The present paper investigates experimentally effect of applied load and different velocity on the coefficient of friction between two interacting surfaces (human skin and Ultra-high-molecular-weight polyethylene (UHMW- polyethylene) at static and dynamic friction. It is possible to conclude specific point based on the above practical part and frictional analysis of this investigation as the most important mechanical phenomenon was creep has been observed a stick time interval where the static friction force is significantly increased during this stroke. The analytical model for stick-slip of skin and UHMWPE is proposed. The difference between static and kinetic friction defines the amplitude of stick-slip phenomena. The contact pressure, the sliding velocity, and rigidity of system determine the stability conditions of the movement between skin and UHMWPE. Experiments were carried out by developing a device (friction measurement). Variations of friction coefficient during the time at different normal load 4.6 and 9.2 N and low sliding velocity 4, 5, 6 and 7 mm/min were experimentally investigated. The results showed that the friction coefficient varied with the normal load and low sliding velocity. At static friction, the coefficient of friction decreased when the time increases, whereas, at dynamic friction, the coefficient of friction decreased when the time increased at normal load 4.6 and 9.2 N.