Effect Of Aloe Vera Research Articles

ALOE VERA- THE BIOHEALER IN PERIODONTICS

Herbal medicines are in use as traditional mode of treatment for various ailments in India, as they produce less side effects and are more economical. Among the herbal medicines, Aloe vera is gaining increased momentum as it is easily available and has numerous health benefits. The utilization of Aloe vera dates back to 4th century. The name Aloe vera is derived from the Arabic word “Alloeh” meaning shining bitter substance, while “Vera” in Latin means true. Aloe vera is known by various terminologies like “lilly of the desert” “plant of immortality” “heaven’s blessing”. The current review article is an attempt to discuss the history, parts, ingredients, general uses, dental uses, periodontal uses, contraindications, and side effects of Aloe vera. KEY WORDS: Aloe vera, Acemannan, Periodontics

Postharvest Aloe vera gel coating application maintains the quality of harvested green chilies during cold storage.

The effect of Aloe vera (ALV) coating was studied on chillies at 10±1°C for 28days. ALV gel-coated chillies showed reduced weight loss, disease incidence, red chili percentage, respiration rate, electrolyte leakage, hydrogen peroxide, and superoxide anion contents. The ALV coating maintained general acceptance in terms of visual quality and marketability index with higher chlorophyll contents, ascorbic acid contents, total phenolic contents, and total antioxidants. In addition, ascorbate peroxidase, catalase, superoxide dismutase, and peroxidase activities were markedly higher in coated chillies compared to control. The biochemical attributes such as soluble solids content, acidity, sugar: acid ratio, and juice pH were non-significantly affected by ALV application; however, the said attributes were comparatively higher in contrast to control. In conclusion, ALV edible coating could be used as an eco-friendly approach for delaying senescence and maintaining the postharvest quality of green chillies up to 28days. PRACTICAL APPLICATIONS: Green chilies being highly perishable exhibit limited postharvest life with rapid loss of water, shrivelling, wilting, disease incidence, and reduced consumer acceptability. ALV gel coating significantly delayed postharvest senescence, reduced disease spread, maintained higher antioxidant activities of green chilies during cold storage. Therefore, ALV coating [50%] would be the suitable alternative to synthetic preservatives for extending the storage life and conserving the quality of green chilies.

Comparative Evaluation of Aloe vera and Diclofenac on Body Weight, Blood Pressure and Renal Function of Hypertensive Rats

Introduction: NSAIDs are known to cause salt and water retention leading to hypertension and renal impairment. Aloe vera gel has been used in medicinal preparations for decades. Limited data is available regarding effect of Aloe vera on renal function. There is a need to search this aspect of Aloe vera, to use it judiciously.
 Aims & Objectives: To estimate and compare the effects of Aloe vera and diclofenac on systolic blood pressure and renal functions of hypertensive rats.
 Place and duration of study: This study was conducted at Post Graduate Medical Institute Lahore, Sargodha Medical College, Sargodha and Department of Pharmacy, University of Sargodha for the period of three months.
 Material & Methods: Male Sprague Dawley rats (n=24) were divided into four groups; Group A (Normal control), Group B (Hypertensive control), Group C (Aloe vera treated) and Group D (Diclofenac treated). Hypertension was induced in groups B, C and D by 20% sucrose diet in 8 weeks. After induction of hypertension, distilled water, dried Aloe vera gel 400 mg/kg and diclofenac 12 mg/kg were given orally to group B, C and D respectively for 2 weeks as a single morning dose. Body weight and systolic blood pressure were measured weekly, while serum creatinine, creatinine clearance and urinary proteins were estimated and compared at 0, 8 and 10 weeks. Data was analyzed using SPSS 23 and p value of ?0.05 was considered significant.
 Results: Diclofenac decreased body weight of rats non-significantly and increased systolic blood pressure significantly (p< 0.03) whereas Aloe vera increased body weight significantly (p<0.012) and had no significant effect on systolic blood pressure. Diclofenac treated group showed deterioration of renal function as compared to Aloe vera treated group numerically. Conclusion: Aloe vera may be safer anti-inflammatory agent than diclofenac for treatment of chronic inflammatory conditions if the patient also has hypertension or renal disease.

Effects of Aloe vera in adults with mucocutaneous problems: A systematic review and meta-analysis.

