Effect Of Iron Deficiency Anemia Research Articles

Effect of iron deficiency anemia on simple and complex febrile seizures in children in Karbala province.

Background: Febrile convulsion is the most common central nervous system disease seen in children. There are hypotheses that threshold of neuron excitation may be affected by iron deficiency anemia. Effect of Iron Deficiency Anemia (IDA) on febrile seizures and recurrent febrile seizure is investigated. Materials and Methods: Across sectional study was conducted among 121 children with febrile convulsion who divided into 2 groups: 70 with simple febrile seizure and 51 with complex febrile seizure. Results: No significant differences had been found between both groups in demographic variables. Analysis of blood showed that low levels of Hemoglobin (HB), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH) and S. ferritin levels and high Red Cell Distribution Width (RDW) were more frequent in complex group than simple group at P value<0.05. Iron deficiency anemia was found in 24% of all patients. Recurrence of febrile seizure was 52.1% of all patient, was more likely to occur in IDA patients than those with no IDA in about 2.5 folds, (OR=2.53, Pvalue= 0.037). Conclusion: Febrile seizures associated with iron deficiency anemia. Complex febrile seizure is more frequent with iron deficiency anemia than in those with simple febrile seizures. Febrile seizures are significantly associated with higher recurrence in patients with iron deficiency anemia.

Effect of Iron Deficiency Anemia on HbA1c Levels in Non-Diabetic Individuals

Background: Glycated hemoglobin (HbA1c) is the parameter of choice to evaluate the long term degree of glycaemic control in patients with diabetes mellitus (DM). Iron Deficiency Anemia is the most common cause of anemia. Objective: We study the effect of iron deficiency anemia on HbA1c levels in non-diabetic individuals. Patients and Methods: This was a case-control study in the period from February 2019 to September 2019. Included 90 cases at outpatient Clinic of Internal Medicine Department in Zagazig University Hospitals. The patients were randomly divided (by alternation) into three groups 30 patients, Group1: who are healthy. Group2: who have iron deficiency anemia. Group3: who has any type of anemia other than iron deficiency anemia. A detailed history of clinical examination and biochemical examination was performed including HbA1c. Results: The study revealed that there was a highly significant difference between the before and after treatment in the iron deficiency group as regard HbA1c and there was no significant difference between the studied groups as regard FBG or PPG. Conclusion: There is a significant relation between HbA1c and iron deficiency anemia while there is no relation between iron deficiency anemia and Fasting blood sugar or Postprandial sugar, Iron deficiency anemia elevates HbA1c levels in non-diabetic individuals.

The Effect of Iron Deficiency Anemia on the Child Death Related to HIV/AIDS Infection: Meta-Analysis

Background: A quarter of the world's popula­tion suffers from iron deficiency anemia with various causes. Anemia has an impact on a child's quality of life, even if it is of mild or moderate severity. This study aims to analyze the effect of hemoglobin levels on the mortality of children infected with HIV/AIDS using a meta-analysis. Subjects and Method: This was a systematic review and meta-analysis. Article searches were conducted using electronic databases, namely Google Scholar and PubMed. Article sub­mission time is 1 month. Article search is done by several methods, namely boolean operators, handsearching, and keywords and MesH. The articles included in this study are articles that have a cohort study design. The systematics of article collection was carried out using the PRISMA-P flow chart. All articles were ana­lyzed using the Review Manager 5.3. Results: Hemoglobin < 10 g/dl (aHR= 2.80; 95% CI=2.02 to 3.89; p<0.001), hemoglobin <9 g/dl (aHR= 1.82; 95% CI=1.31 to 2.51; p<0.001), and hemoglobin <8 g/dl (aHR= 1.77; 95% CI=1.43 to 2.20; p<0.001) has an effect on mortality of children infected with HIV/AIDS. Conclusion : Low hemoglobin levels increase the risk of death in children infected with HIV/AIDS. Keywords: hemoglobin, anemia, iron, child death Correspondence: Dyah Ambarwati. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ambarwati.dyah27@gmail.com. Mobile: +6287735486570 Journal of Epidemiology and Public Health (2021), 06(02): 158-169 https://doi.org/10.26911/jepublichealth.2021.06.02.03

Evaluation of Corneal and Lenticular Parameters in Iron Deficiency Anemia.

