Effects Of Prolotherapy Research Articles

The effect of prolotherapy on TMJ: a literature review

This paper reviewed prolotherapy as an approach to treating temporomandibular joint disorders (TMD), focusing on temporomandibular joint subluxation and hypermobility. Prolotherapy, commonly used in orthopedics, involves injecting substances like dextrose or lidocaine to promote healing in musculoskeletal conditions. Clinical studies in which this prolotherapy was used for TMD were reviewed. Total 13 papers involving 372 patients (Male 90, Female 282) were examined, considering factors such as dextrose concentration (10%~50%), injection frequency (one to four times), injection period (one to four weeks) and injection sites. The assessment primarily focused on pain reduction and changes in maximum mouth opening after prolotherapy. In all papers, a consistent trend of pain reduction after prolotherapy was observed. Regarding maximum mouth opening, there were 6 cases of decreased range and 7 cases of increased range. With prolotherapy's rec-ognition as a new medical technology for TMD, it emerges as a potential alternative treatment, highlighting its significance in the field.

THE EFFECT OF DEXTROSE PROLOTHERAPY ON PAIN IN CHRONIC LATERAL EPICONDYLITIS TREATMENT

The literature describes two treatment modalities for persistent lateral epicondylitis: surgical and conservative. While there are numerous conservative therapy options, there is no consensus in the literature regarding the optimal treatment. Although no treatment guide has been formed in the literature regarding prolotherapy injection, which is one of the conservative treatment modalities, each clinic has created its unique treatment protocol. Highly concentrated dextrose and morrhuate sodium solutions are most commonly used for prolotherapy. In this study, Visual Analogue Scale scores of 37 patients who were treated with double session 15% dextrose before the first injection and 6 months after the last injection were measured and compared statistically. It was also aimed to show possible complications. This study aimed to show the effectiveness of prolotherapy, one of the conservative treatment methods that seem to be ahead of other injection models in chronic lateral epicondylitis treatment because it is easily applicable, easily accessible, and affordable, and contributes to the literature by creating a treatment protocol.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0971/a.php" alt="Hit counter" /></p>

Kronik Bel Ağrısının Tedavisinde Proloterapi ile Faset Eklem Enjeksiyonunun Etkinliğinin Karşılaştırılması: Retrospektif Çalışma

Kronik Bel Ağrısının Tedavisinde Proloterapi ile Faset Eklem Enjeksiyonunun Etkinliğinin Karşılaştırılması: Retrospektif Çalışma

Effects of Prolotherapy with Organic Silicon in Temporomandibular Joint in Rabbits

Effects of Prolotherapy with Organic Silicon in Temporomandibular Joint in Rabbits

The effectiveness of prolotherapy on failed rotator cuff repair surgery

The effectiveness of prolotherapy on failed rotator cuff repair surgery

Effects of Prolotherapy on Medial Collateral Ligament Bursitis of the Knee Joint Identified with High Resolution Ultrasound

Effects of Prolotherapy on Medial Collateral Ligament Bursitis of the Knee Joint Identified with High Resolution Ultrasound

Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled Trial

No consensus has been reached about the best treatment method of plantar fasciitis and the results of the treatment methods have been inconsistent. The objective of the present study was to compare the therapeutic effects of extracorporeal shock wave therapy, platelet-rich plasma injection, local corticosteroid injection, and prolotherapy for the treatment of chronic plantar fasciitis using a randomized, controlled, prospective study. We performed a randomized controlled prospective clinical study of 4 groups. The first group received extracorporeal shock wave therapy, the second group received prolotherapy, the third group received platelet-rich plasma injection, and the fourth group received a local corticosteroid injection. The study included 158 consecutive patients with a diagnosis of chronic plantar fasciitis with a symptomatic heel spur. The clinical outcomes were assessed using the visual analog scale and Revised Foot Function Index. At the end of the follow-up period, the mean visual analog scale scores for all 4 groups were similar to the mean visual analog scale scores before treatment. At the end of the follow-up period, no significant improvement was noted in the Revised Foot Function Index score in any of the groups. The corticosteroid injection was more effective in the first 3 months and extracorporeal shock wave therapy was an effective treatment method in the first 6 months in regard to pain. The corticosteroid injection lost its effectiveness during the follow-up period. The effect of prolotherapy and platelet-rich plasma was seen within 3 to 12 months; however, at the 36-month follow-up point, no differences were found among the 4 treatments.