To analyse the different types of Aloe vera (AV) effects on various mucocutaneous problems among adults. A systematic review and meta-analysis. An exhaustive scanning of PubMed, Medline, ScienceDirect, and Google Scholar databases was conducted from January 2000-December 2019. Randomized controlled trials (RCTs) publishing reports on the effects of AV in various mucocutaneous problems, psoriasis, burn, wound-healing were included. The standardized mean differences (SMD) with 95% confidence Intervals (CIs) were determined for the main outcomes, heterogeneity was analysed using the I2 test and the risk of bias in the studies was reviewed by the Cochrane risk of bias assessment tool. The study included 23 trials with a total of 4,023 participants. Six trials were included in the meta-analysis. The results indicated no significant differences in pain scores as assessed by the Visual Analog Scale (VAS) (SMD=0.11, 95% CI: -0.37 to 0.59). The Psoriasis Area Severity Index (PASI) scores were significantly lower following AV gel application in two of the studies (SMD=-1.32 95% CI: -1.86 to -0.78). Considering results in a systematic manner, AV accelerated tissue epithelialization and wound-healing process (N=3), reduced oral mucositis (N=3), and improved quality of life (N=1). AV might have beneficial effects in reducing pain scores and the severity of mucocutaneous problems compared with placebo, especially with limited mild to moderate adverse effects. AV may be used as an alternative and integrative approach to reducing symptom severity in mucocutaneous problems and the wound-healing process. High quality and well-designed RCTs are still needed to elucidate the effects of AV in a variety of dosages and forms among adults with mucocutaneous problems.

Aloe vera gel coating aggravates superficial scald incidence in ‘Starking’ apples during low-temperature storage

The effects of aloe vera (Aloe vera (L.) Burm. f.) gel treatment on the incidence of superficial scald in ‘Starking’ apples (Malus domestica Borkh. Var. Starking) during cold storage were studied. Apples were harvested at the pre-climacteric stage and treated with aloe vera gel. The treatment increased malondialdehyde content and membrane lipid damage. Furthermore, it inhibited the release of ethylene at the early stage but increased it in the later stage. The expression level of ACC synthase 1 (MdACS1) also increased, and the antioxidant capacity in apples, particularly, catalase, peroxidase, and superoxide dismutase activities, all decreased, while concomitantly, the content of α-farnesene and its oxidation product, conjugated triene increased, thereby aggravating superficial scald incidence during storage at low temperature.

Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis

Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis

Post-transcriptional regulation activity through alternative splicing involved in the effects of Aloe vera on the Wnt/β-catenin and Notch pathways in colorectal cancer cells

Aloe vera (L.) Burm.f. is widely used as laxative drugs, cosmetics, and functional food due to a variety of therapeutic effects. However, several studies indicated a colonic carcinogenic activity of Aloe vera. But the underline mechanism has not been well clarified. This study aimed to explore the potential mechanism at the post-transcriptional level. Identification of Differential Expressed Alternative Splicing (DEAS) genes and events and the corresponding functional enrichment analyses were conducted on RKO cells after treated with Aloe vera aqueous extract and its two active components, aloin and aloesin. And RT-qPCR was conducted for validation. Results indicated that they induced 2200, 2342 and 2133 DEAS events, respectively. The GO enrichment and the COG classification results of DEAS genes showed that they were associated with transcription, as well as functions like signal transduction mechanisms. Moreover, DEAS genes related to the two colorectal cancerous pathways, Wnt and Notch pathways, were annotated. In conclusion, aloe extract, aloin and aloesin significantly regulated the DEAS profile of RKO cells. The colonic carcinogenicity of Aloe vera may due to its post-transcriptional regulatory activity through Alternative Splicing (AS) on genes, especially on Wnt-related and Notch-related key genes.

The Effect of Aloe vera and Glycerol Addition on Edible Film of Lesser Yam Starch (Dioscorea esculenta L. Burkill)

