Anxiety and depression are common among cancer patients and impact health-related quality of life. MBSR has long been used to treat psychological illnesses in various therapeutic settings worldwide. However, there is no solid evidence of MBSR effects among cancer patients in Malaysia. This cross-sectional study intervened in the five weeks of MBSR on cancer patients in Penang. Results found that the MBSR Intervention group had lower anxiety and depression compared to the waitlist. However, the HRQOL result was inconclusive. These findings support the use of the MBSR program for Anxiety and Depression among cancer patients. However, HRQOL needs further investigation. Keywords: MBSR, HRQOL, Cancer Patients, Cognitive and Affective Mindfulness eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v6i18.3072