Effect Of Aluminum Chloride Research Articles

The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid

The claim that AlCl 3 could produce 100% inhibition of cerebrospinal fluid secretion was investigated using ventriculocisternal perfusion in the rabbit, and it was shown that a large part of this inhibition was an artefact due to a pH sensitivity of Blue Dextran, used as an indiffusible marker, caused by AlCl 3. Thus the true inhibition found by us, using [ 3H]labeled markers, was about 33% and usually only partly reversible. Penetration of 22Na from blood into the perfused ventricles was partially inhibited by AlCl 3. The effects of some other acid buffer systems, namely acetate and phosphate, on rate of secretion were measured; the results were highly variable. When mean arterial pressure was measured, it was found to be unaffected by AlCl 3 but elevated with acetate and phosphate buffer mixtures.

Effect of aluminum chloride on ascending colon of the rat

Aluminum chloride (2.48 × 10 −4 to 1.24 × 10 −3 M) inhibits spontaneous motility of ascending colon of the rat. Resting tension was not affected. At concentrations between 2.07 × 10 −5 to 1.24 × 10 −3 M it inhibited in a dose-dependent manner the contractions induced by maximal doses of acetylcholine. Higher doses produced a very marked inhibition that was attributable to acidification of the medium. The inhibiting effect was more intense when the incubation medium contained an excess of calcium (3.6 and 4.3 mM) or theobromine (10 −4 and 10 −3 M). This inhibiting effect tended to be smaller in the presence of low calcium (0.6 and 1.0 mM) or verapamil (3 × 10 −8 and 10 −7 M).

Effect of aluminum chloride on binding of 4-hydroxyamino-quinoline 1-oxide to nucleic acids.

Effect of aluminium chloride on the binding of carcinogenic 4-hydroxyaminoquinoline 1-oxide (4-HAQO) with mouse lung DNA, RNA, and various homopolyribonucleotides was examined in vitro, in the presence of seryl-AMP. Mouse lung DNA, RNA, or homopolyribonucleotide [poly(A), poly(G), poly(I), poly(X), poly(C), or poly(U)] was pretreated with aluminium chloride in an ice bath and the binding with 4-HAQO was examined. Binding with DNA, RNA, poly(A), and poly(G) was markedly inhibited, and their binding rates were 46%, 56%, 53%, and 18% of that of the control, respectively. Binding with poly(C) and poly(U) was hardly different from that of the control. Consequently, effect of aluminium chloride in inhibiting the binding of 4-HAQO with mouse lung DNA and RNA is assumed to be due to the inhibition of its binding with guanine. Effect of various metals (Mg2+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, and Fe3+) on the binding of 4-HAQO with mouse lung DNA was examined and it was found that aluminium chloride had the strongest inhibitory effect, followed by copper and zinc. Trivalent iron showed hardly any inhibition.

Aluminum induced neurofibrillary degeneration, brain electrical activity and alterations in acquisition and retention

In the early stages of an aluminum induced dementia model a positive correlation exists between the occurrence of neurofibrillary degeneration (NFD) in hippocampus, entorhinal and neocortex and the rate of conditioned avoidance response acquisition. Quantitative measurements from appropriate electronmicrographs indicate that the density of microtubules in a region of NFD is profoundly reduced. At the stage in the encephalopathy in which short-term retention and acquisition are impaired the EEG and averaged visual evoked potentials were normal. The observations suggest that a nonelectrical activity of neurons, important to the learning-memory mechanism, may be altered by the effects of aluminum chloride. The disorganization of the dendritic microtubular system is postulated to alter dendroplasmic flow and supports the hypothesis that the translocation of synaptically active agents by the cytoplasmic streaming mechanism may subserve a component of the associative learning mechanism.

Liquid-phase transformations of m-xylene in presence of metal halides

1. A study was made of the transformations of m-xylene in presence of aluminum halides and also in presence of Sn, Ti, Sb, and Zn chlorides and their equimolecular mixtures with aluminum chloride. 2. It was shown that in presence of AlCl3 or AlBr3 m-xylene undergoes isomerization with formation of 18–20% by weight of p-xylene. This yield is 75.6–85.2% of the equilibrium value. 3. It was found that addition of SbCl3 or SnC4 to aluminum chloride results in suppression of the drastic effects of aluminum chloride alone with almost complete elimination of side reactions of demethylation and methylation.

The anthocyanin of Spirodela oligorrhiza

The anthocyanin of Spirodela oligorrhiza is not cyanin. Its behavior in paper chromatography and partition between solvents, and the effect of aluminum chloride on its absorption spectrum indicate that it does not possess vicinal hydroxyl groups in the 2-aryl ring, but bears a polyhydroxylated nuclear substituent. The flavone constituents and the anthocyanin of the plant appear to be structurally closely related.

Effect of aluminum chloride on a radical copolymerization

Effect of aluminum chloride on a radical copolymerization

The Effect of Aluminum Chloride and Antimony Trichloride on the Solubility of Cesium Antimony Chloride in Hydrochloric Acid Solutions

The Effect of Aluminum Chloride and Antimony Trichloride on the Solubility of Cesium Antimony Chloride in Hydrochloric Acid Solutions