Effect Of Different Stages Research Articles

Changes of acute-phase proteins, glucose, and lipid metabolism during pregnancy in lactating dairy cows.

The study aimed to evaluate the effects of different stages of lactation (0 to 300 d) and pregnancy (0 to 180 d) on serum amyloid A (SAA), C-reactive protein (CRP), glucose, total cholesterol (TCho), and triglyceride (TG) concentrations in dairy cows of different breeds. Thus, 40 healthy multiparous cows (10 Holstein, 10 Simmental, 10 Brown, and 10 Modicana) were randomly selected, and blood samples were collected once every 60 d for 1 year. Overall, SAA and CRP serum concentrations progressively increased and became more variable along the lactation, peaking at 240-300 d, and then decreased in the last period ( 300 d). Along pregnancy, SAA and CRP initially increased, with the highest concentrations at 60-120 d, and then decreased until the last phase of pregnancy ( 180 d). However, lactation and gestation phases did not significantly affect SAA and CRP when all the cows were analyzed together. A significant and positive correlation was observed between SAA and CRP both along lactation ( ; ) and pregnancy ( ; ). Breeds only showed differences in CRP levels along gestation ( ), due to a peak registered at 0-60 d in Holstein cows. In pregnant cows, glucose was positively correlated with SAA ( ; ) and CRP ( ; ). Hence, these significant and positive relationships reflect the physiological adaptations of the dairy cows along both gestational and lactational dynamics, suggesting that these proteins may also be involved in non-pathological processes. In this perspective, this study established that the obtained response markedly varies among healthy individuals along lactation and gestation and thus that the physiological range of acute-phase proteins (APPs) is wide; this makes it difficult to use these proteins as a marker of different physiological reproductive and productive periods.

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients.

IntroductionTranscranial pulse stimulation (TPS) is a non-invasive neuromodulation therapy that uses short, repetitive shockwaves through a neuro-navigated device. Current research suggests that these pulses lead to a wide range of vascular, metabolic, and neurotrophic changes. This relatively new CE-marked treatment provided first promising results in a clinical pilot study for improving cognition in mild-to-moderate Alzheimer's. Data from other centers is lacking, so here we analyzed safety and pilot real-world short-term results of TPS from the first center in Germany. To gain information about effects in different stages, patients with not only mild but also moderate-to-severe Alzheimer's were analyzed.MethodsA total of 11 patients were retrospectively examined for cognitive and emotional function before and after the first stimulation series. The effect was assessed using several neuropsychological tests [Alzheimer's Disease Assessment Scale (ADAS), including the ADAS cognitive score (ADAS Cog) and ADAS affective scores, Mini-Mental Status Examination (MMSE), and Montreal Cognitive Assessment (MoCA)] including in comparison between the groups of mild-to-severe patients. Moreover, subjective improvement of symptom severity, potential effects on depressive symptoms, and side effects were analyzed using Numeric Rating Scales (NRS).ResultsSide effects were rare (in 4% of sessions) with moderate subjective severity and only transient. Patients significantly improved in the ADAS and ADAS Cog, while there was no significant effect in MMSE and MoCA. Patients' self-reported symptom severity improved significantly. The depressive symptoms measured in an ADAS subscale also improved significantly. Statistical data analyses revealed no significant correlation of clinical improvement with baseline symptom severity.ConclusionTPS might be a safe and promising add-on therapy for Alzheimer's, even for moderate-to-severe patients. More research on long-term effects in patients as well as studies with sham control groups is needed. Moreover, translational research on the mechanisms of action and effects on cerebral network physiology will be needed to understand this new neuromodulation technique.