The Effects of Prolotherapy in Recreational Athletes with Plantar Fasciitis

The Effects of Prolotherapy in Recreational Athletes with Plantar Fasciitis

The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review.

Osteoarthritis (OA) often leads to symptoms such as pain, stiffness and decreased function. OA is treated with a wide range of modalities, both conservatively and surgically. Prolotherapy has been used to treat various musculoskeletal problems and has shown some promise. Searches of the electronic databases, PubMed, ISI web of science, PEDro and SPORTDiscus, were conducted for all Level 1-4 studies published from inception through to December 2016. Ten studies were evaluated and results show significant improvement in scores for pain, function and range of motion, both in the short term and long term. Patient satisfaction was also high in these patients (82%). Meta-analysis was not possible due to heterogeneity of outcome measures and populations. Moderate evidence suggests that prolotherapy is safe and can help achieve significant symptomatic control in individuals with OA. Future research should focus on larger sample size, standardization of treatment protocol and basic science evidence.

Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions

BackgroundRotator cuff lesions are one of the major causes of shoulder pain and dysfunction. Numerous non-surgical treatment modalities have been described for chronic rotator cuff lesions, but the debate continues over the optimal procedure. The aim of this report is to present the results of prolotherapy in the treatment of chronic refractory rotator cuff lesions. HypothesisDextrose prolotherapy will reduce pain and improve shoulder function and patient satisfaction. Material and methodsWe recruited 120 patients with chronic rotator cuff lesions and symptoms that persisted for longer than 6 months. Patients were divided into two groups: one treated with exercise (control group; n=60) and the other treated with prolotherapy injection (prolotherapy group; n=60). In the latter, ultrasound-guided prolotherapy injections were applied under aseptic conditions. In the former, patients received a physiotherapy protocol three sessions weekly for 12 weeks. Both groups were instructed to carry out a home exercise program. Clinical assessment of shoulder function was performed using a visual analog scale (VAS) for pain, Shoulder Pain and Disability Index (SPADI), Western Ontario Rotatory Cuff (WORC) Index, patient satisfaction, and shoulder range of motion. Patients were examined at baseline, weeks 3, 6, and 12, and last follow-up (minimum of one year). ResultsA total of 101 patients (44 controls and 57 in the prolotherapy group) completed all study protocols and were included in the study. Using a within-group comparison, both groups achieved significant improvements over baseline, as measured by the VAS, SPADI, WORC index, and shoulder range of motion (P<0.001). Using a between-group comparison, a significant difference was found in the VAS scores at baseline, weeks 3, 6, and 12, and last follow-up. In addition, significant differences were found in the SPADIs and WORC indices at weeks 6 and 12 and the last follow-up. Significant differences were found in shoulder abduction and flexion at week 12 and last follow-up, and in internal rotation at last follow-up. However, no significant was found in external rotation at any follow-up period. In the prolotherapy group, 53 patients (92.9%) reported excellent or good outcomes; in the control group, 25 patients (56.8%) reported excellent or good outcomes. ConclusionProlotherapy is an easily applicable and satisfying auxiliary method in the treatment of chronic rotatory cuff lesions. Study typeRandomized prospective comparative trial. Level of evidenceLevel of evidence 1.

The Effects of Prolotherapy (Hypertonic Dextrose) in Recreational Athletes with Patellofemoral Pain Syndrome

Objective: Prolotherapy is recognized as a regenerative injection technique that stimulates the body’s healing processes to strengthen weakened ligaments and tendons. Hypertonic dextrose as an irritant agent which stimulates the healing process agent is widely used in in this technique. The aim of the current study is to assess the efficiency of prolotherapy injections in patellofemoral pain syndrome Methods: The current study was designed as a retrospective clinical study. 44 recreational athletes with unilateral PFPS were enrolled in this study. 10 ml of 15% and 5 ml of 25% hypertonic dextrose were used as extra- and intra-articular injection in the knee with PFPS respectively. Extra and intra articular injections were repeated three times with 21 day intervals according to the tissue repair processing. Results: The knee functional scores, balance and coordination scores were significantly improved in the affected knees at 6 months after treatment (p

