Effective Competitor Research Articles

Geopolitics and International Trade Infrastructure

We develop a simple (incumbent versus entrant) strategic deterrence model to study the economic and geopolitical interactions underlying international trade-related infrastructure projects such as the Panama Canal. We study the incentives for global geopolitical players to support allied satellite countries where these projects are or could potentially be built. We show that even if no effective competitor emerges, the appearance of a geopolitical challenger capable of credibly supporting the entrant has a pro-competition economic effect which benefits consumers all over the world. Institutional subscribers to the NBER working paper series, and residents of developing countries may download this paper without additional charge at www.nber.org.

Anthropogenic disturbance may promote the invasion of forest landscape by an open-habitat specialist introduced dung beetle species in Brazil

Digitonthophagus gazella, a dung beetle species introduced into many countries as a biological control agent for cattle dung removal, is adapted to open pastures and avoid shaded areas such as forests. With a short development period, high fecundity, and long dispersion capability, D. gazella is an effective competitor that is considered an invasive species in many countries. Until recently, only one study evaluated its possible presence in a small forest area, suggesting an invasion process might be occurring. We report here the presence of D. gazella in five distinct forest landscapes (FLs): a regenerating native forest, a reforested native forest, and three forests with exotic plant species. The FLs are embedded in an area with several other FLs, which is surrounded by a river and a pasture. However, cattle have access to these FLs. We found that the anthropogenic disturbances may be facilitating the species dispersal to shaded habitats as there was a higher abundance of D. gazella in areas where cattle were more active. The possibility of this species in invading FLs is worrisome because it has been shown that D. gazella can cause significant negative impacts to the native dung beetle community, which is of great ecological importance for the ecosystem.

The diet of osprey Pandion haliaetus on Marawah Island (Abu Dhabi Emirate, United Arab Emirates) and its implications for the study of archaeological assemblages

The Osprey Pandion haliaetus is one of the most widely distributed raptor species in the world, present on all continents except Antarctica. Since its diet is mainly based on fish, this raptor is typically encountered close both to marine and fresh waters. Ospreys are well represented in the Arabian Peninsula where remote islands are the location for some of their key breeding sites. On Marawah Island (Emirate of Abu Dhabi, United Arab Emirates), ospreys have been reported to build nests on top of abandoned man-made structures, including archaeological sites. The discovery of fish remains associated with numerous bird bones and eggshell fragments in archaeological deposits raises the question of the potential contamination of ancient faunal accumulations by birds of prey. To date, the possible impact of ospreys on zooarchaeological assemblages has been little considered and the taphonomic signature of this fish-eating raptor has never been described. However, ospreys are effective competitors to traditional and small-scale fisheries and should be considered as potential accumulators of fish remains on archaeological sites located close to water bodies. Indeed, zooarchaeological analyses demonstrate that fish had always played a major role in the daily subsistence of the ancient inhabitants of Marawah Island since the first traces of occupation dating back some 8000 years. The present study will enable researchers working in the region as well as in other geographical area to determine if ospreys are accumulation agents for fish remains on archaeological sites.The present diet assessment of ospreys allows us to specify the taphonomic signature of this raptor: targeted species are mainly medium to large-sized fish swimming just beneath the surface (e.g. needlefish and queenfish) and slow benthic fish occurring in shallow waters such as tripodfish, emperors, and groupers. Bone accumulations are almost entirely composed of skull elements, indicating specific discarding behaviours. Certain traces left on jaw bones, in particular maxillae, can also help to differentiate osprey accumulations from archaeological ones.

How to Get the Most from Your Host: Risks and Rewards of Intellectual Property Terms in Governmental Prize Competitions

Prize competitions, or innovation tournaments, incentivize the participation of various perspectives with the possibility of winning a prize from the host. The host invites external participation but retains control over the competition to balance its liability risks and intellectual property rewards. In theory, these competitions are high-risk, high-reward. Therefore, both an effective host and competitor should account for the risks and rewards inherent in the contract terms and the structure of the competition. Whether intentionally or inadvertently, hosts employ one of four values: persuasive, possessive, prudent, or passive. The host’s approach to acquiring intellectual property rights through the competition and its defenses to protect itself from liability determine its distinct legal strategy in prize competitions. Accordingly, hosts structure their competitions to reflect their views while using intellectual property rights as a motivator. For example, the values and constraints of passive governmental hosts, as opposed to persuasive private hosts, enable the competitor to benefit by retaining more of its rights. Therefore, competitors should identify the host’s motivations and know about their intellectual property rights in jeopardy throughout the competition to compete effectively. Governmental competitions may offer lower-reward opportunities than private competitions, but the competition structure and terms of governmental competitions provide competitors with lower-risk opportunities enabling a broad competitor market to compete effectively. Thus, public-sector prize competitions are likely more advantageous to risk-averse competitors, whereas risk-taking competitors with more capital may take on the higher-risk and higher-reward private sector prize competitions.

