Effect Of Fenugreek Research Articles

Effect of fenugreek seed extract (Trigonella foenum-graecum) in letrozole induced polycystic ovary syndrome in female albino rat

Effect of fenugreek seed extract (<i>Trigonella foenum-graecum)</i> in letrozole induced polycystic ovary syndrome in female albino rat

Effects of Fenugreek, Ginger, and Turmeric Supplementation on Human Milk Volume and Nutrient Content in Breastfeeding Mothers: A Randomized Double-Blind Controlled Trial.

Background: Exclusive breastfeeding is the best way to accomplish optimal growth and health in infants. Low milk volume is a major problem that leads to nonexclusive breastfeeding. Objective: This study aimed to examine the effects of mixed herbal supplementation, including fenugreek, ginger, and turmeric on human milk volume and nutrient content. Methods: The study design was a randomized double-blind controlled trial. Fifty exclusively breastfeeding mothers were randomly divided into two groups. The herbal group (n = 25) received mixed herbal supplementation containing fenugreek, ginger, and turmeric, three capsules three times daily for 4 weeks. The control group (n = 25) took a placebo. Anthropometric and dietary data, blood pressure, heart rate, and blood and milk samples were collected at baseline and 4 weeks after the intervention. Milk volume was measured using a manual breast pump and recorded for 2 days at baseline, week 2, and week 4. Results: Breastfeeding mothers receiving herbal supplementation had a 49% increase in milk volume at week 2 and a 103% increase at week 4. These increases were greater than mothers in the placebo group (p < 0.05). There was no difference in milk nutrient content for both groups. Moreover, there were no differences in adverse effects observed in the placebo and herbal groups. Conclusion: Mixed herbal supplementation that contained fenugreek, ginger, and turmeric can increase human milk volume without adverse effects.

Effects of Fenugreek, Antibiotic, Lgnatia amara and Ginger on Growth Performance of Japanese Quail

Effects of Fenugreek, Antibiotic, Lgnatia amara and Ginger on Growth Performance of Japanese Quail

Effects of Fenugreek, Antibiotic, Lgnatia amara and Ginger on Growth Performance of Japanese Quail

Effects of Fenugreek, Antibiotic, Lgnatia amara and Ginger on Growth Performance of Japanese Quail

Effects of fenugreek seed powder on enteral nutrition tolerance and clinical outcomes in critically ill patients: A randomized clinical trial

Background: Enteral nutrition (EN) intolerance is a common complication in critically ill patients that contributes to morbidity and mortality. Based on the evidence of curing effects of fenugreek seeds in some gastrointestinal disorders, this study aimed to determine the effects of fenugreek seed powder on enteral nutrition tolerance and clinical outcomes in critically ill patients.&#x0D; Materials &amp; Methods: A randomized, double-blinded clinical trial of 5-day duration was conducted on 60 mechanically ventilated patients divided in 2 groups (n=30). Group 1 was given fenugreek seed powder by gavage, twice a day in addition to routine care, while Group 2 received only routine care. Enteral nutrition tolerance and clinical outcomes were measured throughout the study. Demographic and clinical data were recorded and clinical responses to the primary outcome (enteral nutrition tolerance) and secondary outcome (other clinical factors) were interpreted. Data were analyzed using the independent t-test, Chi-squared test, covariance analysis, and repeated measure ANOVA via SPSS statistical software (v. 20); statistical significance was set at p&lt; 0.05.&#x0D; Results: Patients who were fed with the fenugreek seed powder showed a significant improvement in enteral nutrition tolerance, as well as some complications of mechanical ventilation for Group 1, as compared with Group 2. The mortality rates were not different between the two groups.&#x0D; Conclusion: This study shows the beneficial effects of fenugreek seeds on food intolerance in critically ill patients and that the seed powder can be used as an add-on therapy with other medications. Thus, the use of fenugreek seeds to treat mechanically ventilated patients is recommended.