Study on a 110 kV combined prefabricated joint fault caused by premature failure of grounding grid

The grounding grid on the outside of the epoxy insulator breaks under the long-term oxidative corrosion of moisture, fails prematurely, and may eventually develop into a breakdown failure. However, the impact of this process has not yet been discovered.In this paper, a 110 kV combined prefabricated cable joint breakdown fault is discussed. Through the inspection and comparative analysis of the faulty joint, it is speculated that the premature failure of the grounding grid causes the breakdown of the epoxy insulator. The fault process can be divided into the grounding failure stage and the insulation damage stage. In this paper, the corresponding two-dimensional electric field simulation calculation model is established, the fault development process is restored, and the possible effects of different stages is analyzed.The results show that due to the corrosive effect of moisture, when the grounding grid is broken, a floating potential will be generated on the surface of the epoxy insulator. With the expansion of the grounding failure range, the local field strength on the surface of the epoxy insulator is distorted, which will cause partial discharge. When the failure range is 220 mm, the electric field distortion of the joint reaches the maximum value of 23.3MV/m, which will destroy the insulation strength of the epoxy insulator and cause insulation breakdown, eventually leading to an accident.The research results point out the importance of the continuity of the grounding grid, and the improvement measure is proposed to reduce the occurrence of such accidents. The analysis method for cable joint failure case can provide a reference for dealing with similar accidents.

Can driving-restriction policies alleviate traffic congestion? A case study in Beijing, China

With ongoing urbanization, traffic congestion and the air pollution it induces are worsening. Using a system dynamics (SD) approach, this study constructed a driving-restriction policy model to explore the effects of different stages of policy implementation on variables such as traffic congestion, emissions, and parking demand. Medium- and long-term dynamic simulation showed that the effect of the policy was obvious in the initial stage but gradually weakened in the medium term, leading to a “fading” effect on traffic-congestion alleviation; a “rebound” effect was even observed at the end of the simulation. Thus, the policy will not effectively reduce traffic congestion in the long term and will induce a new demand for car purchases, resulting in paradoxical effects, which will aggravate parking demand, congestion, and pollution. Yet, it was also found that introducing penalty policies and an air pollution charging fee could weaken the paradoxical effects and compensate for some defects of the policy. Such strategies could help reduce emissions, traffic congestion, parking demand, the number of illegal trips, and the overall number of vehicle trips. These findings can provide not only a theoretical basis for further research but also practical guidance for policy improvement.Graphical abstract

Risk assessment of multi-disaster in Mining Area of Guizhou, China

Increased slope and soil instability due to rainfall infiltration and artificial exploitation is a significant cause of multi-disaster in mining areas. Many kinds of research have been conducted to evaluate the susceptibility of single geological disaster species such as landslides, collapses, ground subsides, and debris flows. However, due to the coupling effect of different stages, the evaluation system index's construction is often disregarded during mining-induced multi-disaster risk assessments. Hence, we propose a relatively complete evaluation index system to assess the multi-disaster risk that considers the assessment processes of disaster susceptibility, hazard, and vulnerability in mining areas. The procedure for the proposed method includes three main steps. In step 1, we analyze the spatial probability assessment due to topographic, geological, and geomorphic indicators. In step 2, the hazard assessment indexes system and multi-disaster models are established using different rainfall probability periods, considering the annual maximum daily rainfall. In step 3, the vulnerability assessment method of multi-disaster was proposed according to the calamity environment and considering hazard distribution and bearing body characteristics. The risk evaluation system for multi-disaster mining areas is established based on the previous three steps. We validated the proposed model by analyzing mining exploitation in Panguan town, China. Our model classifies the likelihood of multi-disaster occurrence in mining areas according to five risk levels: very high, high, moderate, low, and very low. The multi-phase risk assessment map is drawn with different rainfall frequencies (10%, 5%, 2%, and 1%, respectively), providing reasonably scientific guidance on the mining region's emergency response capacity.

Adaptive Responses of Thyroid Hormones, Insulin, and Glucose during Pregnancy and Lactation in Dairy Cows.