Edible films are thin layers made from hydrocolloids, lipids, and their combinations, functioning as a barrier to mass transfer. The hydrocolloid source that commonly used for the edible film is starch. Lesser yam has the potential to be developed into food packaging products. It has a high starch yield (21.4%). The starch properties, which usually obstruct the edible film production are not resistant to high temperature, it produces a starch suspension with viscosity and ability to form a gel is not uniform, cannot stand in acidic conditions, does not resist stirring, limited solubility in water, and starch gel is easy to syneresis and brittle. This study aimed to investigate the effect of glycerol and Aloe vera concentration on the physical and mechanical edible film. Randomized complete block design (RCBD) factorial with two factors was adopted. The first factor was Aloe vera concentration (0, 1%, 0.2% and 0.3% b / v), and the second factor wasglycerol concentration (17.5, 22.5 and 27.5% v/b). The parameters tested included thickness, tensile strength, elongation, solubility, transparency, and water vapor transmission rate (WVTR). The results showed an interaction between the addition of glycerol and Aloe vera to thickness, tensile strength, solubility, transparency, and WVTR. The best characteristics of edible film were produced by the addition of glycerol 17.5% and Aloe vera0.1% with the thickness (0.11 mm), tensile strength (2.03 MPa), elongation (15.38%), solubility (64.44%), transparency (2.88 mm-1), and WVTR (13.27 g m-2 24 h-1).

Efficacy of Aloe-Vera Use for Prevention of Chemotherapy-Induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Controlled Clinical Trial

ABSTRACT Oral mucositis can be caused by chemotherapy and can affect a patient’s quality of life. Nowadays, to prevent chemotherapy-induced oral mucositis (CIOM) is a crucial point in palliative care centers. This trial aimed to assess the effectiveness of aloe-vera in that concept. The trial was accomplished at Hematology Department of Hospital of Children of Damascus University, Syria. Acute lymphoblastic leukemia (ALL) children were the population from which 26 children were enrolled in the study. They were aged between 3 and 6 years old and were randomly referred according to the intervention into two groups, Aloe-vera (AV) and sodium bicarbonate 5% (13 each). Spongeous sticks were used to help in applying the material on tongue, labial and buccal mucosa, lips, floor of the mouth, and hard palate. Two blinded external examiners evaluated oral mucosa weekly for up to 2 months using the World Health Organization grading scale. Mann–Whitney U test was used to analyze data. According to the observed findings, CIOM degrees were less severe in the aloe-vera group than in the sodium bicarbonate group. Statistically significant difference of occurrence of different CIOM degrees between groups was recorded in the 2nd, 3rd, 4th, and 7th weeks of follow-up period. Moreover, Mann–Whitney U test indicated that patients in the sodium bicarbonate group began CIOM sooner than those in the aloe-vera group with a statistically significant difference (p = .001). These findings show that topical application of aloe-vera solution is effective in the prevention of CIOM in ALL children.

The effect of anti-inflammatory agents (glucosamine sulphate and aloe vera) on mouse mesenchymal stem cells

Use of stem cells for treating degenerative diseases like osteoarthritis has been gaining popularity. Glucosamine Sulphate is a nutritional supplement used for relieving inflammation during Osteoarthritis. Aloe vera juice is a widely consumed drink used in traditional practices to help reduce inflammation. In this experiment, the effect of Glucosamine Sulphate and Aloe vera on 2D and 3D proliferation of MSC cells was studied. Initial study to determine a suitable matrix for growing MSC cells was performed by growing the cells on 5mg/ml and 10mg/ml collagen and fibronectin coated wells for seven days. Cells adhered the least on fibronectin 10ug/ml and cells proliferated the highest on fibronectin at 10ug/ml, thus establishing fibronectin 10ug/ml as the matrix for the study. The effect of Glucosamine Sulphate on 2D proliferation of MSC cells growing on 10ug/ml fibronectin matrix was studied by exposing the cells to 0mg/ml, 0.1mg/ml, 0.5mg/ml and 1 mg/ml of Glucosamine Sulphate for seven days. The cells adhered the least on 0.5mg/ml and proliferated the highest on 0.5mg/ml as well (p<0.05). The effect of Aloe vera on MSC cells grown on fibronectin at 10ug/ml was studied by using concentrations of 0%, 2%, 5% and 10% Aloe vera juice for seven days. It was found that cell proliferation radically decreased in all conditions after Day 4 and the least proliferation was observed at 10%. 3D proliferation of MSC cells in a fibrin construct was studied with 0.1 mg/ml of Glucosamine Sulphate and 2% and 5% Aloe vera juice. It was observed that 5% Aloe vera juice allowed highest proliferation of cells, followed by 0.1 mg/ml Glucosamine Sulphate and 2% Aloe vera. This indicated that further analysis with 2% and 5% Aloe vera along with 0.1mg/ml as threshold could help identify an optimum dose range for uptake of Glucosamine Sulphate with Aloe vera juice to enhance relief from inflammation during osteoarthritis

Effect of Aloe vera (L.) Burm.f. on the Prevention of Dermatitis in Women with Breast Cancer under Radiotherapy

Effect of Aloe vera (L.) Burm.f. on the Prevention of Dermatitis in Women with Breast Cancer under Radiotherapy

Differential Biological Behavior of Fibroblasts and Endothelial Cells under Aloe vera Gel Culturing.

