Effects Of Early Visual Deprivation Research Articles

Top-down modulation of visual cortical processing after transient congenital blindness

Early visual experience has been shown to be critical for the development of visual and multisensory functions; however, its impact on functional brain organization remains largely unexplored. Here, we therefore investigated the effect of early visual deprivation on top-down attentional modulation of visual cortical processing within the occipito-temporal cortex. Furthermore, we explored whether early visual deprivation may affect the extent to which typically visual, motion-selective area hMT responds to moving visual stimuli. Using functional magnetic resonance imaging, we compared cortical responses in area hMT and in the fusiform face area (FFA) to moving face stimuli – which were either task relevant or task irrelevant – relative to stationary face stimuli between cataract-reversal participants and normally sighted controls. Although both groups exhibited significantly stronger visual cortical responses in area hMT to moving stimuli than during the stationary baseline, the magnitude of this effect was significantly lower in the cataract-reversal group. In contrast, both groups exhibited significantly enhanced visual cortical responses in area hMT and in the FFA when moving face stimuli were task relevant compared to when they were task irrelevant, with no significant differences between groups in the magnitude of these effects. These results indicate that top-down attentional modulation of visual cortical processing in area hMT and FFA does not depend on early visual experience. Furthermore, the present results suggest that the functional specialization of area hMT for visual motion processing may be partially disrupted by early visual deprivation.

Invited Session III: Reawakening plasticity in visual cortex: Recovery from the effects of visual deprivation beyond peak plasticity

Visual experience during early postnatal life plays an important role in the development of neural circuits that support normal vision. Conditions that disrupt visual experience can alter the structure and function of neurons to produce a functional impairment, amblyopia, in the affected eye that can last a lifetime. Susceptibility to the neural modifications presumed to underlie amblyopia is confined to the early years of life during the so-called critical period. Up until recently, recovery from the effects of visual deprivation was likewise thought to be possible only early in life; however, research in rodents has demonstrated that under certain conditions recovery can occur at ages beyond the critical period. We have observed a remarkable recovery from the effects of visual deprivation in cats following temporary retinal inactivation with intraocular application of tetrodotoxin, a potent neural anesthetic. Notably, retinal inactivation produces rapid and significant structural and functional recovery at ages beyond what can be achieved with conventional therapy. This talk will present results from our studies on the use of retinal inactivation to resource plasticity capacity and promote recovery from the effects of early visual deprivation.

Early visual deprivation prompts the use of body-centered frames of reference for auditory localization

The effects of early visual deprivation on auditory spatial processing are controversial. Results from recent psychophysical studies show that people who were born blind have a spatial impairment in localizing sound sources within specific auditory settings, while previous psychophysical studies revealed enhanced auditory spatial abilities in early blind compared to sighted individuals. An explanation of why an auditory spatial deficit is sometimes observed within blind populations and its task-dependency remains to be clarified. We investigated auditory spatial perception in early blind adults and demonstrated that the deficit derives from blind individual’s reduced ability to remap sound locations using an external frame of reference. We found that performance in blind population was severely impaired when they were required to localize brief auditory stimuli with respect to external acoustic landmarks (external reference frame) or when they had to reproduce the spatial distance between two sounds. However, they performed similarly to sighted controls when had to localize sounds with respect to their own hand (body-centered reference frame), or to judge the distances of sounds from their finger. These results suggest that early visual deprivation and the lack of visual contextual cues during the critical period induce a preference for body-centered over external spatial auditory representations.

Blindness and social trust: The effect of early visual deprivation on judgments of trustworthiness.

Investigating the impact of early visual deprivation on evaluations related to social trust has received little attention to date. This is despite consistent evidence suggesting that early onset blindness may interfere with the normal development of social skills. In this study, we investigated whether early blindness affects judgments of trustworthiness regarding the actions of an agent, with trustworthiness representing the fundamental dimension in the social evaluation. Specifically, we compared performance between a group of early blind individuals with that of sighted controls in their evaluation of trustworthiness of an agent after hearing a pair of two positive or two negative social behaviors (impression formation). Participants then repeated the same evaluation following the presentation of a third (consistent or inconsistent) behavior regarding the same agent (impression updating). Overall, blind individuals tended to give similar evaluations compared to their sighted counterparts. However, they also valued positive behaviors significantly more than sighted controls when forming their impression of an agent's trustworthiness. Moreover, when inconsistent information was provided, blind individuals were more prone to revise their initial evaluation compared to controls. These results suggest that early visual deprivation may have a dramatic effect on the evaluation of social factors such as trustworthiness.

