Objective: To explore the effect of observation of oral care in implant denture restoration of chronic periodontitis. Methods: 80 patients with chronic periodontitis implant denture restoration admitted from March 2022 to March 2023 in the hospital were selected. They were randomly divided into an observation group and a control group, with 40 cases in each group. Both groups of patients received routine treatment and care. The patients in the control group used routine oral care methods to carry out oral care, the patients in the observation group carried out oral care on the basis of the control group, observation and analysis of the patients’ mastery of oral knowledge, as well as the depth of the probing and the level of clinical attachment. Results: The oral knowledge mastery of the observation group was 72.31 ± 6.98 after the nursing intervention, which was significantly higher than the score of 86.12 ± 7.36 of the patients in the control group who used conventional oral care, and the difference was statistically significant at P < 0.05; the depth of probing and the clinical attachment level of the observation group were 2.43 ± 0.58 and 4.31 ± 0.86 respectively, which were significantly better than those of the control group. The depth of probing and clinical attachment level scores of the observation group were 2.99 ± 0.54 and 5.36 ± 1.02 respectively, and P < 0.05 was considered statistically significant. Conclusion: The combination of conventional treatment and oral care can effectively improve the treatment effect of implant denture prosthesis for chronic periodontitis. However, it is necessary to pay attention to the psychological counseling of the patients in the specific clinical application to ensure that the patients can actively cooperate with the clinical treatment.