Objective: Evaluated the effect of early rehabilitation nursing intervention on the recent clinical of patients with cerebral infarction and its meaning. Methods: 56 hospitalized patients diagnosed with cerebral infarction were selected. All the patients were divided into two groups at random: the conventional group and interventional group. The conventional groups were given various specific nursing; the interventional groups were given the early rehabilitation nursing intervention on the base of conventional nursing. Comparison between the Barthel index and the Fugl-Meyer score of patients in the two groups when they went to hospital, 15 d after treatment in hospital and 30 d after discharge. Results: when they went to hospital, the differences of the Barthel index and the Fugl-Meyer score between the two groups were not statistically significant ( p > 0.05); but the differences of the Barthel index and the Fugl-Meyer score between the two groups 15d after treatment and 30d after discharge were( highly ) statistically significant( p < 0.05, p < 0.01). Conclusion: the patients with cerebral infarction should receive the early rehabilitation nursing intervention as early as possible after the illness state became stable, in order to promote the functional recovery and enhance the quality of life.