Effects of fenugreek (Trigonella foenum-graecumL.) seed extract supplementation in different energy density diets on growth performance, nutrient digestibility, blood characteristics, fecal microbiota, and fecal gas emission in growing pigs

This study evaluated the efficacy of fenugreek seed extract (FSE) in growing pigs. About 140 growing pigs [(Yorkshire × Landrace) × Duroc] with an average body weight (BW) of 23.70 ± 2.80 kg were used in a 6 wk trial. Treatments were (on as-fed basis) two levels of FSE (FSE0, 0 or FSE0.2, 2 g kg−1basal diet), and two levels of energy [low-energy diet (LED); 3160 or high-energy diet (HED); 3260 kcal kg−1metabolizable energy (ME)]. Pigs in HED and FSE0.2 diets had higher final BW, average daily gain, and gain:feed ratio (G:F) compared with in LED, and FSE0 diets, respectively (P &lt; 0.05). Pigs fed the FSE0.2 and HED diets had higher energy (E) digestibility than the FSE0 and LED diets, respectively (P &lt; 0.05). Pigs fed the FSE0.2 diet increased serum immunoglobulin G (IgG), and reduced total cholesterol (TC) concentration than the FSE0 diet (P &lt; 0.05). Hydrogen sulfide (H2S) and ammonia (NH3) gas emission in FSE0.2 diet were lower than that in FSE0 group (P &lt; 0.05). In conclusion, results indicated that dietary supplementation of FSE improved growth performance, digestibility, serum IgG, reduced serum TC, and noxious gas emission in growing pigs.

Effect of Fenugreek (Trigonella foenum Graecum) on lipid profile and sexual hormones in induced hyperlipidemic rats

Hyperlipidemia has been ranked as one of the greatest risk factors contributing to the prevalence and severity of coronary heart diseases which considered as the primary causes of death.As hypolipidemic drugs are expensive and of harmful sideffects so, medicinal plant products have been used as an alternative to current management of hyperlipidemia and obesity to some extent as fenugreek leaves and seeds (Trigonella foenum graecum) which were used during Hippocrates and ancient Egyptian times and also, its hypocholesterolemic effect was reported in rats. So, this study aimed to investigate the effect of Fenugreek (Trigonella foenum Graceum) seed powder on hyperlipidemia,atherogenic indices and sexual hormons in induced hyperlipidemic rats.Forty adult male albino rats were used in which they were divided into four groups as : Group I(control group) received basal diet ,GroupII (fenugreek group) received basal diet mixed with 5 % fenugreek seed powder (95 ration diet + 5 gm fenugreek seed powder),GroupIII(hyperlipidemic group) received basal diet, with induction of hyperlipidemia via intraperitoneal injection of triton at adose of (250 mg/kg),GroupIV received basal diet + 5 % fenugreek seed powder after induction of hyperlipidemia via intraperitoneal injection of triton by the same previous method.After 8 weeks, Blood samples were collected (after overnight fasting) , for biochemical analysis and statistical analysis. Result: Triton caused significant increase in serum level of Totalcholesterol(TC) ,Triglycerides(TG), LowDenisityLipoprotein(LDL-c) , very low density lipoprotein (vLDL) ingroup 3(hyperlipidemic group) , with significant decrease in high density lipoprotein (HDL-c).Meanwhile,serum level of TC.,TG.,LDL-c.vLDL-c were significantly decreased in hyperlipidemic group after treating with fenugreek seed powder in group 4 (Hypolipidemic effect) with increasing serum level of high density lipoprotein (HDL-c) with significant improvement in Atherogenic Index as:Cardiac Risk Factors (CRR), Atherogenic Coefficient (AC) and Atherogenic Indices (AI). Also, sexual hormons were improved with fenugreek administration especially group 2 (fenugreek group) compared to group1 (controlgroup). Conclusion: Fenugreek has hypolipidemic effect when added to diet by 5% with improving atherogenic index and sexual hormons.

Effectiveness of fenugreek as a galactagogue: A network meta-analysis.

A systematic review and network-meta analysis (NMA) were performed to test significance of the galactagogue effect of fenugreek administrated to lactating women versus other comparators (i.e., placebo/control/other galactagogues). A pairwise comparison for the treatment effect was carried out to generate the forest plot for the NMA. League tables were generated using treatment effect, weighted mean difference (WMD; 95% confidence interval, CI) for all pairwise comparisons, where WMD>0 favors the column-defining treatment. Five studies were identified with 122 participants receiving treatment with fenugreek. The NMA results of 4 studies indicated that consumption of fenugreek significantly increased amount of the produced breast milk [11.11, CI 95% 6.77, 15.46] versus placebo. The pairwise comparison revealed that fenugreek was effective as a galactagogue compared to placebo, control, and reference groups WMD 17.79 [CI 11.71, 23.88]. However, the effect of fenugreek was substantially inferior to Coleus amboinicus Lour and palm date. The NMA using pairwise comparison demonstrated the effect of C.amboinicus and palm date in the stimulation of the breast milk production was comparable and superior to all comparators.

Effect of Fenugreek on Memory and Learning and also Antioxidant Capacity in Hippocampus of Type II Diabetic Rats

Effect of Fenugreek on Memory and Learning and also Antioxidant Capacity in Hippocampus of Type II Diabetic Rats

Effect of Fenugreek, Coriander and Thyme Essential Oils Addition on Microbiology of Soybean Meal and Sunflower Meal in Different Storage Periods

Effect of Fenugreek, Coriander and Thyme Essential Oils Addition on Microbiology of Soybean Meal and Sunflower Meal in Different Storage Periods

Effect of Fenugreek as a Feed Additive on the Growth, Body Composition and Apparent Nutrients Digestibility of Striped Catfish Pangasius hypophthalmus Fry

Effect of Fenugreek as a Feed Additive on the Growth, Body Composition and Apparent Nutrients Digestibility of Striped Catfish Pangasius hypophthalmus Fry

Effect of Phytoestrogenic Constituents of Fenugreek in Comparison with Synthetic Estradiol on Menopause Induced Hematological Alterations

At menopause the physiological parameters modulated by estrogen are disrupted leading to various symptoms. Hormone replacement therapy though beneficial has its own drawbacks. Fenugreek seeds, commonly used in Indian households, is known to possess phytoestrogens. Considering the lack of literature in support of this, this study was conducted to compare the effects of fenugreek seed extract and 17�-estradiol on menopause induced alterations in hematological parameters, employing the ovariectomised rat model. Female Wistar rats, 8 months old were randomly assigned into 4 groups (n = 6): (1) normal control, (2) ovariectomised and untreated, (3) ovariectomised and treated orally with fenugreek seed extract, (4) ovariectomised and treated with subcutaneous injections of estradiol. Post-treatment blood samples were collected and various hematological parameters were analyzed. Fenugreek treated rats showed higher hemoglobin, hematocrit and RBC counts in comparison to ovariectomised group. Additionally, they showed a higher total leukocyte count (TLC), specifically a higher lymphocyte count than that of control. Estradiol treated groups showed severe leukopenia owing to lymphocytopenia; decreased RBC counts, hemoglobin and hematocrit. However, the changes were statistically significantly only with estradiol treatment. Overall, fenugreek was found to be a better agent to attenuate the menopause induced hematological alterations.

A Narrative Review on Evidence-based Antidiabetic Effect of Fenugreek (Trigonella Foenum-Graecum)

Diabetes mellitus is one of the most common endocrine metabolic disorders. Adverse effects of the conventional antidiabetic therapy are increasing. Many herbs have strong antidiabetic properties, and fenugreek is one among them. Although fenugreek is one of the most common herbs used for diabetes, its antidiabetic effects are not well-documented. The aim of this review was to report the evidence-based antidiabetic effects of fenugreek. We performed PubMed/Medline search to review relevant articles in English literature using keywords “trigonella foenum graecum for the management of diabetes.” Out of 26 articles found, 18 articles were reported in this review. Based on the available literature, this review suggests that the fenugreek has the evidence-based antidiabetic effect, such as stimulating and/or regenerating effect on β cells along with the extrapancreatic effect, that is effective in reducing blood glucose levels in diabetic patients.

