser Therapy (LLLT) in weight training practitioners

Many studies have demonstrated the effectiveness of low-level laser therapy (LLLT) on muscle performance. Nonetheless, ideal application parameters are not known yet. The interval from the laser application moment until the time of the exercise is amongst them. In addition, the literature does not offer adequate studies that analyse different interval times in the same test in humans. Thus, the present study proposes the examination of the two distinct intervals, from the irradiation moment to the instant of the exercise performance. Forty male volunteers were recruited and randomly divided into four groups - control, placebo, immediate laser and 10 min after laser – to participate in this study. The therapy was performed with laser at 830 nm, with a power of 30 mW, energy of 3 J, during a time of 100 seconds per point irradiation, in the belly of the biceps brachii muscle. The comparison of the groups consisted in the Max force analysis, muscular power and muscle fatigue tests executed in the isokinetic dynamometer, and the recruitment of fibers by electromyography surface (EMG) and blood lactate levels in the brachial biceps muscle of weight training practitioners. A significant level of 5% (p &lt;0.05) was considered for data analysis. The parameters adopted in the application of LLT significantly increased muscle activity (RMS) in all protocols (peak force, power and muscular endurance). In addition, LLLT was also effective in maintaining muscle performance. It was concluded that the interval time from the moment of application of the LLLT until the performance of the exercise can influence in a different way the physical capacities tested.

Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis.

Introduction: Autoimmune thyroiditis (AIT) is an autoimmune disorder that is characterized by thyroid gland dysfunction. Low-level laser therapy (LLLT), as a safe and non-invasive intervention, has gained much attention in many clinical applications including pain relief, regenerative medicine, and autoimmune. Methods: In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of AIT. Such keywords as "low-level laser therapy", "photobiomodulation" and "autoimmune thyroiditis" were used to find studies related to laser therapy in AIT in Google Scholar, PubMed and Medline databases. Results: LLLT reduced thyroid gland inflammation and inhibited immune cell trafficking. LLLT modulated inflammatory responses and improved thyroid gland regeneration. Conclusion: Investigations indicated that besides current treatment strategies, LLLT could be a promising therapeutic approach for the treatment of AIT.

Biophotonic Effects of Low-Level Laser Therapy at Different Wavelengths for Potential Wound Healing

Our objective was to assess the effect of low-level laser therapy (LLLT) administered using a diode laser on the growth processes of human fibroblast cells involved in wound healing. Initially, studies were conducted using a diode laser at wavelengths of 633, 520, and 450 nm with an irradiance of 3 mW/cm2. The distance between the light source and culture plate was 3 cm. The mechanism(s) of action of the diode laser illumination on human fibroblast cells were studied by examining different wavelengths to determine the relevant light parameters for optimal treatment. In addition, the percentages of fibroblast-mediated procollagen and matrix metallopeptidase (MMP)-1, -2, and -9 production were compared. In the clinical study, the changes in basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and fibroblast collagen production were assessed in 60 patients with complicated wounds who received LLLT (633 nm). No statistically significant difference was observed between red light versus green and blue light in the viability analysis. In addition, the effects of LLLT on the cell cultures of fibroblast cells in vitro demonstrated a decrease in the relative expression of MMP-1, -2, and -9 while using light with a wavelength of 633 nm. In the clinical study, 633 nm diode laser LLLT at 2–8 J/cm2 was administered to 60 patients with complicated wounds; all patients showed increased levels of bFGF and VEGF and the occurrence of collagen synthesis. Our studies demonstrated that LLLT might affect fibroblast cell growth processes involved in wound healing.

Efficacy of low-level laser therapy on pain, disability, pressure pain threshold, and range of motion in patients with myofascial neck pain syndrome: a systematic review and meta-analysis of randomized controlled trials.

Low-level laser therapy (LLLT) is one of recent modalities for treatment of myofascial neck pain (MNP). Several RCTs have been conducted on its effectiveness. The aim of this comprehensive meta-analysis was to evaluate the effectiveness of LLLT on MNP. Electronic databases were searched for identifying eligible studies comparing the effectiveness of LLLT using any wavelength with placebo or active control in myofascial neck pain up to June 2022. Data related to pain intensity, pain pressure threshold (PPT), range of motion (ROM), and disability was analyzed as a pooled estimate of mean difference or standard mean difference (SMD) with 95% confidence intervals (CIs) using random/fixed-effect model. Funnel plot and Egger's linear regression test were also conducted to examine the risk of publication bias. A total of 13 randomized controlled trials were included in this systematic review and meta-analysis. The data assessing laser effectiveness on different outcomes of 556 patients were considered for meta-analysis. Pooled results revealed that LLLT was significantly effective in pain reduction (MD = - 1.29, 95% CI = - 2.36; - 0.23, P < 0.001). Also, secondary outcomes including PPT (SMD of 2.63, 95% CI = 0.96; 4.30, P < 0.01) and right bending ROM (SMD of 3.44, 95% CI = 0.64; 6.24, P < 0.01) were improved, while disability (MD of - 7.83, 95% CI = - 17.1; 0.08, P = 1.34) did not improve significantly after LLLT. Our meta-data revealed that LLLT may reduce myofascial neck pain and its related outcomes. LLLT is suggested to be used by clinicians along with other therapies such as manual and exercise therapy.