Aloe vera is used for its large variety of biological activities such as wound healing, anti-fungal, anti-inflammatory, hypoglycemic, immunomodulatory, gastroprotective, and anti-cancer. Although the beneficial effects of Aloe vera on wound healing have been proven, little is known about its effects at the cellular level. In this study, we evaluated the angiogenic and migrative effects of Aloe vera gel on fibroblasts and endothelial cells. Fibroblasts and endothelial cells were cultured in monolayer conditions with low glucose DMEM with 10% serum and 1% penicillin-streptomycin. Fresh and mature leaves of Aloe vera were used for gel preparation. Cell proliferation and morphology were studied by an inverted microscope. The migration of fibroblasts was assessed by scratch assay. MTT assay was performed for cell viability assessment, and real-time RT-PCR was used for evaluation of PECAM-1, integrin α1 and β1 transcription. After two days, the protein level of PECAM-1 was detected by flow cytometry. Our results showed that Aloe vera has a higher proliferative effect on fibroblasts in comparison with endothelial cells. Aloe vera also induced the migration of fibroblasts. The viability of both types of cells was similar to control ones. Integrin α1, β1 and PECAM-1 gene expression increased significantly (P <0.005) in Aloe vera treated fibroblasts and endothelial cells in comparison with the control groups. However, the expression of these genes was significantly higher in fibroblasts in comparison with endothelial cells. Protein levels of PECAM-1 showed no change in both cell types upon Aloe vera treatment. Aloe vera gel induced angiogenic and cell adhesion properties in fibroblasts more than endothelial cells. Further investigations are needed to show the main role of fibroblasts rather than endothelial cells in wound healing by Aloe vera administration.

Comparison between the effects of Aloe vera and chlorhexidine on clinical periodontal parameters

Background: Periodontal diseases are one of the major dental pathologies that affect human populations worldwide at high prevalence rates The term periodontal disease usually refers only to plaque related inflammatory disease of the dental supporting tissues. Mouth rinses which act as an anti-plaque agents mostly used as adjuncts to oral hygiene. Aims of the study: To Estimate and compare the effects of Aloe vera relative to chlorhexidine on the clinical periodontal parameters (plaque index, gingival index, bleeding on probing). Material and method: A total of 44 subjects with plaque-induced gingivitis, baseline of data were collected for (PLI, GI, and BOP) and underwent oral hygiene instruction, scaling and polishing, then divided into: Study group I : 15 patients instructed to use Aloe vera mouth wash (100% pure Aloe vera juice) for home application twice daily for 7 days. Study group II: 15 patients instructed to use chlorhexidine (0.2%) mouthwash twice daily for 7 days. Control group: 14 patients instructed not to use any adjunct. Results: PLI and BOP showed significant differences between 1st and 2nd visits in all groups with the larger effects were found in chlorhexidine followed by Aloe vera while the lowest change was found in control group. GI showed significant change between 1st and 2n visits in study groups (chlorhexidine and Aloe vera groups) with the larger effects was in chlorhexidine group, while there was no significant changes were found in control group. Conclusion: chlorhexidine remain the bench mark control as adjunct to periodontal therapy but Aloe vera can be used as alternative to chlorhexidine when it cannot be used.

Effect of Aloe vera and sodium alginate edible coatings on postharvest quality of strawberry

Effect of Aloe vera and sodium alginate edible coatings on postharvest quality of strawberry

Effect of aloe vera as a preprocedural rinse in reducing aerosol contamination during ultrasonic scaling.