Objectives:The aim of this study was to investigate the effects of iron deficiency anemia on corneal and lenticular densitometry.Methods:Thirty-two patients with iron deficiency anemia and 38 healthy participants were enrolled. The Pentacam HR imaging system (Oculus Optikgeräte GmbH, Wetzlar, Germany) was used to record keratometry, corneal densitometry (12-mm corneal diameter), lens densitometry measurements. Endothelial parameters were evaluated using specular microscopy.Results:The corneal densitometry values in the anterior 0–2 mm and 2–6 mm zone were significantly higher in the iron deficiency anemia group than in the control group (p=0.044 and p=0.021, respectively). There was a statistically significant difference in the mean values of the standard deviation and maximum lens densitometry measurements of the iron deficiency anemia group when compared with the control group (p=0.012 and p=0.011, respectively). There were statistically significant correlations between the anterior 2-6 mm zone corneal densitometry and ferritin, iron, and total iron binding capacity (r=-0.275, r=-0.243, r=0.240, respectively). However, ferritin, iron, and total iron binding capacity showed no significant correlation with the lens densitometry values (p>0.05 for all).Conclusion:Iron deficiency anemia had several effects on corneal and lenticular densitometry measurements. Evaluation of the corneal and lenticular changes at an ophthalmology clinic might be recommended for patients with iron deficiency anemia.

The effect of Iron Deficiency Anemia on Intelligence Quotient in children

The effect of Iron Deficiency Anemia on Intelligence Quotient in children

The Effect of Iron Deficiency Anemia and Different Treatment Methods on DNA Damage: 8-hydroxy-2-deoxyguanosine Level

Ionic iron causes damages at the cellular level by forming free radicals. Reactive oxygen species lead to the formation of oxidative base damages in DNA. Among these forms the most common one and the one which has the best known mutagenity is 8-hydroxy-2′-deoxyguanosine (8-OHdG). We aimed to determine iron deficiency anemia (IDA) and its different forms of treatments; probable oxidative damage on DNA by looking at the level of 8-OHdG. The patients were divided into 4 subgroups: Oral treatment (p.o.) group; Intramuscular treatment (i.m.) group; Intravenous treatment (i.v.) group; Healthy control group. Blood and urine samples were taken from all patients totally 4 times. 8-OHdG levels detected in blood and urine samples were compared with the control group. IDA and the treatment of it affect the level of 8-OHdG. p.o. therapy should be the top priority on children.

Relation between iron status and hemoglobin A1c in children with type 1 Diabetes Mellitus

Background: Hemoglobin A1c [HbA1c] is the best standard for measurements of glycemic control level in type 1 diabetes mellitus, especially in children. As iron deficiency anemia is a prevalent finding in children with diabetes, it may affect HbA1c levels in those children. Aim of the work: To determine the effects of iron deficiency anemia on hemoglobin A1c in type 1 diabetes mellitus Patients and methods:This was cross-sectional analytic study was done on 80 children with diabetes with type 1DM receiving insulin therapy; the patients divided into two groups, 21 diabetic children with iron deficiency anemia and 59 diabetic children with iron sufficient state, attending to the pediatric department of Al-Azher University Hospital in Damietta from February 2019 to September 2019. All children included were subjected to complete medical history, general examination, systemic examination, and laboratory investigations; [Complete blood count [CBC], HbA1c, Serum Iron, Serum Ferritin, Total Iron Binding Capacity, Fasting blood glucose, Post Prandial blood glucose, and ESR]. Results:In our study, we divided all patients [80 diabetic children] regarding glycemic control according to HbA1c value into three levels, the first level was optimal glycemic control level [HbA1c 9.0%], there was a statically highly significant increase in HbA1c value of the iron-deficient diabetic group in compared to iron sufficient diabetic group at all levels of glycemic control. Conclusion: Iron deficiency anemia seems to increase HbA1c value in diabetic children Type 1, at the same degree of glycemia.

Effect of iron deficiency Anemia on glycated haemoglobin levels in normoglycemic subjects

Effect of iron deficiency Anemia on glycated haemoglobin levels in normoglycemic subjects

Association of maternal serum ferritin concentration with newborn iron stores in anemic women in late pregnancy