Photobiomodulation vs NSAIDs in the management of postoperative dentoalveolar pain

BackgroundPostoperative pain, the most common complication of dentoalveolar surgery, is routinely controlled by non-steroidal anti-inflammatory drugs (NSAIDs). However, despite its proven efficacy, the long-term consumption of NSAIDs is associated with several serious and adverse effects. As a result, photobiomodulation (PBM) or low-level laser therapy (LLLT) is used in many treatment modalities to reduce pain, inflammation, and promote healing. Aim of the studyTo compare the analgesic effects of LLLT and Ibuprofen after surgical dental extraction. Materials and methodsA clinical trial study was conducted at Umm Al-Qura University Dental Clinics, involving 46 healthy patients between 20 and 60 years of age. The recruited patients were divided into two groups of 23 patients each. Group 1 (positive control group) was prescribed Ibuprofen and Group 2 (experimental group) was treated with LLLT. The pain was measured on days 1, 2, and 7 using the Numeric Pain Rating Scale (NPRS). ResultsThe mean level of pain decreased with both treatments. On the first postoperative day, the pain level in the laser therapy group was significantly lower than in the control group (U = 62.5, p = 0.024). The results indicated a significant decrease in pain level on the second postoperative day for both the control and experimental groups (Z = −3.61, p < 0.005, and Z = −3.1, p = 0.002, respectively). However, the pain level was lower in the control group, although the difference was not statistically significant (U = 79, p = 0.102). ConclusionConsidering the constraints of this study, NSAIDs were found to be significantly better at reducing pain than LLLT.

Effectiveness of Low-Level Laser Therapy on Stability of Dental Implants: A Systematic Review

Effectiveness of Low-Level Laser Therapy on Stability of Dental Implants: A Systematic Review

Effects of low-level laser therapy and therapeutic ultrasound on Freund's complete adjuvant-induced knee arthritis model in rats.

The aim of this study was to evaluate and monitor the effect of low-level laser therapy (LLLT) and therapeutic ultrasound (TU) alone, or combined with intra-articular prednisolone (P) in Freund's complete adjuvant (FCA)-induced knee arthritis model in rats. A total of 56 adult male Wistar rats were divided into seven groups: control (C), disease control (RA), P, TU, LLLT (L), P + TU (P+TU), P + LLLT (P+L) groups. The skin temperature, radiography, joint volume, serum rheumatoid factor (RF), interleukin (IL)-1β, serum tumor necrosis factor-alpha (TNF-α), and histopathological evaluation of joint were performed. Thermal imaging and radiographic examination provided results consistent with the severity of the disease. The mean joint temperature (°C) was the highest in the RA (36.2±1.6) group on Day 28. The P+TU and P+L groups significantly decreased radiological scores at the end of the study. The rat serum TNF-α, IL-1β, and RF levels in all groups were significantly higher compared to the C group (p<0.05). Compared to the RA group, serum TNF-α, IL-1β, and RF levels were significantly lower in the treatment groups (p<0.05). The P+TU and P+L group was showed minimal chondrocyte degeneration and cartilage erosion and mild cartilage fibrillation and mononuclear cell infiltration of synovial membrane compared to the P, TU, and L group. The LLLT and TU effectively reduced inflammation. In addition, a more effective result was obtained from the use of LLLT and TU combined with intra-articular P. This result may be due to insufficient dose of LLLT and TU, thus further studies should be focus on at higher dose ranges on FCA arthritis model in rats.

The Efficacy of Low-Level Laser Therapy Combined with Single Flap Periodontal Surgery in the Management of Intrabony Periodontal Defects: A Randomized Controlled Trial

This study aimed at assessing the clinical outcomes of the Single Flap Approach (SFA) with the additional use of Low-level laser therapy (LLLT). The defects were treated as per the principles of SFA, whereby 20 defects received only SFA (control group) and 20 defects received additional LLLT for bio stimulation/bio modulation (test group). Stable primary closure of the flaps was obtained with vertical internal mattress sutures. Plaque indices (FMPS), clinical attachment levels (CAL), probing pocket depth (PPD), and gingival bleeding scores (FMBS) were calculated at baseline, and at the 3rd and 6th months in both groups. An EHI score of 1 was observed at all sites except for two, where a score of 2 in the control group at week 2 was observed. In the test group, the PPD reduction at 6 months was 3.60 ± 0.95 and in the control group it was 3.75 ± 0.91 mm. CAL gain at 6 months was 2.70 ± 1.36 mm and 3.45 ± 1.2 mm in the test group and showed no statistical significance. These data suggested the positive effect of LLLT over CAL gain; thus, LLLT may be combined with SFA to potentially enhance the early wound healing and higher clinical outcomes in terms of increase in CAL and decrease in PPD.