Background:The use of preprocedural mouth rinse is one of the recommended ways to reduce aerosol contamination during ultrasonic scaling. Different agents have been tried as preprocedural mouth rinse. Chlorhexidine and povidone-iodine significantly reduce the viable microbial content of aerosol when used as a preprocedural rinse. Studies have shown that aloe vera (AV) mouthwash is equally effective as chlorhexidine in reducing plaque and gingivitis. There is no published literature on the role of AV as a preprocedural mouth rinse. Hence, this study compared the effect of 94.5% AV to 0.2% chlorhexidine gluconate (CHX) and 1% povidone-iodine (PVP-I) as preprocedural mouth rinses in reducing the aerosol contamination by ultrasonic scaling.Materials and Methods:Sixty subjects were divided into three groups based on the preprocedural rinse use (0.2% CHX, 1% PVP-I, and 94.5% AV). Ultrasonic scaling was done for 20 min in the same closed operatory for all the subjects after keeping blood agar plates open at two standardized locations. Colony forming units (CFUs) on blood agar plates were counted, and predominant bacteria were identified after incubation at 37°C for 48 h.Results:There was statistically significant difference in the CFU counts between CHX group and PVP-I group and between AV group and PVP-I group. There was no difference between CHX group and AV group at both the locations.Conclusion:94.5% AV as a preprocedural rinse is better than 1% PVP-I and comparable to 0.2% CHX in reducing CFU count.

Effectiveness of Aloe vera in Reducing Formaldehyde Levels on Indian Mackerel Fish (Rastrelliger kanagurta) During Cold Temperature Storage

Aims: This research is aimed to know the impact of Aloe Vera to formaldehyde levels. Specifically, to know how Aloe Vera could reduce the formaldehyde levels on Indian mackerel fish during cold temperature storage.&#x0D; Place and Duration of Study: Fisheries Product Processing Laboratory, Faculty of Fisheries and Marine Sciences, and Central Laboratory, Padjadjaran University between March until April 2019.&#x0D; Methodology: This research used descriptively compared method with five different Aloe vera treatment concentrations (0%, 10%, 20%, 30% and 40%). Parameters of observations such as formaldehyde levels, pH and organoleptic characteristics (fresh fish, formalin fish and after soaked with Aloe vera) descriptively compared with the literature.&#x0D; Results: The results of the research show that Aloe vera could reduce the formaldehyde levels on Indian Mackerel, and the higher concentreation of Aloe vera used and the longer of storage period, the more reduced formaldehyde levels. The reduction caused by presence of saponins in Aloe vera. Saponins was effective in binding formaldehyde particles so that formaldehyde can dissolve with water. The highest percentage of fomaldehyde reduction was on the concentration of 40% Aloe vera solution, with a decrease percentage was 63.47% - 74.48% and the lowest percentage decrease in formalin levels found in the solution concentration Aloe vera 10%, with a decrease percentage was 50.14% - 68.22%. pH value of all treatment at the beggining was close to acidic (range 6.30 – 6.47), caused by Aloe vera gel and formalin which were both acidic. The pH value of all treatment after 10th observations days was still in the range of the pH value of fresh fish, which is 6.77 - 7.03. The increased pH value during cold temperature storage caused by fish undergoing a chemical process in the form of protein overhaul and the formation of alkaline compounds. The organoleptic parameters showed there is a difference between the characteristics of fresh fish, fish in formalin and after the fish soaked on Aloe vera solution. The fresh fish had average value of 7.00 – 8.33 based on the score sheet, which indicates Indian Mackerel was fresh before the treatment. After soaked in formalin, the appearance has changed to be not bright, formaldehyde can be smelled, texture changed slightly hard, and the eye became gloom and murky white. After soaked with Aloe vera, the appearance became a little bright and shiny, could be smelled aroma of Aloe vera, texture became dense, and loss of cloudy corneas. &#x0D; Conclusion: Based on the results, it can be concluded that by increasing Aloe vera solution until 40%, will also increased the reduction of formaldehyde levels on Indian mackerel fish during cold storage until 10th day. At a concentration of 40% Aloe vera solution, it can reduce the highest formaldehyde levels with a range of percentage decreases in formalin levels by 63.47% - 74.48%, so that aloe vera could effectively reduce formalin levels in Indian mackerel during cold temperature storage.

The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children.

To evaluate the effect of two herbal mouthwashes containing aloe vera and tea tree oil, on the oral health of school children. A double-blinded, placebo-controlled prospective interventional study was conducted in school children aged 8-14years. The study participants were divided into four groups depending upon the mouthwash used: Group 1 (aloe vera), Group 2 (chlorhexidine), Group 3 (tea tree oil) and Group 4 (placebo). The variables studied included plaque index, gingival index and salivary Streptococcus mutans counts, which were recorded at baseline, 4weeks after supervised mouth rinse and after 2weeks of stopping the mouth rinse. A total of 89 boys and 63 girls were included. A statistically significant decrease in all variables was noted after the use of both the herbal preparations at the end of 4weeks which was maintained after the 2-week washout period (p < 0.001). The difference in variables between groups using aloe vera, Tea tree oil and chlorhexidine, was not statistically significant. The use of aloe vera and tea tree oil mouthwashes can decrease plaque, gingivitis and S. mutans in the oral cavity in children. The activity of these two agents is comparable to that of chlorhexidine.

