0693 An exaggerated exercise blood pressure response (EEBPR) in normotensive individuals is an independent marker for developing future hypertension. In the Surgeon General's Report on Physical Activity and Health, lifestyle of regular physical activity is emphasized in playing an important role in the prevention pf hypertension. PURPOSE: To investigat the effects of aerobic physical activity on normotensive individuals exhibiting EEBPR. METHODS: Seven 18–26 year-old normotensive African-American women with an exaggerated exercise systolic blood pressure response were screened and subjected to an 8-week aerobic training regimen consisting of supervised exercise on a cycle ergometer at 70% OV2max, 3 times/week for 30 minutes/session. Cardiovascular measures of blood pressure, heart rate, cardiac output, stroke volume, total peripheral vascular resistance, pulse pressure, arterial compliance, and arteriovenous oxygen difference were recorded at baseline, and at work intensities of 30W and 50%OV2max. The statistical significance of pre- vs. post-training differences were evaluated using a paired t −test at P <0.05. RESULTS: A 8.8% post-training increase in OV2max were found. No significance differences were detected in the baseline pre- vs. post-training values. At an absolute work intensity of 30W significant decrements in heart rate, arteriovenous oxygen difference, systolic pressure, and mean arterial pressure were found after training. Submaximal exercise at 50% OV2max was associated with significant increments in the pre- vs. post-training stroke volume, cardiac output and arterial compliance, and with significant decrements in the pre- vs. post-training total peripheral vascular resistance, systolic pressure, mean arterial pressure, and pulse pressure. CONCLUSION: Moderate aerobic exercise attenuated an EEBPR in African-American women, which may be an effective antihypertensive therapy for African-American women at risk for hypertension. Supported by NIH Grant GM-S06018.