Simple SummaryThe effects of different stages of pregnancy and lactation on thyroid, insulin, and glucose responses in 30 dairy cows from different breeds were studied. Thyroxine (T4) and insulin were higher at the end of pregnancy than at >60–120 d or in nonpregnant cows. Along the lactation phase, T4 initially decreased, reaching the lowest values at >60–120 d, and then increased until the end of lactation. Glucose showed the highest concentrations during the first 120 days of lactation, and the lowest values at the end. The monitoring of thyroid hormones, insulin, and glucose changes represents an important tool to evaluate the anabolic and/or catabolic adaptation in response to functional periods in dairy cows, which can potentially predispose the cows to an excessive negative energy balance and related metabolic issues.The study examined the effects of different stages of pregnancy and lactation on thyroid, insulin, and glucose responses in dairy cows. In the present study, 30 dairy cows (10 Holstein, 10 Simmental, and 10 Brown) at 30 ± 20 d of lactation were randomly selected and blood samples were collected once every 60 d for one year to measure circulating thyroid stimulating hormone (TSH), total and free triiodothyronines (T3, fT3) and thyroxines (T4, fT4), insulin, and glucose. Pregnant cows showed higher T4 (p = 0.010) and insulin (p = 0.046) concentrations at >180 d than at >60–120 d of pregnancy and in nonpregnant cows. Along the lactation phase, circulating T4 concentrations showed a biphasic trend, decreasing from 0–60 d to >60–120 d phase, which showed the lowest values, and then increasing until the end of lactation (>300 d) (p = 0.016). Glucose showed the highest concentrations at the start of lactation (0–120 days) and the lowest values at the end (p = 0.008). The monitoring of thyroid hormones, insulin, and glucose changes represents an important tool to evaluate the anabolic and/or catabolic adaptation in response to functional periods in dairy cows, which can potentially predispose the cows to an excessive negative energy balance and related metabolic issues.

Investigating the Impact of Capacity Utilization on Carbon Dioxide Emission: Evidence from China’s Iron and Steel Industry

Abstract In recent years, China’s industrialization and urbanization have deepened, and the economy has grown considerably. But at the same time, they have also brought about many environmental problems. As a pillar of the national economy, the iron and steel (IS) industry is one of the most emitting and energy-consuming sub-sectors of the industrial sector. It is also one of the industries with the most severe overcapacity problem in China. In this paper, we explore the impact of capacity utilization on carbon dioxide emission based on panel data of China’s iron and steel industry from 2005 to 2014. We also tested the heterogeneity in different regions and different sub-samples. Results show that capacity utilization and carbon dioxide emission are positively correlated. However, the impact of capacity utilization on carbon dioxide emission differs when considering regional heterogeneity. Results in all three regions show a positive relationship between capacity utilization and carbon dioxide emission, but the impact intensity is strongest in the western region, followed by the eastern and central regions. Moreover, capacity utilization impacts carbon dioxide emission by influencing firm numbers in the iron and steel industry and energy consumption. Further analysis shows that there exists a threshold effect in different stages of energy consumption and energy structure. Finally, some findings and practical policy recommendations are provided.

Hypoxemia associated with lumbar puncture in neonates

Objectives: The objectives of the study were to study the effect of different stages of lumber puncture (LP) procedure on oxygen saturation (SpO2) in newborn baby. Materials and Methods: It was a 1-year, prospective observational study conducted in a tertiary care hospital. Forty neonates were included who fulfilled the inclusion criteria. SpO2 was measured during the different stages of LP in the recruited newborns and comparison was done between SpO2 changes in LP duration of <5 min and more than 5 min groups and the effect on SpO2 in preterm and term babies during LP. Results: Mean SpO2 during baseline, flexion, needle insertion, immediate repositioning, and 5 min after procedure were 94.5, 91.82, 88.92, 94.7, and 95.38, respectively. When compare to baseline, drop in SpO2 was found during flexion and needle insertion with p = 0.0025 and <0.0001, respectively. While comparing Mean SpO2 during different phases between duration of LP >5 min versus <5 min group, the saturation was less during flexion positioning with maximum fall at the time of needle insertion in LP duration >5 min. The regain of saturation during repositioning was more in LP <5 min versus duration >5 min group. Comparing between LP duration >5 min versus <5 min group, fall in SpO2 from baseline (5 min before LP procedure) was more in LP duration >5 min group during flexion and needle insertion phase. Hypoxemia is more in preterm than term neonates during flexion and during needle insertion, supine repositioning. Furthermore, hypoxia recovered after 5 min of supine repositioning more in term infants. Conclusions: Significant hypoxia was associated in newborn in flexion and needle insertion phase of lumbar puncture, especially in preterm newborns and those with prolonged duration of procedure.

