Human resource being the most vital parameter in success of any organization, needs to be addressed with due diligence. This paper provides some valuable insights in designing a performance management system inspired by systems in human body. Considering Human body organization analogous to corporate organization, some useful comparisons have been developed between the human cells and employees of an organization. A Management Action Grid is proposed which suggests possible actions to the manager for effectively handling employee performance. An attempt has been made to suggest some ways of handling non performing employees based on learning’s derived from cell suicide mechanism in human body. In this paper, based on various learning’s derived from Human Body, Employee Management System like Voluntary Retirement Services (VRS) has also been validated. Perhaps these biological observations can help managers to design an effective performance management system.