Effective Rate Research Articles

Application of Bacillus sp Liquid Formula Using Root Infusion Technique To Control VSD (Vascular Streak Dieback) Disease In Cocoa

This study aims to explore the potential of liquid organic waste formula made from Bacillus sp to suppress the severity of vascular streak dieback (VSD) disease in cocoa plants. The research was conducted on smallholder cocoa plantations in Patimbe Village, Palolo Subdistrict, Sigi Regency, Central Sulawesi. The research was arranged in a non-factorial Randomised Group Design (RAK) with 5 treatments and 5 replications. The treatments consisted of control (P0=no formula); coconut water + Bacillus sp (P1); rice washing water + Bacillus sp (P2); tofu water + Bacillus sp (P3); and a combination of coconut water, rice washing water, and tofu water + Bacillus sp (P4). Each experimental unit consisted of 10 cocoa plants infected with VSD disease. The liquid organic waste formula was applied using the root infusion technique in months 1 and 3 at a dose of 250 ml/root. Observations of disease symptoms, disease development, disease severity, and disease suppression efficacy were conducted monthly. The results showed that the combination of organic waste of coconut water, tofu water, and rice washing water with Bacillus sp active ingredient was more effective in suppressing VSD disease than liquid organic waste alone with an effectiveness rate of 81.7%.

Comparative efficacy of eight oral Chinese patent medicines for dilated cardiomyopathy with heart failure: a Bayesian network meta-analysis

BackgroundChinese patent medicines (CPMs) are widely used in China as an adjuvant treatment in dilated cardiomyopathy with heart failure (DCM-HF). However, comprehensive and systematic evidence supporting the beneficial effects of CPMs combined with current complementary and alternative medicine (CAM) treatments against DCM-HF was limited. This network meta-analysis (NMA) aimed to assess and rank the relative efficacy of eight different CPMs for DCM-HF.MethodsTo retrieve randomized controlled trials (RCTs) focusing on the use of CPMs combined with CAM for DCM-HF, the databases of PubMed, Embase, Web of Science Core Collection, Cochrane Library, ProQuest, China National Knowledge Infrastructure (CNKI), China Science Periodical Database (CSPD), Chinese Citation Database (CCD), Chinese Biomedical Literature Database (CBM), and ClinicalTrials.gov were comprehensively searched from their inception to 29 February 2024. The quality of the included RCTs was examined using the Cochrane Risk of Bias assessment tool, version 2.0 (RoB 2). Surface under the cumulative ranking curve (SUCRA) probability values were applied to rank the relative efficacy. Bayesian network meta-analysis was designed to assess the efficacy of different CPMs.ResultsAfter applying the inclusion and exclusion criteria, a total of 77 eligible RCTs involving 6980 patients were enrolled. The outcomes assessed included clinical effectiveness rate (CER), left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), 6-min walk test (6MWT), brain natriuretic peptide (BNP), and cardiac output (CO). The results of the NMA indicated that Qili Qiangxin capsule (QLQX), Wenxin granule (WX), Tongxinluo capsule (TXL), Qishen Yiqi dropping pill (QSYQ), Shexiang Baoxin pill (SXBX), Yangxinshi tablet (YXST), Yixinshu capsule (YXSC), and Getong Tongluo capsule (GTTL) combined with CAM significantly improved performance compared with CAM alone in treating DCM-HF. YXST + CAM (MD = − 9.93, 95% CI − 12.83 to − 7.03) had the highest probability of being the best treatment on account of the enhancement of LVEF. WX + CAM had the highest likelihood of being the best treatment considering the improvement in LVEDD (MD = − 11.7, 95% CI − 15.70 to − 7.79) and 6MWT (MD = − 51.58, 95% CI − 73.40 to − 29.76). QLQX + CAM (MD = − 158.59, 95% CI − 267.70 to − 49.49) had the highest likelihood of being the best intervention for the reduction in BNP. TXL + CAM (MD = − 0.93, 95% CI − 1.46 to − 0.40) might be the optimal choice for increasing CO levels in DCM-HF patients. No serious treatment-emergent adverse events were observed.ConclusionThis NMA suggested that adding CPMs to the current CAM treatment exerted a more positive effect on DCM-HF. Thereinto, QLQX + CAM, TXL + CAM, WX + CAM, and YXST + CAM showed a preferable improvement in patients with DCM-HF when unified considering the clinical effectiveness rate and other outcomes. Furthermore, due to the lack of information on CPMs against DCM-HF and the uneven distribution of included studies among interventions, more high-quality studies are needed to provide more robust evidence to support our findings.Systematic review registrationPROSPERO (CRD42023482669).

