Effect Of Sulfadiazine Research Articles

In Vitro Effects of Low Concentrations of Penicillin and Sulfadiazine on Streptococcus mutans

Investigations were conducted to determine the in vitro effects of low levels of penicillin and sulfadiazine on the growth, plaque formation, and agglutination of Streptococcus mutans and on the synthesis and activity of enzymes synthesizing extracellular polymers. The concentrations tested were equivalent to those expected in the saliva of subjects receiving oral therapy with the agents. Penicillin at 0.5 ng/ml and sulfadiazine at 1 mug/ml substantially inhibited in vitro plaque formation. At these concentrations, sulfadiazine but not penicillin also inhibited growth of the organism. Neither antimicrobial agent affected the agglutination of S. mutans with dextran or the synthesis or activity of enzymes synthesizing extracellular polymers. The effect of sulfadiazine on plaque formation was attributed, at least in part, to the inhibitory action of that agent on S. mutans growth.

Isolation, Propagation, Freeze Preservation and Studies of Drug Sensitivity of Toxoplasma Gondii in Human Tissue Culture

Toxoplasma gondii was isolated antemortum in human fibroblast cultures (Detroit-532) from buffy coat of peripheral blood, minced tissue, and ascitic fluid of both experimentally infected mice and human patient. Cytopathic changes were evident within 2–3 days in all cases. The subculture and passage of T. gondii in Det-532 cells were found consistently facile and reproducible. Infected cultures could be stored in the frozen state (liquid nitrogen) and reactivated. Using experimental infections of tissue cultured human cells, the effect of sulfadiazine at ranges from 250 mcg/cc-8,000 mcg/ml were evaluated with regards to parasite proliferation, host cell growth and survival. This study provides a new body of knowledge to which the effects of new therapeutic agents could be compared in the assay of their effectiveness. The hospital pharmacy has a deep responsibility to provide the leadership in the determination of the efficacy of new drugs. Studies such as ours are an integral part of this responsibility.

Prevention of rheumatic fever by treatment of previous streptococcic infections; effect of sulfadiazine.

• Patients receiving sulfadiazine for acute streptococcic pharyngitis were compared with patients receiving other therapy for the same condition. The sulfadiazine reduced the incidence of complications during the acute phase. After the first week, however, the incidence of suppurative complications was about the same in both groups. The streptococci were not eradicated. The subsequent incidence of recurrent pharyngitis in the sulfadiazine group was three times that in the contratest group, and the sulfadiazine did not prevent rheumatic fever.

Prothrombin in the newborn infant: VI. Effect of sulfadiazine on prothrombin of the newborn infant

Prothrombin in the newborn infant: VI. Effect of sulfadiazine on prothrombin of the newborn infant

Effect of sulfadiazine on survival of the mammalian embryo.

Effect of sulfadiazine on survival of the mammalian embryo.

Inhibition of the Antimalarial Activity of Chlorguanide by Pteroylglutamic Acid

SummaryThe antimalarial activity of chlorguanide against Plasmodium gallinaceum in the chick could be significantly but not completely inhibited by pteroylglutamic acid in vivo. Pteroylglutamic acid had no significant effect on the antimalarial activity of quinine, chloroquine or pamaquine, but completely inhibited the effect of sulfadiazine.

Effect of Sulfadiazine on Cholera *

Summary 1. In a cholera epidemic, 10 patients were given sulfadiazine in addition to saline infusions with 10 other patients without sulfadiazine treatment as control. 2. The average duration of diarrhea of the sulfadiazine-treated patients (4.6 days) is shorter than that of the controls (7.1 days). 3. One case of lobar pneumonia resulting in death and one case of parotitis occurred among the patients without sulfadiazine therapy. 4. Oral administration of fluid and alkalies in the treatment of cholera has been emphasized.

The effect of sulfadiazine, antitoxins, globulins, and dog plasma on dogs in traumatic shock under sodium pentobarbital anesthesia: Ricca, R. A., Fink, K., and Warren, S. L.: J. Clin. Investigation 24: 146, 1945

The effect of sulfadiazine, antitoxins, globulins, and dog plasma on dogs in traumatic shock under sodium pentobarbital anesthesia: Ricca, R. A., Fink, K., and Warren, S. L.: J. Clin. Investigation 24: 146, 1945

The Prophylactic Effect of Sulfadiazine and Sulfaguanidine against Mosquito-Borne Plasmodium gallinaceum Infection in the Domestic Fowl (Preliminary Report)

The Prophylactic Effect of Sulfadiazine and Sulfaguanidine against Mosquito-Borne Plasmodium gallinaceum Infection in the Domestic Fowl (Preliminary Report)

Comparative Study of Effect of Sulfadiazine and Sulfathiazole on Staphylococcus aureus.

ConclusionsSulfadiazine increases the bactericidal action of normal blood when added in vitro or when exhibited orally. Comparative tests show that sulfathiazole is somewhat superior to sulfadiazine in its effect on Staphylococcus aureus.