Production Response of Guinea Fowls Provided Fenugreek and Kalonji Seed Powder

Fenugreek (Trigonella foenum-graecum) and kalonji (Nigella sativa) seeds have a wide range of anti-microbial, therapeutic, antioxidant, hepatoprotective, antidiabetic and growth promoting effects. A study was conducted on 100, day old guinea fowls (Pearl variety) for a period of 12 weeks to study the effect of fenugreek and kalonji seed powder supplementation on the growth performance of guinea fowls. The experimental guinea fowls were randomly divided into five treatment groups viz. group T1 control, T2 ( 2.0% fenugreek seed powder), T3 (1.0% kalonji seed powder), T4 (2.0% fenugreek + 1.0% kalonji seed powder) and T5 (1.0% fenugreek + 0.5% kalonji seed powder), each group with two replications consisting of ten guinea fowls each. The respective fenugreek and kalonji seed powder supplementation as per the groups was done for 84 days, excluding the guinea fowls of control group which were given feed without any supplementation. Growth parameters were studied in three different period viz. starter (1st-4th week), grower (5th-8th week), finisher (9th-12th week) and overall period (1st-12th week). The results of the trial indicated that inclusion of the fenugreek and kalonji seed powder through diet in guinea fowls at all levels increased body weight gain, reduced feed intake and improved feed conversion ratio (P≤0.05) with best performance during all the periods was noted in T4 group of guinea fowls provided diet containing 2.0% fenugreek +1.0% kalonji seed powder. It can be concluded that combination of fenugreek (2%) and kalonji (1%) seed powder through feed may be advised to improve growth performance of guinea fowls.

The Effect of Fenugreek and WPI on Release of Aromatic Acids from Shiraz Cheese ― Iranian Traditional Cheese Produced from Bovine Milk

The Effect of Fenugreek and WPI on Release of Aromatic Acids from Shiraz Cheese ― Iranian Traditional Cheese Produced from Bovine Milk

281 The interactive effects of fenugreek seed extract supplementation and dietary metabolizable energy levels in growing pigs

281 The interactive effects of fenugreek seed extract supplementation and dietary metabolizable energy levels in growing pigs

Physiological Studies on the Effect of Fenugreek on Productive Performance of White New-Zealand Rabbit Does

The objective of the current work is to investigate the possible beneficial effects of forced feeding of fenugreek to rabbit does on their milk composition, milk yield, anemia screening parameters, immunity and the growth performance of bunnies. Twenty white New Zealand female rabbits were randomly assigned into 5 groups: normal control and 4 treated groups (vehicle (molasses), fenugreek powdered seeds + molasses, sprouted fenugreek + molasses, and fenugreek oil + molasses). All treated groups took the given doses orally for two days before parturition and 13 days after parturition for 2 successive pregnancies. Blood samples were collected from each doe on the 13th day of lactation for determination of hematological, biochemical and immunological parameters. Milk samples were taken for evaluation of milk composition. All rabbit does and their bunnies were weighed for calculation of the milk yield. The fenugreek seeds and oil administered groups (G3 & G5) recorded the highest percent values of fat, protein, lactose, total solids and solid not fat contents of the rabbits’ milk in both 1st and 2nd lactation periods relative to other tested groups. At the beginning and mid of lactation periods, the milk yields recorded non-significant differences either between tested groups or between 1st and 2nd pregnancy in the same group. Whereas, at the end of lactation, germinated seeds (G4) and oil (G5) treated groups recorded significantly higher rates of milk yield relative to control and fenugreek seeds groups. Bunnies’ body weights suckling from dams of group III (G3) recorded the highest weights relative to other tested groups in both 1st and 2nd pregnancy. During the 1st lactation period, all experimental groups showed significant reduction of white blood cells, while, G3 and G4 recorded significant elevation during 2nd lactation period. Rabbits treated with fenugreek seeds powder (G3) showed a significant raise of phagocytic activity and phagocytic index. Fenugreek seeds group (G3) and germinated one (G4) showed significant red blood corpuscles and packed cell volume raise relative to other groups during both 1st and 2nd lactation periods.

