Effective Interventions Research Articles

Unravelling Migraine Stigma: A Comprehensive Review of Its Impact and Strategies for Change.

Migraine-related stigma is a pervasive issue impacting nearly half of chronic migraine patients, with significant consequences for their quality of life, disability and mental health. Despite its profound effects, migraine stigma remains under-recognised in both clinical practice and research. This narrative review explores the three primary types of stigmas affecting migraine patients: public, structural and internalised. Public stigma involves negative societal attitudes and stereotypes that trivialise the condition. Structural stigma is reflected in policies that restrict access to necessary care and resources. Internalised stigma occurs when patients absorb these negative views, leading to self-blame and diminished self-worth. Addressing these different types of stigmas is crucial for improving the understanding, diagnosis and treatment of migraine. Educational efforts, advocacy and policy reform are essential strategies in this context. A deep understanding of stigma is vital for developing effective interventions that enhance clinical management and patient quality of life. Ultimately, reducing stigma can lead to better health outcomes and a more comprehensive approach to migraine care.

Systematic review of adherence to technology-based falls prevention programs for community-dwelling older adults: Reimagining future interventions.

Prevention programs, and specifically exercise, can reduce falls among community-dwelling older adults, but low adherence limits the benefits of effective interventions. Technology may overcome some barriers to improve uptake and engagement in prevention programs, although less is known on adherence for providing them via this delivery mode. We aimed to synthesize evidence for adherence to technology-based falls prevention programs in community-dwelling older adults 60 years and older. We conducted a systematic review following standard guidelines to identify randomized controlled trials for remote delivered (i.e., no or limited in-person sessions) technology-based falls prevention programs for community-dwelling older adults. We searched nine sources using Medical Subject Headings (MeSH) terms and keywords (2007-present). The initial search was conducted in June 2023 and updated in December 2023. We also conducted a forward and backward citation search of included studies. Two reviewers independently conducted screening and study assessment; one author extracted data and a second author confirmed findings. We conducted a random effects meta-analysis for adherence, operationalized as participants' completion of program components, and aimed to conduct meta-regressions to examine factors related to program adherence and the association between adherence and functional mobility. We included 11 studies with 569 intervention participants (average mean age 74.5 years). Studies used a variety of technology, such as apps, exergames, or virtual synchronous classes. Risk of bias was low for eight studies. Five interventions automatically collected data for monitoring and completion of exercise sessions, two studies collected participants' online attendance, and four studies used self-reported diaries or attendance sheets. Studies included some behavior change techniques or strategies alongside the technology. There was substantial variability in the way adherence data were reported. The mean (range) percent of participants who did not complete planned sessions (i.e., dropped out or lost to follow-up) was 14% (0-32%). The pooled estimate of the proportion of participants who were adherent to a technology-based falls prevention program was 0.82 (95% CI 0.68, 0.93) for studies that reported the mean number of completed exercise sessions. Many studies needed to provide access to the internet, training, and/or resources (e.g., tablets) to support participants to take part in the intervention. We were unable to conduct the meta-regression for adherence and functional mobility due to an insufficient number of studies. There were no serious adverse events for studies reporting this information (n = 8). The use of technology may confer some benefits for program delivery and data collection. But better reporting of adherence data is needed, as well as routine integration and measurement of training and skill development to use technology, and behavior change strategies within interventions. There may be an opportunity to rethink or reimagine how technology can be used to support people's adoption and integration of physical activity into daily life routines.

Solid waste management awareness and practices in coastal communities

Effective solid waste management (SWM) is paramount for environmental sustainability and public health, particularly in coastal communities. This cross-sectional descriptive study determines SWM awareness and practices among 399 households in selected coastal barangays in the City of Mati, Davao Oriental, Philippines. Employing a structured four-point Likert-type survey through KoboCollect applications, this study evaluates SWM awareness and practices while examining the impact of socio-demographic factors on these aspects. The results reveal moderate SWM awareness (X̄=2.55) and practices (X̄=2.66) in these coastal communities, indicating a baseline level of environmental consciousness and waste management efforts. However, there was lack of familiarity with legal and regulatory frameworks (X̄=1.97), including the Republic Act 9003 and local ordinances related to SWM. Notable gaps are also identified in SWM practices, mainly in waste segregation (X̄ = 2.55) and avoidance to waste-burning (X̄=2.56). Socio-demographic factors, such as age, educational attainment, household size, and family income, significantly influence SWM awareness and practices. These findings underscore the need for targeted educational campaigns and community engagement strategies to enhance awareness of SWM regulations. Addressing these gaps is necessary for developing effective interventions to promote sustainable waste management practices in these coastal areas, thus protecting marine ecosystems and supporting the well-being of local communities.

