Effect Of Shenmai Injection Research Articles

Effects of shenmai and aminophylline on apoptosis of small airway smooth muscle cells and the expression of relevant genes in rats with emphysema.

The effects of Shenmai injection (SMI) and aminophylline on apoptosis of small airway smooth muscle cells (SASMC) and the Fas/FasL expression in rats with papain-induced emphysema were investigated. Rat emphysema model was established by a single intratracheal instillation of papain. Apoptosis and Fas/FasL expression of SASMC were detected by immunohistochemistry SABC and TUNEL assay at day 1, 3, 5, 7, 15, 30 after modeling, and the effect of SMI and aminophylline on them were observed. The results indicated that the Fas/FasL expression positive rate in SASMC was 2.31 +/- 0.55/1.28 +/- 0.47 respectively. After a single intratracheal instillation of papain, the expression of Fas/FasL positive rate in the placebo group was increased in a time-dependent manner. SMI could inhibit the expression of Fas/FasL, but aminophylline couldn't. The positive rate of apoptosis in the control group was 0.87 +/- 0.32. After a single intratracheal instillation of papain, the SASMC apoptosis positive rate in the placebo group was increased in a time-dependent manner. The SASMC apoptosis rate in all groups was declined after treatment with SMI, but the effect of aminophylline was not obvious. It was demonstrated that in the pathogenesis of emphysema Fas/FasL played an important role in the regulation of SASMC apoptosis. SMI influenced the expression of Fas/FasL and declined SASMC apoptosis by inhibiting the releasing of inflammatory media and played an important role in the therapy of emphysema.

Observation on effect of Shenmai injection in treating patients of congestive heart failurein treating patients of congestive heart failure

Objective: To observe the clinical therapeutic effect of Shenmai Injection (SMI) in treating patients of congestive heart failure.Methods: Effect of 16 cases treated with either SMI or potassium magnesium aspartate was observed by randomized crossover method and compared.Results: By using SMI for 2 weeks, the patients’ left ventricular ejective fraction (LVEF) was increased from 29.5 ± 9.0 to 36.6 ± 10.2 (P < 0.05), the heart function of 68.75% patients was improved, no side effect or toxicity was observed. Potassium magnesium aspartate improved the heart function in 37. 50% patients only but showed no effect on LVEF.Conclusion: SMI is an effective and safe drug in treating patients with congestive heart failure.

Effect of Shenmai injection on cardiac function and cellular immunity of patients with infantile viral myocarditis) on cardiac function and cellular immunity of patients with infantile viral myocarditis

Objective: To evaluate the clinical effect of Shenmai injection (SMI) on infantile viral myocarditis.Methods: Fifty patients were treated with SMI combined with routine Western medicines, the effects were observed and compared with those treated with Western medicines alone or compound Salviae liquid.Results: The cardiac function and cellular immunity of patients treated with SMI were significantly improved. The effect of SMI was superior to that of control groups.Conclusion: Using SMI as supplementary treatment in treating infantile viral myocarditis was helpful in recovery of cardiac function and cellular immunity.

Effect of Shenmai injection on immunologic function in stomach cancer patients after chemotherapy) on immunologic function in stomach cancer patients after chemotherapy

Sixty-three cases with stomach cancer were randomized into 2 groups and observed, the results showed that the count of T lymphocytes in chemotherapy combined with Shenmai injection (SMI) group increased, while in the control group it decreased, the difference being quite significant (P<0.05). The results also showed that the count of OKT1 cells and the OKT4/OKT8 ratio decreased after chemotherapy, but in SMI group both parameters increased in advance, which were higher in the 4th week after chemotherapy than that before chemotherapy. However in the meantime, the count of OKT1 cells and OKT4/OKT8 ratio of control group were still in low level. After chemotherapy the serum interleukin-2 receptor (sIL-2R) level also decreased (P<0.05), while activities of natural killer cell (NK) and lymphokine activated killer cell (LAK) level increased (P<0.05) in SMI group. But in the control group, although the sIL-2R level had no change, both NK and Lak level decreased significantly (P<0.05). In addition, the difference of IgA, IgM, IgG levels was not significant between these two groups. These results suggested that SMI might improve human immunologic function to facilitate the chemotherapy of patients with stomach cancer.

Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma

Serum interleukin-2 receptor (sIL-2R) level activities of natural killer cell (NK) and lymphokine activated killer cell (LAK) cells were determined in 60 patients with advanced carcinoma (AC) before and after treatment with Shenmai injection (SMI), 40 healthy persons were taken as non-carcinoma control (NC). The results showed that: Serum sIL-2R level in AC were much higher than those in NC (P < 0.05) and activities of NK and LAK cells in AC were much lower than those in NC (P < 0.05) before treatment. There was no significant difference among gastric cancer, colonic carcinoma and lung cancer (P < 0.05). After treatment with SMI we also found that the level of sIL-2R in all patients were obviously lower (P < 0.05) while the activity of NK and LAK cells were significantly higher than that prior treatment (P < 0.05). Linear correlation was not found between sIL-2R and NK, LAK cells. These data suggested that the immune function was compromised in AC. The mechanism of the inhibitory effect of SMI on carcinoma might be related to the activity of biological response modifier.