The effect of Ca content in Zn1-x, CaxO(x=0-0.20) powders on its bactericidal action against Staphylococcus aureus was investigated. The bactericidal action increased with an increase of Ca content in Zn1-x, CaxO, indicating the possibility of control of the antimicrobial efficacy. The death of S. aureus by the powder slurries followed first-order kinetics, and the concentration of Ca dopant slightly enhanced the dilution coefficient of the bactericidal action. Though the pH value of as-prepared powder slurries also increased with the increase of Ca content, its bactericidal action was greater than NaOH solution with the same pH value as the slurries.