Due to significant interaction dynamics and time delays in multivariable processes, designing a well-tuned PI controller is always challenging. When tuning multi-loop PI controllers, effective open-loop transfer function should be used instead of the diagonal transfer function element. The complexity of the effective open-loop transfer function (EOTF) increase rapidly for high-dimensional multivariable processes. Therefore, in this manuscript, it is proposed to use equivalent transfer functions (ETFs) under perfect control approximation. Subsequently, a dead-time compensation (DTC) scheme is used for ETFs and PI controllers are tuned. DTC can facilitate eliminating the impact due to time delay from the multivariable process, making the task of tuning PI controllers relatively less complex. The proposed multi-loop control topology minimizes the controller effort, and a good controller design for a multivariable process can be achieved. The PI controller parameters for dead-time compensated ETFs are calculated using simple IMC PI tuning rules, where the filter factor is taken based on the paired element relative gain value. To examine the effectiveness of the proposed controller tuning approach, the proposed control strategy was applied to a wide range of multivariable processes. Compared to state-of-the-art control strategies, the proposed control strategy provides superior closed-loop performance indices, even when there is a significant plant-model mismatch.
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