Beyond Borders: The Accelerating Momentum of Domestic Violence Research Worldwide

This paper covers publication trends, co-author networks, and research keyword co-occurrences on academic research related to domestic violence between 2000 and 2023. Throughout these years, first, the number of published articles dealing with this topic was very limited, from just four articles in the year 2000 to 37 in 2013. Still, after an imposing surge in publications registered after 2013, particularly between 2020 and 2023, the numbers increased from 217 to 653, establishing a significantly increased impact on the reviewed issue at a global level. This network identifies some central figures in the research community, such as Gene Feder, Louise M. Howard, and Nicky Stanley among others. It underlines the existence of collaboration clusters around issues such as gender, domestic violence, mental health, and social work, hence emphasizing the very essence of interdisciplinary research. Through keyword co-occurrence analysis, the word cloud shows some central themes to include intimate partner violence and the effect of COVID-19 on different population focuses, including strong qualitative research methods. The second word cloud, that of author affiliation, demonstrates the concentration of research output by leading institutions, with a high volume emanating from the UK, but also global collaboration - significant contributions from universities in Australia being one of them. Domestic violence is a complicated issue that affects individuals and communities of all ages, genders, sexual orientations, educational backgrounds, and more. These terminological complications in defining domestic violence can result in confusion during the practice of identification, assessment, and intervention. This study follows a holistic approach to bibliometrics in reviewing scholarly literature on domestic violence by drawing on data from Lens.org along with the visualization tools of VOSviewer. Improvement in understanding the domestic violence research landscape, major contributors, collaboration patterns, and the gap in research is what this study attempts to address. A total of 92,443 documents in their study were filtered to 2,362 scholarly works that included research articles published from 1999 up to 2023. The findings indicate the important factors of institutions and countries, the necessity of interdisciplinary-wise collaboration, and emerging hotspots of research. A bibliometric approach emphasizes that for effective intervention and prevention, there is a need for systematic reviews and synthesis of the available literature to provide informed evidence-based policy and practice in the context of domestic violence.

Next-Generation Therapeutic Antibodies for Cancer Treatment: Advancements, Applications, and Challenges.

The field of cancer treatment has evolved significantly over the last decade with the emergence of next-generation therapeutic antibodies. Conventional treatments like chemotherapy pose significant challenges, including adverse side effects. Monoclonal antibodies have paved the way for more targeted and effective interventions. The evolution from chimeric to humanized and fully human antibodies has led to a reduction in immunogenicity and enhanced tolerance in vivo. The advent of next-generation antibodies, including bispecific antibodies, nanobodies, antibody-drug conjugates, glyco-engineered antibodies, and antibody fragments, represents a leap forward in cancer therapy. These innovations offer increased potency, adaptability, and reduced drug resistance. Challenges such as target validation, immunogenicity, and high production costs exist. However, technological advancements in antibody engineering techniques provide optimism for addressing these issues. The future promises a paradigm shift, where ongoing research will propel these powerful antibodies to the forefront, revolutionizing the fight against cancer and creating new preventive and curative treatments. This review provides an overview of three next-generation antibody-based molecules, namely bispecific antibodies, antibody-drug conjugates, and nanobodies that have shown promising results in cancer treatment. It discusses the evolution of antibodies from conventional forms to next-generation molecules, along with their applications in cancer treatment, production methods, and associated challenges. The review aims to offer researchers insights into the evolving landscape of next-generation antibody-based cancer therapeutics and their potential to revolutionize treatment strategies.