PENGARUH LEVERAGE, INTENSITAS MODAL, DAN KOMISARIS INDEPENDEN TERHADAP TARIF PAJAK EFEKTIF

This research aims to determine the effect of Leverage (X1), Capital Intensity (X2), and Independent Commissioner (X3) on Effective Tax Rates. The independent variables in this research are Leverage with the Debt Equity Ratio (DER) indicator, Capital Intensity with the Capital Intensity Ratio (CIR) indicator, Independent Commissioner with the proportion of independent commissioners as an indicator. The Dependent Variable in this research uses the Effective Tax Rate which is measured using the Effective Tax Rate (ETR) indicator. The method used in this research is quantitative using secondary data sourced from the financial reports of all manufacturing sector companies during the 2020-2021 period. The sampling method in this research used a purposive sampling method with 172 observations. This research uses panel data regression analysis method which is processed with the Eviews 12 application. The results obtained from this research show that Leverage has a positive effect on Effective Tax Rates. Capital Intensity has a positive effect on Effective Tax Rates. Independent Commissioners have no influence on the Effective Tax Rate

Effects of Transmission Mechanism of Monetary Policy Channels on Economic Growth in Ethiopia: Cointegration and Causality Analysis Approach

The study aimed at investigating and analyzing factors those effects of transmission mechanism of monetary policy channels on economic growth in Ethiopia using a 36 years’ time series data. To this end, variables such as economic growth (dependent variable), and other regress variables such as real lending rate, real effective exchange rate, credit for private sector, consumer price index, trade of opens, gross capital formation, and money supply are considered. An empirical model linking the real GDP to its theoretical effects is then specified. This study had employed the co-integration and vector error correction model (VECM) analysis with impulse response and variance decomposition analysis to provide robust long run effects and short run dynamic effects on the real GDP. All variables under consideration are integrated of order one I (1) and also co-integrated. Vector Error Correction Model/VECM/ results show that real GDP was positively and significantly affected by the real effective exchange rate, money supply, gross capital formation (investment), credit for private sector, trade of openness over a period of long-run; while real leading interest rate and consumer price index (inflation) have significant negative effect. The estimate of the speed of adjustment coefficient found in this study indicates that about a 31 percent of the variation in the real GDP from its equilibrium level is corrected within a year. The study suggests that lowering the lending interest rate can encourage more private investment because it will encourage private investors to borrow more, which will increase investment in Ethiopia. Since investment is one of the factors that determine the gross domestic product, this will result in an increase in the GDP.

Tax Avoidance in F&B Companies in Relation Among Leverage, Sales Growth, and Firm Size with Profitability as Mediating

The objective of this research is to examine how leverage, sales growth, and firm size have an effect on tax avoidance through profitability as mediating in food and beverage companies listed on the Indonesia Stock Exchange (IDX). The research utilizes three independent variables: leverage measured by Debt to Asset Ratio (DAR); sales growth measured by the change in current sales relative to previous sales; and firm size measured by the natural logarithm of total assets. The mediating variable is profitability, measured by Return on Assets (ROA), while the dependent variable is tax avoidance, measured by Cash Effective Tax Rate (CETR). The population of this research is all of the food and beverage companies listed on the Indonesia Stock Exchange (IDX) from 2020 to 2023. The purposive sampling method was used in determining the sample and there were 21 companies obtained with a total research sample of 84 obtained over four years. The results of this research show that leverage and sales growth partially have a significant effect on profitability, while firm size partially has no significant effect on profitability. Leverage, sales growth, firm size and profitability partially have no significant effect on tax avoidance.

Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions

ObjectivesThis study aims to evaluate the therapeutic outcomes of Paiteling and CO2 laser therapy on high-risk human papillomavirus. MethodsWe retrospectively analyzed the data of 558 patients with HR-HPV low-grade squamous intraepithelial neoplasia (CIN1) from 2021 to 2023. Patients were selected and put into two groups: Paiteling and CO2 laser. Out of the 558 patients who were included in our final study, 239 (42.8 %) were treated with Paiteling, and 319 (57.2 %) were treated with CO2 laser vaporization. The mean age was 49.55 ± 12.10 years old. We observed that 27 (4.83 %) were younger than 30 years and 531 (95.1 %) were older than 30 years. We reviewed the patient’s results at intervals of 3 months, 6 months, 12 months, and 24 months after each therapy. The results of the recurrence rate, effective viral clearance rate, and the effectiveness of both therapies on low-grade cervical lesions were determined using multivariate and univariate cox-regression analysis. The Kaplan-Meier curve was used to determine the HR-HPV conversion rate of each therapy. ResultsThe median time for HR-HPV clearance was 6.00 months (95 % CI: 4.26–6.89) in the Paiteling group and 9.00 months (95 % CI: 15.92–22.67) in the CO2 laser group. There was a significant difference between the two groups (χ2 = 25.118, p-Value = 0.000). The HR-HPV clearance rate during 6–12 months for Paiteling and CO2 laser was 100 (55.6 %) and 80 (44.4 %), respectively. The clearance rate for both therapies from 6 to 18 months was statistically significant (6–12 months: p < 0.010, 12–18 months: p < 0.011). The Paiteling HR-HPV negative rate over 24 months 214 (89.5 %) is higher than CO2 laser 176 (55.2 %). Paiteling has a 5.4 % re-infection rate, which is marginally lower than the 5.6 % rate for CO2 lasers.The clearance rate for both therapies from 12 to 18 months [Paiteling: 20 (4.7 %) to 10 (3.6 %) and CO2 laser: 22 (8.4 %) to 15 (4.2 %)] was also significant (p < 0.011). The percentage of persistent Hr-HPV clearance rate for Paiteling patients was higher than carbon dioxide laser vaporization. No severe side effects were reported by the Paiteling patients compared to laser vaporization. This is due to the fact that Paiteling, as a traditional Chinese medicine, is a topical, non-invasive medicine, thus preserving the integrity of the cervix. ConclusionsPaiteling is an effective noninvasive therapy that can clear persistent HR-HPV associated with cervical low-grade squamous lesions in a relatively shorter period of time compared to CO2 laser ablation.

How are green stocks and monetary policy related?

We propose and test the hypothesis that green stocks and monetary policies are interdependent. Using time-series data for two large economies (India and Indonesia), that have adopted inflation targeting regimes, we develop a structural vector autoregressive model of monetary policy and green stocks that combines with output. We find that green stock prices fall (rise) in response to inflation with a lagged effect and policy rate shocks for India (Indonesia). Currency depreciation, on the other hand, increases green stock prices for India but has a muted effect for Indonesia. We also discover that, for India, monetary policies hardly respond to green stock price shocks while, for Indonesia, green stock prices do influence the evolution of monetary price variables. Our main contribution is that we decipher the effects of green stocks from aggregate market shocks and show each of these market price shocks is related to the monetary aggregates.