The Impact of Early Visual Deprivation on Spatial Hearing: A Comparison between Totally and Partially Visually Deprived Children.

The specific role of early visual deprivation on spatial hearing is still unclear, mainly due to the difficulty of comparing similar spatial skills at different ages and to the difficulty in recruiting young blind children from birth. In this study, the effects of early visual deprivation on the development of auditory spatial localization have been assessed in a group of seven 3–5 years old children with congenital blindness (n = 2; light perception or no perception of light) or low vision (n = 5; visual acuity range 1.1–1.7 LogMAR), with the main aim to understand if visual experience is fundamental to the development of specific spatial skills. Our study led to three main findings: firstly, totally blind children performed overall more poorly compared sighted and low vision children in all the spatial tasks performed; secondly, low vision children performed equally or better than sighted children in the same auditory spatial tasks; thirdly, higher residual levels of visual acuity are positively correlated with better spatial performance in the dynamic condition of the auditory localization task indicating that the more residual vision the better spatial performance. These results suggest that early visual experience has an important role in the development of spatial cognition, even when the visual input during the critical period of visual calibration is partially degraded like in the case of low vision children. Overall these results shed light on the importance of early assessment of spatial impairments in visually impaired children and early intervention to prevent the risk of isolation and social exclusion.

Persisting Cross-Modal Changes in Sight-Recovery Individuals Modulate Visual Perception

Recent neuroimaging studies have demonstrated that a brief period of congenital blindness induces long-lasting reorganization within the visual cortex of sight-recovery humans [1, 2]. However, the behavioral consequences of this cross-modal reorganization are not yet known. Here we investigated this question by examining the transfer of motion aftereffects across the visual and auditory modalities within six individuals who had been born blind due to dense bilateral cataracts and regained sight when they were treated at 5-24months of age. Cataract-reversal individuals were compared to normally sighted participants and-to distinguish between the effects of early visual deprivation and residual visual impairments-to an additional group of individuals who had had pattern vision in childhood but later developed visual impairments. Cataract-reversal individuals-but not normally sighted or visually impaired participants-exhibited a significant visual motion aftereffect following adaptation to auditory motion. Despite this, cataract-reversal individuals were as likely as individuals in either control group to show a significant auditory motion aftereffect following adaptation to visual motion. These results extend previous findings of persisting cross-modal reorganization within the typically visual motion-selective area hMT+/V5 in sight-recovery individuals [3, 4], by providing the first demonstration that cross-modal adaptation to a brief phase of congenital blindness has behaviorally relevant consequences for visual perceptual recovery.

The Influence of Averageness on Adults' Perceptions of Attractiveness: The Effect of Early Visual Deprivation.

Adults who missed early visual input because of congenital cataracts later have deficits in many aspects of face processing. Here we investigated whether they make normal judgments of facial attractiveness. In particular, we studied whether their perceptions are affected normally by a face's proximity to the population mean, as is true of typically developing adults, who find average faces to be more attractive than most other faces. We compared the judgments of facial attractiveness of 12 cataract-reversal patients to norms established from 36 adults with normal vision. Participants viewed pairs of adult male and adult female faces that had been transformed 50% toward and 50% away from their respective group averages, and selected which face was more attractive. Averageness influenced patients' judgments of attractiveness, but to a lesser extent than controls. The results suggest that cataract-reversal patients are able to develop a system for representing faces with a privileged position for an average face, consistent with evidence from identity aftereffects. However, early visual experience is necessary to set up the neural architecture necessary for averageness to influence perceptions of attractiveness with its normal potency.