Emotion recognition using machine learning: Opportunities and challenges for supporting those with autism or depression

Facial recognition technology, driven by advancements in machine learning, has become integral to various applications, from mobile security to access control. Recent developments in deep learning, particularly through convolutional and recurrent neural networks, have paved the way for enhanced emotion recognition capabilities. This paper explores the potential of facial emotion recognition (FER) and voice emotion recognition technologies, assessing their current state and future prospects. While FER techniques have evolved from traditional methods to deep learning approaches, and voice emotion recognition has shown promising results, challenges remain due to the inherent variability in human facial expressions and vocal characteristics. The paper further examines the impact of emotion recognition technologies on mental health, highlighting their potential to provide significant support to individuals with mental health disorders. By addressing the accuracy and application of these technologies, the research underscores the importance of continued innovation and careful implementation to maximize their benefits and mitigate potential risks. Ultimately, emotion recognition provides promising avenues for supporting those with mental illnesses. Aimed at fostering more personalized and effective interventions, these technologies hold the potential to revolutionize mental health care and improve the overall well-being of individuals.

Neurobiology and medico-legal aspects of suicides among older adults: a narrative review.

The task of preventing suicide in older adults is an important social burden as older adults aged above 65 are exposed to singular psychological aspects that increase suicide risks. Moreover, when an older adult corpse is found, the medico-legal inspection represents a fundamental tool to identify the exact cause of death, classifying or excluding it as suicide. In this scenario, this review aims to explore the neurobiological factors that could be related to suicidal behavior in older adults. A further goal of this review is the exploration of the medico-legal aspects surrounding older adult suicides, clarifying the importance of forensic investigation. Particularly, this review examines issues such as neurotransmitter imbalances, cognitive impairment, neuroinflammation, psychosocial factors related to geriatric suicide, and neurodegenerative diseases. Additionally, medico-legal aspects such as policy considerations, legal frameworks, mental health assessments, ethical implications and forensic investigation were explored. Considering the importance of this phenomenon, especially in western countries, a need has emerged for focused screening tools on suicidal behavior among older adults, in order to contain it. Therefore, this review makes an exhaustive appraisal of the literature giving insights into the delicate interplay between neurobiology as well as mental health in relation to older adult suicide within a medico-legal context. The comprehension of different aspects about this complex phenomenon is fundamental to propose new and more effective interventions, supporting tailored initiatives such as family support and improving healthcare, specifically towards vulnerable ageing societies to reduce older adult suicide risks.

Beyond Pharmacotherapy: Investigating the Role of Classical Music in Preoperative Anxiety Management for Cesarean Sections

Preoperative anxiety is a prevalent concern among women undergoing cesarean sections (C-sections), potentially impacting maternal and neonatal outcomes. While pharmacotherapy is commonly used to manage anxiety, non-pharmacological interventions like music therapy offer a promising alternative or adjunct. This study aimed to investigate the efficacy of classical music in reducing preoperative anxiety levels in women scheduled for C-sections. A randomized controlled trial was conducted involving 100 women scheduled for elective C-sections. Participants were randomly assigned to either the intervention group (classical music listening) or the control group (standard care). Anxiety levels were assessed using the State-Trait Anxiety Inventory (STAI) before and after the intervention. Physiological parameters such as heart rate and blood pressure were also monitored. The intervention group demonstrated a significant reduction in both state and trait anxiety scores compared to the control group (p < 0.05). Additionally, the intervention group exhibited lower heart rate and blood pressure levels post-intervention. In conclusion, classical music listening can be an effective non-pharmacological intervention for reducing preoperative anxiety in women undergoing C-sections. The findings suggest that integrating music therapy into standard preoperative care may enhance patient well-being and contribute to improved surgical outcomes.