The effect of different stages of chemical refining process on the oxidative stability of Bene kernel oil during intense and long thermal process

The effect of different stages of chemical refining process on the oxidative stability of Bene kernel oil during intense and long thermal process

Alzheimer disease effects of different stages on intestinal flora: A protocol for systematic review and meta-analysis.

Background:Alzheimer disease (AD) is a common degenerative disease of the central nervous system that can be divided into 3 stages, according to the degree of cognitive impairment. The clinical manifestations are cognitive dysfunction and memory loss, impacting the daily activities of the affected individuals. In recent years, studies have demonstrated a relationship between intestinal flora and AD. However, no meta-analysis has documented the correlation between AD and intestinal flora, to the best of our knowledge. Herein, we sought to assess the correlation between different stages of AD and intestinal flora. A systematic and comprehensive understanding of this relationship is of great significance for developing prevention and treatment strategies against AD.Methods:A comprehensive search of the medical literature in Chinese and English language was performed in databases, such as PubMed, EBSCO, CNKI, web of science, WanFang, Cochrane Library, and CBM databases. Pre-defined search strategies were used to retrieve clinical studies of Alzheimer disease and gut microbiota. The included studies were independently analyzed by the 2 researchers who extracted the data. The quality of the data was evaluated according to the “Cochrane system evaluator manual.” Finally, Endnote and RevMan software were used for systematic regression and meta-analysis of evidence.Results:We documented the intestinal flora changes in the 3 stages of Alzheimer disease, according to currently available clinical evidence, and revealed the correlation between the abundance and diversity of flora and treatment efficacy. These findings are essential for developing new strategies for the prevention and treatment of Alzheimer disease.INPLASY registration number:INPLASY2021100093Ethics and dissemination:Since all data utilized in this systematic review and meta-analysis are published, ethical approval was not needed.

Design of floating photovoltaic power plant and its environmental effects in different stages: A review

With the accelerated development of clean energies for carbon emission reduction, floating photovoltaic (FPV) has become an emerging solution. With its advantages of saving land, suppressing evaporation, and improving power generation efficiency, it has attracted the attention of the global clean energy field. According to the available surface area of artificial water bodies worldwide and system assumptions, the maximum global technical potential of FPV power plants is estimated to be 1000 GW. As FPV interacts tightly with the constructed water area, design of FPV is still lacking in theory, data, and experience. Environmental effects of FPV should also be clarified. This article introduces the current FPV power plant construction and future development trends. The site selection conditions of FPV power plant, the design elements of the upper power generation structure, and the overall characteristics of different types of lower floating structures are summarized. Finally, the complex interaction between the FPV power plant and the ecological environment is explained in terms of construction and operation. This review has a significant reference value for the design and construction of FPV power plants and the formulation of related construction codes.

Experimental analysis of mechanical behaviour and residual stresses of EN-36C alloy steel with and without tempering

The intense demands of nickel chromium case hardened steel (EN-36C) alloy steel in different engineering applications are increasing day by day due to its cheap and easy availability. The effect of different stages of tempering on EN-36C alloy steel has been carried out to check the mechanical behavioural, microstructural properties and residual stresses in the present work. The effect of tempering on response variables viz., material removal rate, surface roughness, tool tip temperature and residual stresses are evaluated. The cosα method is used to measure the residual stresses in the specimen using two-dimensional detectors such as imaging plates. Further, the influence of tempering on mechanical properties such as tensile strength, hardness, toughness and percentage elongation has been observed. Experimental results depicted that the ductility and toughness are improved without significant change in hardness in the specimen tempered at 500°C. The mechanical properties of specimens tempered at 500°C are found to be a tensile strength of 680.42 MPa, hardness 92 Rockwell hardness of scale B and toughness 187 J. The maximum value of material removal rate (12596.80 mm3/min), minimum tool tip temperature (61.33°C), average surface roughness ( Ra = 1.93, Rq = 2.36, Rz = 10.30) and lowest residual stress 217 MPa are observed in the specimens tempered at 500°C.