Response surface optimization of prodigiosin production by phthalate degrading Achromobacter denitrificans SP1 and exploring its antibacterial activity

The role of various parameters like temperature, pH, blood bag concentration, agitation and incubation that influence the production of prodigiosin by Achromobacter denitrificans SP1 was determined. The Plackett–Burman and Box–Behnken experimental designs were employed to statistically optimize and find out the best combinational effect of parameters for the better yield of prodigiosin using blood bag as sole carbon and energy source for the growth of A. denitrificans SP1. The maximum (1.314 mg/ml) prodigiosin production was attained at a temperature of 24 °C, pH (8.8), and blood bag (1 g) as optimum; while the predicted value was 1.319 mg/ml with a correlation coefficient of 0.987; which signifies the fitness of the model. Antimicrobial activity of the prodigiosin was also evaluated and found to be an effective agent against bacterial pathogens including Staphylococcus aureus and Proteus mirabilis. Utilization of the plasticizer di (2-ethylhexyl)phthalate (DEHP) in blood bag and the production of antibacterial prodigiosin makes A. denitrificans SP1, an effective competitor toward the pathogenic bacterial disinfection and wastewater treatment processes.

Effects of Fairness and Relationship Quality on Relational Behavior

To be an effective global competitor requires to be a trusted cooperator in some network. This argument defines the essence of marketing channel partnerships. Relational behaviors have a conclusive effect in the success of marketing initiatives; hence, they are amongst the variables that set apart a good partnership. How do fairness and relationship quality affect relational behaviors? This study aims to answer these questions for a channel setting that comprises the marketing firm and the retailers. Research data were gathered from four hundred Tekel shops, Turkish tobacco and liquor convenience shops by using face to face interviewing technique. Prior research mostly studied the effects of fairness on relational behaviors and on relationship quality dimensions. This study aims to explore the mediating role of relationship quality. Scales were developed from the existing literature, adopted for the research context, and tested for reliability and validity. Structural equation modeling was used to test the research data. The study establishes the mediating role of the relationship quality for the effect of fairness on relational behaviors.

Garlic mustard (Alliaria petiolata) is associated with an overall reduction in plant diversity, but is more likely to co-exist with native than alien species

ABSTRACTBackground: Alliaria petiolata (garlic mustard) is a widespread allelopathic invasive species in North America, but despite extensive research we do not fully understand how it impacts plant communities.Aims: We tested the hypothesis that A. petiolata facilitates the introduction of additional alien species as predicted by the invasional meltdown hypothesis.Methods: We conducted co-occurrence surveys to compare the numbers of alien and native species in communities surrounding A. petiolata plants with those surrounding an allelopathic native species. We also conducted an experiment to compare recruitment of native and alien species in pots dominated by either A. petiolata or a native species.Results: A. petiolata plots in the co-occurrence surveys had relatively high proportions of bare ground, suggesting habitat modification, plus lower species richness and disproportionately fewer alien species. There was a greater tendency for native species than alien species to establish in A. petiolata pots.Conclusions: A. petiolata does not promote additional alien species, and in fact may be a more effective competitor against alien than native species in North America. This could help explain its invasive success in disturbed habitats, and illustrates the need to consider separately alien and native species when assessing the outcomes of competition.