Exploring COVID-19 anxiety across demographics: psychometric validation and application of the COVID-19-Anxiety Questionnaire in Arabic

BackgroundThe emergence of the COVID-19 pandemic in 2019 imposed significant shifts in global health, particularly in understanding and addressing anxiety disorders precipitated by pandemic-related stressors. The current study aimed to adapt and validate the COVID-19 Anxiety Questionnaire (C-19 A) for Arabic-speaking populations (C-19 A-A), assessing its structural integrity, concurrent validity, factorial validity, and reliability.MethodsThe data of 571 individuals, including age range, educational history, gender, and marital status, were collected through online platforms. The translation process of C-19 A-A underwent rigorous verification by linguistic and subject matter experts. Several advanced statistical procedures were used to examine the C-19 A-A’s reliability, validity, and measurement invariances across demographic subsets.ResultsThe results indicated robust internal consistency, with a Cronbach’s alpha coefficient of 0.889, confirming the questionnaire’s reliability. Concurrent validity showed significant and positive correlations between C-19-A and FCV-19S (r = 0.77, p < 0.000). EFA revealed a dominant factor explaining 60.4% of the variance, bolstering the questionnaire’s factorial validity. CFA further validated the model’s adequacy across different demographic groups. Specifically, demographic factors such as age, gender, and educational level showed distinct patterns of COVID-19-related anxiety.ConclusionThe validated Arabic version of the C-19 A-A represents a pivotal tool for assessing pandemic-induced anxiety within Arabic-speaking communities. Its deployment enables targeted identification of vulnerable individuals, facilitating tailored health interventions and informing clinical strategies. This research underscores the pivotal role of culturally attuned assessment instruments in shaping effective public health responses and therapeutic interventions aimed at mitigating the psychological sequelae of global health crises.

Management of cubitus varus deformity by three-dimensional osteotomy: analysis of outcome

Background: Cubitus varus deformity, commonly resulting from malunited supracondylar fractures of the humerus, is prevalent in pediatric and adolescent populations. Traditional treatment methods often fall short in addressing the complex three-dimensional nature of this deformity. This study aims to evaluate the efficacy and outcomes of three-dimensional osteotomy in correcting cubitus varus deformity. Methods: This prospective interventional study was conducted at the Department of Orthopaedic Surgery, BSMMU, Shahbag, Dhaka, from March 2016 to September 2018. A total of 40 patients aged 8 to 20 years with cubitus varus deformity were enrolled. Participants underwent three-dimensional osteotomy, and outcomes were assessed using the Mayo Elbow Performance Score (MEPS) and functional recovery parameters. Results: The majority of patients (75%) achieved bone union within 8-10 weeks post-osteotomy. The MEPS results were promising, with 40% of patients scoring 'Excellent' and 45% scoring 'Good'. Functional outcomes were predominantly positive, with 95% of patients reporting satisfactory results. The complication rate was low, with 80% of patients experiencing no postoperative complications. Conclusions: Three-dimensional osteotomy is an effective and reliable surgical intervention for treating cubitus varus deformity, offering high rates of patient satisfaction, minimal complications, and improved functional outcomes. This technique presents a promising option for orthopedic surgeons in managing this complex deformity.

Impact of Climate Change on Human Lactation: Biological, Socioeconomic, and Public Health Implications

Global climate change poses significant challenges to human health and nutrition, particularly affecting lactating individuals and their infants. This review examines the impact of climate change on lactation, focusing on physiological, socioeconomic, and public health implications. Rising temperatures and heat stress can reduce milk production and alter milk composition, while malnutrition and water scarcity exacerbate these effects. Vulnerable populations face heightened risks, emphasizing the need for targeted mitigation strategies. Recommendations include enhancing nutritional support, securing water supplies, reducing environmental toxin exposure, and integrating lactation considerations into climate policies. Employing a social-ecological lens, this review underscores the necessity of a holistic approach to support lactating individuals in a warming world. Future research should explore the complex interactions between climate stressors and lactation to develop effective public health interventions.