FINANCIAL DISTRESS DAN TAX AVOIDANCE: POTRET PERUSAHAAN MANUFAKTUR DALAM ANALISIS DESKRIPTIF KUANTITATIF

Tax avoidance can be driven by several factors, including declining financial conditions. Based on some cases that have occurred in companies in Indonesia, the research questions for this study are: 1) Do companies experiencing financial difficulties tend to engage in tax avoidance? 2) Do companies not experiencing financial difficulties also tend to engage in tax avoidance? The purpose of this study is to investigate and describe the tendency of tax avoidance based on the financial conditions of companies. The sample for this study includes manufacturing companies in the sub-sectors of Household Goods, Leisure Goods, and Tobacco listed on the Indonesia Stock Exchange for the period 2020-2022. The sample selection was done using purposive sampling, resulting in 33 samples from 11 companies that met specific criteria. This research is a descriptive quantitative study, describing financial distress using the Springate S-Score method and tax avoidance using the Cash Effective Tax Rate. The scores and ratios were then analyzed using Microsoft Excel Office 2021. The results of this study indicate that companies experiencing financial difficulties tend to engage in tax avoidance practices. There are also companies that are not experiencing financial difficulties but are still indicated to be engaging in tax avoidance practices. Additionally, it was found that some companies categorized as experiencing financial difficulties do not engage in tax avoidance practices

Taxation models for international groups of companies

Taxation of international groups of companies can be based on two models: These are: 1) unitary taxation, whichinvolves determining the income of the group as a whole and then dividing it between individual companies, 2)separate entity taxation, which involves each entity being taken into account separately and its income beingdetermined as if it were an independent entity. In practice, it was decided to choose separate entity taxation, whichresulted in legislation on transfer pricing. However, using this model did not protect against tax optimization usedby international groups of companies, which prompted the OECD and the EU to take various actions to combat it.The latest initiative in the area of taxation of international groups of companies is the global minimum tax model.Its essence comes down to charging an additional amount of tax if the effective tax rate in a given tax jurisdictionis lower than 15%. In Poland, this model has not yet been implemented, it will most likely happen from 2025, hencethe lack of practical experience with its application

Clinical efficacy and pharmacological mechanism analysis of Xubi Capsule in the treatment of patients with liver and kidney deficiency osteoarthritis.

To explore the clinical efficacy and pharmacological mechanism analysis of Xubi capsule in the treatment of patients with liver and kidney deficiency osteoarthritis (OA). In this single-center retrospective study, 120 patients with liver and kidney deficiency OA admitted to the Hangzhou Fuyang Hospital of Traditional Chinese Medicine from January 2020 to May 2022 were included, and patients were divided into the intervention group (n = 60) and the control group (n = 60) according to their treatment. The control group was treated with Ibuprofen, while the intervention group was treated with Xubi capsule combined with Ibuprofen. According to the network pharmacology method, the mechanism of the Xubi capsule in the treatment of patients with liver and kidney deficiency OA was analyzed. After the treatment, the total effective rate in the intervention group was 93.33%, which was significantly higher than that in the control group (P < .001). After treatment, compared with the control group, the degree of joint swelling and tenderness in the intervention group were lighter, the muscle strength was better, the level of erythrocyte sedimentation rate was lower, and the pain visual score was lower (P < .05), while the C-reactive protein level was significantly lower (P < .001). The effective chemical composition of Xubi capsules is 176, with quercetin and palmitoleic acid being the most associated with diseases. There are 209 intersection targets between drugs and diseases. A total of 119 gene ontology cellular components were significantly enriched. The combination of traditional Chinese medicine and Western medicine adopted in this study can effectively treat patients with liver and kidney deficiency OA and relieve the joint pain of patients. In a multicomponent and multitarget approach, the Xubi capsule breaks through the limitations of traditional nonsteroidal anti-inflammatory drugs and has good clinical application value.