Novel mechanism of endocrine disruption by fungicides through binding to the membrane androgen receptor, ZIP9 (SLC39A9), and antagonizing rapid testosterone induction of the intrinsic apoptotic pathway

A variety of pesticides including vinclozolin, its metabolite M2 (3′,5′-dichloro-2-hydroxy-2-methylbut-3-enanilide), and prochloraz have been shown to exert antiandrogenic effects in animal models by competing with androgen binding to nuclear androgen receptors (nAR) and decreasing transcription of androgen-responsive genes. However, it is not known whether these pesticide antiandrogens also interfere with rapid (often described as nongenomic, nonclassical) androgen actions mediated by membrane androgen receptors (mARs). We recently discovered that ZIP9, a member of the zinc transporter ZIP (SLC39A) family, is a specific, high-affinity mAR that mediates rapid testosterone-dependent signaling, zinc influx, and apoptosis in breast and prostate cancer cell lines. Possible disruption by prochloraz, vinclozolin, and M2 of androgen actions through this mAR was investigated in vitro in PC-3 prostate cancer cells (nAR-) over expressing human ZIP9 (PC3-ZIP9 cells). Single-point competitive binding assays showed 1 μM and 10 μM concentrations of all three pesticides displaced specific [3H]-testosterone binding to PC3-ZIP9 cell membranes with binding affinities <10% that of testosterone. The pesticides also exerted antiandrogen actions through ZIP9. Co-treatments with 100 nM prochloraz, vinclozolin and M2 blocked or attenuated the 20 nM testosterone-induced increases in apoptosis, intracellular free zinc levels, and expression of the proapoptotic gene, Bax. Prochloraz also attenuated testosterone activation of MAPkinase. The finding that prochloraz, vinclozolin and M2 are effective competitors of [3H]-testosterone binding to ZIP9 and block testosterone actions mediated through ZIP9 in vitro at nanomolar concentrations suggests that androgen functions mediated by ZIP9 are also susceptible to disruption by pesticide antiandrogens with potential adverse effects on human health.

Social Media Monitoring: An Innovative Intelligent Approach

Digital marketers have a range of tools at their disposal for understanding customers and prospects on social media. These tools allow for better social media monitoring and analysis through the provision of vital insights. The use of artificial intelligence (AI) to such analysis enables for marketing tasks automation, accuracy improvement and human efforts reduction. In this respect, this paper proposes an AI-powered social media monitoring platform, which has been designed with an innovative approach, towards enabling digital marketers to better understand customers with intelligent insights in a manner like never before. The proposed platform helps by analyzing insights for effective online reputation management and competitors monitoring. In addition, this paper elaborates on contributions in respect to social media monitoring issues, mentions analysis uncovering knowledge, smarter insights and personalized advice to help in improving brands web and social presence, negative and positive conversations, competitors analysis ensuring brands are on top of the marketing game and social media strategy improvement.

Regulating for Telecommunications Competition in Developing Countries: The Case of Papua New Guinea

Papua New Guinea is a low-middle income developing Asia-Pacific island country with a relatively long history of telecommunications market development under firstly Australian administration, and latterly under a pro-competitive set of regulatory arrangements strongly influenced by Australian policy-making. Nevertheless, it demonstrates some of the weakest sector performance statistics of a range of comparable low-middle income countries in its region. Why does a country with a regulatory regime drawing on current international recommended “best practice” perform so poorly? To address this question, we develop an inquiry framework (checklist) for assessing the effectiveness of regulatory arrangements in a developing, as opposed to developed country. Whilst the framework is based on guidelines from the World Bank and the International Telecommunications Union (Blackman & Srivastava, 2011), we adapt these to take account of specific challenges arising in developing countries: limited capacity, limited commitment, limited accountability, limited fiscal efficiency and trade-offs between factors that take account of these limits (Laffont, 2005; Estache & Wren-Lewis, 2010). Applying the inquiry framework to Papua New Guinea, we find that, the most likely explanation for poor performance derives from the government being both regulator and owner of the incumbent, Telikom. Lack of investment and an unstable set of ownership arrangements have constrained Telikom from being an effective competitor. Weaknesses exist in the monitoring and enforcement of regulator accountability provisions, but are unlikely to have altered sector outcomes, although they may have contributed to obscuring poor performance. Introduction of at least one more foreign operator will be beneficial, but only if the government can clearly separate its ownership and regulatory activities and political agents can credibly commit to refraining from interfering in the operational activities of both the incumbent firm and regulatory agencies.