Pregnant women are particularly vulnerable to Iron deficiency because of the increased metabolic demands imposed by pregnancy involving a growing placenta, fetus and maternal tissues, coupled with associated dietary risks. Maternal iron deficiency has effects on fetal iron stores. The fetus receives iron indirectly from the maternal circulation through a rapid and unidirectional process. Thus, this study was planned to determine association between maternal serum ferritin and new born serum ferritin levels. In this observational cross sectional study randomized sample of 100 antenatal women, &amp;#62;20years of age with Hb &amp;#60;11gm/dl and period of gestation &amp;#62;37 weeks was taken for study. Serum ferritin was estimated by ELISA technique. Hb levels ranged from 3.8-10.7grams/dl with a mean value of 9.77±1.55gram/dl. Parity is of significance for severity of Anaemia (p=0.002). Mean gestational age was 38.35±0.85. No correlation was found between the maternal haemoglobin and maternal serum ferritin levels in women with mild and moderate Anaemia. But in cases of severe Anaemia a positive correlation was found with a p&amp;#60;0.001. The mean cord blood serum ferritin was 57.36±19.48 micrograms. This study establishes the effect of iron deficiency anaemia on neonatal iron status with increasing severity of anaemia and emphasizes on the need for iron supplementation during pregnancy.

Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia.

To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness. Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiography was used to determine RNFL thickness and RPCvd measurements. In addition, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ferritin laboratory values were evaluated. Analysis of retinal regions (whole images, peripapillary, superior-hemi, inferior-hemi, inferior-nasal, inferior-temporal, temporal-inferior, temporal-superior, superior-nasal) showed that RPCvd values were significantly lower in patients with IDA compared to the control group values (p < 0.05 for all). However, there were no significant differences in RNFL thickness values between the IDA patient group and the control group (p > 0.05 for all). In addition, there were significant positive correlations between RPCvd values and hematological values for Hb, HCT, MCV, MCH, MCHC, and ferritin. It is important to identify changes in retinal vascularity to prevent possible ocular problems in patients with IDA. Specifically, the significant positive correlations between RPCvd values and hematological values suggest that anemia treatment is important for optic nerve perfusion.

Effect of Iron Deficiency Anemia on HbA1c in Non-Diabetics

Background: Glycated hemoglobin A1c is a well-known indicator of glycemic control in diabetes patients. It comprises of 5% of total hemoglobin in non-diabetic patients as well. Iron Deficiency Anemia is most common cause of anemia, especially in this part of the world. So, we study the effects of Iron deficiency Anemia on HbA1c levels in non-diabetic adults to determine whether the HbA1c levels increase if any.&#x0D; Methods: A 100 non-diabetic adult patients with Iron Deficiency anemia admitted in various medicine wards and attending OPDs of J.L.N. Medical College and 100 healthy controls were enrolled after fulfilled inclusion and exclusion criteria. Detailed history of clinical examination and biochemical examination was performed including HbA1c.&#x0D; Results: Mean HbA1c level is more in iron deficient Anemic non-diabetic patients in comparison to non-Anemic non-diabetic patients. Mean HbA1c is 5.01 ± 0.41 in control group. While mean HbA1c level in case group is 6.11 ± 0.42. The difference is statistically significant (p value &lt;.001).&#x0D; Conclusion: Iron deficiency Anemia is independent factor affecting HbA1c level in non diabetic patients &amp; it should be interpreted carefully in all iron deficient anemic patients.

Effects of Iron Deficiency Anemia and Its Rapid Correction on the Serum Metabolomic Profile of Rhesus Infants.

To determine whether rapid correction of iron deficiency using intramuscular iron dextran normalizes serum metabolomic changes in a nonhuman primate model of iron deficiency anemia (IDA). Blood was collected from naturally iron-sufficient (IS; n=10) and IDA (n=12) male and female infant rhesus monkeys (Macaca mulatta) at 6 months of age. IDA infants were treated with intramuscular injections of iron dextran, 10mg/weekly for 4-8 weeks. Iron status was reevaluated following treatment using hematological measurements and sera were metabolically profiled using HPLC/MS with isobaric standards for identification and quantification. Early-life iron deficiency anemia negatively affects many cellular metabolic processes, including energy production, electron transport, and oxidative degradation of toxins. Slow iron repletion with dietary supplementation restores iron deficient monkeys from a hematological perspective, but the serum metabolomic profile remains differed from monkeys that had been iron sufficient their entire life. Whether rapid iron restoration through intramuscular injections of iron dextran normalizes serum metabolomic profile is not known. A total of 654 metabolites were measured with differences in 53 metabolites identified between IS and IDA monkeys at 6 months (P0.05). Pathway analyses provided evidence of altered liver function, hypometabolic state, differential essential fatty acid production, irregular inosine and guanosine metabolism, and atypical bile acid production in IDA infants. After treatment, iron-related hematological parameters had recovered, but the formerly IDA infants remained metabolically distinct from the IS infants, with 225 metabolites differentially expressed between the groups. As with slow iron repletion, rapid iron repletion does not normalize the altered serum metabolomic profile in rhesus infants with IDA, suggesting the need for iron supplementation in the pre-anemic stage. National Institutes of Health.