Studying the Effect of Aloe Vera Ointment on Wound Healing of CABG Surgery in Diabetic Patients

Background and Purpose: one of morbidities of diabetes is delay in wound healing. Among treatment common procedures in diabetic patients with coronary artery bypass graft. Therefore, delay in CABG wound healing is one of common problems of diabetic patients. Aloe vera plant contains collagen which heightens the tissue granules and contributes in wound healing process with its anti-inflammatory properties. Thus, the researcher tries to examine the effect of Aloe vera on wound healing. Methodology: the study was random clinical trial with intervention and control groups. 60 diabetic patients who attended to Imam Ali Hospital, Kermanshah for CABG surgery have been assigned to two 30-person groups as intervention and control groups. From second day after surgery, after putting out the sternum area chip pipe of intervention group patients, after washing with betadine they were bandaged by 2% aloe vera ointment which was made by Karaj academic Jihad organization medicinal herbs research center in a daily basis. In control group only daily washing with betadine and bandage has been done. This has been conducted till 14 days after surgery. Wound healing in days 7, 4 and 14 after surgery has been evaluated by Bates Jenson wound healing scale. One used SPSS version 16 for analyzing the data. In this study, for describing the samples, one used descriptive statistical methods including tables of frequency distribution, determining average, SD and when it comes to study objectives and hypothesis, determining the homogeneity of samples one uses Chi two and Mann Whitman non-parametric test. Findings: mean and SD of total score of wound healing of two groups is calculated at day 4 after intervention by independent Mann Whitman test that P>0,5 therefore two groups had no significant different in wound healing, in day 7 after intervention the mean and SD of wound healing score had significant different based on Mann Whitman test P<0.001 at day 14 after intervention based on Mann Whitman test, there was a significant different between two groups in terms of wound healing p<0.001. Conclusion: 2% Aloe vera ointment can speed up the healing of wound of CABG surgery in diabetic patients after at least one week use.

Alelopatski utjecaj vrste Aloe vera (L.) Burm. F. na klijavost sjemena i rast klijanaca žitarica, industrijskog bilja i povrća

Alelopatski utjecaj vrste Aloe vera (L.) Burm. F. na klijavost sjemena i rast klijanaca žitarica, industrijskog bilja i povrća

Effects of Aloe vera and Eucalyptus methanolic extracts on experimental toxoplasmosis in vitro and in vivo

Toxoplasmosis is a worldwide disease caused by the protozoan parasite Toxoplasma gondii (T. gondii), which is most commonly treated by pyrimethamine and sulfadiazine. However, this treatment presents several adverse side effects; Thus, new drugs with lower toxicities are urgently needed. In this study the anti-T. gondii activity of A. vera and Eucalyptus extracts were evaluated in vitro using a MTT (3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyltetrazolium bromide) assay and in vivo by measuring the survival rates of mice infected with 2 × 103 tachyzoites of RH strain of T. gondii and then injected intraperitoneally by different concentrations of extracts for 4 days. Biochemical parameters such as Ferric Reducing Antioxidant Potential (FRAP) and malondialdehyde (MDA) assay were also evaluated. As results, in the in vitro assay, the IC50 values were 13.2, 24.7, 2.63 μg/ml, and the selectivity indexes were 3.3, 2.4, 3.03 for the A. vera, Eucalyptus and pyrimethamine, respectively. The mice treated with Eucalyptus showed a better survival rate than others (P < 0.05). The increased weight of liver and spleen, due to infection, was reduced by treatments. In FRAP assay Eucalyptus showed a better antioxidant activity than the other extracts. MDA levels in both liver and spleen were reduced by treatment. The results show that A. Vera and Eucalyptus possess anti-T. gondii activities in vitro and in vivo, in addition, Eucalyptus shows antioxidant activity with a higher survival rate. Therefore, Eucalyptus may be a useful candidate for treating Toxoplasma infection. Moreover, further studies are required to investigate the fractionations of this plant against T. gondii.