The present study was conducted to evaluate the efficiency and effectiveness of some plant extracts of Helianthus annuus L., Sesbania sesban and Olea europea concentrations 100, 500, 1000, 5000 ppm. and the effect of Nd: YAG laser with wavelength of( 1064nm) and different energies which conducted at (10,15 and 20) within (5 pulses/sec) to destruction of the Tribolium castaneum, the study found different results according to the different concentrations used, time period and the different energies of the laser during the treatment. Treatment with plant extracts The extract of the Helianthus annuus L. was hightst to the rest of the plant extracts. It gave a 100% mortality rate at 5000 ppm concentration 72 hours of treatment. Then the seesban seed extract came in terms of effect, giving 96.6% mortality rate at the same concentration after 72 hours. While the effect of Olea europea extract was the last impact"on the insect, where the rate of mortality 86.5% in the same concentration also and within ( 72 hours ) of treatment.
 The results showed that the effect of laser radiation on the life of the insect, where it gave the highest mortality rate 73.6% when irradiation at the highest power of 420mj and exposure time 20Sec. the results were obtained after observation of the effect of plant extracts and Nd : YAG at different time intervals 24, 48 hours and 72 hours after the treatment of the Tribolium castaneum .