Modeling of hive buildings with the architectonics of cells close to the natural sample against the background of stimulating additives can become an effective biological and technological lever not only in increasing the productivity of bee families, but also in rearing complete offspring in bee generations. This is especially relevant in association to the reproduction of the spring generation of honey bees. A characteristic feature of this period is that bee colonies should show high nesting activity and increase their strength. At the same time, the amino acids of honey bees play an important role in the detoxification of poisons, which is especially characteristic of histidine. The importance of tyrosine in the metabolism of honey bees as a class of insects is difficult to overestimate, because its derivatives play the important role not only in the formation of the exoskeleton of insects, but also in the creation of body color, they are also part of protective secretions and probably serve as chemical mediators of the nervous system. It has been proved that the spring-summer development of bee families was most active after wintering against the background of stimulating additives with inverted sugar syrup with the addition of cobalt chloride or drug Apinik, or in combination with 10 % bee bread and the construction of new-generation wax honeycombs, which compared with the control group, ensured the achievement of the maximum parameters of the growth indices of strength and construction activity for the construction of honeycombs – in 3,0, 4,26, 4,52 and in 0,86, 1,0 and 1,0 (in the control group – 2,61 and 0,57) and increased the live weight of bee individuals of the summer generation by 4,18, 4,6 and 4,7 %. It has been found that minerals, essential amino acids of the drug Apinik, associated with str. Fasium microorganisms, and 10 % bee bread as part of stimulating additives top dressing against the background of the renewal of new-generation wax combs before the main honey collection, increase the volume of hemolymph in inactive worker bees by 6,76–7,63 %, the degree of development of the fat body by 10,0 %, and in nectar-collecting bees by 6,75–8,16 % and 5,56–7,88 %, respectively. At the same time, the increase in the level of the amino acids histidine and tyrosine was recorded in inactive worker bees by 0,76–1,56 % and by 16,56–17,72 %, in nectar-collecting bees by 2,53–3,19 % and 28,68–30,08 %, respectively. This indicates the receipt of the complete generation of working bees of the summer generation, which will actively work on the main honey collection, providing economically useful traits of bee families.