Fabrication of polyacrylonitrile based metal-organic frameworks membranes with super adsorption performance for potential kidney dialysis

One popular technique to remove extra metabolic waste from the blood during renal replacement therapy is blood refining. Enough removal of these toxins from the blood can reduce complications and lengthen survival in dialysis patients. The current blood purification materials are not ideal, there is a need for novel materials with better biocompatibility, less toxicity, and, in particular, more effective toxin uptake rates and cheaper production costs. This requirement has been satisfied in metal-organic frameworks (MOFs). Here, polyacrylonitrile membranes containing MOFs based in different metal sources (Ce, Ca, and Fe) were produced and characterized using PXRD, FTIR, SEM and EDX. The prepared MOFs worked really well at getting rid of a lot of dangerous toxins, such creatinine and p-cresyl sulphate. The adsorption capacities of p-cresyl sulphate onto PAN, Ca-BTC/PAN, Cu-BTC/PAN, Ce-BTC/PAN, and Fe-BTC/PAN were 101.15, 122.70, 270.52, 358.15 and 449.25 mg g−1, respectively; while in the case of creatinine the adsorption capacities were 62.68, 105.9, 225.83, 311.48 and 422.27 mg g−1, respectively. Moreover, the developed membranes showed excellent selectivity and best recyclability of about 6 times.

Nd: YAG laser irradiation in the treatment of live pulp preservation in pediatric cariogenic pulpitis.

Dental pulpitis significantly impacts oral function and quality of life. Treatments like direct pulp capping aim to preserve pulp vitality. This study aims to investigate the application value of Nd:YAG laser irradiation in preserving pulp vitality in children with caries-induced pulpitis. This study, conducted from June 2019 to June 2023, included 89 children undergoing pulp vitality preservation treatment for caries-induced pulpitis. The children were divided into two groups using sealed envelopes: 44 in the control group received pulp capping treatment, while the study group received Nd:YAG laser-assisted pulp capping treatment. The efficacy, oral indicators, oral function, changes in root apex diameter and root length, changes in gingival crevicular fluid inflammatory factors, and incidence of complications were compared between the two groups before and 3 months after treatment. The total effective rates were 97.78% in the study group and 95.45% in the control group, with no significant difference between the groups (p> 0.05). Before treatment, there were no differences in gingival index, plaque index, and probing bleeding index between the groups (p> 0.05). After treatment, both groups showed decreased periodontal indexes compared to before treatment, with the study group showing lower values than the control group (p< 0.05). Chewing and biting function scores were similar between the groups before and after treatment (p> 0.05), but both groups showed decreased scores after treatment (p< 0.05). The study group had a higher percentage decrease in root apex diameter and a greater increase in root length compared to the control group (p< 0.05). During treatment, one case of tooth discoloration occurred in the study group (2.27%), while the control group had two cases of tooth discoloration and one case of secondary caries, resulting in a complication rate of 6.67%. There was no significant difference in the incidence of complications between the groups (p> 0.05). Nd:YAG laser irradiation effectively preserves pulp vitality in children with caries-induced pulpitis, improving periodontal health, reducing root apex diameter, and increasing root length with high safety.

Knowledge of, and attitude towards, the treatment of hepatitis C in people who inject drugs