Adverse Health Effects of Frailty: Systematic Review and Meta-Analysis of Middle-Aged and Older Adults With Implications for Evidence-Based Practice.

Scholars have noted that frailty easily leads to functional deterioration and proneness to complications. Little literature addresses the stages of frailty in middle-aged and older adults and the effects of frailty on overall health. This study explores the effect of different stages of frailty on the prospective health (falls, bone fractures, disability, dementia, hospitalization, and death) of middle-aged and older adults. In addition, different frailty indicators were compared to determine their usefulness in predicting future adverse health outcomes. The authors of this study separately reviewed and extracted data from the literature obtained while searching the following keywords: "frailty" OR "frail" and "fall" OR "disability" OR "fracture" OR "hospitalization" OR "mortality" OR "cognitive function" "dementia" OR "Alzheimer's disease" and "middle-aged people" OR "older people" OR "elderly" OR "geriatric" OR "senior." The literature search was performed from January 2001 to November 2019 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Specifically, we performed a systematic literature search in multiple databases-Embase, PubMed, MEDLINE, CINAHL, and Cochrane Library-and analyzed all obtained literature results using a random-effects model. We collected a total of 29 prospective studies for the systematic literature review and meta-analysis. The main results indicated that the frail groups had significantly higher risks of adverse health effects (falls, bone fractures, disability, dementia, hospitalization, and death) than the robust or prefrail groups. Frailty is a crucial healthcare topic among geriatric syndromes. Considering that older adults with frailty are most likely to develop severe adverse health outcomes, professional nursing personnel should assess frailty among middle-aged and older adults and offer relevant care strategies to reduce the adverse effects of frailty in this population.

Model Based Evaluation of Hypersensitivity Adverse Drug Reactions to Antimicrobial Agents in Children.

Drug use in children is–in most cases–supported by extrapolation of data generated from clinical trials in adult populations. This puts children at higher risk of developing adverse drug reactions (ADRs) due to “off-label” use of drugs and dosing issues. Major types of ADRs are drug hypersensitivity reactions, an idiosyncratic type of ADRs that are largely unpredictable and can cause high morbidity and mortality in a hard-to-identify specific population of patients. Lack of a complete understanding of the pathophysiology of DHRs and their unpredictive nature make them problematic in clinical practice and in drug development. In addition, ethical and legal obstacles hinder conducting large clinical trials in children, which in turn make children a “therapeutic orphan” where clear clinical guidelines are lacking, and practice is based largely on the personal experience of the clinician, hence making modeling desirable. This brief review summarizes the current knowledge of model-based evaluation of diagnosis and management of drug hypersensitivity reactions (DHRs) to antimicrobial drugs in the pediatric population. Ethical and legal aspects of drug research in children and the effect of different stages of child development and other factors on the risk of DHRs are discussed. The role of animal models, in vitro models and oral provocation test in management of DHRs are examined in the context of the current understanding of the pathophysiology of DHRs. Finally, recent changes in drug development legislations have been put forward to encourage drug developers to conduct trials in children clearly indicate the urgent need for evidence to support drug safety in children and for modeling to guide these clinical trials.

CircRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22.

Background As a newly discovered regulatory RNA, circular RNA (circRNA) has become a hot spot in many tumor pieces of research. In recent years, it has been discovered that circRNAs have multiple biological effects in different stages of cancer. However, the expression pattern and mechanism of circFAT1(e2) in non-small-cell lung cancer (NSCLC) are still unclear. Methods The expressions of circFAT1(e2) in NSCLC tissues and cell lines were studied. Functionally, CCK-8 and transwell experiments were performed in A549 and H1299. In addition, we also performed a dual-luciferase report analysis to clarify the mechanism of action of circFAT1(e2). Results circFAT1(e2) was significantly upregulated in NSCLC tissues and cell lines. circFAT1(e2) gene knockdown could significantly inhibit the proliferation, migration, and invasion of NSCLC cells. Loss of function testing found that circFAT1(e2) functioned as an oncogene in NSCLC cells. In addition, circFAT1(e2) acted as a ceRNA to spongy miR-30e-5p, which led to the increase in USP22 and promoted cell growth. Conclusions The circFAT1(e2)-miR-30e-5p-USP22 axis is a crucial part of the progression of NSCLC. This study suggests that circFAT1(e2) may be an important potential of prognostic prediction and treatment targets for NSCLC patients.

