PurposeWhile the literature has highlighted the impacts of COVID-19, there is limited evidence on the gendered determinants of the impact of COVID-19 among small-scale rural traders in developing and emerging economies.Design/methodology/approachCross-border fish traders who had operated before and during the COVID-19 pandemic were interviewed in a survey conducted in Zambia and Malawi. Logistic regressions among male and female traders were employed to assess the gendered predictors.FindingsHeterogeneous effects in geographical location, skills, and knowledge were reported among male cross-border traders. Effects of household structure and composition significantly influenced the impact of COVID-19 among female traders. Surprisingly, membership in trade associations was associated with the high impact of COVID-19.Research limitations/implicationsDue to the COVID-19 pandemic and the migratory nature of cross-border fish traders, the population of cross-border fish traders at the time of the study was unknown and difficult to establish, cross-border fish traders (CBFT) at the landing sites and market areas were targeted for the survey without bias.Originality/valueThis paper addresses a gap in the literature on understanding gendered predictors of the impacts of COVID-19 among small-scale cross-border traders.