BackgroundDirect acting antivirals (DAAs) as a curative treatment of hepatitis C have been available for several years and have replaced interferon-containing therapies. However, treatment rates of people who inject drugs (PWID) are declining in Germany, putting the elimination of hepatitis C by 2030 at risk. This study aimed at elucidating the knowledge of, and attitude towards, hepatitis C treatment in a clinical sample of PWID.MethodsParticipants were recruited between February 2019 and October 2020 at two opioid agonist therapy (OAT) clinics and two in-patient drug detoxification wards. Based on the European Addiction Severity Index (Europ-ASI), a standardized interview focusing on: sociodemographic data, drug history, risky behavior, infection with hepatitis C virus (HCV) and HIV, and previous experience with HCV treatment was carried out. In addition, participants filled in a questionnaire evaluating 13 statements relating to HCV treatment (right/wrong) and 15 statements on their personal ‘pros and cons’ views to start such a treatment assessed with the means of a 6-point Likert scale.ResultsA total of 153 patients (average age 45 years, male 78%; 106 (69.3%) currently in opioid maintenance treatment, 47 (30.7%) currently admitted to an inpatient detoxification) with an opioid use disorder were investigated. All of them reported having injected drugs at least once in their lives; 97 participants (63.3%) stated that they had been previously diagnosed with HCV infection. Among them, 27/97 patients (27.8%) reported a previous treatment with interferon; 27/97 (27.8%) with DAAs; and 32/97 (33.0%) reported a currently active hepatitis C. Most patients knew about the availability and efficacy of DAAs. However, DAAs’ low rate of side effects, their short treatment duration, and their replacement of interferon, were not correctly evaluated by up to 50.3% of patients. 25–40% of 32 patients with currently active hepatitis C prioritized handling of social and other medical issues, e.g., reduction of heroin use, over treatment of hepatitis C.ConclusionsAlthough current levels of risky behavior have reportedly been reduced by active PWID over the past few years, educational and motivational interventions to increase hepatitis C treatment uptake should address the gaps in patients’ knowledge.

Peri-Tumoural Lipid Composition and Hypoxia for Early Immune Response to Neoadjuvant Chemotherapy in Breast Cancer.

The deregulation of monounsaturated, polyunsaturated, and saturated fatty acids (MUFAs, PUFAs, SFAs) from de novo synthesis and hypoxia are central metabolic features of breast tumour. Early response markers for neoadjuvant chemotherapy (NACT) are critical for stratified treatment for patients with breast cancer, and restoration of lipid metabolism and normoxia might precede observable structural change. In this study, we hypothesised that peri-tumoural lipid composition and hypoxia might be predictive and early response markers in patients with breast cancer undergoing NACT. Female patients with breast cancer were scanned on a 3T clinical MRI scanner at baseline and Cycle1, with acquisition of lipid composition maps of MUFAs, PUFAs, and SFAs, and hypoxia maps of effective transverse relaxation rate R2*. The percentage change in lipid composition and hypoxia at Cycle1 was calculated with reference to baseline. Tumour-associated macrophages were analysed based on immunostaining of CD163 from biopsy and resection, with the percentage change in the resected tumour calculated across the entire NACT. We found no significant difference in lipid composition and R2* between good and poor responders at baseline and Cycle1; however, the correlation between the percentage change in MUFAs and PUFAs against CD163 suggested the modulation in lipids with altered immune response might support the development of targeted therapies.

US Dollar Exchange Rate Elasticity of Gold Returns at Different Federal Fund Rate Zones

We examine the relationship between gold prices and the U.S. dollar exchange rate, arguing that their interactions are state-dependent and asymmetric under different market conditions. State dependency hinges on different short-term interest rate zones. To prove this point, we determine three distinct levels or zones of the effective federal funds rate using SETAR(2,p) tests. Subsequently, we perform conditional least square estimations of log changes in gold prices as a function of log changes in the nominal broad U.S. dollar exchange rate index for each of the obtained zones. Their relationship is consistently inverse, suggesting that gold and the U.S. dollar are risk-hedging substitutes for normal market periods. This also implies that gold is a safe-haven asset against the U.S. dollar exchange rate risk against a broad range of currencies. The substitution is weaker in the low-interest rate zone, more robust in the intermediate zone, and very pronounced in the high zone. We also perform a Markov switching test on the double-log function of gold prices and the exchange rate. The tests show a pronounced inverse relationship, i.e., substitution between assets, at normal market conditions. The relationship becomes significantly positive during episodes of financial distress, indicating complementarity between gold and U.S. dollar assets.

