BackgroundAlthough bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses.ObjectiveWe aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection.Materials and methodsWe evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day.ResultsThe bursting pressures of Group II, Group III, and Group V were significantly higher than controls (P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups (P = 0.047).ConclusionsAlthough bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses.