The study of bubble’s behavior in turbulent flows is fundamental to the understanding of many engineering applications that are concerned with bubbly/two-phase flow. In turbomachinery, for example, tiny gas nuclei present in the liquid may grow to macroscopic size if the instantaneous pressure dips below the vapor pressure for a time long enough to incite cavitation events. In this paper, the Lagrangian pressure statistics of finite sized bubbles in homogeneous isotropic turbulence is investigated using highly-resolved direct numerical simulations of the Navier-Stokes equations at Reλ = 150. A modified Maxey-Riley equation is used for Lagrangian tracking of bubbles in the turbulence field. The Lagrangian pressure statistics (probability density function, frequency of low-pressure events and their duration) are analyzed as functions of the bubble size. The overall picture that emerges is consistent with finite-sized bubbles being driven towards vortex cores, resulting in an average pressure further below the mean value and longer and more frequent low-pressure events as the considered size is increased.