EVALUATING WASTEWATER TREATMENT EFFICIENCY OF MEDICAL CENTERS IN BINH DUONG PROVINCE

This paper presents a comprehensive analysis of the wastewater management system implemented at a medical center located within the Bau Bang Industrial Park in Binh Duong province, Vietnam. With a staff of 166 and 60 beds, the facility operates in accordance with TCVN 4470:2012 General Hospital design standards, serving a diverse range of water demands including domestic, medical, and auxiliary requirements. The wastewater management system is meticulously designed to handle both rainwater and wastewater separately. Rainwater is efficiently collected through surface and roof drainage networks, while domestic and medical wastewater undergo discrete collection processes. The medical center's wastewater treatment facility, operating at a capacity of 100 m³/day, employs a multistage treatment process to ensure compliance with stringent regulatory standards (QCVN 28:2010/BTNMT, column B, K = 1). This process includes preliminary treatment, anaerobic and aerobic biological treatment, membrane filtration, and disinfection. The facility consistently meets quality parameters outlined in QCVN 28:2010/BTNMT, exhibiting effective removal rates for organic pollutants, suspended solids, ammonia, phosphates, and pathogens. Furthermore, the medical center demonstrates commendable environmental stewardship through its stormwater drainage infrastructure, which integrates seamlessly with the local drainage network, safeguarding against environmental contamination. Overall, the wastewater management practices at the medical center exemplify best practices in environmental management within the healthcare sector. This study provides valuable insights into the design, implementation, and performance evaluation of wastewater treatment systems in industrial settings, contributing to the global discourse on sustainable wastewater management practices.

Characterization and differences of acoustic signals response of semi-circular red sandstone under combined monotonous and cyclic loadings

After underground coal mining, rocks are often subjected to tensile damage by the interaction of dynamic and static loadings. The process of rock fracture development under dynamic and static loadings will be released in the form of acoustic energy to form an acoustic signal. In addition, the acoustic signals in dynamic loading differ from that in static loading. Therefore, this study conducted three-point bending experiments with continuous dynamic loading and dynamic–static coupling loading on semi-circular red sandstone specimens. The acoustic signals during red sandstone specimens’ tensile damage were monitored in real-time. The results show that red sandstone’s tensile strength and deformation are enhanced under dynamic–static coupling loading. The red sandstone has a more effective acoustic emission hit rate, energy rate, and r during tensile damage under continuous dynamic loading. In dynamic loading, macroscopic fractures are developed in red sandstone, which has few acoustic emission events but releases strong acoustic signals. In static loading, the pores inside the red sandstone are compacted, the rock particles are rearranged, and the tiny fractures are closed, and its acoustic emission events are many but low in energy. In addition, the rock particles in the front area of the static loading fracture are tightly cemented, which increases the difficulty of separating the rock particles in the front area of the fracture under dynamic loading. Then weakening the red sandstone fracture development process and suppressing its acoustic signals. The research results provide more insight into the differences in tensile damage processes in red sandstone under the interaction of dynamic and static loadings.

Clinical Effectiveness of Dienogest in the Treatment of Endometriosis

Objective: This paper aims to investigate the efficacy of desogestrel in the treatment of endometriosis. Methods: In this study, 61 patients with endometriosis in our hospital from January 2023 to December 2023 were selected and divided using the random sampling method. All the patients were treated with desogestrel and the pain symptom scores and HDL-C (high-density lipoprotein cholesterol) levels of the patients were compared before and after the treatment. The treatment effects and adverse effects during the administration of the drug were closely observed. Results: After the patients were treated with desogestrel, the effective rate of treatment was as high as 98.36%, and the incidence of adverse reactions during treatment was 6.55%. Compared with the pre-treatment period, the scores of various pain symptoms were significantly reduced and the HDL-C level was improved after treatment, with P &lt; 0.05. Conclusion: Desogestrel showed significant efficacy in the treatment of endometriosis, effectively relieving patients’ pain while elevating HDL-C levels. In addition, the incidence of adverse reactions to this drug is relatively low, which is worth utilizing.