Effects of low-level laser therapy on utricular hair cell regeneration: a review of the efficacy of available treatment parameters

Effects of low-level laser therapy on utricular hair cell regeneration: a review of the efficacy of available treatment parameters

Effect of Low-Level Laser Therapy on Trismus, Facial Swelling, and Pain Following Surgical Extraction of Impacted Lower Third Molars

Background: Light amplification by the stimulated emission of radiation (laser) is currently used as a therapy method for decreasing inflammation followed by oral surgeries. Therefore, the present study aimed at evaluating the effect of using diode low-power laser irradiation (photobiomodulation) on the amount of pain, swelling, and trismus due to latent mandibular third molar surgery (surgical removal of latent mandibular third molars). Methods: In this double-blind randomized clinical trial study, 16 individuals with latent mandibular third molars with an identical condition were selected. The teeth were randomly assigned to two groups of laser irradiated intervention group and a non-irradiated control group. A 940 nm diode laser with an output power of 200 mW and an energy density of 12 J/cm2 was applied for 60 seconds at a distance of 1 cm three intraoral points and an extraoral point. The distance between incisal edges of upper and lower central teeth, the horizontal distance between corners of lips and auricle (LE), the vertical distance between the outer canthus of the eye and the mandibular angle (EA), and pain visual analogue scale were measured before surgery and two and seven days after surgery. Results: There was no statistically significant difference between the two groups regarding EA and LE before intervention and on days 2 and 7 after intervention (P&gt;0.05). However, the pain score was significantly higher before intervention (3.31±0.7 vs. 2.38±0.8, P=0.001) and on day 2 after intervention (6.5±1.32 vs. 4.5±0.97, P&lt;0.001) in the control group. On day 7, a higher maximum jaw opening (MJO) was observed in the intervention group (40.68±5.76 vs. 36.81±4.35, P=0.04). Conclusions: Adjunctive diode laser photobiomodulation after third molar surgery was associated with a significant reduction in pain and trismus.

Response of osteoblastic cells to low-level laser treatment: a systematic review.

Low-level laser therapy (LLLT)-induced photobiomodulation (PBM) stimulates bone tissue regeneration by inducing osteoblast differentiation and mitochondrial activation. However, the role of reactive oxygen species (ROS) in this process remains controversial. The aim of this systematic review was to collect and analyze the available literature on the cellular and molecular effects of LLLT on osteoblasts and the role of ROS in this process. A search was conducted in PubMed, ScienceDirect, Scopus, and Web of Science. Studies published in English over the past 15years were selected. Fourteen articles were included with moderate (n = 9) and low risk of bias (n = 5). Thirteen studies reported the use of diode lasers with wavelengths (λ) between 635 and 980nm. One study used an Nd:YAG laser (λ1064nm). The most commonly used λ values were 808 and 635nm. The energy densities ranged from 0.378 to 78.75J/cm2, and irradiation times from 1.5 to 300s. Most studies found increases in proliferation, ATP synthesis, mitochondrial activity, and osteoblastic differentiation related to moderate and dose-dependent increases in intracellular ROS levels. Only two studies reported no significant changes. The data presented heterogeneity owing to the variety of LLLT protocols. Although several studies have shown a positive role of ROS in the induction of proliferation, migration, and differentiation of different cell types, further research is required to determine the specific role of ROS in the osteoblastic cell response and the molecular mechanisms involved in triggering previously reported cellular events.

Short- and Long-Term Effectiveness of Low-Level Laser Therapy Combined with Strength Training in Knee Osteoarthritis: A Randomized Placebo-Controlled Trial.

Background: Both physical activity and low-level laser therapy (LLLT) can reduce knee osteoarthritis (KOA) inflammation. We conducted a randomized clinical trial to investigate the short- and long-term effectiveness of LLLT combined with strength training in persons with KOA. Methods: Fifty participants were randomly divided in two groups, one with LLLT plus strength training (n = 26) and one with placebo LLLT plus strength training (n = 24). LLLT and strength training were performed triweekly for 3 and 8 weeks, respectively. In the laser group, 3 joules 904 nm wavelength laser was applied to fifteen points (45 joules) per knee per session. Patient-reported outcomes, physical tests, and ultrasonography assessments were performed at baseline and 3, 8, 26, and 52 weeks after initial LLLT or placebo therapy. The primary outcomes were pain on movement, at rest, at night (Visual Analogue Scale), and globally (Knee injury and Osteoarthritis Outcome Score (KOOS) subscale). Parametric data were assessed with analysis of variance using Šidák’s correction. Results: There were no significant between-group differences in the primary outcomes. However, in the laser group there was a significantly reduced number of participants using analgesic and non-steroidal anti-inflammatory drugs and increased performance in the sit-to-stand test versus placebo-control at week 52. The joint line pain pressure threshold (PPT) improved more in the placebo group than in the laser group, but only significantly at week 8. No other significant treatment effects were present. However, pain on movement and joint line PPT were worse in the placebo group at baseline, and therefore, it had more room for improvement. The short-term percentage of improvement in the placebo group was much higher than in similar trials. Conclusions: Pain was reduced substantially in both groups. LLLT seemed to provide a positive add-on effect in the follow-up period in terms of reduced pain medication usage and increased performance in the sit-to-stand test.