Whole-Genome Sequencing Reveals Temporal Trends in Antibiotic Resistance Genes in Escherichia coli Causing Pediatric Urinary Tract Infections in Central Vietnam

(1) Background: Pediatric urinary tract infections (UTIs) pose significant challenges due to drug-resistant Escherichia coli (E. coli) strains. This study utilizes whole-genome sequencing to analyze temporal trends in antibiotic resistance genes (ARGs) in clinical E. coli isolates from pediatric UTI cases in central Vietnam. (2) Methods: We conducted whole-genome sequencing on 71 E. coli isolates collected from pediatric UTI patients between 2018 and 2020. ARGs were identified, and their prevalence over time was analyzed. Statistical tests were used to correlate ARG presence with antibiotic resistance. (3) Results: Of the 47 E. coli isolates with complete data, 40 distinct ARGs were identified, with a median of 10 resistance genes per isolate. A significant increase in the total number of ARGs per isolate was observed over time, from an average of 8.88 before June 2019 to 11.63 after. Notably, the prevalence of the aadA2 gene (aminoglycoside resistance) rose from 0% to 26.7%, and that of the blaNDM-5 gene (beta-lactam and carbapenem resistance) increased from 0% to 23.3%. Key correlations include blaEC with cephalosporin resistance, blaNDM-5 with carbapenem resistance, and sul2 with sulfamethoxazole/trimethoprim resistance. (4) Conclusions: Whole-genome sequencing reveals complex and evolving antibiotic resistance patterns in pediatric E. coli UTIs in central Vietnam, with a marked increase in ARG prevalence over time. Continuous surveillance and targeted treatments are essential to address these trends. Understanding genetic foundations is crucial for effective intervention strategies.

Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms

Stress profoundly affects physical and mental health, particularly when experienced early in life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse, neglect, violence, or chronic poverty. These stressors can induce long-lasting changes in brain structure and function, impacting areas involved in emotion regulation, cognition, and stress response. Consequently, individuals exposed to high levels of ELS are at an increased risk for mental health disorders like depression, anxiety, and post-traumatic stress disorders, as well as physical health issues, including metabolic disorders, cardiovascular disease, and cancer. This review explores the biological and psychological consequences of early-life adversity paradigms in rodents, such as maternal separation or deprivation and limited bedding or nesting. The study of these experimental models have revealed that the organism’s response to ELS is complex, involving genetic and epigenetic mechanisms, and is associated with the dysregulation of physiological systems like the nervous, neuroendocrine, and immune systems, in a sex-dependent fashion. Understanding the impact of ELS is crucial for developing effective interventions and preventive strategies in humans exposed to stressful or traumatic experiences in childhood.

Knowledge and Perceptions on Child Sexual Abuse: A Comparative Study Between Children and Parents in Morogoro Municipality, Tanzania

Owing to the increasing violence against children's rights, particularly in the cases of child sexual abuse (CSA), this study aimed at assessing the knowledge and perception of children and parents in Morogoro municipality. The Urie Bronfenbrenner Ecological system theory was used to guide the study. Semi-structured questionnaires were administered to one hundred eighty-eight (188) research subjects, through face-to-face interviews. The findings from this study indicate that 114 (74.5%) of the 153 children interviewed had heard about CSA compared to 32 (91.4%) of the 35 parents who had heard about CSA. The knowledge about CSA, was significantly higher among parents compared to children (p=0.0302). The interviewed children reported having known CSA through hearing at school (36.6%), hearing from neighbours (24.8) and experiencing cases of CSA at home (13.1%). Further, parents noted that radio and Television were dependable source of information on CSA. On the other hand, children reported to rely mainly on information received at schools and sometimes from neighbours. It was further observed that mothers played more significant role of passing knowledge to their children about CSA than fathers, the observation which was also statistically significant (p=0.0101). Most parents considered forced sexual intercourse (97.1%) with perpetrators and anal penetration (82.9%) to be the most evidence of CSA in children. The study has found that parents believe more in teachers and community members to play a key role in ending CSA than themselves. It is therefore recommended to conduct more in-depth analysis to identify key factors contributing to the prevalence of CSA in Morogoro municipality which would help to devise appropriate and effective intervention strategies to end CSA

Long-Term Impact of Community Psychiatric Care on Quality of Life amongst People Living with Schizophrenia: A Systematic Review.