Clinical efficacy and computed tomography diagnostic value of bedaquiline‐containing regimens in the treatment of drug‐resistant pulmonary tuberculosis

AbstractObjectiveThis study investigated the clinical efficacy of bedaquiline‐containing regimens in the treatment of drug‐resistant pulmonary tuberculosis and the diagnostic value of computed tomography (CT).MethodsWe retrospectively analyzed the clinical diagnosis, treatment, and CT imaging data of patients with drug‐resistant pulmonary tuberculosis treated in Wenzhou Central Hospital from 1 January to 31 December 2022. According to whether the treatment regimen contained bedaquiline, the patients were divided into an observation group (bedaquiline tablets + background regimen) and a control group (background regimen). The clinical efficacy and pulmonary CT changes before and after treatment were analyzed in both groups.ResultsAfter 24 weeks of treatment, there was no statistically significant difference in the white blood cell count or concentrations of hemoglobin, alanine aminotransferase, serum albumin, or creatinine between the two groups (t = 0.71, 0.93, 0.05, 0.18, and 0.08, respectively; p &gt; 0.05). After 4, 8, and 12 weeks of treatment, there was no statistically significant difference in the sputum culture‐negative conversion rate between the two groups (χ2 = 2.67, 0.48, and 1.82, respectively; p &gt; 0.05). At 24 weeks of treatment, the sputum culture‐negative conversion rate in the observation group reached 100%, which was significantly higher than that in the control group (χ2 = 3.97, p &lt; 0.05). The effective absorption rates on chest imaging in the two groups of patients at 12 weeks were 83.33% and 57.89%, respectively. At 24 weeks of treatment, the effective absorption rates were 88.00% and 65.85% in the two groups, with a statistically significant difference (χ2 = 3.98; p &lt; 0.05). There were significant differences in cavity absorption at 24 weeks (χ2 = 4.33, p &lt; 0.05) and 48 weeks after treatment (χ2 = 10.63, p &lt; 0.05).ConclusionThe addition of bedaquiline to the background regimen improved the sputum culture‐negative conversion rate and chest imaging effective rate. Patients achieved good results at the end of the 24‐week treatment period.

Role of physical structure on performance index of crossflow microchannel heat exchanger with regression analysis

Microchannel heat exchangers have become the preferred choice in contemporary technologies like electronics, refrigeration, and thermal management systems. Their popularity stems from their compact design and exceptional efficiency, which outperform traditional heat exchangers (HE). Despite ongoing efforts, the optimal microchannels for enhancing heat management, minimizing pressure drop, and boosting overall performance have yet to be identified. This study seeks to deepen our understanding of heat transmission and fluid dynamics within a cross-flow microchannel heat exchanger (CFMCHE). Utilizing numerical modeling, it examines how various physical aspects—such as channel geometry, spacing between channels, the number of channels, and the velocity at the inlet—affect key performance indicators like pressure drop, effectiveness, Nusselt number, and overall efficiency. To enhance the design, we analyze six unique shapes of crossflow microchannel heat exchangers: circular, hexagonal, trapezoidal, square, triangular, and rectangular. We employ the Galerkin-developed weighted residual finite element method to numerically address the governing three-dimensional conjugate partial differential coupled equations. The numerical results for each shape are presented, focusing on the surface temperature, pressure drop, and temperature contours. Additionally, calculations include the efficacy, the heat transfer rate in relation to pumping power, and the overall performance index. The findings reveal that while circular shapes achieve the highest heat transfer rates, they underperform compared to square-shaped CFMCHEs. This underperformance is largely due to the increased pressure drop in circular channels, which also exhibit a 1.03% greater reduction in effectiveness rate than their square-shaped counterparts. Consequently, square-shaped channels, boasting a performance index growth rate of 53.57%, emerge as the most effective design among the six shapes evaluated. Additionally, for the square-shaped CFMCHE, we include residual error plots and present a multiple-variable linear regression equation that boasts a correlation coefficient of 0.8026.