Effects of dissolved humic acid on fluoroquinolones sorption and retention to kaolinite

Fluoroquinolones (FQs) are widely used in human and veterinary medicaments, and as such are ubiquitous environmental contaminants. Dissolved organic matter (DOM) is widely distributed in natural water and sediment and dissolved humic acid (DHA) is a major component of DOM. The coexistence of DHA might influence the sorption, migration and transformation of FQs, thus determining their environmental fate. In this study, the interaction of DHA and ofloxacin (OFL)/flumequine (FLU) was evaluated using dialysis-bag assays. The sorption of OFL and FLU to kaolinite in the presence of DHA under different pH conditions was investigated. The results revealed that the binding affinities of FQs to DHA were weakened with increasing pH from 4.0 to 10.0 due to the increased negative charge of DHA and subsequent electrostatic repulsion. Sorption experiments indicated that co-precipitation was an important mechanism for OFL/FLU removal from the aqueous phase under acidic conditions. At pH 7.0, the affinity of OFL-DHA/FLU-DHA to kaolinite was weaker than that of OFL/FLU thus suppressed its sorption. At pH 9.5, the affinity of OFL-DHA to kaolinite was stronger than that of OFL and consequently promoted its sorption, but there was no observed effect of DHA on FLU sorption. During desorption, DHA could bind to OFL/FLU and promote its desorption from kaolinite at neutral pH. In binary solute systems of OFL and FLU, OFL was a more effective competitor for the sorption sites of kaolinite than FLU.

Functional tests of the competitive exclusion hypothesis for multituberculate extinction.

Multituberculate mammals thrived during the Mesozoic, but their diversity declined from the mid-late Paleocene onwards, becoming extinct in the late Eocene. The radiation of superficially similar, eutherian rodents has been linked to multituberculate extinction through competitive exclusion. However, characteristics providing rodents with a supposed competitive advantage are currently unknown and comparative functional tests between the two groups are lacking. Here, a multifaceted approach to craniomandibular biomechanics was taken to test the hypothesis that superior skull function made rodents more effective competitors. Digital models of the skulls of four extant rodents and the Upper Cretaceous multituberculate Kryptobaatar were constructed and used (i) in finite-element analysis to study feeding-induced stresses, (ii) to calculate metrics of bite force production and (iii) to determine mechanical resistances to bending and torsional forces. Rodents exhibit higher craniomandibular stresses and lower resistances to bending and torsion than the multituberculate, apparently refuting the competitive exclusion hypothesis. However, rodents optimize bite force production at the expense of higher skull stress and we argue that this is likely to have been more functionally and selectively important. Our results therefore provide the first functional lines of evidence for potential reasons behind the decline of multituberculates in the changing environments of the Paleogene.

Regulating for telecommunications competition in developing countries: Papua New Guinea

Papua New Guinea is a low‐middle income, developing, Pacific country whose telecommunications market has developed under regulatory arrangements strongly influenced by Australian policymaking. Nevertheless, it demonstrates very weak performance compared to similar low‐middle income countries. Why does a country whose regulatory regime draws on current international recommended ‘best practice’ perform so poorly? We develop an inquiry framework based on World Bank and the International Telecommunications Union guidelines for assessing the effectiveness of regulatory arrangements in a developing country. The framework takes account of developing country challenges: limited capacity, limited commitment, limited accountability, limited fiscal efficiency, and trade‐offs between factors that take account of these limits. The analysis indicates the most likely explanation for poor performance derives from lack of investment and an unstable set of ownership arrangements constraining government‐owned Telikom from being an effective competitor. Weaknesses in regulator accountability provisions may have contributed to obscuring poor performance. Introducing at least one more foreign operator will improve outcomes only with clear separation of government ownership and regulatory activities and credible commitment from political agents to refrain from interfering in operations of both the incumbent firm and regulatory agencies.

Soft but Strong: Software-Based Innovation, Product Market Competition, and Value Creation in the IT Hardware Industry

It has been argued in recent years that software is a significant value-creating factor within the manufacturing sector, leading to an increased interest in understanding the mechanisms by which firms may benefit from software-based innovation. Empirical work in evaluating these mechanisms remains under-developed however. In this paper, we examine one such process by which software-based innovation may provide value for information technology hardware firms in the U.S. Specifically, we examine the influence of software patents on the extent to which firms are able to benefit from product differentiation in their product markets. Using data on over 380,000 patent grants for innovations filed by 730 public IT hardware firms over the time-period 19962015, we find that greater levels of software-based innovation within the firm are associated with higher levels of product differentiation in product markets: increases in the intensity of software patents within the firm’s patent stock, which we refer to as software intensity, are associated with lower total similarity of product offerings relative to those offered by rivals as well as fewer effective competitors in the market. Furthermore, using a different dataset consisting of 23,000 new IT hardware product announcements, we show that firms with greater software intensity subsequently launch a higher number of new products. Moreover, these firms are more likely to launch products that are not only differentiated from those of rivals but also distinct from their own product lines. Our research contributes to the emerging literature on software-based innovation by substantiating an important mechanism by which software helps transform industry sectors, specifically through product differentiation.