English

English

Effect of iron deficiency anemia on language development in preschool Egyptian children

BackgroundIron deficiency anemia (IDA) is the most common nutritional deficiency primarily in developing countries. ObjectiveThis study evaluates the effect of IDA on language development in preschool children. MethodologyThe study is a multicenter, comparative cross-sectional study included 226 children between ages 4–6 years. The children were classified into two groups’ anemic (patients) and non anemic (controls) according to the hemoglobin level. All anemic children subjected to complete iron study including; Serum iron, total iron binding capacity (TIBC), Serum ferritin level, to confirm the diagnosis of iron deficiency anemia. Cognitive assessment was done using the Arabic translation Stanford Binet intelligence scale, version four which comprised of four cognitive area scores; visual reasoning, verbal reasoning, quantitative reasoning and short-term memory. Measurement of IQ and mental age were calculated for each child. Language evaluation was done using the Arabic Language test. Receptive language quotient, expressive language quotient and total language quotient were calculated for each child. Results122 children were anemic and 90 were non-anemic with hemoglobin level 10.65 and 11.96 g/dL, respectively (P < 0.000). Anemic children had significantly lower serum ferritin (p < 0.0001), and serum iron (p < 0.0001) compared to the controls. Both groups were matched as regards age, sex, socioeconomic levels and parental educational level. No significant differences observed regarding IQ, mental age, receptive, expressive and total language quotients between anemic and non-anemic children. ConclusionsIDA does not seem to have an effect on language development in preschool Egyptian Children. Future large controlled studies with long follow-up time for the younger age group are needed to determine whether there are existent associations between IDA with language development.

HbA1c level decreases in iron deficiency anemia.

Hemoglobin A1c (HbA1c) is the major form of glycosylated hemoglobin. There are conflicting data on changes in HbA1c levels in patients with iron deficiency anemia (IDA). The present study aimed to investigate the effects of HbA1c levels in the presence of IDA, the effects of iron treatment on HbA1c levels, as well as the relationship between the severity of anemia and HbA1c levels in patients without diabetes. Atotal of 263 patients without diabetes mellitus (DM) who were admitted to Cukurova University, Faculty of Medicine, Department of Endocrinology and Hematology or who were followed up in this clinic and diagnosed as having IDA were included in the study. Atotal of 131 patients had IDA. The control group comprised 132 age-matched and sex-matched healthy individuals. The mean HbA1c level was significantly lower in the group with IDA (5.4%) than in the healthy control group (5.9%; p < 0.05). When the patients were divided into three groups according to the severity of anemia through Hb levels, HbA1c levels were observed to decrease as the severity of the anemia increased (5.5%, 5.4%, and 5%, respectively; p > 0.05). The HbA1c levels of the patients with IDA were higher after iron therapy (from 5.4 ± 0.5 to 5.5 ± 0.3; p = 0.057). The mean hemoglobin (Hb), hematocrit (Hct), mean cell volume (MCV), mean corpusculer hemoglobin (MCH), and ferritin values also increased after iron therapy (p < 0.05). The study results showed that IDA was associated with low HbA1c levels, and increased after iron therapy. Based on the study findings, it is necessary to consider the possible effects of IDA on HbA1c levels.

Effects of iron deficiency anemia on peripapillary and macular vessel density determined using optical coherence tomography angiography on children.