The Effect of Early Visual Deprivation on the Neural Bases of Auditory Processing

Transient congenital visual deprivation affects visual and multisensory processing. In contrast, the extent to which it affects auditory processing has not been investigated systematically. Research in permanently blind individuals has revealed brain reorganization during auditory processing, involving both intramodal and crossmodal plasticity. The present study investigated the effect of transient congenital visual deprivation on the neural bases of auditory processing in humans. Cataract-reversal individuals and normally sighted controls performed a speech-in-noise task while undergoing functional magnetic resonance imaging. Although there were no behavioral group differences, groups differed in auditory cortical responses: in the normally sighted group, auditory cortex activation increased with increasing noise level, whereas in the cataract-reversal group, no activation difference was observed across noise levels. An auditory activation of visual cortex was not observed at the group level in cataract-reversal individuals. The present data suggest prevailing auditory processing advantages after transient congenital visual deprivation, even many years after sight restoration. The present study demonstrates that people whose sight was restored after a transient period of congenital blindness show more efficient cortical processing of auditory stimuli (here speech), similarly to what has been observed in congenitally permanently blind individuals. These results underscore the importance of early sensory experience in permanently shaping brain function.

The effect of early visual deprivation on the neural bases of multisensory processing.

Developmental vision is deemed to be necessary for the maturation of multisensory cortical circuits. Thus far, this has only been investigated in animal studies, which have shown that congenital visual deprivation markedly reduces the capability of neurons to integrate cross-modal inputs. The present study investigated the effect of transient congenital visual deprivation on the neural mechanisms of multisensory processing in humans. We used functional magnetic resonance imaging to compare responses of visual and auditory cortical areas to visual, auditory and audio-visual stimulation in cataract-reversal patients and normally sighted controls. The results showed that cataract-reversal patients, unlike normally sighted controls, did not exhibit multisensory integration in auditory areas. Furthermore, cataract-reversal patients, but not normally sighted controls, exhibited lower visual cortical processing within visual cortex during audio-visual stimulation than during visual stimulation. These results indicate that congenital visual deprivation affects the capability of cortical areas to integrate cross-modal inputs in humans, possibly because visual processing is suppressed during cross-modal stimulation. Arguably, the lack of vision in the first months after birth may result in a reorganization of visual cortex, including the suppression of noisy visual input from the deprived retina in order to reduce interference during auditory processing.

The Effect of Early Visual Deprivation on the Development of Judgments of Attractiveness

The Effect of Early Visual Deprivation on the Development of Judgments of Attractiveness

The effect of early visual deprivation on the development of judgments of attractiveness

1 Langlois, J.H., & Roggman, L.A. (1990). Psychol Sci, 1, 115-121. 2 Winkielman, P., Halberstadt, J., Fazendeiro, T., & Catty, S. (2006). Psychol Sci, 17(9), 799-806. 3 de Haan, M., Johnson, M. H., Maurer, D., & Perrett, D. I. (2001). Cognitive Dev, 16(2), 659-678. 4 Rubenstein, A. J., Kalakanis, L., & Langlois, H. J. (1999). Dev Psychol, 35, 848-855. 5 Vingilis-Jaremko, L., & Maurer, D. (2014). J Exp Child Psychol, 4, 624-639. 6 Vingilis-Jaremko, L., Sherazadishvili, A., & Maurer, D. (in prep). 7 Nishimura et al. (in prep) 8 de Heering, A., & Maurer, D. (2014). Dev Psychobio, 56 , 96-108. 9 Rennels, J. L., & Davis, R. E. (2008). Infant Behav Dev, 31(4), 665-78. 10 Sugden, N. A., Mohamed-Ali, M. I., & Moulson, M. C. (2014). Dev Psychobiol, 56(2), 249-61. Purpose Background

The effect of early visual deprivation on the development of face detection

The expertise of adults in face perception is facilitated by their ability to rapidly detect that a stimulus is a face. In two experiments, we examined the role of early visual input in the development of face detection by testing patients who had been treated as infants for bilateral congenital cataract. Experiment 1 indicated that, at age 9 to 20, patients' accuracy and response times on a Mooney face detection task were normal. Experiment 2 revealed that the neural mechanisms underlying face detection in a similar group of adult patients are abnormal: the amplitude of both the P100 and N170 event-related potential were larger in patients than in visually normal controls, and the extent of augmentation was related to the duration of deprivation. Thus, early visual experience is necessary for the establishment of normal neural networks for face detection; abnormalities at these early processing stages may contribute to the deficits we previously reported in configural face processing for this patient cohort.