LIPID CHARACTERISTICS OF MANGO SEED KERNEL OIL AS AFFECTED BY DIFFERENT RIPENING STAGES OF FRUIT

In this study, the effect of different stages of ripening, i.e. unripe, semi-ripe and ripe, on quality parameters of oils extracted from the kernels of Mango (Magnifera indica) seeds was investigated. The kernels were oven-dried and oil extracted from them using soxhlet apparatus and n-hexane as solvent. The fatty acid profile, phospholipids, sterol contents and some chemical properties such as saponification value, peroxide value, iodine value and acid value of oils obtained from the seeds at different level of maturity were determined. The results show that the oils are rich in saturated fatty acid most especially stearic and palmitic acids varying from 34.36 - 37.86% and 8.84 -10.66 % respectively. The predominant unsaturated fatty acid present in the oils is oleic acid ranging from 41.96 – 45.65 %. For the chemical parameters, the peroxide values (1.82 - 2.23 %) meq/kg, acid values (5.00 – 5.50) mg/KOH/g decreased with fruit maturity. For phospholipids, phosphatidyl choline (380 – 451 mg/100 g) and phosphatidyl ethanolamine (217.42 - 342.63 mg/100 g) having the highest quantities, they all increased with fruit maturity except sphingomyelin and phosphatidic acid. Stigmasterol, sitosterol and cholesterol contents of the oils decreased with fruit maturity while Δ-5-avenasterol, campesterol and the cholestanol contents increased with fruit maturity. Sitosterol and stigmasterol and had the highest values at 345.81 - 386.96 mg/100 g and 83.70 – 137.09 mg/100 g respectively. Conclusively, the kernel oils have potential for use as domestic and industrially as a non-conventional source of vegetable oil in chocolate and confectionery products.

A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model

The pathophysiology of extensive cortical tissue destruction observed in hemispheric hypodensity, a severe type of brain injury observed in young children, is unknown. Here, we utilize our unique, large animal model of hemispheric hypodensity with multifactorial injuries and insults to understand the pathophysiology of this severe type of traumatic brain injury, testing the effect of different stages of development. Piglets developmentally similar to human infants (1 week old, “infants”) and toddlers (1 month old, “toddlers”) underwent injuries and insults scaled to brain volume: cortical impact, creation of mass effect, placement of a subdural hematoma, seizure induction, apnea, and hypoventilation or a sham injury while anesthetized with a seizure-permissive regimen. Piglets receiving model injuries required overnight intensive care. Hemispheres were evaluated for damage via histopathology. The pattern of damage was related to seizure duration and hemorrhage pattern in “toddlers” resulting in a unilateral hemispheric pattern of damage ipsilateral to the injuries with sparing of the deep brain regions and the contralateral hemisphere. While “infants” had the equivalent duration of seizures as “toddlers”, damage was less than “toddlers”, not correlated to seizure duration, and was bilateral and patchy as is often observed in human infants. Subdural hemorrhagewas associate with adjacent focal subarachnoid hemorrhage. The percentage of the hemisphere covered with subarachnoid hemorrhage was positively correlated with damage in both developmental stages. In “infants”, hemorrhage over the cortex was associated with damage to the cortex with sparing of the deep gray matter regions; without hemorrhage, damage was directed to the hippocampus and the cortex was spared. “Infants” had lower neurologic scores than “toddlers”. This multifactorial model of severe brain injury caused unilateral, wide-spread destruction of the cortex in piglets developmentally similar to toddlers where both seizure duration and hemorrhage covering the brain were positively correlated to tissue destruction. Inherent developmental differences may affect how the brain responds to seizure, and thus, affects the extent and pattern of damage. Study into specifically how the “infant” brain is resistant to the effects of seizure is currently underway and may identify potential therapeutic targets that may reduce evolution of tissue damage after severe traumatic brain injury.