To evaluate retinal vascular parameters by optical coherence tomography angiography (OCT-A) in iron deficiency anemia (IDA). Thirty-two patients with IDA (study group) and 30 healthy children (control group) were enrolled in the study. All subjects underwent a complete ocular examination. OCT-A scans were performed in a 6 × 6mm area centered on the macula. Foveal avascular zone (FAZ), non-flow area (NFA), FAZ perimeter (PERIM), acircularity index (AI) of FAZ, and foveal density (FD) were measured in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). SCP and DCP were also scanned centered on the optic disk. Hemoglobin (Hb), mean corpuscular volume (MCV), serum iron, total iron-binding capacity (TIBC), and ferritin were also studied and compared for both groups. The mean age was 12.22 ± 4.48years (ranged 5-18years) in the study group and 12.37 ± 3.76years (ranged 6-18years) in the control group. The mean FAZ value was 0.290 ± 0.09mm2 in the study group and 0.298 ± 0.11mm2 in the control group. The mean NFA value was 0.477 ± 0.10mm2 in the study group and 0.486 ± 0.13mm2 in the control group (p > 0.05). FD and AI were not statistically significant between the study group and control group (p > 0.05). The mean value for SCP was statistically significant between the study group and control group (p < 0.05). The mean value for DCP was not significantly different between the study and control groups (p > 0.05). The mean values for capillary density on optic disk were also statistically significant between the study group and control group (p < 0.05). A negative correlation was found between serum iron, TIBC, and capillary plexus density (p < 0.05). A positive correlation was found between MCV and ferritin values and capillary plexus density (p < 0.05). IDA had significantly lower capillary plexus density. We detected retinal microvascular changes in young IDA patients before significant ocular anomalies, especially ischemic changes, developed.

Prevalence and foetomaternal effects of iron deficiency anaemia among pregnant women in Lagos, Nigeria.

Anaemia in pregnancy is a major health problem and an important cause of adverse foetomaternal outcomes in developing countries. Iron deficiency is the cause of the overwhelming majority of the cases of anaemia in pregnancy. Iron deficiency anaemia (IDA) has been linked with adverse foetal and maternal outcomes. This study investigated the prevalence of IDA and evaluated its effects on foetomaternal outcomes among parturients in Lagos, Nigeria. This was a cross-sectional study that enrolled 220 women aged 15–49 years with singleton gestation at term, between May 1, 2016, and March 31, 2017. Participants were selected by systematic sampling and baseline data were collected through interviews. Venous blood samples were obtained to measure haemoglobin and serum ferritin concentrations, and the associations between IDA (defined as anaemia and iron deficiency) and pregnancy outcomes were examined. A P-value <0.05 was considered as statistically significant. The prevalence of IDA was 12.3%. Routine antenatal iron supplementation (adjusted odds ratio 0.18, 95% confidence interval 0.07–0.46; P = 0.001) and interpregnancy interval of at least 2 years (adjusted odds ratio 0.20, 95% confidence interval 0.05–0.97; P = 0.021) have significant association with IDA. Iron deficiency anaemia was not significantly associated with adverse perinatal outcomes but there were significant associations with increased risk of blood transfusion (P = 0.001) and maternal infectious morbidities such as puerperal pyrexia (P = 0.041) and wound infection (P = 0.020). IDA is still a fairly common condition among parturients in Lagos and it’s mostly associated with maternal peripartum morbidities. Adequate pregnancy spacing through the use of effective contraception and routine antenatal iron supplementations in pregnancy is a recommended preventive measure against IDA and its adverse sequelae. Future studies should adopt the use of transferrin saturation (TSAT) in compliment with serum ferritin assay as a more sensitive marker of iron deficiency.

A study on effect of iron deficiency anemia on glycosylated hemoglobin levels in non-diabetic south Indian population

A study on effect of iron deficiency anemia on glycosylated hemoglobin levels in non-diabetic south Indian population

Iron deficiency anaemia revisited.

Iron deficiency anaemia is a global health concern affecting children, women and the elderly, whilst also being a common comorbidity in multiple medical conditions. The aetiology is variable and attributed to several risk factors decreasing iron intake and absorption or increasing demand and loss, with multiple aetiologies often coexisting in an individual patient. Although presenting symptoms may be nonspecific, there is emerging evidence on the detrimental effects of iron deficiency anaemia on clinical outcomes across several medical conditions. Increased awareness about the consequences and prevalence of iron deficiency anaemia can aid early detection and management. Diagnosis can be easily made by measurement of haemoglobin and serum ferritin levels, whilst in chronic inflammatory conditions, diagnosis may be more challenging and necessitates consideration of higher serum ferritin thresholds and evaluation of transferrin saturation. Oral and intravenous formulations of iron supplementation are available, and several patient and disease-related factors need to be considered before management decisions are made. This review provides recent updates and guidance on the diagnosis and management of iron deficiency anaemia in multiple clinical settings.

Effect of Iron Deficiency Anemia on HBA1C in Patients With Diabetic Foot Ulcer Grade (1and2)

Effect of Iron Deficiency Anemia on HBA1C in Patients With Diabetic Foot Ulcer Grade (1and2)