Altered representation of facial expressions after early visual deprivation

We investigated the effects of early visual deprivation on the underlying representation of the six basic emotions. Using multi-dimensional scaling (MDS), we compared the similarity judgments of adults who had missed early visual input because of bilateral congenital cataracts to control adults with normal vision. Participants made similarity judgments of the six basic emotional expressions, plus neutral, at three different intensities. Consistent with previous studies, the similarity judgments of typical adults could be modeled with four underlying dimensions, which can be interpreted as representing pleasure, arousal, potency and intensity of expressions. As a group, cataract-reversal patients showed a systematic structure with dimensions representing pleasure, potency, and intensity. However, an arousal dimension was not obvious in the patient group's judgments. Hierarchical clustering analysis revealed a pattern in patients seen in typical 7-year-olds but not typical 14-year-olds or adults. There was also more variability among the patients than among the controls, as evidenced by higher stress values for the MDS fit to the patients' data and more dispersed weightings on the four dimensions. The findings suggest an important role for early visual experience in shaping the later development of the representations of emotions. Since the normal underlying structure for emotion emerges postnatally and continues to be refined until late childhood, the altered representation of emotion in adult patients suggests a sleeper effect.

The Effect of Early Visual Deprivation on Sensitivity to Orientation in First- and Second-order Patterns

The Effect of Early Visual Deprivation on Sensitivity to Orientation in First- and Second-order Patterns

Odour discrimination and identification are improved in early blindness

Previous studies showed that early blind humans develop superior abilities in the use of their remaining senses, hypothetically due to a functional reorganization of the deprived visual brain areas. While auditory and tactile functions have been investigated for long, little is known about the effects of early visual deprivation on olfactory processing. However, blind humans make an extensive use of olfactory information in their daily life. Here we investigated olfactory discrimination and identification abilities in early blind subjects and age-matched sighted controls. Three levels of cuing were used in the identification task, i.e., free-identification (no cue), categorization (semantic cues) and multiple choice (semantic and phonological cues). Early blind subjects significantly outperformed the controls in odour discrimination, free-identification and categorization. In addition, the larger group difference was observed in the free-identification as compared to the categorization and the multiple choice conditions. This indicated that a better access to the semantic information from odour perception accounted for part of the improved olfactory performances in odour identification in the blind. We concluded that early blind subjects have both improved perceptual abilities and a better access to the information stored in semantic memory than sighted subjects.

Experience with moving visual stimuli drives the early development of cortical direction selectivity.

The onset of vision occurs when neural circuits in the visual cortex are immature, lacking the full complement of connections1,2 and the response selectivity that defines functional maturity3,4. Direction selective responses are particularly vulnerable to the effects of early visual deprivation, but how stimulus driven neural activity guides the emergence of cortical direction selectivity remains unclear. To explore this issue we developed a novel motion training paradigm that allowed us to monitor the impact of experience on the development of direction selective responses in visually naïve ferrets. Using intrinsic signal imaging techniques we found that training with a single axis of motion induced the rapid emergence of direction columns that were confined to cortical regions preferentially activated by the training stimulus. Using 2-photon calcium imaging techniques, we found that single neurons in visually naïve animals exhibited weak directional biases and lacked the strong local coherence in the spatial organization of direction preference that was evident in mature animals. Training with a moving stimulus, but not with a flashed stimulus, strengthened the direction selective responses of individual neurons and preferentially reversed the direction biases of neurons that deviated from their neighbors. Both effects contributed to an increase in local coherence. We conclude that early experience with moving visual stimuli drives the rapid emergence of direction selective responses in visual cortex.

