Effect Of Aminocaproic Acid Research Articles

Effects of aminocaproic acid on perioperative hidden blood loss in elderly patients with femoral intertrochanteric fracture treated with proximal femoral nail anti-rotation.

ObjectiveTo determine the efficacy of aminocaproic acid on perioperative hidden blood loss (HBL) in elderly patients with femoral intertrochanteric fracture treated with proximal femoral nail anti-rotation (PFNA).MethodsSeventy consecutively admitted elderly patients with femoral intertrochanteric fracture treated with PFNA between 1 May 2017 and 1 May 2018 were recruited. The patients were randomised into the experimental and control groups receiving 1 g aminocaproic acid in 200 mL saline and only 200 mL normal saline intravenously, respectively. The following factors were recorded: demographic characteristics, haemoglobin and haematocrit levels on preoperative day 1 and postoperative days 1 and 3, surgical blood loss, postoperative drainage, the rate and volume of transfusion, and complications.ResultsNo significant differences were seen in surgical blood loss and postoperative drainage between the experimental and control groups, though total blood loss was greater in the control group. Visible blood loss and HBL were significantly lower in the experimental group than in the control group, and a lower rate and volume of transfusion were also recorded in the experimental group.ConclusionAminocaproic acid significantly reduced perioperative HBL and volume and rate of transfusion in elderly patients with femoral intertrochanteric fracture receiving PFNA.

Кровосберегающий эффект аминокапроновой кислоты при тотальном протезировании коленного сустава

Кровосберегающий эффект аминокапроновой кислоты при тотальном протезировании коленного сустава

Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis.

OBJECTIVE To determine pharmacodynamic and pharmacokinetic profiles of aminocaproic acid (ACA) by use of a thromboelastography (TEG)-based in vitro model of hyperfibrinolysis and high-performance liquid chromatography-mass spectrometry. ANIMALS 5 healthy adult dogs. PROCEDURES A single dose of injectable ACA (20, 50, or 100 mg/kg) or an ACA tablet (approximately 100 mg/kg) was administered orally. Blood samples were collected at 0, 15, 30, 45, 60, 90, 120, and 240 minutes after ACA administration for pharmacokinetic analysis. Samples were obtained at 0, 60, and 240 minutes for pharmacodynamic analysis by use of a TEG model of hyperfibrinolysis. RESULTS No adverse effects were detected. In the hyperfibrinolysis model, after all doses, a significantly higher TEG maximum amplitude (clot strength), compared with baseline, was detected at 60 and 240 minutes. Additionally, the percentage of fibrinolysis was reduced from the baseline value at 60 and 240 minutes, with the greatest reduction at 60 minutes. At 240 minutes, there was significantly less fibrinolysis for the 100 mg/kg dose than the 20 mg/kg dose. Maximum plasma ACA concentration was dose dependent. There was no significant difference in pharmacokinetic parameters between 100 mg/kg formulations. CONCLUSIONS AND CLINICAL RELEVANCE In an in vitro model of hyperfibrinolysis, ACA inhibited fibrinolysis at all doses tested. At 240 minutes after administration, the 100 mg/kg dose inhibited fibrinolysis more effectively than did the 20 mg/kg dose. Thus, ACA may be useful for in vivo prevention of fibrinolysis in dogs. IMPACT FOR HUMAN MEDICINE These data may improve research models of hyperfibrinolytic diseases.

Systemic Steroids: An Alternative to Systemic Aminocaproic Acid to Prevent Rebleeding in Traumatic Hyphema-Reply

<h3>In Reply.</h3> —The effectiveness of aminocaproic acid in preventing secondary hemorrhage in traumatic hyphemas has been demonstrated both in a prospective, randomized, double-masked, controlled clinical study¹and in basic pharmacologic studies.²Three additional clinical studies and one animal model have confirmed these results.^3-6The secondary hemorrhage rate in these studies with placebo was very similar (28% to 33%). The rate of secondary hemorrhage in those patients treated with aminocaproic acid was 0% to 4%. These scientific studies by different authors at different institutions provide ample scientific evidence to support the use of aminocaproic acid in the treatment of traumatic hyphema. Dr Romano has suggested the use of systemic steroids in traumatic hyphema treatment to circumvent the problems with aminocaproic acid. Unfortunately, there is little basic pharmacologic research to support his claim. Low concentrations of glucocorticoids have been demonstrated to retard the ability of neutrophils to promote conversion

The Effect of Aminocaproic Acid on Bleeding Following Transurethral Prostatectomy

The Effect of Aminocaproic Acid on Bleeding Following Transurethral Prostatectomy

Effect of Epsilon Aminocaproic Acid on Bleeding after Prostatectomy

No AccessJournal of Urology1 Jun 1961Effect of Epsilon Aminocaproic Acid on Bleeding after Prostatectomy Theodore R. Fetter, Leandro M. Tocantins, Robert N. Cottone, Claude Brosseau, and Warren D. Bowman Theodore R. FetterTheodore R. Fetter More articles by this author , Leandro M. TocantinsLeandro M. Tocantins More articles by this author , Robert N. CottoneRobert N. Cottone More articles by this author , Claude BrosseauClaude Brosseau More articles by this author , and Warren D. BowmanWarren D. Bowman Present address: Billings, Montana. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)65462-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1961 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMadsen P, Strauch A, Barquin O and Malek G (2018) The Lack of Hemostatic Effect of Polyestradiol Phosphate and Carbazochrome Salicylate in Transurethral ProstatectomyJournal of Urology, VOL. 99, NO. 6, (786-787), Online publication date: 1-Jun-1968.Madsen P and Strauch A (2018) The Effect of Aminocaproic Acid on Bleeding Following Transurethral ProstatectomyJournal of Urology, VOL. 96, NO. 2, (255-256), Online publication date: 1-Aug-1966. Volume 85Issue 6June 1961Page: 970-972 Advertisement Copyright & Permissions© 1961 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Theodore R. Fetter More articles by this author Leandro M. Tocantins More articles by this author Robert N. Cottone More articles by this author Claude Brosseau More articles by this author Warren D. Bowman Present address: Billings, Montana. More articles by this author Expand All Advertisement Loading ...