The use of columns of the zeolite clinoptilolite in the remediation of aqueous nuclear waste streams

Mud Hills clinoptilolite has been used in an effluent treatment plant (SIXEP) at the Sellafield nuclear reprocessing site. This material has been used to remove 134/137Cs and 90Sr successfully from effluents for 3 decades. Samples of the zeolite have been tested in column experiments to determine their ability to remove radioactive Cs+ and Sr2+ ions under increasing concentrations of competing ions, Ca2+, Mg2+, Na+ and K+. These ions caused increased elution of Cs+ and Sr2+. Ca2+, Mg2+ and K+ were more effective competitors than Na+. For Na+, it was found that if concentration was reduced, then column performance recovered rapidly.

Improving the production of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cell cultures by inhibition of undesirable endocytosis.

Endocytic regulation serves a critical role in modulating the extracellular level of signaling molecules, such as bone morphogenetic proteins (BMPs). Unfortunately, endocytosis may result in poor yields of recombinant human BMP-4 (rhBMP-4) from Chinese hamster ovary (CHO) cell cultures. When rhBMP-4 was incubated with CHO cells, rhBMP-4 was actively internalized into cells. Cell surface bound heparan sulfate proteoglycans (HSPGs) served as the major receptors for rhBMP-4 internalization. Removal of cell surface heparan sulfate (HS) by heparinases or reduction of HSPG synthesis by knockdown of xylosyltransferase2 (xylt2) in CHO cells decreased internalization of rhBMP-4. In addition, treatment with endocytosis inhibitors (chlorpromazine, genistein, and dynasore) identified a clathrin- and dynamin-dependent endocytic pathway as the major route for rhBMP-4 internalization. To enhance product yield by minimizing rhBMP-4 internalization in recombinant CHO (rCHO) cell cultures, we have tested various strategies to reduce HSPG synthesis (knockdown of xylt2 and sodium chlorate treatment) or inhibit the binding of rhBMP-4 to cell-surface-bound HSPGs (supplementation with heparin or dextran sulfate [DS]). Among these approaches, DS, which is a linear anionic sulfated polysaccharide with similarity to HS chains, was the most effective in enhancing rhBMP-4 production in rCHO cell cultures. Compared with the control cultures, DS addition to the culture medium (1.0 g/L) resulted in 1.4-fold and 2.3-fold increases in maximum rhBMP-4 concentration in batch and fed-batch cultures, respectively. Taken together, the addition of DS, an effective competitor of HSPGs, improved rhBMP-4 production in rCHO cell cultures through blockage of rhBMP-4 internalization.

Bis(1,10-phenanthroline) copper complexes with tailored molecular architecture: from electrochemical features to application as redox mediators in dye-sensitized solar cells

In the last few years, copper coordination compounds turned out to be effective competitors of cobalt complexes as redox mediators in the formulation of iodine-free electrolytes for dye-sensitized solar cells (DSSCs). However, the lack of a clear correlation between electrochemical signatures of copper complexes (i.e. half-wave potential and heterogeneous electron transfer rate) and photoelectrochemical performance of solar devices makes difficult the optimization of their coordination sphere. Therefore, to partially fill this gap and to elucidate the intrinsic correlation between the molecular architecture of these complexes and their electrochemical features, we prepared four Cu+/2+ redox couples in which the copper center is coordinated by two 1,10-phenanthrolines bearing various substituents in position 2. These complexes were well characterized, from both electrochemical and spectroscopic point of view, and tested as electron shuttles in lab-scale photoelectrochemical cells sensitized with two efficient π-extended benzothiadiazole dyes. It appeared that 2-aryl-1,10-phenanthrolines effectively combine suitable optical and electrochemical properties. While a fast electron transfer kinetics generally positively affects the dye regeneration process, an optimal balance between dye regeneration efficiency, mass transport and heterogeneous electron transfer at both the counter electrode and at the TiO2 interface, must be achieved in order to optimize DSSC performance. Within our series, the top performer was [Cu(2-tolyl-1,10-phenanthroline)2]+/2+ which achieved a relative 20% and 15% improvement in power conversion efficiency (under 100 mW s−1 simulated AM 1.5G illumination) with respect to control cells filled with [Co(bpy)3]2+/3+ (bpy = 2,2′-bipyridine) and I−/I3− electrolytes, respectively.