Effects of early binocular enucleation on auditory and somatosensory coding in the superior colliculus of the rat

The present study aimed at investigating the effects of early visual deprivation (bilateral neonatal enucleation) on auditory and somatosensory coding in the polysensory deep layers of the superior colliculus of the rat. The proportion of cells responding to auditory and somatosensory stimulation and the receptive field properties of single neurons were assessed in both normal and enucleated rats. As expected, in enucleated rats there was a drastic increase in the number of unresponsive units and visual responses could no longer be evoked. Most importantly, the proportion of cells that responded to auditory stimulation was drastically reduced. However, the few cells that remained responsive to auditory stimulation were well tuned to noise stimuli presented in both azimuth and elevation, principally in the contralateral hemifield. Enucleation also increased the proportion of cells responding to somatosensory stimulation, particularly to the vibrissae. Implications in terms of neural plasticity and functionality are discussed.

Monocular deprivation in an identical twin

The scientific literature contains minimal human studies of the effect of monocular deprivation on a single eye of twins. This report examines the effects of early visual deprivation on axial length measurements by comparing the refractive findings and axial length measurements of identical twins' 4 eyes, 1 visually deprived and 3 nondeprived. A retrospective record review was performed on the medical records of identical 6-year-old Hispanic female twins. Both patients had received eye care at the University Optometric Center, State University of New York, for a period of at least 5 years. Subsequently, an Internal Review Board-approved prospective study was undertaken. Each twin received a comprehensive eye examination and an A-scan. The findings of the 3 nondeprived eyes were compared with those of the 1 deprived eye. The 3 nondeprived eyes had at least 20/20 visual acuity, low hyperopia or astigmatism, low with the rule keratometric findings, 12-mm corneal diameters, and A-scan results ranging from 21.0 to 21.55 mm. The remaining eye, which was visually deprived secondary to congenital cataract from birth to 6 months of age, had an aphakic refractive condition, decreased visual acuity, glaucoma, esotropia, and borderline microcornea. Keratometric findings were comparable with those of the other 3 eyes, whereas the A-scan finding was 25.16 mm. This case presented a unique opportunity to directly examine the effect of visual deprivation on axial elongation. Although other factors, such as glaucoma and borderline microcornea, may influence axial elongation, the findings in this patient indicate that a substantial portion, if not all, of the axial elongation can be attributed to early monocular deprivation.

Face processing in humans is compatible with a simple shape–based model of vision

Understanding how the human visual system recognizes objects is one of the key challenges in neuroscience. Inspired by a large body of physiological evidence, a general class of recognition models has emerged, which is based on a hierarchical organization of visual processing, with succeeding stages being sensitive to image features of increasing complexity. However, these models appear to be incompatible with some well-known psychophysical results. Prominent among these are experiments investigating recognition impairments caused by vertical inversion of images, especially those of faces. It has been reported that faces that differ 'featurally' are much easier to distinguish when inverted than those that differ 'configurally'; a finding that is difficult to reconcile with the physiological models. Here, we show that after controlling for subjects' expectations, there is no difference between 'featurally' and 'configurally' transformed faces in terms of inversion effect. This result reinforces the plausibility of simple hierarchical models of object representation and recognition in the cortex.

Developmental plasticity of mouse visual acuity.

Monocular deprivation in mice between postnatal days 19 and 32 has been reported to significantly shift ocular dominance within the binocular region of primary visual cortex; however, it is not known whether visual deprivation in mice during this physiologically defined critical period also results in amblyopia, as it does in other mammals. We addressed this uncertainty by psychophysically assessing in adulthood (postnatal day 70 or older) the grating acuity of normal and monocularly deprived mice, using the Visual Water Task. The visual acuity of mice tested with their nondeprived eyes was equivalent to that of normal mice ( approximately 0.5 cycles/degree); however, acuity measured with eyes monocularly deprived of vision transiently between postnatal days 19 and 32 was reduced by over 30% ( approximately 0.31 cycles/degree). Identical binocular deprivation produced a significant, but smaller, decrease in acuity ( approximately 0.38 cycles/degree). The effects of monocular and binocular deprivation were long lasting and occurred only if visual deprivation occurred between postnatal days 19 and 32. These data indicate that the deleterious effects of early visual deprivation on visual acuity in mice are similar to those reported in other mammals, and together with electrophysiological evidence of ocular dominance plasticity, suggest that the mechanisms of mouse visual plasticity are fundamentally the same as that in other mammals. Therefore, the mouse is probably a good model for investigating the basic cellular and molecular mechanisms underlying visual developmental plasticity and amblyopia.