Effects Of Vincamine Research Articles

Effects of Vincamine on Testicular Dysfunction in Alloxan-induced Diabetic Male Rats.

Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis. Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen's score. Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg group. It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis.

Фармакологическая коррекция винкамином системы антиоксидантной защиты в мозге в модели рассеянного склероза

Objective. In the course of the research, the effect of vincamine (nootropic drug) on neurological status, as well as the activity of antioxidant enzymes and the level of their coding genes’ expression in the somatosensory cortex of rats within the model of experimental allergic encephalomyelitis (EAE) were being studied. Relevance: the topicality of studying the mechanisms of multiple sclerosis in the early stages of its development is dictated by the need to search for markers of the disease and its therapy before the onset of its clinical manifestation. Materials and methods. The animals’ neurological status was studied using muscular strength, balance, tenacity and traction tests. Rates of survival and the rats’ body weight were also being evaluated. The study of activity antioxidant enzymes: superoxide dismutase (SOD), glutathione peroxidase (GPO), and glutathione reductase (GR), as well as the expression of SOD1, GPX4, GPX6, and GSR genes was conducted on the 14th and 30th day of immunization. Results. The percentage of vincamine-injected animals’ survival was 100% versus 87% among rats that were not injected with the nootropic drug during immunization (р<0,05) . Besides, after the injection of vincamine, a less significant decrease in body weight (р<0,01) and a less pronounced neurological deficit (р<0,05) in comparison with immunized non-injected animals were reported. The vincamine injection contributed to an increase in all studied antioxidant enzymes’ activity and the level of their genes’ expression in the somatosensory cortex. Conclusion. Against the background of vincamine injection, a minimization of neurological deficit is being observed, probably due to a decrease in oxidative stress in the rat brain during the clinical stage of experimental allergic encephalomyellitis.

Experimental, adsorption, quantum chemical and molecular dynamics simulation studies on the corrosion inhibition performance of Vincamine on J55 steel in acidic medium

The effect of Vincamine (VCA) as an inhibitor for the corrosion of J55 steel in 1 M HCl was examined utilizing gravimetric and electrochemical methods. Surface morphology was studied using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. The outcome showed that VCA hindered the dissolution of J55 steel in the acidic medium. From the gravimetric method, results showed that inhibition efficacy depended on the concentration of VCA and the temperature of the medium. Electrochemical impedance spectroscopy (EIS) studies revealed a rise in resistance of charge transfer, with a corresponding decline in the capacitance of double layer when there is a rise in the concentration of VCA. Polarization results indicated that VCA exhibited mixed-type corrosion inhibitor characteristics. The range of inhibition efficiencies obtained is; 79.4 to 90.2% for EIS studies, 76.0 to 91.4% for weight loss and 77.4 to 88.6% for polarization studies at 30 °C. SEM, FTIR, and AFM investigations established the adsorption of VCA on the surface of J55, thereby reducing the deterioration reaction. The adsorption of VCA on the surface of J55 steel followed the Freundlich adsorption isotherm. The adsorption characteristics were theoretically evaluated by quantum chemical studies and molecular dynamics (MD) simulation to relate the restraint capability of VCA with its electronic structural parameters.

Vincamine: A psychogeriatric agent blocking synaptic potentiation in hippocampus

The action of vincamine on the physiology of the CAl region of the in vitro hippocampal slice preparation was investigated. At concentrations of 1, 10 and 100 μM, a five-minute perfusion with vincamine did not affect the synaptically-mediated activation of pyramidal neurons evoked by stimulation of the Schaffer-commissural fiber system. The effect of vincamine on the excitability of the pyramidal neurons was investigated by studying its effect on the antidromically-elicited field potential and the input-output relation of Schaffer-commissural fiber input. No effect on either of the two parameters was seen at a concentration of 100 μM of vincamine. Vincamine did, however, attenuate both the post-tetanic (PTP) and long-term potentiation (LTP) evoked by repetitive stimulation of the Schaffer-commissural fiber system. At a concentration of 100 μM of vincamine, PTP was significantly reduced and LTP was almost completely suppressed.

The effect of vincamine, hydergine and piracetam on the firing rate of locus coeruleus neurons.

Vincamine, hydergine and piracetam are used for the treatment of memory disturbances as well as for the treatment of various other brain dysfunctions seen in the elderly patient. The action of these three psychogeriatric compounds on the activity of noradrenergic neurons in the rat locus coeruleus was investigated. All three compounds, when administered intraperitoneally, increased the firing rate of noradrenergic neurons in the chloral hydrate anaesthetized animals. Vincamine and hydergine had a similar potency producing a maximal mean increase of about 70% at a dose of 1 mg/kg. Likewise, piracetam was significantly less potent eliciting a 30 to 40% increase in firing at doses of 300 and 1000 mg/kg, respectively. A role for the locus coeruleus in processes related to attention, cortical and behavioral arousal, learning and memory has been proposed on the basis of behavioral and electrophysiological experiments. In the awake rat, the firing rate of noradrenergic neurons in this brain nucleus has previously been shown to relate directly to the level of vigilance. The activating action of vincamine, hydergine and piracetam on these neurons may be linked with some of the drugs' beneficial therapeutic effects.

The activating action of vincamine, piracetam, and hydergine on the activity of the noradrenergic neurons of the locus coeruleus

The effect of vincamine, hydergine, and piracetam on the discharge rate of noradrenergic neurons of the locus coeruleus (LC) was studied using conventional single-cell recording techniques. Experiments were performed on 103 male rats (RAI f (SPF)) anaesthetized with chloral hydrate. Intraperitoneally applied vincamine and hydergine affected LC-neuronal firing already at a dose of 0.1 mg/kg. Both compounds increased the mean discharge rate of LC neurons by about 70% at a dose of 1 mg/kg. Piracetam elicited a 30–40% increase in firing at doses of 300 and 1000 mg/kg ip, respectively. It is conceivable that the activating action of vincamine, piracetam, and hydergine on noradrenergic neurons of LC is linked with the therapeutic action of the drugs on cognitive function or mood.

The effect of vincamine on the regional cerebral blood flow in man.

The cerebral hemodynamic action of Vincamine is measured in 17 patients with primary or secondary cerebral circulation disorders, by use of the multiregional 133Xe clearance technique. The statistical analysis of the results justifies the grouping of all the cases and the distinction between reference, ischemic and hyperemic zones by determining for each subject a range of + or - 15% of his own mean regional cerebral blood flow. The drug, in a single injection in the internal carotid artery, shows a significant beneficial hemodynamic effect on the ischemic regions of the brain. No steal phenomenon is recorded in the middle cerebral artery territory. The action of the drug leads to a decrease and an equalization of the hemodynamic resistances of the cerebral vascular bed.