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

Metal based therapeutics are a precious class of drugs in oncology research that include examples of theranostic drugs, which are active in both diagnostic, specifically imaging, and therapeutics applications. Ruthenium compounds have shown selective bioactivity and the ability to overcome the resistance that platinum-based therapeutics face, making them effective oncotherapeutic competitors in rational drug invention approaches. The development of antineoplastic ruthenium therapeutics is of particular interest because ruthenium containing complexes NAMI-A, KP1019, and KP1339 entered clinical trials and DW1/2 is in preclinical levels. The very robust, conformationally rigid organometallic Ru(II) compound DW1/2 is a protein kinase inhibitor and presents new Ru(II) compound designs as anticancer agents. Over the recent years, numerous strategies have been used to encapsulate Ru(II) derived compounds in a nanomaterial system, improving their targeting and delivery into neoplastic cells. A new photodynamic therapy based Ru(II) therapeutic, TLD-1433, has also entered clinical trials. Ru(II)-based compounds can also be photosensitizers for photodynamic therapy, which has proven to be an effective new, alternative, and noninvasive oncotherapy modality.

Nitrogen uptake pattern of herbaceous plants: coping strategies in altered neighbor species

The mechanisms for maintaining the species diversity of plant communities under conditions of resource limitation is an important subject in ecology. How interspecific relationships influence the pattern of nutrient absorption by coexisting species in N-limited ecosystems is still disputed. We investigated the effect of neighbor species on the uptake of inorganic and organic N by three common plant species using 15N tracer techniques in a semi-arid alpine steppe on the northern Tibet. The results showed that the plant species varied in their capacity to absorb NO3 −-N, NH4 +-N, and glycine-N with or without neighbor species. Carex moorcroftii and Leontopodium nanum showed much more plasticity in resource utilization than Stipa purpurea when neighbor species were present. When C. moorcroftii and S. purpurea coexisted, they all increased their 15N uptake for the NO3 −-N (C. moorcroftii 2.2-fold increase and S. purpurea 2.2-fold increase) and glycine-N treatments (C. moorcroftii 2.9-fold increase and S. purpurea 3.4-fold increase), which indicated that neighborhood had a positive effect for N absorption between the two species. However, L. nanum was a less effective competitor for N utilization than the neighbor species across almost all treatments. The dominant species appeared to have an inhibitory effect on N absorption by the accompanying species in this alpine steppe environment. Thus, interspecific neighbor pairs may result in both a mutually beneficial cooperative relationship and a competitive relationship among neighbors in resource use patterns in extreme environments. Resource use plasticity in altered neighbor species may be due to phenotypic plasticity based on the conditions of the realized niche, offering a valuable insight into niche complementarity and providing a general and important mechanism for resource partitioning in an alpine area.

Mogamulizumab for the treatment of T-cell lymphoma

ABSTRACTIntroduction: T-cell lymphoma is a relatively rare hematologic malignancy that accounts for 10–20% of non-Hodgkin lymphomas. Treatment strategies for T-cell lymphomas are different from that for B-cell lymphomas and have poor prognoses. Among various subtypes of T-cell lymphomas, adult T-cell leukemia-lymphoma (ATL) has the worst prognosis. To achieve further improvement in the treatment outcome of T-cell lymphomas, several novel agents such as brentuximab vedotin, lenalidomide, romidepsin, and pralatrexate are actively being studied. Mogamulizumab, an anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, is one of the promising agents for CCR4-positive T-cell lymphomas, especially for ATL.Areas covered: First, basic information about the current treatment strategy of T-cell lymphomas including ATL is described. Then, the authors discuss the current clinical development of mogamulizumab and its clinical implications for T-cell lymphomas.Expert opinion: Mogamulizumab has potent clinical efficacy against CCR4-positive T-cell lymphomas, especially against ATL. Among various toxicities associated with mogamulizumab, skin eruptions are the most significant. Although there are several effective competitors, mogamulizumab has a unique mechanism and is expected to be a key agent for treating CCR4-positive T-cell lymphomas, especially ATL.