The review examines the long-term impact of community psychiatric care on improving the quality of life of people with schizophrenia. It addresses the global burden of this disorder and the need for effective community-based care strategies. A systematic literature search was conducted in databases such as CINAHL, Medline, Web of Science, Sage and ScienceDirect, with the search lasting until March 2024 and following the PRISMA guidelines. The inclusion criteria targeted studies that addressed the long-term effects of community mental health care for people aged 18 years and older with schizophrenia and included both quantitative and qualitative research designs. Studies unrelated to the research question or with significant methodological flaws were excluded. The risk of bias was assessed using GRADE and GRADECERqual, in addition to critical appraisal using the Joanna Briggs Institute (JBI) checklists. Independent screening and data extraction was performed, with results summarised by thematic analysis. In total, 11 studies met the inclusion criteria and included cross-sectional, cohort, qualitative and randomised controlled trial designs. The results showed that community psychiatric care significantly improves the quality of life, well-being and social integration of people with schizophrenia. Effective interventions identified include psychoeducation, cognitive behavioural therapy, social skills training and individualised care plans. However, challenges such as limited resources, labour shortages and social stigma, particularly in low-income neighbourhoods, were also identified. This study highlights the importance of continuous, personalised, multidisciplinary community-based care for sustainable mental health outcomes. Further research is recommended to investigate the long-term impact and strategies to overcome implementation challenges.

The Best Practices for Designing Built Environments to Promote Healthy Food Access and Dietary Behaviors in Low-Income and Underserved Communities

Background: The built environment can influence health outcomes, including access to good dietary options. Aims: The current study intends to thoroughly evaluate the literature on best practices for building environments that promote healthy food access and nutritional behaviors in low-income and underserved communities in Indonesia. Method: To discover relevant studies on this topic, a thorough literature review was done using databases from PubMed, Web of Science, and Scopus extracting. Result: The final analysis included 32 studies after removing duplicates and applying inclusion and exclusion criteria. Extracting and assessing data from the chosen research and thematic synthesis was applied. The data was extracted and processed into a detailed narrative that provided an overview of the best practices. Conclusion: According to the findings of the literature study, built environment design can have a considerable impact on healthy food availability and eating patterns in Indonesian communities. It might be possible to develop effective interventions that enhance health outcomes for all Indonesians by addressing these gaps in the evidence.

Fine Particulate Matter and Osteoporosis: Evidence, Mechanisms, and Emerging Perspectives.

Air pollution, particularly fine particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5), has been recognized for its adverse effects on multiple organs beyond the lungs. Among these, the bone began to garner significant attention. This review covers epidemiological, animal and cell studies on PM2.5 exposure and bone health as well as studies on PM2.5-induced diseases with skeletal complications. Emerging evidence from epidemiological studies indicates a positive association between PM2.5 exposure and the incidence of osteoporosis and fractures, along with a negative association with bone mineral density. Experimental studies have demonstrated that PM2.5 can disrupt the metabolic balance between osteoclasts and osteoblasts through inflammatory responses, oxidative stress, and endocrine disruption, thereby triggering bone loss and osteoporosis. Additionally, this review proposes a secondary mechanism by which PM2.5 may impair bone homeostasis via pathological alterations in other organs, offering new perspectives on the complex interactions between environmental pollutants and bone health. In conclusion, this contemporary review underscores the often-overlooked risk factors of PM2.5 in terms of its adverse effects on bone and elucidates the mechanisms of both primary and secondary toxicity. Further attention should be given to exploring the molecular mechanisms of PM2.5-induced bone impairment and developing effective intervention strategies. With global climate change, increasing ozone pollution, emerging pollutants, and multifactorial exposure to environmental factors, these issues are likely to become of greater concern in the near future.

Assessment of drug-drug interactions among patients with hematologic malignancy: A clinical pharmacist-led study.