Phloridzin as a marker for evaluation of fruit products authenticity

Abstract: Phloridzin (phloretin-2'-O-glucoside) is a phenolic compound characteristic of the genus Malus. This study aimed to evaluate phloridzin as a marker of undeclared addition of apples in fruit products. To test this proposal, the heat and oxidation stability of phloridzin was firstly confirmed. Then the distribution and variability of phloridzin in apples were studied, showing no difference between the tested apple varieties (Golden Delicious, Granny Smith, Rubin and Champion) but a significant difference in phloridzin content in seeds (2 380 ± 755 mg kg<sup>–1</sup>) compared to peel, flesh and core, which contained less than 70 mg kg<sup>–1</sup>. The effects of different stages of apple purée production at an industrial scale were also investigated. The kinetics of phloridzin diffusion from seeds to apple homogenate played an important role in the final phloridzin content in 16 analysed apple purées (26–39 mg kg<sup>–1</sup>). Finally, the survey of phloridzin content in 31 fruit products in the market was carried out. Phloridzin was also measured in eight jams and fillings which did not declare the presence of apples on their labels; findings from 2 to 6 mg kg<sup>–1 </sup>indicate the addition of apples from 5% to 20%. It was confirmed that phloridzin appears to be a suitable marker for detecting the undeclared presence of apples, which are a cheap substitute for the declared fruit types.

Impact of Climate Change on Small Ruminants Production: A Review

Approaches in Poultry, Dairy & Veterinary Sciences Effect of Different Stages of Biological DevelopmentGoats Fed Diets Detoxified Castor Cake on the Function Hepatic and Renal Ricardo Alves de Araújo1*, Roberto Cláudio Fernandes Franco Pompeu2, Luiza de Nazaré Carneiro da Silva3 and José Neuman Miranda Neiva3 1State University of Maranhão, Itapecuru Mirim, Maranhão, Brazil 2Brazilian Agricultural Research Corporation, Sobral, Ceará, Brazil 3Federal University of Tocantins, Araguaina, Tocantins, Brazil *Corresponding author: Ricardo Alves de Araújo, State University of Maranhão, Itapecuru Mirim, Maranhão, Brazil Submission: January 05, 2021;Published: February 05, 2021 DOI: 10.31031/APDV.2021.08.000681 ISSN: 2576-9162 Volume8 Issue2

Progressive gray matter hypertrophy with severity stages of insomnia disorder and its relevance for mood symptoms.

To investigate the gray matter (GM) alterations in patients with insomnia disorder (ID) at different severity stages and the relationship between GM alterations and sleep, mood, and cognitive measures. One hundred one ID patients and 63 healthy controls (HC) were included. Each patient underwent structural MRI and completed sleep-, mood-, and cognitive-related questionnaires. The ID patients were further grouped into subthreshold insomnia (SI) group and clinical insomnia (CI) group. We investigated changes in GM volumes in ID patients via diffeomorphic anatomical registration through exponentiated lie algebra voxel-based morphometry (DARTEL-VBM). We first compared voxel-wise differences in GM volumes between the HC group and the ID group. Analysis of variance was performed on individual GM maps in the SI, CI, and HC groups to further investigate the effects of different stages of ID severity on GM volumes. Multiple regression was used to model the relationship between altered GM volumes in SI and CI groups and clinical measures. GM hypertrophies in the left anterior and middle cingulate gyrus, right middle and inferior temporal gyrus, and right cerebellum Crus II were detected in ID. Increased GM volume in the right middle temporal gyrus was detected in the SI group, whereas all three regions in the CI group. Regression analysis showed that mood- and cognitive-related measures had a positive correlation with GM volumes, while sleep-related measures had a negative correlation with GM volumes in the CI group. Our findings of the progressively increased GM volumes in ID suggest that a hypertrophic cortical morphological mechanism may underlie the altered neuroanatomy induced by insomnia. • Insomnia-induced GM hypertrophies in the cingulate gyrus, temporal gyrus, and cerebellum Crus II. • The middle temporal gyrus was early detectable in the SI group. • The increased GM volumes in the CI group were correlated with clinical measures.