The Effect of Fenugreek (Trigonella foenum-graecum) Seed and 17-β Estradiol on Serum Apelin, Glucose, Lipids, and Insulin in Ovariectomized Rats

Background: Menopause, a natural phenomenon, is defined by the fall of ovarian hormones mainly estrogens causing major problems such as insulin resistance. Fenugreek (Trigonella foenum-graecum) is known to have some useful properties such as insulin sensitizing effect. Apelin is an adipokine, which has several roles such as regulation of insulin secretion. Objectives: The objective of the present study was to evaluate the effect of fenugreek seed and 17-β estradiol on serum Apelin along with glucose, lipids and insulin in ovariectomized rats. Materials and Methods: Forty-nine adult female Wistar rats were randomly divided to seven groups: normal control, ovariectomized control, ovariectomized treated with ethanolic and hexanic extract of fenugreek seed (50 and 150 mg/kg/daily for each), and ovariectomized treated with 17-β estradiol (10 μg/kg/daily) for 42 days. Serum Apelin, glucose, lipids and insulin were measured. Results: Serum Apelin, glucose, lipids and insulin significantly increased in ovariectomized controls in comparison with normal controls (P < 0.05). Serum glucose, lipids and insulin in ovariectomized rats treated with fenugreek seed extract and 17-β estradiol were remarkably lower than ovariectomized controls (P < 0.05). Furthermore, 17-β estradiol caused a significant decrease (P < 0.05) in serum Apelin in ovariectomized rats. Conclusions: It appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum Apelin. Furthermore, 17-β estradiol could have similar effects along with possible inhibitory effects on serum Apelin. The complicated role of Apelin in menopause needs to be further explored. Keywords: Apelin-13; Trigonella Foenum-Graecum; 17 Beta-Estradiol; Ovariectomized; Insulin; Lipids

Anti-Urolithiatic and Anti-Oxidant Effects of Fenugreek on Ethylene Glycol-Induced Kidney Calculi in Rats

Anti-Urolithiatic and Anti-Oxidant Effects of Fenugreek on Ethylene Glycol-Induced Kidney Calculi in Rats

Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in obese diabetic albino rats

Background and study aimNonalcoholic fatty liver disease (NAFLD) occurs in approximately 80% of cases of type 2 diabetes mellitus (T2DM). This study investigated the effects of some plants used in Saudi Arabia as antidiabetic agents on T2DM and associated fatty liver. Materials and methodsA total of 150 adult male albino rats were divided into six experimental groups, each consisting of 25 rats. Twenty-five rats were considered as the control group. Experimental diabetes was induced in the remaining rats by administering a subcutaneous injection of 120mg/kg of freshly prepared alloxan solution; these rats were classified into five groups: one group did not receive any treatment; the second group was treated with an aqueous extract of a mixture containing fenugreek, Nigella, and termis seeds; the third group was treated with an aqueous extract of Nigella sativa seeds; the fourth group was treated with an aqueous extract of fenugreek seeds; and finally the fifth group was treated with an aqueous extract of termis seeds at a dose of 100mg/kg body weight. After 4weeks of treatment, biochemical parameters were calculated, including blood sugar and serum insulin levels. Pancreatic and liver samples were obtained and processed for microscopic evaluation. ResultsThe usage of each plant alone or a mixture of the plants corrected the glucose and insulin levels. Microscopically, a definite improvement in the number and diameter of β-cells in the diabetic group was observed. Furthermore, considerable improvement in fatty changes occurring in the liver of experimental animals was observed. The activity of the mixture was the most effective. ConclusionsThe aqueous extract of the seed mixture of the used plants appeared to be a useful agent in improving fatty changes in the liver texture associated with T2DM by reducing hyperglycaemia through an increase in insulin levels, regeneration of β-cells of the pancreas, and an amelioration of associated dyslipidemia.