Patients with hematologic malignancies often receive multiple medications, leading to potential drug-drug interactions (DDIs). Identifying and managing these DDIs is crucial for ensuring patient safety and effective care. This study aimed to identify and describe DDIs and associated factors in hematologic malignancy patients. This prospective interventional study was conducted at a referral center and included hospitalized patients with hematologic malignancies who were receiving at least four concurrent medications. A pharmacist initially compiled a comprehensive list of all medications through patient interviews and medication reviews, and subsequently, identified and categorized potential DDIs using the Lexi-interact® and Micromedex® databases. The clinical pharmacist then evaluated the clinical impact of the identified DDIs in every individual patient and provided appropriate interventions to resolve them. A total of 200 patients met the inclusion criteria for the study, with 1281 DDIs identified across 337 distinct types. The majority of identified DDIs exhibited major severity (52.1%) and pharmacokinetic mechanisms (50.3%), with an unspecified onset (79.4%) and fair evidence (67%). Of the identified DDIs, 81.1% were considered clinically significant, prompting 1059 pharmacotherapy interventions by the clinical pharmacist. Additionally, a significant relationship was observed between the number of drugs used during hospitalization and the occurrence of DDIs (P < 0.001, r = 0.633). DDIs are highly prevalent among hospitalized patients with hematologic malignancies, with their occurrence increasing alongside the number of medications administrated. The intervention of a clinical pharmacist is crucial to evaluate the clinical impact of these DDIs and implement effective interventions for their management.

Foliar applications of phenylalanine and prohexadione calcium for managing tannin content in cold-hardy hybrid grape cultivars

Cold-hardy hybrid grape cultivars have low tannin content compared to Vitis vinifera cultivars, which leads to unbalanced red wines and therefore low-quality wines. Viticultural practices, such as nitrogen fertilisation and the use of plant growth regulators, have shown to be effective interventions to modify tannin content in V. vinifera cultivars and may be effective with cold-hardy hybrids. Foliar applications of phenylalanine (Phe, 100 mg/L) and prohexadione calcium (ProCa, 50 mg/L) were applied separately and in combination (ProCa+Phe) to Marquette grapevines grown in Iowa, USA in 2022 and 2023. Treatments were assigned following a split-plot design. Berry weight, diameter, seeds per berry, tannin content, and iron-reactive phenolics content of skins and seeds were analysed at five phenological time points. Samples from treated vines were compared to untreated control samples using a random-intercepts linear regression model. Overall, the effect of year was more impactful than the individual effects of treatments due to differences in temperature and rainfall during berry development. However, skin and seed tannin and IRP were significantly affected by the Year2023:ProCa interaction at 3 weeks post fruit set and véraison, respectively, suggesting ProCa treatment may be more effective with multiple applications in consecutive years. Low application rate may be a reason for limited treatment effectiveness and further work on dose response may demonstrate foliar sprays of Phe and ProCa to be effective tools at managing phenolics content in Marquette grapes.

Foreign Aid, Economic Growth, and Poverty Reduction in Bolivia

ABSTRACT: Foreign aid has been a critical instrument in addressing economic development and poverty reduction in many low-income countries. This article investigates the relationship between foreign aid, economic growth, and poverty reduction in Bolivia, shedding light on how various factors, including institutional quality, human capital, economic freedom, and the level of democracy influence the effectiveness of foreign aid. Employing smooth transition autoregressive models, the analysis highlights the intricate interplay between foreign aid, economic growth, and poverty reduction. The empirical findings provide evidence that foreign aid exerts a positive influence on both economic growth and poverty reduction, especially when aligned with investments in human capital and the enhancement of economic freedom. However, the revelations brought forth by this study challenge the conventional wisdom, revealing that these relationships are not linear. In emphasizing the nuanced nature of aid’s impact on economic development and poverty reduction, this study contributes significantly to the ongoing discourse on foreign aid efficacy. It underscores the importance of tailoring aid interventions to the specific contextual intricacies of the recipient country. The interplay between foreign aid, institutional quality, human capital, economic freedom, and democratic governance makes clear that a tailored, context-specific approach is needed for foreign aid to have the best possible impact. If the case of Bolivia serves as a useful example for other developing nations, the principal recommendation emanating from these findings is that foreign aid must be carefully tailored to the unique needs and challenges of the recipient nation. A one-size-fits-all approach is insufficient in harnessing aid’s full potential to foster sustainable economic growth and meaningful poverty reduction. The findings presented here serve not only as a contribution to the academic literature but also as a roadmap for policymakers and development practitioners navigating the complex terrain of foreign aid. By emphasizing the intricate dynamics of foreign aid and other important institutional, economic, and human capital factors, the empirical findings in this article advance the understanding of foreign aid’s role as a catalyst for transformative change and set the stage for more targeted, effective interventions in the pursuit of economic development and poverty eradication.