Long-term effect of Prolotherapy on symptomatic rotator cuff tendinopathy

Introduction: The objective of this study was to assess a long-term clinical effect of Prolotherapy on chronic symptomatic rotator cuff tendinopathy.Methods: We conducted a retrospective, uncontrolled study in the outpatient setting with 12 months follow-up. Adults diagnosed clinically and radiologically with rotator cuff tendinopathy that has been persisting for a minimum of six months were included. Patients received 15% extra-articular and 25% intra-articular hyperosmolar dextrose injections, repeated at weeks 5, 9, 13, 17 and 21. Primary outcome measure was validated Shoulder Pain and Disability Index (SPADI). Secondary outcome measure was validated visual pain analogue scale (VAS 0-10). The third outcome measures were patient’s satisfaction with Prolotherapy and adverse reactions after injections.Results: Twenty-one patients, 14 male and 7 female were treated with 6 sessions of hyperosmolar dextrose Prolotherapy repeated every 4 weeks. Average SPADI before starting the treatment was 73.995 ± 13.6, while 12 months after completed treatment was 20.84 ± 26.03 (P&lt; 0.0001). Average VAS score before starting the treatment was 8.14 ± 1.2, while 12 months after completed treatment was 2.29 ± 2.8 (P&lt;0.0001). Out of 21 patients, 18 (85.71%) would recommend Prolotherapy to other people with the similar condition, and no one participant reported any side effect that was not resolved within one week after the treatment.Conclusion: Hyperosmolar dextrose Prolotherapy may result in significant reduction of pain and disability index in adult patients with chronic rotator cuff tendinopathy, without eliciting long-lasting side effects. Results of this pilot study need to be validated in prospective controlled randomized trials.

Testing the effectiveness of prolotherapy compared to physiotherapy for tennis elbow: A randomised control trial

Testing the effectiveness of prolotherapy compared to physiotherapy for tennis elbow: A randomised control trial

Effect of prolotherapy on cellular proliferation and collagen deposition in MC3T3-E1 and patellar tendon fibroblast populations

Proliferative therapy, or prolotherapy, is a treatment for damaged connective tissues involving the injection of a solution (proliferant) which causes local cell death and triggers the body's wound healing cascade. Physicians vary in their use of this technique; it is employed for ligaments but has also been investigated for tissues such as cartilage. Physicians also vary in treatment regiments using different dosses of the proliferant. This study evaluates several proliferant dosages develop an optimal dosage that maximizes cell and collagen regeneration. This study also looks at cell and collagen regeneration in response to proliferant exposure outside of the healing cascade. MC3T3-E1 cells and patellar tendon fibroblasts were exposed to various amounts of the proliferant P2G and monitored over several weeks. The results showed an inverse relationship between proliferant concentration and cell viability and collagen production in MC3T3-E1 cells. Following exposure, cell populations experienced an initial decrease in cell number followed by increased proliferation. Trichrome staining over 4 weeks showed an increase in collagen production after proliferant exposure. However the cell numbers and amounts of collagen from the treated groups never surpassed those of the untreated groups, although collagen production was comparable in fibroblasts. The results of this basic study show that there is an effective proliferant dosage and point to a local response to the proliferant that increases cell proliferation and collagen production separate from the wound healing cascade. This local response may not be adequate for complete healing and assistance from the body's healing cascade may be required.

The effectiveness of prolotherapy in the management of recalcitrant medial tibial stress syndrome: a pilot study

ObjectiveTo study the effectiveness of dextrose prolotherapy in the treatment of recalcitrant medial tibial stress syndrome (MTSS).DesignA prospective case-series.SettingA London private hospital.ParticipantsSeven patients: five male and two female; (mean age=36...

The effect of prolotherapy on sacro-iliac joint stiffness: a pilot study

AbstractThe aim of this pilot study was to measure stiffness of the sacro-iliac joints (SIJ) using Doppler imaging of vibration (DIV) before and after prolotherapy injections. Ten subjects, who were already scheduled for prolotherapy injections to their posterior pelvic girdle, were assessed by DIV, a visual analog scale (VAS) and a Roland Morris Back Disability (RMQ) Questionnaire on two occasions before prolotherapy and once 3 months after prolotherapy injections. Vibrations were applied independently to both anterior superior iliac spines of prone subjects. The vibrations were recorded by a color Doppler imaging transducer placed over the ipsilateral SIJ. The intensity of the vibrations on the sacrum and the ilium was measured in threshold units. The differences between the threshold scores were interpreted as the power loss of vibrations through the SIJ. A paired samples t-test was used to analyze the pain and disability data while the DIV data were analyzed with a Wilcoxon Rank Sign test; statistical...

Comparison of Effect of Prolotherapy and Paraffin Waxes for Hand Osteoarthritis

Comparison of Effect of Prolotherapy and Paraffin Waxes for Hand Osteoarthritis